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Aliases for OR5L1 Gene

Aliases for OR5L1 Gene

  • Olfactory Receptor Family 5 Subfamily L Member 1 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor OR11-151 3 4
  • OST262 3 4
  • Olfactory Receptor, Family 5, Subfamily L, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 5, Subfamily L, Member 1 3
  • Olfactory Receptor 5L1 3
  • OR11-151 3

External Ids for OR5L1 Gene

Previous GeneCards Identifiers for OR5L1 Gene

  • GC11U990235
  • GC11P055355
  • GC11P055335
  • GC11P055579

Summaries for OR5L1 Gene

Entrez Gene Summary for OR5L1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR5L1 Gene

OR5L1 (Olfactory Receptor Family 5 Subfamily L Member 1 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5L2.

UniProtKB/Swiss-Prot for OR5L1 Gene

  • Odorant receptor.

Gene Wiki entry for OR5L1 Gene

Additional gene information for OR5L1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5L1 Gene

Genomics for OR5L1 Gene

GeneHancer (GH) Regulatory Elements for OR5L1 Gene

Top Transcription factor binding sites by QIAGEN in the OR5L1 gene promoter:
  • Chx10
  • CHOP-10
  • C/EBPalpha
  • AP-1
  • deltaCREB
  • CREB
  • Pax-4a
  • STAT3
  • AML1a
  • c-Ets-1

Genomic Locations for OR5L1 Gene

Genomic Locations for OR5L1 Gene
1,110 bases
Plus strand
1,099 bases
Plus strand

Genomic View for OR5L1 Gene

Genes around OR5L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5L1 Gene

Proteins for OR5L1 Gene

  • Protein details for OR5L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 5L1
    Protein Accession:
    Secondary Accessions:
    • B2RNK6
    • Q6IFD0

    Protein attributes for OR5L1 Gene

    311 amino acids
    Molecular mass:
    34559 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5L1 Gene

Post-translational modifications for OR5L1 Gene

  • Glycosylation at isoforms=195 and isoforms=5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5L1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5L1 Gene

Domains & Families for OR5L1 Gene

Gene Families for OR5L1 Gene

Protein Domains for OR5L1 Gene

Suggested Antigen Peptide Sequences for OR5L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5L1: view

Function for OR5L1 Gene

Molecular function for OR5L1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5L1: view
genes like me logo Genes that share phenotypes with OR5L1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5L1 Gene

Localization for OR5L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5L1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5L1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5L1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5L1 Gene

Pathways & Interactions for OR5L1 Gene

genes like me logo Genes that share pathways with OR5L1: view

Pathways by source for OR5L1 Gene

Interacting Proteins for OR5L1 Gene

Gene Ontology (GO) - Biological Process for OR5L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA,IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5L1: view

No data available for SIGNOR curated interactions for OR5L1 Gene

Drugs & Compounds for OR5L1 Gene

No Compound Related Data Available

Transcripts for OR5L1 Gene

mRNA/cDNA for OR5L1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR5L1 Gene

Olfactory receptor, family 5, subfamily L, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5L1 Gene

No ASD Table

Relevant External Links for OR5L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR5L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5L1 Gene

Protein differential expression in normal tissues from HIPED for OR5L1 Gene

This gene is overexpressed in Tlymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR5L1 Gene

Protein tissue co-expression partners for OR5L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5L1 Gene:


SOURCE GeneReport for Unigene cluster for OR5L1 Gene:

genes like me logo Genes that share expression patterns with OR5L1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5L1 Gene

Orthologs for OR5L1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466538 33
  • 99.14 (n)
(Canis familiaris)
Mammalia OR5L1 33
  • 83.82 (n)
(Mus musculus)
Mammalia Or5l14 51 Olfr1157 16 33
  • 80.39 (n)
Or5l13 51 Olfr1156
  • chr2:87,949,281-87,950,231
(Bos Taurus)
Mammalia OR5L1 33
  • 79.94 (n)
(Rattus norvegicus)
Mammalia LOC102555599 33
  • 79.42 (n)
Species where no ortholog for OR5L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5L1 Gene

Gene Tree for OR5L1 (if available)
Gene Tree for OR5L1 (if available)

Paralogs for OR5L1 Gene

Paralogs for OR5L1 Gene

(451) SIMAP similar genes for OR5L1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR5L1: view

Variants for OR5L1 Gene

Sequence variations from dbSNP and Humsavar for OR5L1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs193921144 uncertain-significance, Malignant tumor of prostate 55,811,960(+) G/T coding_sequence_variant, missense_variant
rs1001288327 -- 55,811,193(+) C/T upstream_transcript_variant
rs1001315815 -- 55,810,319(+) T/A upstream_transcript_variant
rs1001345117 -- 55,810,491(+) T/C upstream_transcript_variant
rs1002137211 -- 55,810,911(+) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR5L1 Gene

Variant ID Type Subtype PubMed ID
dgv1193n100 CNV loss 25217958
dgv1204n100 CNV loss 25217958
dgv1205n100 CNV gain 25217958
dgv12n64 CNV loss 17921354
dgv13n68 CNV loss 17160897
dgv150n27 CNV loss 19166990
dgv1905n54 CNV gain 21841781
dgv1941n54 CNV loss 21841781
dgv212e199 CNV deletion 23128226
dgv50e55 CNV loss 17911159
dgv51e55 CNV loss 17911159
esv22842 CNV gain+loss 19812545
esv2744537 CNV deletion 23290073
esv2751030 CNV gain 17911159
esv2756713 CNV loss 18971310
esv2759828 CNV gain+loss 17122850
esv2760216 CNV loss 21179565
esv3579771 CNV gain 25503493
esv3579782 CNV gain 25503493
esv3626453 CNV loss 21293372
esv3626454 CNV gain 21293372
nsv1044174 CNV loss 25217958
nsv428256 CNV loss 18775914
nsv437717 CNV loss 16327808
nsv469885 CNV loss 16826518
nsv469958 CNV loss 18288195
nsv517440 CNV gain+loss 19592680
nsv554801 CNV loss 21841781
nsv821668 CNV loss 15273396
nsv832158 CNV gain 17160897

Variation tolerance for OR5L1 Gene

Residual Variation Intolerance Score: 77.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.55; 77.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5L1 Gene

Disorders for OR5L1 Gene

Additional Disease Information for OR5L1

No disorders were found for OR5L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5L1 Gene

Publications for OR5L1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 3 58
  4. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I … Lancet D (BMC bioinformatics 2006) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for OR5L1 Gene

Sources for OR5L1 Gene

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