Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR5L1 Gene

Aliases for OR5L1 Gene

  • Olfactory Receptor Family 5 Subfamily L Member 1 2 3 5
  • OST262 2 3 4
  • Olfactory Receptor OR11-151 3 4
  • Olfactory Receptor 5L1 3 4
  • Olfactory Receptor, Family 5, Subfamily L, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor Family 5 Subfamily L Member 1 (Gene/Pseudogene) 2
  • OR11-151 3
  • OR5L1 5

External Ids for OR5L1 Gene

Previous GeneCards Identifiers for OR5L1 Gene

  • GC11U990235
  • GC11P055355
  • GC11P055335
  • GC11P055579

Summaries for OR5L1 Gene

Entrez Gene Summary for OR5L1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR5L1 Gene

OR5L1 (Olfactory Receptor Family 5 Subfamily L Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR5L2.

UniProtKB/Swiss-Prot Summary for OR5L1 Gene

Gene Wiki entry for OR5L1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR5L1 Gene

Genomics for OR5L1 Gene

GeneHancer (GH) Regulatory Elements Pubs


Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR5L1

Top Transcription factor binding sites by QIAGEN in the OR5L1 gene promoter:
  • AML1a
  • AP-1
  • c-Ets-1
  • C/EBPalpha
  • CHOP-10
  • Chx10
  • CREB
  • deltaCREB
  • Pax-4a
  • STAT3

Genomic Locations for OR5L1 Gene

Latest Assembly
chr11:55,811,367-55,812,476
(GRCh38/hg38)
Size:
1,110 bases
Orientation:
Plus strand

Previous Assembly
chr11:55,578,843-55,579,952
(GRCh37/hg19 by Entrez Gene)
Size:
1,110 bases
Orientation:
Plus strand

Genomic View for OR5L1 Gene

Genes around OR5L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5L1 Gene

Proteins for OR5L1 Gene

  • Protein details for OR5L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGL2-OR5L1_HUMAN
    Recommended name:
    Olfactory receptor 5L1
    Protein Accession:
    Q8NGL2
    Secondary Accessions:
    • B2RNK6
    • Q6IFD0

    Protein attributes for OR5L1 Gene

    Size:
    311 amino acids
    Molecular mass:
    34559 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5L1 Gene

Post-translational modifications for OR5L1 Gene

  • Glycosylation at Asn5 and Asn195
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5L1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5L1 Gene

Domains & Families for OR5L1 Gene

Gene Families for OR5L1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5L1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR5L1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-151 (OR5L1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGL2

UniProtKB/Swiss-Prot:

OR5L1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5L1: view

Function for OR5L1 Gene

Molecular function for OR5L1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR5L1: view

Phenotypes for OR5L1 Gene

genes like me logo Genes that share phenotypes with OR5L1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5L1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5L1 Gene

Localization for OR5L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5L1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5L1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5L1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5L1 Gene

Pathways & Interactions for OR5L1 Gene

genes like me logo Genes that share pathways with OR5L1: view

Pathways by source for OR5L1 Gene

Interacting Proteins for OR5L1 Gene

Gene Ontology (GO) - Biological Process for OR5L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IBA 21873635
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5L1: view

No data available for SIGNOR curated interactions for OR5L1 Gene

Drugs & Compounds for OR5L1 Gene

No Compound Related Data Available

Transcripts for OR5L1 Gene

mRNA/cDNA for OR5L1 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5L1

Alternative Splicing Database (ASD) splice patterns (SP) for OR5L1 Gene

No ASD Table

Relevant External Links for OR5L1 Gene

GeneLoc Exon Structure for
OR5L1

Expression for OR5L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR5L1 Gene

Protein differential expression in normal tissues from HIPED for OR5L1 Gene

This gene is overexpressed in Tlymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR5L1 Gene



Protein tissue co-expression partners for OR5L1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR5L1

SOURCE GeneReport for Unigene cluster for OR5L1 Gene:

Hs.553623
genes like me logo Genes that share expression patterns with OR5L1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5L1 Gene

Orthologs for OR5L1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5L1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466538 29
  • 99.14 (n)
Dog
(Canis familiaris)
Mammalia OR5L1 29
  • 83.82 (n)
Mouse
(Mus musculus)
Mammalia Or5l14 45 Olfr1157 29 16
  • 80.39 (n)
Or5l13 45 Olfr1156
  • chr2:87,949,281-87,950,231
Cow
(Bos Taurus)
Mammalia OR5L1 29
  • 79.94 (n)
Rat
(Rattus norvegicus)
Mammalia LOC102555599 29
  • 79.42 (n)
Species where no ortholog for OR5L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR5L1 Gene

ENSEMBL:
Gene Tree for OR5L1 (if available)
TreeFam:
Gene Tree for OR5L1 (if available)
Alliance of Genome Resources:
Additional Orthologs for OR5L1

Paralogs for OR5L1 Gene

(451) SIMAP similar genes for OR5L1 Gene using alignment to 1 proteins:

  • OR5L1_HUMAN
genes like me logo Genes that share paralogs with OR5L1: view

Variants for OR5L1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR5L1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs193921144 Uncertain Significance: Malignant tumor of prostate 55,811,960(+) G/T
NM_001004738.2(OR5L1):c.494G>T (p.Arg165Met)
MISSENSE
rs12790505 -- p.Ser287Pro
rs2869020 -- p.Ile46Phe
rs34961497 -- p.Arg54Trp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR5L1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR5L1 Gene

Variant ID Type Subtype PubMed ID
dgv1193n100 CNV loss 25217958
dgv1204n100 CNV loss 25217958
dgv1205n100 CNV gain 25217958
dgv12n64 CNV loss 17921354
dgv13n68 CNV loss 17160897
dgv150n27 CNV loss 19166990
dgv1905n54 CNV gain 21841781
dgv1941n54 CNV loss 21841781
dgv212e199 CNV deletion 23128226
dgv50e55 CNV loss 17911159
dgv51e55 CNV loss 17911159
esv22842 CNV gain+loss 19812545
esv2744537 CNV deletion 23290073
esv2751030 CNV gain 17911159
esv2756713 CNV loss 18971310
esv2759828 CNV gain+loss 17122850
esv2760216 CNV loss 21179565
esv3579771 CNV gain 25503493
esv3579782 CNV gain 25503493
esv3626453 CNV loss 21293372
esv3626454 CNV gain 21293372
nsv1044174 CNV loss 25217958
nsv428256 CNV loss 18775914
nsv437717 CNV loss 16327808
nsv469885 CNV loss 16826518
nsv469958 CNV loss 18288195
nsv517440 CNV gain+loss 19592680
nsv554801 CNV loss 21841781
nsv821668 CNV loss 15273396
nsv832158 CNV gain 17160897

Variation tolerance for OR5L1 Gene

Residual Variation Intolerance Score: 77.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.55; 77.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5L1
Leiden Open Variation Database (LOVD)
OR5L1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5L1 Gene

Disorders for OR5L1 Gene

Additional Disease Information for OR5L1

No disorders were found for OR5L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5L1 Gene

Publications for OR5L1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I … Lancet D (BMC bioinformatics 2006) 3

Products for OR5L1 Gene

Sources for OR5L1 Gene