Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR5K4 Gene

Aliases for OR5K4 Gene

  • Olfactory Receptor Family 5 Subfamily K Member 4 2 3 5
  • Olfactory Receptor 5K4 3 4
  • Olfactory Receptor, Family 5, Subfamily K, Member 4 2
  • OR5K4 5

External Ids for OR5K4 Gene

Previous GeneCards Identifiers for OR5K4 Gene

  • GC03U900519
  • GC03P099556
  • GC03P098072

Summaries for OR5K4 Gene

Entrez Gene Summary for OR5K4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5K4 Gene

OR5K4 (Olfactory Receptor Family 5 Subfamily K Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR5K3.

UniProtKB/Swiss-Prot Summary for OR5K4 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR5K4 Gene

Genomics for OR5K4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR5K4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J098324 Enhancer 1 FANTOM5 ENCODE dbSUPER 11.9 -27.5 -27529 2.9 POLR2A IRF4 YY1 BATF ELF1 TAF1 ATF2 JUNB ZNF644 MNT HSALNG0027482 lnc-CLDND1-3 piR-30791-067 OR5K4 OR5H2 ENSG00000251088
GH03J098038 Promoter/Enhancer 1.2 ENCODE CraniofacialAtlas 10.1 -314.5 -314452 0.9 ZNF207 ZNF654 BRCA1 CTCF CEBPB REST KLF11 TRIM22 HOMEZ SIN3A OR5K4 CRYBG3 GABRR3 OR5BM1P OR5AC2
GH03J098329 Enhancer 0.8 ENCODE dbSUPER 11.9 -24.2 -24172 0.2 ZNF654 REST TRIM22 CTCF FOXA2 RAD21 SMC3 FOXA1 FOXK2 ZNF384 piR-30791-067 OR5K4 OR5H2 ENSG00000251088
GH03J098512 Enhancer 0.9 Ensembl ENCODE dbSUPER 10.1 +159.4 159379 2.3 POLR2A ZNF10 CEBPB FEZF1 EP300 PRDM6 JUND REST SP7 FOS CPOX OR5K4 OR5K2 HSALNG0027487 CLDND1
GH03J098511 Enhancer 0.4 Ensembl dbSUPER 9.8 +157.8 157847 0.2 SP7 OR5K4 CPOX OR5K2 HSALNG0027487 CLDND1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR5K4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR5K4

Top Transcription factor binding sites by QIAGEN in the OR5K4 gene promoter:
  • AML1a
  • GATA-1
  • HNF-3beta
  • HTF
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c

Genomic Locations for OR5K4 Gene

Latest Assembly
chr3:98,353,854-98,354,819
(GRCh38/hg38)
Size:
966 bases
Orientation:
Plus strand

Previous Assembly
chr3:98,072,698-98,073,663
(GRCh37/hg19 by Entrez Gene)
Size:
966 bases
Orientation:
Plus strand

chr3:98,072,698-98,073,663
(GRCh37/hg19 by Ensembl)
Size:
966 bases
Orientation:
Plus strand

Genomic View for OR5K4 Gene

Genes around OR5K4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5K4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5K4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5K4 Gene

Proteins for OR5K4 Gene

  • Protein details for OR5K4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMS3-OR5K4_HUMAN
    Recommended name:
    Olfactory receptor 5K4
    Protein Accession:
    A6NMS3

    Protein attributes for OR5K4 Gene

    Size:
    321 amino acids
    Molecular mass:
    36711 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5K4 Gene

Post-translational modifications for OR5K4 Gene

  • Glycosylation at Asn5

Other Protein References for OR5K4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5K4 Gene

Domains & Families for OR5K4 Gene

Gene Families for OR5K4 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5K4 Gene

Suggested Antigen Peptide Sequences for OR5K4 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 5K4 (OR5K4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NMS3

UniProtKB/Swiss-Prot:

OR5K4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5K4: view

Function for OR5K4 Gene

Molecular function for OR5K4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR5K4 Gene

Gene Ontology (GO) - Molecular Function for OR5K4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR5K4: view
genes like me logo Genes that share phenotypes with OR5K4: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5K4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5K4 Gene

Localization for OR5K4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5K4 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5K4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5K4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5K4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5K4 Gene

Pathways & Interactions for OR5K4 Gene

genes like me logo Genes that share pathways with OR5K4: view

Pathways by source for OR5K4 Gene

Interacting Proteins for OR5K4 Gene

Gene Ontology (GO) - Biological Process for OR5K4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5K4: view

No data available for SIGNOR curated interactions for OR5K4 Gene

Drugs & Compounds for OR5K4 Gene

No Compound Related Data Available

Transcripts for OR5K4 Gene

mRNA/cDNA for OR5K4 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5K4

Alternative Splicing Database (ASD) splice patterns (SP) for OR5K4 Gene

No ASD Table

Relevant External Links for OR5K4 Gene

GeneLoc Exon Structure for
OR5K4

Expression for OR5K4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR5K4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR5K4

SOURCE GeneReport for Unigene cluster for OR5K4 Gene:

Hs.554710
genes like me logo Genes that share expression patterns with OR5K4: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5K4 Gene

Orthologs for OR5K4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5K4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC738524 29
  • 97.36 (n)
Cow
(Bos Taurus)
Mammalia OR5K4 29
  • 83.11 (n)
Dog
(Canis familiaris)
Mammalia OR5K4 30
  • 83 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Or5k16 45 Olfr180 29 16 30
  • 82.9 (n)
OneToMany
Or5k17 45 Olfr181 30
  • 78 (a)
OneToMany
Or5k15 45 Olfr178 30
  • 75 (a)
OneToMany
Or5k8 45 Olfr175
  • chr16:58,823,784-58,824,707
Rat
(Rattus norvegicus)
Mammalia Olr1559 29
  • 82.49 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 68 (a)
ManyToMany
-- 30
  • 67 (a)
ManyToMany
-- 30
  • 67 (a)
ManyToMany
Species where no ortholog for OR5K4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR5K4 Gene

ENSEMBL:
Gene Tree for OR5K4 (if available)
TreeFam:
Gene Tree for OR5K4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR5K4: view image
Alliance of Genome Resources:
Additional Orthologs for OR5K4

Paralogs for OR5K4 Gene

(450) SIMAP similar genes for OR5K4 Gene using alignment to 1 proteins:

  • OR5K4_HUMAN
genes like me logo Genes that share paralogs with OR5K4: view

Variants for OR5K4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR5K4 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs9822460 -- p.Ile206Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR5K4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR5K4 Gene

Variant ID Type Subtype PubMed ID
nsv1000834 CNV gain 25217958
nsv1013060 CNV gain 25217958

Variation tolerance for OR5K4 Gene

Residual Variation Intolerance Score: 97.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.44; 95.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5K4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5K4
Leiden Open Variation Database (LOVD)
OR5K4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5K4 Gene

Disorders for OR5K4 Gene

Additional Disease Information for OR5K4

No disorders were found for OR5K4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5K4 Gene

Publications for OR5K4 Gene

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  2. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4

Products for OR5K4 Gene

Sources for OR5K4 Gene