Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR5K3 Gene

Aliases for OR5K3 Gene

  • Olfactory Receptor Family 5 Subfamily K Member 3 2 3 5
  • Olfactory Receptor 5K3 3 4
  • Olfactory Receptor, Family 5, Subfamily K, Member 3 2
  • OR5K3 5

External Ids for OR5K3 Gene

Previous GeneCards Identifiers for OR5K3 Gene

  • GC03U900518
  • GC03P099592
  • GC03P098110

Summaries for OR5K3 Gene

Entrez Gene Summary for OR5K3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5K3 Gene

OR5K3 (Olfactory Receptor Family 5 Subfamily K Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR5K4.

UniProtKB/Swiss-Prot Summary for OR5K3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR5K3 Gene

Genomics for OR5K3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR5K3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J097981 Enhancer 0.9 FANTOM5 Ensembl ENCODE 3.8 -407.7 -407690 3 FOXA2 RXRA RARA JUND BCL6 BATF HNF4A SP1 ATF3 ARL6 RIOX2 OR5K3 OR5AC2 ENSG00000285614 HSALNG0027470 GABRR3
GH03J098644 Enhancer 0.6 FANTOM5 Ensembl 5.1 +254.2 254235 1.4 MNT SPI1 ST3GAL6-AS1 CPOX OR5K3 OR5K2 COL8A1 ST3GAL6 WWP1P1 RPL19P7
GH03J098445 Enhancer 0.8 Ensembl ENCODE 0.2 +55.4 55356 1.4 POLR2A BCL11A IRF4 TAF1 BATF IKZF1 BMI1 ATF2 PKNOX1 TARDBP RF00994-664 lnc-OR5K1-1 OR5K1 OR5K3 ENSG00000251088
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR5K3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR5K3

Top Transcription factor binding sites by QIAGEN in the OR5K3 gene promoter:
  • aMEF-2
  • AML1a
  • C/EBPalpha
  • CHOP-10
  • Lhx3a
  • LHX3b
  • MEF-2A
  • MZF-1
  • POU2F1
  • POU2F1a

Genomic Locations for OR5K3 Gene

Latest Assembly
chr3:98,390,666-98,391,631
(GRCh38/hg38)
Size:
966 bases
Orientation:
Plus strand

Previous Assembly
chr3:98,109,510-98,110,475
(GRCh37/hg19 by Entrez Gene)
Size:
966 bases
Orientation:
Plus strand

chr3:98,109,510-98,110,475
(GRCh37/hg19 by Ensembl)
Size:
966 bases
Orientation:
Plus strand

Genomic View for OR5K3 Gene

Genes around OR5K3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5K3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5K3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5K3 Gene

Proteins for OR5K3 Gene

  • Protein details for OR5K3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NET4-OR5K3_HUMAN
    Recommended name:
    Olfactory receptor 5K3
    Protein Accession:
    A6NET4

    Protein attributes for OR5K3 Gene

    Size:
    321 amino acids
    Molecular mass:
    36711 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5K3 Gene

Post-translational modifications for OR5K3 Gene

  • Glycosylation at Asn5

Other Protein References for OR5K3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5K3 Gene

Domains & Families for OR5K3 Gene

Gene Families for OR5K3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5K3 Gene

Suggested Antigen Peptide Sequences for OR5K3 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 5K3 (OR5K3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NET4

UniProtKB/Swiss-Prot:

OR5K3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5K3: view

Function for OR5K3 Gene

Molecular function for OR5K3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR5K3: view
genes like me logo Genes that share phenotypes with OR5K3: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5K3

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5K3 Gene

Localization for OR5K3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5K3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5K3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5K3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5K3 Gene

Pathways & Interactions for OR5K3 Gene

genes like me logo Genes that share pathways with OR5K3: view

Pathways by source for OR5K3 Gene

Interacting Proteins for OR5K3 Gene

Gene Ontology (GO) - Biological Process for OR5K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5K3: view

No data available for SIGNOR curated interactions for OR5K3 Gene

Drugs & Compounds for OR5K3 Gene

No Compound Related Data Available

Transcripts for OR5K3 Gene

mRNA/cDNA for OR5K3 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5K3

Alternative Splicing Database (ASD) splice patterns (SP) for OR5K3 Gene

No ASD Table

Relevant External Links for OR5K3 Gene

GeneLoc Exon Structure for
OR5K3

Expression for OR5K3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR5K3 Gene

Protein differential expression in normal tissues from HIPED for OR5K3 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR5K3 Gene



Protein tissue co-expression partners for OR5K3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR5K3

SOURCE GeneReport for Unigene cluster for OR5K3 Gene:

Hs.554709
genes like me logo Genes that share expression patterns with OR5K3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5K3 Gene

Orthologs for OR5K3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5K3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC100609927 29
  • 98.44 (n)
OR5K3 30
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC785848 29
  • 84.04 (n)
-- 30
  • 79 (a)
OneToMany
-- 30
  • 76 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Olr1542 29
  • 83.5 (n)
Dog
(Canis familiaris)
Mammalia LOC100685267 29
  • 83.17 (n)
-- 30
  • 77 (a)
OneToMany
-- 30
  • 76 (a)
OneToMany
-- 30
  • 76 (a)
OneToMany
-- 30
  • 76 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Or5k3 45 Olfr195 29 16 30
  • 82.6 (n)
OneToMany
Or5k14 45 Olfr177 30
  • 79 (a)
OneToMany
Olfr175-ps1 30
  • 76 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 70 (a)
ManyToMany
-- 30
  • 67 (a)
ManyToMany
-- 30
  • 67 (a)
ManyToMany
Species where no ortholog for OR5K3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR5K3 Gene

ENSEMBL:
Gene Tree for OR5K3 (if available)
TreeFam:
Gene Tree for OR5K3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR5K3: view image
Alliance of Genome Resources:
Additional Orthologs for OR5K3

Paralogs for OR5K3 Gene

(435) SIMAP similar genes for OR5K3 Gene using alignment to 1 proteins:

  • OR5K3_HUMAN
genes like me logo Genes that share paralogs with OR5K3: view

Variants for OR5K3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR5K3 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs13068323 -- p.Gly44Asp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR5K3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR5K3 Gene

Variant ID Type Subtype PubMed ID
dgv293n21 CNV loss 19592680
nsv1013060 CNV gain 25217958
nsv1160965 CNV deletion 26073780
nsv834774 CNV loss 17160897

Variation tolerance for OR5K3 Gene

Residual Variation Intolerance Score: 86.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.21; 96.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5K3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5K3
Leiden Open Variation Database (LOVD)
OR5K3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5K3 Gene

Disorders for OR5K3 Gene

Additional Disease Information for OR5K3

No disorders were found for OR5K3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5K3 Gene

Publications for OR5K3 Gene

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  2. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4

Products for OR5K3 Gene

Sources for OR5K3 Gene