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Aliases for OR5K2 Gene

Aliases for OR5K2 Gene

  • Olfactory Receptor Family 5 Subfamily K Member 2 2 3 5
  • Olfactory Receptor OR3-9 3 4
  • Olfactory Receptor, Family 5, Subfamily K, Member 2 2
  • Olfactory Receptor 5K2 3
  • OR3-9 3

External Ids for OR5K2 Gene

Previous GeneCards Identifiers for OR5K2 Gene

  • GC03U990188
  • GC03P099538
  • GC03P099699
  • GC03P098216

Summaries for OR5K2 Gene

Entrez Gene Summary for OR5K2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5K2 Gene

OR5K2 (Olfactory Receptor Family 5 Subfamily K Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5K1.

UniProtKB/Swiss-Prot for OR5K2 Gene

  • Odorant receptor.

Gene Wiki entry for OR5K2 Gene

Additional gene information for OR5K2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5K2 Gene

Genomics for OR5K2 Gene

GeneHancer (GH) Regulatory Elements for OR5K2 Gene

Promoters and enhancers for OR5K2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J098521 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 15.5 +24.9 24878 2.4 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 YBX1 ZBTB7B YY1 CLDND1 ENSG00000248839 OR5K2 CPOX
GH03J098731 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.9 +235.5 235450 3.1 HDGF FOXA2 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF213 ATF7 RUNX3 ST3GAL6-AS1 ST3GAL6 OR5K2 DCBLD2 GC03P098755
GH03J098560 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +67.3 67345 8.4 HDGF PKNOX1 SMAD1 RB1 STAT5A BMI1 FEZF1 BATF KLF5 IRF4 CPOX OR5K2 ST3GAL6-AS1 ST3GAL6 GPR15 CLDND1 GC03M098547
GH03J098574 Enhancer 1.1 ENCODE dbSUPER 10.7 +77.6 77639 0.8 ELF3 FOXA2 MLX ARID4B RAD21 RARA YY1 SLC30A9 ZNF614 CREM OR5K2 ST3GAL6-AS1 CPOX GC03M098547
GH03J098535 Promoter/Enhancer 1.8 EPDnew FANTOM5 ENCODE dbSUPER 5.2 +41.0 41048 5.3 PKNOX1 ATF1 SMAD1 RB1 STAT5A BMI1 BATF KLF5 IRF4 CHAMP1 CLDND1 GPR15 ST3GAL6-AS1 OR5K2 OR5K4 CPOX ST3GAL6 GC03M098547
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR5K2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR5K2 gene promoter:
  • Nkx2-2
  • AML1a
  • MEF-2A
  • aMEF-2
  • TGIF
  • PPAR-gamma1
  • PPAR-gamma2
  • PPAR-alpha
  • TBP
  • Cdc5

Genomic Locations for OR5K2 Gene

Genomic Locations for OR5K2 Gene
1,060 bases
Plus strand
1,049 bases
Plus strand

Genomic View for OR5K2 Gene

Genes around OR5K2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5K2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5K2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5K2 Gene

Proteins for OR5K2 Gene

  • Protein details for OR5K2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 5K2
    Protein Accession:
    Secondary Accessions:
    • B2RN70
    • Q6IF47

    Protein attributes for OR5K2 Gene

    316 amino acids
    Molecular mass:
    35763 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5K2 Gene

Post-translational modifications for OR5K2 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5K2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5K2 Gene

Domains & Families for OR5K2 Gene

Gene Families for OR5K2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5K2 Gene

Suggested Antigen Peptide Sequences for OR5K2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5K2: view

Function for OR5K2 Gene

Molecular function for OR5K2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5K2: view
genes like me logo Genes that share phenotypes with OR5K2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5K2 Gene

Localization for OR5K2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5K2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5K2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5K2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5K2 Gene

Pathways & Interactions for OR5K2 Gene

genes like me logo Genes that share pathways with OR5K2: view

Pathways by source for OR5K2 Gene

Interacting Proteins for OR5K2 Gene

Gene Ontology (GO) - Biological Process for OR5K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA,IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5K2: view

No data available for SIGNOR curated interactions for OR5K2 Gene

Drugs & Compounds for OR5K2 Gene

No Compound Related Data Available

Transcripts for OR5K2 Gene

mRNA/cDNA for OR5K2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR5K2 Gene

Olfactory receptor, family 5, subfamily K, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5K2 Gene

No ASD Table

Relevant External Links for OR5K2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR5K2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5K2 Gene

mRNA expression in normal human tissues for OR5K2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5K2 Gene:


SOURCE GeneReport for Unigene cluster for OR5K2 Gene:

genes like me logo Genes that share expression patterns with OR5K2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5K2 Gene

Orthologs for OR5K2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5K2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 34
  • 82 (a)
(Canis familiaris)
Mammalia -- 34
  • 81 (a)
(Mus musculus)
Mammalia Olfr173 34
  • 79 (a)
Olfr177 16 33
  • 76.76 (n)
(Rattus norvegicus)
Mammalia Olr1563 33
  • 76.87 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 68 (a)
-- 34
  • 67 (a)
-- 34
  • 65 (a)
Species where no ortholog for OR5K2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5K2 Gene

Gene Tree for OR5K2 (if available)
Gene Tree for OR5K2 (if available)
Evolutionary constrained regions (ECRs) for OR5K2: view image

Paralogs for OR5K2 Gene

Paralogs for OR5K2 Gene

(447) SIMAP similar genes for OR5K2 Gene using alignment to 1 proteins:

  • OR5K2_HUMAN Pseudogenes for OR5K2 Gene

genes like me logo Genes that share paralogs with OR5K2: view

Variants for OR5K2 Gene

Sequence variations from dbSNP and Humsavar for OR5K2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000903604 -- 98,496,216(+) TTTT/TTT upstream_transcript_variant
rs1001106577 -- 98,498,998(+) C/T downstream_transcript_variant
rs1003060929 -- 98,496,489(+) G/A upstream_transcript_variant
rs1003113358 -- 98,496,361(+) T/A/C upstream_transcript_variant
rs1005356522 -- 98,496,725(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR5K2 Gene

Variant ID Type Subtype PubMed ID
dgv293n21 CNV loss 19592680
nsv591065 CNV gain 21841781
nsv834774 CNV loss 17160897
nsv834775 CNV gain 17160897
nsv979861 CNV duplication 23825009

Variation tolerance for OR5K2 Gene

Residual Variation Intolerance Score: 52.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.59; 65.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5K2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5K2 Gene

Disorders for OR5K2 Gene

Additional Disease Information for OR5K2

No disorders were found for OR5K2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5K2 Gene

Publications for OR5K2 Gene

  1. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 3 4 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR5K2 Gene

Sources for OR5K2 Gene

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