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Aliases for OR5K1 Gene

Aliases for OR5K1 Gene

  • Olfactory Receptor Family 5 Subfamily K Member 1 2 3 5
  • Olfactory Receptor OR3-8 3 4
  • HTPCRX10 3 4
  • Olfactory Receptor, Family 5, Subfamily K, Member 1 2
  • Olfactory Receptor 5K1 3
  • HSHTPCRX10 3
  • OR3-8 3

External Ids for OR5K1 Gene

Previous GeneCards Identifiers for OR5K1 Gene

  • GC03U990132
  • GC03P099509
  • GC03P099127
  • GC03P099671
  • GC03P098188

Summaries for OR5K1 Gene

Entrez Gene Summary for OR5K1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5K1 Gene

OR5K1 (Olfactory Receptor Family 5 Subfamily K Member 1) is a Protein Coding gene. Diseases associated with OR5K1 include Ichthyosis, Congenital, Autosomal Recessive 11. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5K2.

UniProtKB/Swiss-Prot for OR5K1 Gene

  • Odorant receptor.

Gene Wiki entry for OR5K1 Gene

Additional gene information for OR5K1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5K1 Gene

Genomics for OR5K1 Gene

GeneHancer (GH) Regulatory Elements for OR5K1 Gene

Promoters and enhancers for OR5K1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J098445 Enhancer 0.7 ENCODE 0.4 -17.2 -17179 1.4 PKNOX1 BMI1 BATF IRF4 RELA POLR2A SCRT2 EED IKZF2 RUNX3 UBFD1P1 OR5K1 ENSG00000251088
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR5K1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR5K1 gene promoter:
  • AML1a
  • SRF (504 AA)
  • SRF
  • Zic3
  • AREB6
  • Pbx1a
  • PPAR-gamma2
  • PPAR-gamma1
  • MEF-2A
  • aMEF-2

Genomic Locations for OR5K1 Gene

Genomic Locations for OR5K1 Gene
chr3:98,463,201-98,472,924
(GRCh38/hg38)
Size:
9,724 bases
Orientation:
Plus strand
chr3:98,188,324-98,189,420
(GRCh37/hg19)
Size:
1,097 bases
Orientation:
Plus strand

Genomic View for OR5K1 Gene

Genes around OR5K1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5K1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5K1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5K1 Gene

Proteins for OR5K1 Gene

  • Protein details for OR5K1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHB7-OR5K1_HUMAN
    Recommended name:
    Olfactory receptor 5K1
    Protein Accession:
    Q8NHB7
    Secondary Accessions:
    • B9EGY5
    • Q6IF46

    Protein attributes for OR5K1 Gene

    Size:
    308 amino acids
    Molecular mass:
    35185 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05718.1; Type=Frameshift; Positions=308; Evidence={ECO:0000305};

neXtProt entry for OR5K1 Gene

Post-translational modifications for OR5K1 Gene

Other Protein References for OR5K1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5K1 Gene

Domains & Families for OR5K1 Gene

Gene Families for OR5K1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5K1 Gene

Suggested Antigen Peptide Sequences for OR5K1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NHB7

UniProtKB/Swiss-Prot:

OR5K1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5K1: view

Function for OR5K1 Gene

Molecular function for OR5K1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5K1: view

Phenotypes for OR5K1 Gene

genes like me logo Genes that share phenotypes with OR5K1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5K1 Gene

Localization for OR5K1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5K1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5K1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5K1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5K1 Gene

Pathways & Interactions for OR5K1 Gene

genes like me logo Genes that share pathways with OR5K1: view

Pathways by source for OR5K1 Gene

Interacting Proteins for OR5K1 Gene

Gene Ontology (GO) - Biological Process for OR5K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA,IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5K1: view

No data available for SIGNOR curated interactions for OR5K1 Gene

Drugs & Compounds for OR5K1 Gene

No Compound Related Data Available

Transcripts for OR5K1 Gene

mRNA/cDNA for OR5K1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR5K1 Gene

Olfactory receptor, family 5, subfamily K, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5K1 Gene

No ASD Table

Relevant External Links for OR5K1 Gene

GeneLoc Exon Structure for
OR5K1
ECgene alternative splicing isoforms for
OR5K1

Expression for OR5K1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5K1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5K1 Gene:

OR5K1

SOURCE GeneReport for Unigene cluster for OR5K1 Gene:

Hs.621533
genes like me logo Genes that share expression patterns with OR5K1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5K1 Gene

Orthologs for OR5K1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5K1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC470870 33
  • 99.13 (n)
cow
(Bos Taurus)
Mammalia OR5K1 33
  • 88.2 (n)
-- 34
  • 83 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC100856070 33
  • 87.77 (n)
-- 34
  • 84 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Or5k1 51 Olfr173 16 33
  • 84.09 (n)
Or5k1b 51 Olfr172 34
  • 82 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 68 (a)
ManyToMany
-- 34
  • 68 (a)
ManyToMany
-- 34
  • 66 (a)
ManyToMany
Species where no ortholog for OR5K1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5K1 Gene

ENSEMBL:
Gene Tree for OR5K1 (if available)
TreeFam:
Gene Tree for OR5K1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR5K1: view image

Paralogs for OR5K1 Gene

Paralogs for OR5K1 Gene

(453) SIMAP similar genes for OR5K1 Gene using alignment to 1 proteins:

  • OR5K1_HUMAN
genes like me logo Genes that share paralogs with OR5K1: view

Variants for OR5K1 Gene

Sequence variations from dbSNP and Humsavar for OR5K1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1001551429 -- 98,469,454(+) G/A/T upstream_transcript_variant
rs1002176442 -- 98,471,060(+) C/T downstream_transcript_variant
rs1002305841 -- 98,470,150(+) C/T coding_sequence_variant, missense_variant
rs1002389724 -- 98,468,845(+) G/A upstream_transcript_variant
rs1002744117 -- 98,468,572(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR5K1 Gene

Variant ID Type Subtype PubMed ID
dgv293n21 CNV loss 19592680
nsv1013060 CNV gain 25217958
nsv834774 CNV loss 17160897
nsv834775 CNV gain 17160897
nsv965191 CNV duplication 23825009

Variation tolerance for OR5K1 Gene

Residual Variation Intolerance Score: 87.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.95; 67.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5K1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5K1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5K1 Gene

Disorders for OR5K1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR5K1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ichthyosis, congenital, autosomal recessive 11
  • arci11
- elite association - COSMIC cancer census association via MalaCards
Search OR5K1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR5K1

genes like me logo Genes that share disorders with OR5K1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR5K1 Gene

Publications for OR5K1 Gene

  1. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PMID: 1370859) Parmentier M … Perret J (Nature 1992) 2 3 4 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for OR5K1 Gene

Sources for OR5K1 Gene

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