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Aliases for OR5I1 Gene

Aliases for OR5I1 Gene

  • Olfactory Receptor Family 5 Subfamily I Member 1 2 3 5
  • Olfactory Receptor-Like Protein OLF1 3 4
  • Olfactory Receptor OR11-159 3 4
  • OLF1 3 4
  • Olfactory Receptor, Family 5, Subfamily I, Member 1 2
  • Olfactory Receptor 5I1 3
  • HSOlf1 3

External Ids for OR5I1 Gene

Previous GeneCards Identifiers for OR5I1 Gene

  • GC11M058096
  • GC11M057215
  • GC11M055953
  • GC11M055456
  • GC11M055478
  • GC11M055459
  • GC11M055703

Summaries for OR5I1 Gene

Entrez Gene Summary for OR5I1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5I1 Gene

OR5I1 (Olfactory Receptor Family 5 Subfamily I Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and odorant binding.

UniProtKB/Swiss-Prot for OR5I1 Gene

  • Odorant receptor.

Gene Wiki entry for OR5I1 Gene

Additional gene information for OR5I1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5I1 Gene

Genomics for OR5I1 Gene

GeneHancer (GH) Regulatory Elements for OR5I1 Gene

Top Transcription factor binding sites by QIAGEN in the OR5I1 gene promoter:
  • Pax-4a
  • NF-AT4
  • NF-AT3
  • NF-AT2
  • NF-AT1
  • NF-AT
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • Pbx1a

Genomic Locations for OR5I1 Gene

Genomic Locations for OR5I1 Gene
945 bases
Minus strand
945 bases
Minus strand

Genomic View for OR5I1 Gene

Genes around OR5I1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5I1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5I1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5I1 Gene

Proteins for OR5I1 Gene

  • Protein details for OR5I1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 5I1
    Protein Accession:
    Secondary Accessions:
    • Q6IEU4

    Protein attributes for OR5I1 Gene

    314 amino acids
    Molecular mass:
    36049 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5I1 Gene

Post-translational modifications for OR5I1 Gene

  • Glycosylation at isoforms=7
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5I1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5I1 Gene

Domains & Families for OR5I1 Gene

Gene Families for OR5I1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5I1 Gene

Suggested Antigen Peptide Sequences for OR5I1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5I1: view

Function for OR5I1 Gene

Molecular function for OR5I1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 5,subfamily I,member 1,G protein coupled receptor superfamily

Gene Ontology (GO) - Molecular Function for OR5I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5I1: view
genes like me logo Genes that share phenotypes with OR5I1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5I1 Gene

Localization for OR5I1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5I1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5I1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5I1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5I1 Gene

Pathways & Interactions for OR5I1 Gene

genes like me logo Genes that share pathways with OR5I1: view

Pathways by source for OR5I1 Gene

1 KEGG pathway for OR5I1 Gene

Gene Ontology (GO) - Biological Process for OR5I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 9787077
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA,IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5I1: view

No data available for SIGNOR curated interactions for OR5I1 Gene

Drugs & Compounds for OR5I1 Gene

No Compound Related Data Available

Transcripts for OR5I1 Gene

mRNA/cDNA for OR5I1 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR5I1 Gene

Olfactory receptor, family 5, subfamily I, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5I1 Gene

No ASD Table

Relevant External Links for OR5I1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR5I1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5I1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5I1 Gene:


SOURCE GeneReport for Unigene cluster for OR5I1 Gene:

genes like me logo Genes that share expression patterns with OR5I1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5I1 Gene

Orthologs for OR5I1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5I1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC747283 33
  • 98.83 (n)
OR5I1 34
  • 97 (a)
(Bos Taurus)
Mammalia -- 34
  • 90 (a)
OR5I1 33
  • 87.69 (n)
-- 34
  • 85 (a)
-- 34
  • 84 (a)
-- 34
  • 80 (a)
(Canis familiaris)
Mammalia -- 34
  • 90 (a)
  • 89 (a)
LOC100686849 33
  • 87.79 (n)
(Monodelphis domestica)
Mammalia OR5I1 34
  • 86 (a)
(Mus musculus)
Mammalia Or5i1 51 Olfr152 16 34 33
  • 82.85 (n)
(Rattus norvegicus)
Mammalia Olr588 33
  • 81.85 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 53 (a)
(Gallus gallus)
Aves LOC428827 33
  • 60.33 (n)
OR5I1 34
  • 55 (a)
Species where no ortholog for OR5I1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5I1 Gene

Gene Tree for OR5I1 (if available)
Gene Tree for OR5I1 (if available)
Evolutionary constrained regions (ECRs) for OR5I1: view image

Paralogs for OR5I1 Gene

(450) SIMAP similar genes for OR5I1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR5I1: view

No data available for Paralogs for OR5I1 Gene

Variants for OR5I1 Gene

Sequence variations from dbSNP and Humsavar for OR5I1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000031776 -- 55,937,066(-) A/G upstream_transcript_variant
rs1002087040 -- 55,935,780(-) T/C coding_sequence_variant, synonymous_variant
rs1002156235 -- 55,938,105(-) T/G upstream_transcript_variant
rs1003533758 -- 55,935,246(-) G/A downstream_transcript_variant
rs1005829474 -- 55,937,421(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR5I1 Gene

Variant ID Type Subtype PubMed ID
dgv1205n100 CNV gain 25217958
dgv1206n100 CNV loss 25217958
dgv151n27 CNV loss 19166990
dgv1905n54 CNV gain 21841781
dgv1944n54 CNV loss 21841781
dgv1945n54 CNV loss 21841781
dgv1946n54 CNV loss 21841781
dgv1947n54 CNV loss 21841781
dgv52e55 CNV loss 17911159
esv2751030 CNV gain 17911159
esv2759829 CNV loss 17122850
esv3579771 CNV gain 25503493
esv3579782 CNV gain 25503493
esv3626459 CNV loss 21293372
esv3626460 CNV gain 21293372
nsv1037046 CNV loss 25217958
nsv1044174 CNV loss 25217958
nsv437718 CNV loss 16327808
nsv468568 CNV loss 19166990
nsv468571 CNV loss 19166990
nsv469959 CNV loss 18288195
nsv517590 CNV loss 19592680
nsv555080 CNV loss 21841781
nsv555087 CNV gain 21841781
nsv555089 CNV loss 21841781
nsv821668 CNV loss 15273396

Variation tolerance for OR5I1 Gene

Residual Variation Intolerance Score: 77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.30; 81.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5I1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5I1 Gene

Disorders for OR5I1 Gene

Additional Disease Information for OR5I1

No disorders were found for OR5I1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5I1 Gene

Publications for OR5I1 Gene

  1. The evolution of mammalian olfactory receptor genes. (PMID: 9017400) Issel-Tarver L … Rine J (Genetics 1997) 2 3 4 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Organization and evolution of olfactory receptor genes on human chromosome 11. (PMID: 9787077) Buettner JA … Evans GA (Genomics 1998) 2 3 58
  5. Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene. (PMID: 15037199) Cayla C … Paris H (Biochemical pharmacology 2004) 22 58

Products for OR5I1 Gene

Sources for OR5I1 Gene

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