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Aliases for OR5H6 Gene

Aliases for OR5H6 Gene

  • Olfactory Receptor Family 5 Subfamily H Member 6 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 5, Subfamily H, Member 6 2 3
  • Olfactory Receptor OR3-11 3 4
  • Olfactory Receptor, Family 5, Subfamily H, Member 6 (Gene/Pseudogene) 2
  • Olfactory Receptor 5H6 3
  • OR3-11 3

External Ids for OR5H6 Gene

Previous GeneCards Identifiers for OR5H6 Gene

  • GC03U990191
  • GC03P099466
  • GC03P097983

Summaries for OR5H6 Gene

Entrez Gene Summary for OR5H6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jul 2015]

GeneCards Summary for OR5H6 Gene

OR5H6 (Olfactory Receptor Family 5 Subfamily H Member 6 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5H14.

UniProtKB/Swiss-Prot for OR5H6 Gene

  • Odorant receptor.

Gene Wiki entry for OR5H6 Gene

Additional gene information for OR5H6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5H6 Gene

Genomics for OR5H6 Gene

GeneHancer (GH) Regulatory Elements for OR5H6 Gene

Promoters and enhancers for OR5H6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J098550 Promoter/Enhancer 1.8 EPDnew FANTOM5 ENCODE dbSUPER 2.7 +291.8 291810 8.2 HDGF PKNOX1 SMAD1 IRF4 TCF12 GATA2 ATF7 RUNX3 RXRA JUNB CLDND1 CPOX GPR15 DCBLD2 ST3GAL6-AS1 OR5H6 OR5H2 GC03M098547
GH03J098573 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 2.8 +310.3 310251 0.9 NFIB ZNF133 FEZF1 RAD21 ZNF366 ZNF143 ATF7 IKZF2 ZNF680 ZNF362 CPOX CLDND1 OR5H6 OR5H2 GC03M098547
GH03J098341 Enhancer 0.2 FANTOM5 10.9 +78.0 78048 0 OR5H2 OR5H6 OR5K4 OR5AC2 GC03M098326 ENSG00000251088
GH03J098255 Enhancer 0.2 ENCODE 0.4 -7.1 -7110 0.6 OR5H2 OR5H5P OR5H6 OR5H7P ENSG00000251088
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR5H6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR5H6 gene promoter:
  • E47
  • FOXD1
  • GCNF-2
  • GCNF-1
  • GCNF
  • Evi-1
  • TBP
  • GATA-1
  • MyoD
  • Lmo2

Genomic Locations for OR5H6 Gene

Genomic Locations for OR5H6 Gene
2,105 bases
Plus strand
1,113 bases
Plus strand

Genomic View for OR5H6 Gene

Genes around OR5H6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5H6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5H6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5H6 Gene

Proteins for OR5H6 Gene

  • Protein details for OR5H6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 5H6
    Protein Accession:
    Secondary Accessions:
    • Q6IF88

    Protein attributes for OR5H6 Gene

    325 amino acids
    Molecular mass:
    36713 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05893.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR5H6 Gene

Post-translational modifications for OR5H6 Gene

  • Glycosylation at Asn21
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5H6 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5H6 Gene

Domains & Families for OR5H6 Gene

Gene Families for OR5H6 Gene

Protein Domains for OR5H6 Gene

Suggested Antigen Peptide Sequences for OR5H6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5H6: view

Function for OR5H6 Gene

Molecular function for OR5H6 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5H6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5H6: view
genes like me logo Genes that share phenotypes with OR5H6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5H6

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5H6 Gene

Localization for OR5H6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5H6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5H6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5H6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5H6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5H6 Gene

Pathways & Interactions for OR5H6 Gene

genes like me logo Genes that share pathways with OR5H6: view

Pathways by source for OR5H6 Gene

Interacting Proteins for OR5H6 Gene

Gene Ontology (GO) - Biological Process for OR5H6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA,IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5H6: view

No data available for SIGNOR curated interactions for OR5H6 Gene

Drugs & Compounds for OR5H6 Gene

No Compound Related Data Available

Transcripts for OR5H6 Gene

mRNA/cDNA for OR5H6 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR5H6 Gene

Olfactory receptor, family 5, subfamily H, member 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5H6

Alternative Splicing Database (ASD) splice patterns (SP) for OR5H6 Gene

No ASD Table

Relevant External Links for OR5H6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR5H6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5H6 Gene

mRNA differential expression in normal tissues according to GTEx for OR5H6 Gene

This gene is overexpressed in Testis (x17.3).

NURSA nuclear receptor signaling pathways regulating expression of OR5H6 Gene:


SOURCE GeneReport for Unigene cluster for OR5H6 Gene:

genes like me logo Genes that share expression patterns with OR5H6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5H6 Gene

Orthologs for OR5H6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5H6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC738707 33
  • 97.95 (n)
OR5H6 34
  • 97 (a)
(Mus musculus)
Mammalia Olfr187 16 33
  • 78.39 (n)
Olfr193 34
  • 72 (a)
(Bos Taurus)
Mammalia -- 34
  • 75 (a)
-- 34
  • 74 (a)
-- 34
  • 72 (a)
(Canis familiaris)
Mammalia -- 34
  • 75 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 60 (a)
Species where no ortholog for OR5H6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5H6 Gene

Gene Tree for OR5H6 (if available)
Gene Tree for OR5H6 (if available)

Paralogs for OR5H6 Gene

Paralogs for OR5H6 Gene

(454) SIMAP similar genes for OR5H6 Gene using alignment to 1 proteins:

  • OR5H6_HUMAN Pseudogenes for OR5H6 Gene

genes like me logo Genes that share paralogs with OR5H6: view

Variants for OR5H6 Gene

Sequence variations from dbSNP and Humsavar for OR5H6 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000375550 -- 98,265,429(+) A/G downstream_transcript_variant
rs1000749866 -- 98,265,717(+) G/C/T downstream_transcript_variant
rs1001788276 -- 98,264,269(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1003457557 -- 98,263,127(+) TCACTGTTTC/TC upstream_transcript_variant
rs1003532930 -- 98,262,876(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR5H6 Gene

Variant ID Type Subtype PubMed ID
dgv4818n100 CNV gain 25217958
esv2725674 CNV deletion 23290073
nsv1000834 CNV gain 25217958
nsv1013060 CNV gain 25217958
nsv834773 CNV gain 17160897
nsv963344 CNV duplication 23825009

Variation tolerance for OR5H6 Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.36; 96.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5H6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5H6 Gene

Disorders for OR5H6 Gene

Additional Disease Information for OR5H6

No disorders were found for OR5H6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5H6 Gene

Publications for OR5H6 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 3 58
  3. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I … Lancet D (BMC bioinformatics 2006) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for OR5H6 Gene

Sources for OR5H6 Gene

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