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Aliases for OR5H14 Gene

Aliases for OR5H14 Gene

  • Olfactory Receptor Family 5 Subfamily H Member 14 2 3 5
  • Olfactory Receptor, Family 5, Subfamily H, Member 14 2

External Ids for OR5H14 Gene

Previous GeneCards Identifiers for OR5H14 Gene

  • GC03U900516
  • GC03P099350
  • GC03P097868

Summaries for OR5H14 Gene

Entrez Gene Summary for OR5H14 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5H14 Gene

OR5H14 (Olfactory Receptor Family 5 Subfamily H Member 14) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5H1.

UniProtKB/Swiss-Prot for OR5H14 Gene

  • Odorant receptor.

Additional gene information for OR5H14 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5H14 Gene

Genomics for OR5H14 Gene

GeneHancer (GH) Regulatory Elements for OR5H14 Gene

Top Transcription factor binding sites by QIAGEN in the OR5H14 gene promoter:

Genomic Locations for OR5H14 Gene

Genomic Locations for OR5H14 Gene
9,136 bases
Plus strand

Genomic View for OR5H14 Gene

Genes around OR5H14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5H14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5H14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5H14 Gene

Proteins for OR5H14 Gene

  • Protein details for OR5H14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 5H14
    Protein Accession:
    Secondary Accessions:
    • B9EH15

    Protein attributes for OR5H14 Gene

    310 amino acids
    Molecular mass:
    35099 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5H14 Gene

Post-translational modifications for OR5H14 Gene

Other Protein References for OR5H14 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5H14 Gene

Domains & Families for OR5H14 Gene

Gene Families for OR5H14 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5H14 Gene

Suggested Antigen Peptide Sequences for OR5H14 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5H14: view

Function for OR5H14 Gene

Molecular function for OR5H14 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5H14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5H14: view
genes like me logo Genes that share phenotypes with OR5H14: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5H14 Gene

Localization for OR5H14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5H14 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5H14 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5H14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5H14: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5H14 Gene

Pathways & Interactions for OR5H14 Gene

genes like me logo Genes that share pathways with OR5H14: view

Pathways by source for OR5H14 Gene

Interacting Proteins for OR5H14 Gene

Gene Ontology (GO) - Biological Process for OR5H14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5H14: view

No data available for SIGNOR curated interactions for OR5H14 Gene

Drugs & Compounds for OR5H14 Gene

No Compound Related Data Available

Transcripts for OR5H14 Gene

mRNA/cDNA for OR5H14 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5H14 Gene

No ASD Table

Relevant External Links for OR5H14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR5H14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5H14 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR5H14 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5H14 Gene:


SOURCE GeneReport for Unigene cluster for OR5H14 Gene:

genes like me logo Genes that share expression patterns with OR5H14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5H14 Gene

Orthologs for OR5H14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5H14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC738383 33
  • 96.45 (n)
(Mus musculus)
Mammalia Olfr193 33 16
  • 78.03 (n)
Olfr191 34
  • 72 (a)
(Rattus norvegicus)
Mammalia Olr1547 33
  • 76.39 (n)
(Bos Taurus)
Mammalia -- 34
  • 76 (a)
-- 34
  • 71 (a)
-- 34
  • 71 (a)
(Canis familiaris)
Mammalia -- 34
  • 75 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 60 (a)
Species where no ortholog for OR5H14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5H14 Gene

Gene Tree for OR5H14 (if available)
Gene Tree for OR5H14 (if available)

Paralogs for OR5H14 Gene

Paralogs for OR5H14 Gene

(451) SIMAP similar genes for OR5H14 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR5H14: view

Variants for OR5H14 Gene

Sequence variations from dbSNP and Humsavar for OR5H14 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000387265 -- 98,150,268(+) A/C/G coding_sequence_variant, missense_variant
rs1005577302 -- 98,150,468(+) A/T downstream_transcript_variant
rs1005761733 -- 98,148,348(+) TTTTT/TTTT upstream_transcript_variant
rs1006249652 -- 98,148,596(+) C/T upstream_transcript_variant
rs1006325084 -- 98,147,467(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR5H14 Gene

Variant ID Type Subtype PubMed ID
dgv776e201 CNV deletion 23290073
dgv777e201 CNV deletion 23290073
dgv872e199 CNV deletion 23128226
esv2667633 CNV deletion 23128226
esv2677041 CNV deletion 23128226
esv3597108 CNV loss 21293372
nsv1000834 CNV gain 25217958
nsv1013060 CNV gain 25217958
nsv460768 CNV gain 19166990
nsv591043 CNV gain 21841781
nsv834773 CNV gain 17160897

Variation tolerance for OR5H14 Gene

Residual Variation Intolerance Score: 97.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.31; 62.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5H14 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5H14 Gene

Disorders for OR5H14 Gene

Additional Disease Information for OR5H14

No disorders were found for OR5H14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5H14 Gene

Publications for OR5H14 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for OR5H14 Gene

Sources for OR5H14 Gene

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