Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR5F1 Gene

Aliases for OR5F1 Gene

  • Olfactory Receptor Family 5 Subfamily F Member 1 2 3 5
  • OR11-10 2 3 4
  • Olfactory Receptor OR11-167 3 4
  • Olfactory Receptor 11-10 3 4
  • Olfactory Receptor 5F1 3 4
  • Olfactory Receptor, Family 5, Subfamily F, Member 1 2
  • OR5F1 5

External Ids for OR5F1 Gene

Previous GeneCards Identifiers for OR5F1 Gene

  • GC11M058154
  • GC11M057274
  • GC11M056012
  • GC11M055536
  • GC11M055517
  • GC11M055761
  • GC11M056239
  • GC11M056256
  • GC11M056269
  • GC11M059771
  • GC11M056220
  • GC11M056233
  • GC11M061207
  • GC11M063672

Summaries for OR5F1 Gene

Entrez Gene Summary for OR5F1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5F1 Gene

OR5F1 (Olfactory Receptor Family 5 Subfamily F Member 1) is a Protein Coding gene. Diseases associated with OR5F1 include Kallmann Syndrome. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR8I2.

UniProtKB/Swiss-Prot Summary for OR5F1 Gene

Gene Wiki entry for OR5F1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR5F1 Gene

Genomics for OR5F1 Gene

GeneHancer (GH) Regulatory Elements Pubs


Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR5F1

Top Transcription factor binding sites by QIAGEN in the OR5F1 gene promoter:
  • AREB6
  • Evi-1
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • Meis-1b

Genomic Locations for OR5F1 Gene

Latest Assembly
chr11:55,993,681-55,994,625
(GRCh38/hg38)
Size:
945 bases
Orientation:
Minus strand

Previous Assembly
chr11:55,761,157-55,762,101
(GRCh37/hg19 by Entrez Gene)
Size:
945 bases
Orientation:
Minus strand

chr11:55,761,157-55,762,101
(GRCh37/hg19 by Ensembl)
Size:
945 bases
Orientation:
Minus strand

Genomic View for OR5F1 Gene

Genes around OR5F1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5F1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5F1 Gene

Proteins for OR5F1 Gene

  • Protein details for OR5F1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95221-OR5F1_HUMAN
    Recommended name:
    Olfactory receptor 5F1
    Protein Accession:
    O95221
    Secondary Accessions:
    • Q495D1
    • Q6IFB9

    Protein attributes for OR5F1 Gene

    Size:
    314 amino acids
    Molecular mass:
    35132 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5F1 Gene

Post-translational modifications for OR5F1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5F1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5F1 Gene

Domains & Families for OR5F1 Gene

Gene Families for OR5F1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5F1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR5F1 Gene

GenScript: Design optimal peptide antigens:
  • OR5F1 protein (A0AUJ7_HUMAN)
  • Olfactory receptor OR11-167 (OR5F1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95221

UniProtKB/Swiss-Prot:

OR5F1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5F1: view

Function for OR5F1 Gene

Molecular function for OR5F1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 5,subfamily F,member 1,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR5F1 Gene

Gene Ontology (GO) - Molecular Function for OR5F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 9787077
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR5F1: view
genes like me logo Genes that share phenotypes with OR5F1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5F1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5F1 Gene

Localization for OR5F1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5F1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5F1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 9787077
genes like me logo Genes that share ontologies with OR5F1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5F1 Gene

Pathways & Interactions for OR5F1 Gene

genes like me logo Genes that share pathways with OR5F1: view

Pathways by source for OR5F1 Gene

1 KEGG pathway for OR5F1 Gene

Gene Ontology (GO) - Biological Process for OR5F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 9787077
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5F1: view

No data available for SIGNOR curated interactions for OR5F1 Gene

Drugs & Compounds for OR5F1 Gene

No Compound Related Data Available

Transcripts for OR5F1 Gene

mRNA/cDNA for OR5F1 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5F1

Alternative Splicing Database (ASD) splice patterns (SP) for OR5F1 Gene

No ASD Table

Relevant External Links for OR5F1 Gene

GeneLoc Exon Structure for
OR5F1

Expression for OR5F1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR5F1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR5F1

SOURCE GeneReport for Unigene cluster for OR5F1 Gene:

Hs.553702
genes like me logo Genes that share expression patterns with OR5F1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5F1 Gene

Orthologs for OR5F1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5F1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC747344 29
  • 98.09 (n)
OR5F1 30
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia OR5F1 30
  • 83 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 30
  • 83 (a)
OneToMany
-- 30
  • 81 (a)
OneToMany
-- 30
  • 81 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia OPOR117 30
  • 75 (a)
OneToMany
-- 30
  • 71 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 53 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Olfr1323 30
  • 50 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves COR3 30
  • 51 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 55 (a)
OneToMany
-- 30
  • 54 (a)
OneToMany
Species where no ortholog for OR5F1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR5F1 Gene

ENSEMBL:
Gene Tree for OR5F1 (if available)
TreeFam:
Gene Tree for OR5F1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR5F1: view image
Alliance of Genome Resources:
Additional Orthologs for OR5F1

Paralogs for OR5F1 Gene

(457) SIMAP similar genes for OR5F1 Gene using alignment to 2 proteins:

  • OR5F1_HUMAN
  • A0AUJ7_HUMAN

Pseudogenes.org Pseudogenes for OR5F1 Gene

genes like me logo Genes that share paralogs with OR5F1: view

Variants for OR5F1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR5F1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs11825964 -- p.Tyr278His
rs2449134 -- p.Ser294Asn
rs35607186 -- p.Thr192Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR5F1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR5F1 Gene

Variant ID Type Subtype PubMed ID
dgv1205n100 CNV gain 25217958
dgv1206n100 CNV loss 25217958
dgv1905n54 CNV gain 21841781
dgv52e55 CNV loss 17911159
esv2666045 CNV deletion 23128226
esv2751030 CNV gain 17911159
esv2759829 CNV loss 17122850
esv3579771 CNV gain 25503493
esv3579782 CNV gain 25503493
esv3626462 CNV loss 21293372
esv3626463 CNV gain 21293372
esv3626466 CNV loss 21293372
esv3626467 CNV gain 21293372
esv3892014 CNV loss 25118596
nsv1044174 CNV loss 25217958
nsv437718 CNV loss 16327808
nsv468568 CNV loss 19166990
nsv469959 CNV loss 18288195
nsv517590 CNV loss 19592680
nsv555080 CNV loss 21841781
nsv555093 CNV loss 21841781
nsv821668 CNV loss 15273396

Variation tolerance for OR5F1 Gene

Residual Variation Intolerance Score: 66.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.33; 76.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5F1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5F1
Leiden Open Variation Database (LOVD)
OR5F1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5F1 Gene

Disorders for OR5F1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR5F1 Gene - From: COP

Disorder Aliases PubMed IDs
kallmann syndrome
  • familial hypogonadism with anosmia
- elite association - COSMIC cancer census association via MalaCards
Search OR5F1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR5F1

genes like me logo Genes that share disorders with OR5F1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR5F1 Gene

Publications for OR5F1 Gene

  1. Organization and evolution of olfactory receptor genes on human chromosome 11. (PMID: 9787077) Buettner JA … Evans GA (Genomics 1998) 2 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3

Products for OR5F1 Gene

Sources for OR5F1 Gene