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Aliases for OR5F1 Gene

Aliases for OR5F1 Gene

  • Olfactory Receptor Family 5 Subfamily F Member 1 2 3 5
  • Olfactory Receptor OR11-167 3 4
  • Olfactory Receptor 11-10 3 4
  • OR11-10 3 4
  • Olfactory Receptor, Family 5, Subfamily F, Member 1 2
  • Olfactory Receptor 5F1 3

External Ids for OR5F1 Gene

Previous GeneCards Identifiers for OR5F1 Gene

  • GC11M058154
  • GC11M057274
  • GC11M056012
  • GC11M055536
  • GC11M055517
  • GC11M055761

Summaries for OR5F1 Gene

Entrez Gene Summary for OR5F1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5F1 Gene

OR5F1 (Olfactory Receptor Family 5 Subfamily F Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR5AU1.

UniProtKB/Swiss-Prot for OR5F1 Gene

  • Odorant receptor.

Gene Wiki entry for OR5F1 Gene

Additional gene information for OR5F1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5F1 Gene

Genomics for OR5F1 Gene

GeneHancer (GH) Regulatory Elements for OR5F1 Gene

Top Transcription factor binding sites by QIAGEN in the OR5F1 gene promoter:
  • AREB6
  • Evi-1
  • Meis-1b
  • Meis-1
  • HOXA9B
  • HOXA9
  • Meis-1a

Genomic Locations for OR5F1 Gene

Genomic Locations for OR5F1 Gene
945 bases
Minus strand
945 bases
Minus strand

Genomic View for OR5F1 Gene

Genes around OR5F1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5F1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5F1 Gene

Proteins for OR5F1 Gene

  • Protein details for OR5F1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 5F1
    Protein Accession:
    Secondary Accessions:
    • Q495D1
    • Q6IFB9

    Protein attributes for OR5F1 Gene

    314 amino acids
    Molecular mass:
    35132 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5F1 Gene

Post-translational modifications for OR5F1 Gene

  • Glycosylation at isoforms=5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5F1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5F1 Gene

Domains & Families for OR5F1 Gene

Gene Families for OR5F1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5F1 Gene

Suggested Antigen Peptide Sequences for OR5F1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5F1: view

Function for OR5F1 Gene

Molecular function for OR5F1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 5,subfamily F,member 1,G protein coupled receptor superfamily

Gene Ontology (GO) - Molecular Function for OR5F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 9787077
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5F1: view
genes like me logo Genes that share phenotypes with OR5F1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5F1 Gene

Localization for OR5F1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5F1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5F1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 9787077
genes like me logo Genes that share ontologies with OR5F1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5F1 Gene

Pathways & Interactions for OR5F1 Gene

genes like me logo Genes that share pathways with OR5F1: view

Pathways by source for OR5F1 Gene

1 KEGG pathway for OR5F1 Gene

Gene Ontology (GO) - Biological Process for OR5F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell NAS 9787077
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5F1: view

No data available for SIGNOR curated interactions for OR5F1 Gene

Drugs & Compounds for OR5F1 Gene

No Compound Related Data Available

Transcripts for OR5F1 Gene

mRNA/cDNA for OR5F1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR5F1 Gene

Olfactory receptor, family 5, subfamily F, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5F1 Gene

No ASD Table

Relevant External Links for OR5F1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR5F1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5F1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5F1 Gene:


SOURCE GeneReport for Unigene cluster for OR5F1 Gene:

genes like me logo Genes that share expression patterns with OR5F1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5F1 Gene

Orthologs for OR5F1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5F1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC747344 33
  • 98.09 (n)
OR5F1 34
  • 96 (a)
(Bos Taurus)
Mammalia -- 34
  • 83 (a)
-- 34
  • 81 (a)
-- 34
  • 81 (a)
(Canis familiaris)
Mammalia OR5F1 34
  • 83 (a)
(Monodelphis domestica)
Mammalia OPOR117 34
  • 75 (a)
-- 34
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 53 (a)
(Mus musculus)
Mammalia Olfr1323 34
  • 50 (a)
(Gallus gallus)
Aves COR3 34
  • 51 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 55 (a)
-- 34
  • 54 (a)
Species where no ortholog for OR5F1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5F1 Gene

Gene Tree for OR5F1 (if available)
Gene Tree for OR5F1 (if available)
Evolutionary constrained regions (ECRs) for OR5F1: view image

Paralogs for OR5F1 Gene

Paralogs for OR5F1 Gene

(457) SIMAP similar genes for OR5F1 Gene using alignment to 2 proteins:

  • A0AUJ7_HUMAN Pseudogenes for OR5F1 Gene

genes like me logo Genes that share paralogs with OR5F1: view

Variants for OR5F1 Gene

Sequence variations from dbSNP and Humsavar for OR5F1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000084850 -- 55,994,473(-) G/T coding_sequence_variant, synonymous_variant
rs1002155086 -- 55,994,998(-) G/A upstream_transcript_variant
rs1002208725 -- 55,994,809(-) T/A upstream_transcript_variant
rs1004541080 -- 55,994,799(-) G/A upstream_transcript_variant
rs1005836403 -- 55,996,178(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR5F1 Gene

Variant ID Type Subtype PubMed ID
dgv1205n100 CNV gain 25217958
dgv1206n100 CNV loss 25217958
dgv1905n54 CNV gain 21841781
dgv52e55 CNV loss 17911159
esv2666045 CNV deletion 23128226
esv2751030 CNV gain 17911159
esv2759829 CNV loss 17122850
esv3579771 CNV gain 25503493
esv3579782 CNV gain 25503493
esv3626462 CNV loss 21293372
esv3626463 CNV gain 21293372
esv3626466 CNV loss 21293372
esv3626467 CNV gain 21293372
esv3892014 CNV loss 25118596
nsv1044174 CNV loss 25217958
nsv437718 CNV loss 16327808
nsv468568 CNV loss 19166990
nsv469959 CNV loss 18288195
nsv517590 CNV loss 19592680
nsv555080 CNV loss 21841781
nsv555093 CNV loss 21841781
nsv821668 CNV loss 15273396

Variation tolerance for OR5F1 Gene

Residual Variation Intolerance Score: 66.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.33; 76.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5F1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5F1 Gene

Disorders for OR5F1 Gene

Additional Disease Information for OR5F1

No disorders were found for OR5F1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5F1 Gene

Publications for OR5F1 Gene

  1. Organization and evolution of olfactory receptor genes on human chromosome 11. (PMID: 9787077) Buettner JA … Evans GA (Genomics 1998) 2 3 4 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for OR5F1 Gene

Sources for OR5F1 Gene

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