Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR5B3 Gene

Aliases for OR5B3 Gene

  • Olfactory Receptor Family 5 Subfamily B Member 3 2 3 5
  • Olfactory Receptor OR11-239 3 4
  • Olfactory Receptor 5B13 3 4
  • OR5B13 3 4
  • Olfactory Receptor, Family 5, Subfamily B, Member 13 3
  • Olfactory Receptor, Family 5, Subfamily B, Member 3 2
  • Olfactory Receptor 5B3 3
  • OR11-239 3
  • OST129 3

External Ids for OR5B3 Gene

Previous HGNC Symbols for OR5B3 Gene

  • OR5B13

Previous GeneCards Identifiers for OR5B3 Gene

  • GC00U990607
  • GC11U900574
  • GC11M057926
  • GC11M058169

Summaries for OR5B3 Gene

Entrez Gene Summary for OR5B3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5B3 Gene

OR5B3 (Olfactory Receptor Family 5 Subfamily B Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5B2.

UniProtKB/Swiss-Prot for OR5B3 Gene

  • Odorant receptor.

Gene Wiki entry for OR5B3 Gene

Additional gene information for OR5B3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5B3 Gene

Genomics for OR5B3 Gene

GeneHancer (GH) Regulatory Elements for OR5B3 Gene

Promoters and enhancers for OR5B3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I057946 Enhancer 0.3 FANTOM5 8.8 +460.4 460440 0 GC11M057948 OR5BD1P OR10W1 OR10Q1 OR9Q2 OR5B2 OR9Q1 OR5B12 MED19 OR5B3
GH11I058632 Enhancer 0.2 FANTOM5 11 -225.4 -225367 0.1 OR5B12 OR1S1 OR5B3 OR10W1 OR10Q1 OR5B2 OR9Q2 OR1S2 ENSG00000280010 GC11P058595
GH11I058392 Enhancer 0.6 ENCODE 0.4 +12.8 12842 2.9 FOXA2 JUN CEBPB EP300 GATA3 JUND POLR2A STAT3 RCOR1 FOS CTNND1 LPXN OR5B15P OR5B3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR5B3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR5B3 gene promoter:

Genomic Locations for OR5B3 Gene

Genomic Locations for OR5B3 Gene
4,411 bases
Minus strand

Genomic View for OR5B3 Gene

Genes around OR5B3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5B3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5B3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5B3 Gene

Proteins for OR5B3 Gene

  • Protein details for OR5B3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 5B3
    Protein Accession:
    Secondary Accessions:
    • Q6IEV6

    Protein attributes for OR5B3 Gene

    314 amino acids
    Molecular mass:
    35258 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5B3 Gene

Post-translational modifications for OR5B3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR5B3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5B3 Gene

Domains & Families for OR5B3 Gene

Gene Families for OR5B3 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5B3 Gene

Suggested Antigen Peptide Sequences for OR5B3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5B3: view

Function for OR5B3 Gene

Molecular function for OR5B3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5B3: view
genes like me logo Genes that share phenotypes with OR5B3: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5B3 Gene

Localization for OR5B3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5B3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5B3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5B3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5B3 Gene

Pathways & Interactions for OR5B3 Gene

genes like me logo Genes that share pathways with OR5B3: view

Pathways by source for OR5B3 Gene

Interacting Proteins for OR5B3 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)
Selected Interacting proteins: ENSP00000308270 Q8NH48-OR5B3_HUMAN for OR5B3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR5B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5B3: view

No data available for SIGNOR curated interactions for OR5B3 Gene

Drugs & Compounds for OR5B3 Gene

No Compound Related Data Available

Transcripts for OR5B3 Gene

mRNA/cDNA for OR5B3 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5B3 Gene

No ASD Table

Relevant External Links for OR5B3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR5B3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5B3 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5B3 Gene:


SOURCE GeneReport for Unigene cluster for OR5B3 Gene:

genes like me logo Genes that share expression patterns with OR5B3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5B3 Gene

Orthologs for OR5B3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5B3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC748371 33
  • 97.98 (n)
(Canis familiaris)
Mammalia LOC483470 33
  • 84.35 (n)
-- 34
  • 81 (a)
-- 34
  • 80 (a)
(Mus musculus)
Mammalia Or5b3 51 Olfr1469 34
  • 81 (a)
Or5b113 51 Olfr1467 34
  • 78 (a)
Or5b111 51 Olfr1465 34
  • 77 (a)
Or5b109 51 Olfr1463 33 16 34
  • 76.55 (n)
Or5b104 51 Olfr1457 34
  • 75 (a)
Or5b105 51 Olfr1458 34
  • 75 (a)
Or5b112 51 Olfr1466 34
  • 74 (a)
Or5b102 51 Olfr1454 34
  • 73 (a)
Or5b106 51 Olfr1459 34
  • 73 (a)
Or5b101 51 Olfr1453 34
  • 72 (a)
Olfr1461 34
  • 72 (a)
Or5b108 51 Olfr1462 34
  • 71 (a)
Olfr1447 34
  • 70 (a)
Olfr1446 34
  • 69 (a)
Or5b100-ps 51 Olfr1452-ps1
  • chr19:13,016,225-13,017,146
Or5b103-ps 51 Olfr1455-ps1
  • chr19:13,068,886-13,069,674
Or5b110-ps 51 Olfr1464-ps1
  • chr19:13,282,137-13,283,056
Or5b114-ps 51 Olfr1468-ps1
  • chr19:13,374,964-13,375,885
Or5b94 51 Olfr1442
  • chr19:12,674,207-12,675,142
Or5b95 51 Olfr1443
  • chr19:12,680,110-12,681,045
Or5u1-ps 51 Olfr1460-ps1
  • chr19:13,158,191-13,159,313
(Rattus norvegicus)
Mammalia LOC687088 33
  • 79.76 (n)
(Bos Taurus)
Mammalia LOC526857 33
  • 78.95 (n)
OR5B3 34
  • 74 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 75 (a)
-- 34
  • 71 (a)
-- 34
  • 71 (a)
-- 34
  • 70 (a)
-- 34
  • 69 (a)
-- 34
  • 69 (a)
-- 34
  • 68 (a)
-- 34
  • 68 (a)
-- 34
  • 68 (a)
-- 34
  • 67 (a)
-- 34
  • 66 (a)
-- 34
  • 66 (a)
-- 34
  • 66 (a)
-- 34
  • 65 (a)
-- 34
  • 65 (a)
-- 34
  • 65 (a)
-- 34
  • 64 (a)
-- 34
  • 64 (a)
-- 34
  • 64 (a)
-- 34
  • 60 (a)
-- 34
  • 58 (a)
-- 34
  • 55 (a)
Species where no ortholog for OR5B3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5B3 Gene

Gene Tree for OR5B3 (if available)
Gene Tree for OR5B3 (if available)

Paralogs for OR5B3 Gene

Paralogs for OR5B3 Gene

(448) SIMAP similar genes for OR5B3 Gene using alignment to 1 proteins: Pseudogenes for OR5B3 Gene

genes like me logo Genes that share paralogs with OR5B3: view

Variants for OR5B3 Gene

Sequence variations from dbSNP and Humsavar for OR5B3 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000714478 -- 58,402,353(-) C/G downstream_transcript_variant
rs1001282710 -- 58,404,223(-) C/T upstream_transcript_variant
rs1002163535 -- 58,404,937(-) C/T upstream_transcript_variant
rs1003822430 -- 58,402,184(-) C/A/G downstream_transcript_variant
rs1006714773 -- 58,405,267(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR5B3 Gene

Variant ID Type Subtype PubMed ID
nsv1133165 CNV tandem duplication 24896259
nsv517849 CNV gain 19592680

Variation tolerance for OR5B3 Gene

Residual Variation Intolerance Score: 88.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.84; 99.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5B3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5B3 Gene

Disorders for OR5B3 Gene

Additional Disease Information for OR5B3

No disorders were found for OR5B3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5B3 Gene

Publications for OR5B3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58

Products for OR5B3 Gene

Sources for OR5B3 Gene

Loading form....