Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR5B3 Gene

Aliases for OR5B3 Gene

  • Olfactory Receptor Family 5 Subfamily B Member 3 2 3 5
  • Olfactory Receptor OR11-239 3 4
  • Olfactory Receptor 5B13 3 4
  • Olfactory Receptor 5B3 3 4
  • OR5B13 3 4
  • OST129 2 3
  • Olfactory Receptor, Family 5, Subfamily B, Member 13 3
  • Olfactory Receptor, Family 5, Subfamily B, Member 3 2
  • OR11-239 3
  • OR5B3 5

External Ids for OR5B3 Gene

Previous HGNC Symbols for OR5B3 Gene

  • OR5B13

Previous GeneCards Identifiers for OR5B3 Gene

  • GC00U990607
  • GC11U900574
  • GC11M057926
  • GC11M058169

Summaries for OR5B3 Gene

Entrez Gene Summary for OR5B3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5B3 Gene

OR5B3 (Olfactory Receptor Family 5 Subfamily B Member 3) is a Protein Coding gene. Diseases associated with OR5B3 include Atypical Autism. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR5B2.

UniProtKB/Swiss-Prot Summary for OR5B3 Gene

Gene Wiki entry for OR5B3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR5B3 Gene

Genomics for OR5B3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR5B3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J058632 Enhancer 0.2 FANTOM5 11 -225.4 -225367 0.1 OR5B12 OR1S1 OR5B3 OR10W1 OR10Q1 OR5B2 OR9Q2 OR1S2 ENSG00000280010 HSALNG0084356
GH11J057946 Enhancer 0.2 FANTOM5 8.8 +460.4 460440 0 OR5BD1P piR-38352-080 lnc-OR9I1-4 piR-50308-086 OR10W1 OR10Q1 OR9Q2 OR5B2 OR9Q1 OR5B12
GH11J058392 Enhancer 0.7 Ensembl ENCODE 0.4 +12.9 12930 3.1 JUND CEBPB EP300 FOXA2 PRDM1 STAT3 POLR2A FOS CTNND1 LPXN piR-58297-077 OR5B3 OR5B17 HSALNG0084341
GH11J058399 Enhancer 0.2 Ensembl 0.4 +6.9 6874 0.4 OR5B3 piR-58297-077 OR5B17 HSALNG0084341
GH11J058396 Enhancer 0.2 Ensembl 0.4 +11.0 10973 0.6 LPXN piR-58297-077 OR5B3 OR5B17 HSALNG0084341
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR5B3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR5B3

Top Transcription factor binding sites by QIAGEN in the OR5B3 gene promoter:
  • E47
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • Pax-5
  • Pbx1a
  • Tal-1beta

Genomic Locations for OR5B3 Gene

Latest Assembly
chr11:58,402,464-58,406,874
(GRCh38/hg38)
Size:
4,411 bases
Orientation:
Minus strand

Previous Assembly
chr11:58,169,937-58,174,347
(GRCh37/hg19 by Entrez Gene)
Size:
4,411 bases
Orientation:
Minus strand

chr11:58,169,937-58,170,882
(GRCh37/hg19 by Ensembl)
Size:
946 bases
Orientation:
Minus strand

Genomic View for OR5B3 Gene

Genes around OR5B3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5B3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5B3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5B3 Gene

Proteins for OR5B3 Gene

  • Protein details for OR5B3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH48-OR5B3_HUMAN
    Recommended name:
    Olfactory receptor 5B3
    Protein Accession:
    Q8NH48
    Secondary Accessions:
    • Q6IEV6

    Protein attributes for OR5B3 Gene

    Size:
    314 amino acids
    Molecular mass:
    35258 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5B3 Gene

Post-translational modifications for OR5B3 Gene

  • Glycosylation at Asn3, Asn17, and Asn153
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5B3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5B3 Gene

Domains & Families for OR5B3 Gene

Gene Families for OR5B3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5B3 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR5B3 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-239 (OR5B3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NH48

UniProtKB/Swiss-Prot:

OR5B3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5B3: view

Function for OR5B3 Gene

Molecular function for OR5B3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR5B3 Gene

Gene Ontology (GO) - Molecular Function for OR5B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR5B3: view
genes like me logo Genes that share phenotypes with OR5B3: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5B3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5B3 Gene

Localization for OR5B3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5B3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5B3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5B3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5B3 Gene

Pathways & Interactions for OR5B3 Gene

genes like me logo Genes that share pathways with OR5B3: view

Pathways by source for OR5B3 Gene

Interacting Proteins for OR5B3 Gene

Gene Ontology (GO) - Biological Process for OR5B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IBA 21873635
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5B3: view

No data available for SIGNOR curated interactions for OR5B3 Gene

Drugs & Compounds for OR5B3 Gene

No Compound Related Data Available

Transcripts for OR5B3 Gene

mRNA/cDNA for OR5B3 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5B3

Alternative Splicing Database (ASD) splice patterns (SP) for OR5B3 Gene

No ASD Table

Relevant External Links for OR5B3 Gene

GeneLoc Exon Structure for
OR5B3

Expression for OR5B3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR5B3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR5B3

SOURCE GeneReport for Unigene cluster for OR5B3 Gene:

Hs.553826
genes like me logo Genes that share expression patterns with OR5B3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5B3 Gene

Orthologs for OR5B3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5B3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC748371 29
  • 97.98 (n)
Dog
(Canis familiaris)
Mammalia LOC483470 29
  • 84.35 (n)
-- 30
  • 81 (a)
OneToMany
-- 30
  • 80 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Or5b3 45 Olfr1469 30
  • 81 (a)
OneToMany
Or5b113 45 Olfr1467 30
  • 78 (a)
OneToMany
Or5b111 45 Olfr1465 30
  • 77 (a)
OneToMany
Or5b109 45 Olfr1463 29 16 30
  • 76.55 (n)
OneToMany
Or5b104 45 Olfr1457 30
  • 75 (a)
OneToMany
Or5b105 45 Olfr1458 30
  • 75 (a)
OneToMany
Or5b112 45 Olfr1466 30
  • 74 (a)
OneToMany
Or5b106 45 Olfr1459 30
  • 73 (a)
OneToMany
Or5b102 45 Olfr1454 30
  • 73 (a)
OneToMany
Olfr1461 30
  • 72 (a)
OneToMany
Or5b101 45 Olfr1453 30
  • 72 (a)
OneToMany
Or5b108 45 Olfr1462 30
  • 71 (a)
OneToMany
Olfr1447 30
  • 70 (a)
OneToMany
Olfr1446 30
  • 69 (a)
OneToMany
Or5b100-ps 45 Olfr1452-ps1
  • chr19:13,016,225-13,017,146
Or5b103-ps 45 Olfr1455-ps1
  • chr19:13,068,886-13,069,674
Or5b110-ps 45 Olfr1464-ps1
  • chr19:13,282,137-13,283,056
Or5b114-ps 45 Olfr1468-ps1
  • chr19:13,374,964-13,375,885
Or5b94 45 Olfr1442
  • chr19:12,674,207-12,675,142
Or5b95 45 Olfr1443
  • chr19:12,680,110-12,681,045
Or5u1-ps 45 Olfr1460-ps1
  • chr19:13,158,191-13,159,313
Rat
(Rattus norvegicus)
Mammalia LOC687088 29
  • 79.76 (n)
Cow
(Bos Taurus)
Mammalia LOC526857 29
  • 78.95 (n)
OR5B3 30
  • 74 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 75 (a)
ManyToMany
-- 30
  • 71 (a)
ManyToMany
-- 30
  • 71 (a)
ManyToMany
-- 30
  • 70 (a)
ManyToMany
-- 30
  • 69 (a)
ManyToMany
-- 30
  • 69 (a)
ManyToMany
-- 30
  • 68 (a)
ManyToMany
-- 30
  • 68 (a)
ManyToMany
-- 30
  • 68 (a)
ManyToMany
-- 30
  • 67 (a)
ManyToMany
-- 30
  • 66 (a)
ManyToMany
-- 30
  • 66 (a)
ManyToMany
-- 30
  • 66 (a)
ManyToMany
-- 30
  • 65 (a)
ManyToMany
-- 30
  • 65 (a)
ManyToMany
-- 30
  • 65 (a)
ManyToMany
-- 30
  • 64 (a)
ManyToMany
-- 30
  • 64 (a)
ManyToMany
-- 30
  • 64 (a)
ManyToMany
-- 30
  • 60 (a)
ManyToMany
-- 30
  • 58 (a)
ManyToMany
-- 30
  • 55 (a)
ManyToMany
Species where no ortholog for OR5B3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR5B3 Gene

ENSEMBL:
Gene Tree for OR5B3 (if available)
TreeFam:
Gene Tree for OR5B3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR5B3: view image
Alliance of Genome Resources:
Additional Orthologs for OR5B3

Paralogs for OR5B3 Gene

(448) SIMAP similar genes for OR5B3 Gene using alignment to 1 proteins:

  • OR5B3_HUMAN

Pseudogenes.org Pseudogenes for OR5B3 Gene

genes like me logo Genes that share paralogs with OR5B3: view

Variants for OR5B3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR5B3 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs11229409 -- p.Gly247Ala
rs11229410 -- p.Ile198Val
rs11229411 -- p.Ala181Thr
rs11229413 -- p.Trp49Arg
rs12279895 -- p.Lys296Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR5B3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR5B3 Gene

Variant ID Type Subtype PubMed ID
nsv1133165 CNV tandem duplication 24896259
nsv517849 CNV gain 19592680

Variation tolerance for OR5B3 Gene

Residual Variation Intolerance Score: 88.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.84; 99.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5B3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5B3
Leiden Open Variation Database (LOVD)
OR5B3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5B3 Gene

Disorders for OR5B3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR5B3 Gene - From: COP

Disorder Aliases PubMed IDs
atypical autism
  • pdd
- elite association - COSMIC cancer census association via MalaCards
Search OR5B3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OR5B3

genes like me logo Genes that share disorders with OR5B3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR5B3 Gene

Publications for OR5B3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR5B3 Gene

Sources for OR5B3 Gene