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Aliases for OR5B21 Gene

Aliases for OR5B21 Gene

  • Olfactory Receptor Family 5 Subfamily B Member 21 2 3 5
  • Olfactory Receptor, Family 5, Subfamily B, Member 21 2

External Ids for OR5B21 Gene

Previous GeneCards Identifiers for OR5B21 Gene

  • GC00U903077
  • GC11U900560
  • GC11M058031
  • GC11M058274

Summaries for OR5B21 Gene

Entrez Gene Summary for OR5B21 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5B21 Gene

OR5B21 (Olfactory Receptor Family 5 Subfamily B Member 21) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5B12.

UniProtKB/Swiss-Prot for OR5B21 Gene

  • Odorant receptor.

Additional gene information for OR5B21 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5B21 Gene

Genomics for OR5B21 Gene

GeneHancer (GH) Regulatory Elements for OR5B21 Gene

Promoters and enhancers for OR5B21 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I058572 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.4 -69.4 -69381 9.5 CLOCK DMAP1 IRF4 YY1 E2F8 ZNF143 ZNF263 SP3 NFYC PPARGC1A LPXN ZFP91 ZFP91-CNTF ENSG00000269570 ENSG00000255008 OR5B21 CLP1 ENSG00000197254 CTNND1 ZDHHC5
GH11I058776 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.3 -269.0 -269047 1.4 ATF1 ARNT NCOA2 TCF12 ZNF766 ATF7 NCOA1 REST ZNF592 MEF2D ENSG00000269570 OR5B21 LPXN MPEG1 GC11M058796 LOC100420019
GH11I058495 Enhancer 0.4 FANTOM5 22.6 +12.3 12275 0.4 IKZF1 JUNB OR5B21 LPXN ENSG00000255299 GC11M058441 LOC105369313 OR5B12
GH11I059000 Enhancer 0.3 FANTOM5 5.8 -492.1 -492103 0.1 LOC100287485 LPXN OR5B21 MPEG1 GLYATL1P4 LOC283194 GLYATL1 GC11M058947
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR5B21 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR5B21 gene promoter:

Genomic Locations for OR5B21 Gene

Genomic Locations for OR5B21 Gene
931 bases
Minus strand

Genomic View for OR5B21 Gene

Genes around OR5B21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5B21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5B21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5B21 Gene

Proteins for OR5B21 Gene

  • Protein details for OR5B21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 5B21
    Protein Accession:

    Protein attributes for OR5B21 Gene

    309 amino acids
    Molecular mass:
    34174 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5B21 Gene

Post-translational modifications for OR5B21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR5B21 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5B21 Gene

Domains & Families for OR5B21 Gene

Gene Families for OR5B21 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5B21 Gene

Suggested Antigen Peptide Sequences for OR5B21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5B21: view

Function for OR5B21 Gene

Molecular function for OR5B21 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR5B21 Gene

Gene Ontology (GO) - Molecular Function for OR5B21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5B21: view

Phenotypes for OR5B21 Gene

genes like me logo Genes that share phenotypes with OR5B21: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5B21 Gene

Localization for OR5B21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5B21 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5B21 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5B21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5B21: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5B21 Gene

Pathways & Interactions for OR5B21 Gene

genes like me logo Genes that share pathways with OR5B21: view

Pathways by source for OR5B21 Gene

Interacting Proteins for OR5B21 Gene

Gene Ontology (GO) - Biological Process for OR5B21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5B21: view

No data available for SIGNOR curated interactions for OR5B21 Gene

Drugs & Compounds for OR5B21 Gene

No Compound Related Data Available

Transcripts for OR5B21 Gene

mRNA/cDNA for OR5B21 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5B21 Gene

No ASD Table

Relevant External Links for OR5B21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR5B21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5B21 Gene

mRNA differential expression in normal tissues according to GTEx for OR5B21 Gene

This gene is overexpressed in Testis (x15.3).

NURSA nuclear receptor signaling pathways regulating expression of OR5B21 Gene:


SOURCE GeneReport for Unigene cluster for OR5B21 Gene:

genes like me logo Genes that share expression patterns with OR5B21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5B21 Gene

Orthologs for OR5B21 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5B21 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia OR5B21 33 34
  • 87.12 (n)
(Mus musculus)
Mammalia Or5b21 51 Olfr1444 33 16 34
  • 84.04 (n)
(Rattus norvegicus)
Mammalia Olr339 33
  • 83.98 (n)
(Monodelphis domestica)
Mammalia OR5B21 34
  • 76 (a)
Species where no ortholog for OR5B21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5B21 Gene

Gene Tree for OR5B21 (if available)
Gene Tree for OR5B21 (if available)

Paralogs for OR5B21 Gene

Paralogs for OR5B21 Gene

(452) SIMAP similar genes for OR5B21 Gene using alignment to 1 proteins: Pseudogenes for OR5B21 Gene

genes like me logo Genes that share paralogs with OR5B21: view

Variants for OR5B21 Gene

Sequence variations from dbSNP and Humsavar for OR5B21 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000010801 -- 58,507,026(-) C/G/T downstream_transcript_variant
rs1000814702 -- 58,507,505(-) C/T coding_sequence_variant, missense_variant
rs1002022746 -- 58,507,162(-) C/T downstream_transcript_variant
rs1004492409 -- 58,509,374(-) T/C upstream_transcript_variant
rs1004539889 -- 58,509,136(-) A/C upstream_transcript_variant

Variation tolerance for OR5B21 Gene

Residual Variation Intolerance Score: 63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.19; 61.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5B21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR5B21 Gene

Disorders for OR5B21 Gene

Additional Disease Information for OR5B21

No disorders were found for OR5B21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5B21 Gene

Publications for OR5B21 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58

Products for OR5B21 Gene

Sources for OR5B21 Gene

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