Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR5B21 Gene

Aliases for OR5B21 Gene

  • Olfactory Receptor Family 5 Subfamily B Member 21 2 3 5
  • Olfactory Receptor 5B21 3 4
  • Olfactory Receptor, Family 5, Subfamily B, Member 21 2
  • OR5B21 5

External Ids for OR5B21 Gene

Previous GeneCards Identifiers for OR5B21 Gene

  • GC00U903077
  • GC11U900560
  • GC11M058031
  • GC11M058274
  • GC11M058507
  • GC11M061237
  • GC11M063705

Summaries for OR5B21 Gene

Entrez Gene Summary for OR5B21 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5B21 Gene

OR5B21 (Olfactory Receptor Family 5 Subfamily B Member 21) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR5B12.

UniProtKB/Swiss-Prot Summary for OR5B21 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR5B21 Gene

Genomics for OR5B21 Gene

GeneHancer (GH) Regulatory Elements Pubs


GeneHancers around OR5B21 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR5B21

Top Transcription factor binding sites by QIAGEN in the OR5B21 gene promoter:
  • AML1a
  • Bach1
  • FOXJ2
  • FOXJ2 (long isoform)
  • Nkx3-1
  • POU2F1
  • POU2F1a
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for OR5B21 Gene

Latest Assembly
chr11:58,506,807-58,508,105
(GRCh38/hg38)
Size:
1,299 bases
Orientation:
Minus strand

Previous Assembly
chr11:58,274,280-58,275,773
(GRCh37/hg19 by Entrez Gene)
Size:
1,494 bases
Orientation:
Minus strand

chr11:58,274,648-58,275,578
(GRCh37/hg19 by Ensembl)
Size:
931 bases
Orientation:
Minus strand

Genomic View for OR5B21 Gene

Genes around OR5B21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5B21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5B21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5B21 Gene

Proteins for OR5B21 Gene

  • Protein details for OR5B21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NL26-OR5BL_HUMAN
    Recommended name:
    Olfactory receptor 5B21
    Protein Accession:
    A6NL26

    Protein attributes for OR5B21 Gene

    Size:
    309 amino acids
    Molecular mass:
    34174 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5B21 Gene

Post-translational modifications for OR5B21 Gene

  • Glycosylation at Asn3 and Asn260
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5B21 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5B21 Gene

Domains & Families for OR5B21 Gene

Gene Families for OR5B21 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5B21 Gene

Suggested Antigen Peptide Sequences for OR5B21 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 5B21 (OR5BL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NL26

UniProtKB/Swiss-Prot:

OR5BL_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5B21: view

Function for OR5B21 Gene

Molecular function for OR5B21 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR5B21 Gene

Gene Ontology (GO) - Molecular Function for OR5B21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR5B21: view
genes like me logo Genes that share phenotypes with OR5B21: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5B21

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5B21 Gene

Localization for OR5B21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5B21 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5B21 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5B21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5B21: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5B21 Gene

Pathways & Interactions for OR5B21 Gene

genes like me logo Genes that share pathways with OR5B21: view

Pathways by source for OR5B21 Gene

Interacting Proteins for OR5B21 Gene

Gene Ontology (GO) - Biological Process for OR5B21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IBA 21873635
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5B21: view

No data available for SIGNOR curated interactions for OR5B21 Gene

Drugs & Compounds for OR5B21 Gene

No Compound Related Data Available

Transcripts for OR5B21 Gene

mRNA/cDNA for OR5B21 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5B21

Alternative Splicing Database (ASD) splice patterns (SP) for OR5B21 Gene

No ASD Table

Relevant External Links for OR5B21 Gene

GeneLoc Exon Structure for
OR5B21

Expression for OR5B21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR5B21 Gene

mRNA differential expression in normal tissues according to GTEx for OR5B21 Gene

This gene is overexpressed in Testis (x15.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR5B21

SOURCE GeneReport for Unigene cluster for OR5B21 Gene:

Hs.553647
genes like me logo Genes that share expression patterns with OR5B21: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5B21 Gene

Orthologs for OR5B21 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5B21 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia OR5B21 29 30
  • 87.12 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Or5b21 45 Olfr1444 29 16 30
  • 84.04 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr339 29
  • 83.98 (n)
Oppossum
(Monodelphis domestica)
Mammalia OR5B21 30
  • 76 (a)
OneToOne
Species where no ortholog for OR5B21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR5B21 Gene

ENSEMBL:
Gene Tree for OR5B21 (if available)
TreeFam:
Gene Tree for OR5B21 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR5B21: view image
Alliance of Genome Resources:
Additional Orthologs for OR5B21

Paralogs for OR5B21 Gene

(452) SIMAP similar genes for OR5B21 Gene using alignment to 1 proteins:

  • OR5BL_HUMAN

Pseudogenes.org Pseudogenes for OR5B21 Gene

genes like me logo Genes that share paralogs with OR5B21: view

Variants for OR5B21 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR5B21 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs58454093 -- p.Ser272Tyr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR5B21 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for OR5B21 Gene

Residual Variation Intolerance Score: 63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.19; 61.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5B21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5B21
Leiden Open Variation Database (LOVD)
OR5B21

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR5B21 Gene

Disorders for OR5B21 Gene

Additional Disease Information for OR5B21

No disorders were found for OR5B21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5B21 Gene

Publications for OR5B21 Gene

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4

Products for OR5B21 Gene

Sources for OR5B21 Gene