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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR5B2 (Olfactory Receptor Family 5 Subfamily B Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR5B3.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J057946 | Enhancer | 0.2 | FANTOM5 | 10.1 | +481.7 | 481687 | 0 | OR5BD1P lnc-OR9I1-4 piR-38352-080 piR-50308-086 OR10W1 OR10Q1 OR9Q2 OR5B2 OR9Q1 OR5B12 | ||
GH11J058316 | Enhancer | 0.5 | Ensembl | 3.9 | +111.7 | 111720 | 0.8 | FOS MAFK JUND ZNF24 NFE2L2 SPI1 | lnc-OR5B17-2 OR10W1 OR1S2 CTNND1 OR5B2 piR-31922-003 OR5B17 | |
GH11J058632 | Enhancer | 0.2 | FANTOM5 | 6.4 | -204.1 | -204120 | 0.1 | OR5B12 OR1S1 OR5B3 OR10W1 OR10Q1 OR5B2 OR9Q2 OR1S2 ENSG00000280010 lnc-CNTF-2 | ||
GH11J058423 | Enhancer | 0.2 | Ensembl | 0.7 | +3.6 | 3620 | 1.4 | ENSG00000197254 LPXN OR5B2 OR5B3 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IBA | -- |
GO:0005549 | odorant binding | IBA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IBA | -- |
GO:0007608 | sensory perception of smell | IBA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | OR5B2 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LOC785258 30 |
|
||
OR5B2 31 |
|
OneToOne | |||
Dog (Canis familiaris) |
Mammalia | OR5B2 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Or5b99 46 Olfr1451 31 |
|
OneToOne |
|
Or5b115-ps 46 Olfr1470-ps1 |
|
|
|||
Or8aa1-ps 46 Olfr1078-ps1 |
|
|
|||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs10466659 | - | p.Val208Ala | |||
rs4298923 | - | p.Met200Thr |
No disorders were found for OR5B2 Gene.