OR5B2 Gene (Protein Coding)

Olfactory Receptor Family 5 Subfamily B Member 2

GC11M059020
GIFtS:
27
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR5B2 Gene

Aliases for OR5B2 Gene

  • Olfactory Receptor Family 5 Subfamily B Member 2 2 3 5
  • Olfactory Receptor OR11-240 3 4
  • Olfactory Receptor 5B2 3 4
  • OST073 3 4
  • Olfactory Receptor, Family 5, Subfamily B, Member 2 2
  • OR11-240 3

External Ids for OR5B2 Gene

Previous GeneCards Identifiers for OR5B2 Gene

  • GC00U990608
  • GC11M057946
  • GC11M058189
  • GC11M058422
  • GC11M058631

Summaries for OR5B2 Gene

Entrez Gene Summary for OR5B2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5B2 Gene

OR5B2 (Olfactory Receptor Family 5 Subfamily B Member 2) is a Protein Coding gene. Among its related pathways are Olfactory transduction and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR5B3.

UniProtKB/Swiss-Prot Summary for OR5B2 Gene

Gene Wiki entry for OR5B2 Gene

Additional gene information for OR5B2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR5B2 Gene

Genomics for OR5B2 Gene

GeneHancer (GH) Regulatory Elements for OR5B2 Gene

Promoters and enhancers for OR5B2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11J057946 Enhancer 0.2 FANTOM5 10.1 +481.7 481687 0 OR5BD1P lnc-OR9I1-4 piR-38352-080 piR-50308-086 OR10W1 OR10Q1 OR9Q2 OR5B2 OR9Q1 OR5B12
GH11J058316 Enhancer 0.4 Ensembl 3.9 +111.7 111720 0.8 ZNF24 FOS JUND lnc-OR5B17-2 OR10W1 OR1S2 CTNND1 OR5B2 piR-31922-003
GH11J058632 Enhancer 0.2 FANTOM5 6.5 -204.1 -204120 0.1 OR5B12 OR1S1 OR5B3 OR10W1 OR10Q1 OR5B2 OR9Q2 OR1S2 ENSG00000280010 lnc-CNTF-2
GH11J058423 Enhancer 0.2 Ensembl 0.6 +3.6 3620 1.4 ENSG00000197254 LPXN OR5B2 OR5B3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR5B2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR5B2 gene promoter:
  • E47
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • Pax-5
  • POU2F1
  • POU2F1a
  • Tal-1beta
  • YY1

Genomic Locations for OR5B2 Gene

Genomic Locations for OR5B2 Gene
chr11:58,421,264-58,428,121
(GRCh38/hg38)
Size:
6,858 bases
Orientation:
Minus strand
chr11:58,189,738-58,190,786
(GRCh37/hg19)
Size:
1,049 bases
Orientation:
Minus strand

Genomic View for OR5B2 Gene

Genes around OR5B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5B2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OR5B2 Gene

Proteins for OR5B2 Gene

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  1. Antibody
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  • Protein details for OR5B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96R09-OR5B2_HUMAN
    Recommended name:
    Olfactory receptor 5B2
    Protein Accession:
    Q96R09
    Secondary Accessions:
    • B2RNJ6
    • B9EGY7
    • Q6IEV7
    • Q8NGF5

    Protein attributes for OR5B2 Gene

    Size:
    309 amino acids
    Molecular mass:
    34568 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5B2 Gene

Post-translational modifications for OR5B2 Gene

  • Glycosylation at Asn3

Other Protein References for OR5B2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5B2 Gene

Domains & Families for OR5B2 Gene

Gene Families for OR5B2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5B2 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OR5B2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-240 (OR5B2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96R09

UniProtKB/Swiss-Prot:

OR5B2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5B2: view

Function for OR5B2 Gene

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Molecular function for OR5B2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR5B2 Gene

Gene Ontology (GO) - Molecular Function for OR5B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR5B2: view
genes like me logo Genes that share phenotypes with OR5B2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5B2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5B2 Gene

Localization for OR5B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5B2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5B2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5B2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5B2 Gene

Pathways & Interactions for OR5B2 Gene

genes like me logo Genes that share pathways with OR5B2: view

Pathways by source for OR5B2 Gene

1 KEGG pathway for OR5B2 Gene

Interacting Proteins for OR5B2 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000303076 Q96R09-OR5B2_HUMAN for OR5B2 Gene via STRING IID

GPS-Prot Interaction Network for OR5B2

Gene Ontology (GO) - Biological Process for OR5B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IBA 21873635
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5B2: view

No data available for SIGNOR curated interactions for OR5B2 Gene

Drugs & Compounds for OR5B2 Gene

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  1. Drug
No Compound Related Data Available

Transcripts for OR5B2 Gene

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mRNA/cDNA for OR5B2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5B2

Alternative Splicing Database (ASD) splice patterns (SP) for OR5B2 Gene

No ASD Table

Relevant External Links for OR5B2 Gene

GeneLoc Exon Structure for
OR5B2
ECgene alternative splicing isoforms for
OR5B2

Expression for OR5B2 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5B2 Gene

mRNA expression in normal human tissues for OR5B2 Gene
mRNA expression by GTEx for OR5B2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5B2 Gene:

OR5B2

SOURCE GeneReport for Unigene cluster for OR5B2 Gene:

Hs.553753
genes like me logo Genes that share expression patterns with OR5B2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5B2 Gene

Orthologs for OR5B2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5B2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia OR5B2 33
  • 97 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia LOC785258 32
  • 81.65 (n)
OR5B2 33
  • 77 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia OR5B2 33
  • 81 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Or5b99 49 Olfr1451 33
  • 73 (a)
 OneToOne
Or5b115-ps 49 Olfr1470-ps1
  • chr19:13,434,089-13,435,095
Or8aa1-ps 49 Olfr1078-ps1
  • chr2:86,529,801-86,530,386
oppossum
(Monodelphis domestica)
 Mammalia -- 33
  • 72 (a)
 ManyToMany
-- 33
  • 70 (a)
 ManyToMany
-- 33
  • 68 (a)
 ManyToMany
-- 33
  • 68 (a)
 ManyToMany
-- 33
  • 67 (a)
 ManyToMany
-- 33
  • 67 (a)
 ManyToMany
-- 33
  • 67 (a)
 ManyToMany
-- 33
  • 67 (a)
 ManyToMany
-- 33
  • 66 (a)
 ManyToMany
-- 33
  • 66 (a)
 ManyToMany
-- 33
  • 66 (a)
 ManyToMany
-- 33
  • 65 (a)
 ManyToMany
-- 33
  • 65 (a)
 ManyToMany
-- 33
  • 65 (a)
 ManyToMany
-- 33
  • 65 (a)
 ManyToMany
-- 33
  • 65 (a)
 ManyToMany
-- 33
  • 65 (a)
 ManyToMany
-- 33
  • 64 (a)
 ManyToMany
-- 33
  • 64 (a)
 ManyToMany
-- 33
  • 63 (a)
 ManyToMany
-- 33
  • 59 (a)
 ManyToMany
-- 33
  • 57 (a)
 ManyToMany
Species where no ortholog for OR5B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5B2 Gene

ENSEMBL:
Gene Tree for OR5B2 (if available)
TreeFam:
Gene Tree for OR5B2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR5B2: view image

Paralogs for OR5B2 Gene

Paralogs for OR5B2 Gene

(449) SIMAP similar genes for OR5B2 Gene using alignment to 1 proteins:

  • OR5B2_HUMAN
genes like me logo Genes that share paralogs with OR5B2: view

Variants for OR5B2 Gene

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Sequence variations from dbSNP and Humsavar for OR5B2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000137295 -- 58,423,501(-) G/A upstream_transcript_variant
rs1001168008 -- 58,422,191(-) A/G downstream_transcript_variant
rs1001617765 -- 58,422,782(-) G/A coding_sequence_variant, synonymous_variant
rs1004513561 -- 58,425,120(-) T/C upstream_transcript_variant
rs1004575838 -- 58,423,605(-) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR5B2 Gene

Variant ID Type Subtype PubMed ID
nsv517849 CNV gain 19592680

Variation tolerance for OR5B2 Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.25; 88.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5B2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5B2 Gene

Disorders for OR5B2 Gene

Additional Disease Information for OR5B2

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OR5B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5B2 Gene

Publications for OR5B2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 56
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 56
  3. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3 56
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 56

ExternalLinks

View latest publications for OR5B2 gene in Mastermind

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