Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR5AU1 Gene

Aliases for OR5AU1 Gene

  • Olfactory Receptor Family 5 Subfamily AU Member 1 2 3 5
  • Olfactory Receptor OR14-38 3 4
  • Olfactory Receptor 5AU1 3 4
  • Olfactory Receptor, Family 5, Subfamily AU, Member 1 2
  • OR14-38 3
  • OR5AU1 5

External Ids for OR5AU1 Gene

Previous GeneCards Identifiers for OR5AU1 Gene

  • GC14U990431
  • GC14M019614
  • GC14M020692
  • GC14M021623

Summaries for OR5AU1 Gene

Entrez Gene Summary for OR5AU1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5AU1 Gene

OR5AU1 (Olfactory Receptor Family 5 Subfamily AU Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR5B12.

UniProtKB/Swiss-Prot Summary for OR5AU1 Gene

Gene Wiki entry for OR5AU1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR5AU1 Gene

Genomics for OR5AU1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR5AU1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J021202 Enhancer 0.9 Ensembl ENCODE 15 -44.6 -44619 2.6 SSRP1 POLR2A ZSCAN16 ZNF639 ZNF511 MIER3 RBM22 FOSL2 ZNF205 SOX5 METTL17 METTL3 OR5AU1 TEP1 SNORA79B APEX1 SUPT16H SNORD9 SNORD8 ENSG00000241035
GH14J021191 Enhancer 0.8 ENCODE 10.9 -33.2 -33173 0.9 ZNF600 ZSCAN16 ZIC2 ZNF341 ZFP64 KLF9 SP2 SAP130 DMAP1 YY1 OR5AU1 ZNF219 TMEM253 ENSG00000255472 RNASE13 TPPP2 piR-54764-162 lnc-RPGRIP1-2 HNRNPC
GH14J020582 Enhancer 0.4 Ensembl 4.9 +575.0 574959 3.4 NFE2 MYC POLR2A POU5F1 RNASE11 RNASE9 RNASE10 RNA5SP382 TEP1 PNP PIP4P1 OR5AU1 piR-41306-072 RNASE12
GH14J021195 Enhancer 0.2 Ensembl 10.4 -36.6 -36641 0.2 OR5AU1 RPGRIP1 lnc-RPGRIP1-2 piR-54764-162 HNRNPC
GH14J021216 Enhancer 0.4 FANTOM5 2.9 -57.7 -57730 0.3 RBM22 TRAV8-5 OR10G2 OR5AU1 RNASE8 OR4E2 OR10G3 LINC00641 HSALNG0021083 HNRNPC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR5AU1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR5AU1

Top Transcription factor binding sites by QIAGEN in the OR5AU1 gene promoter:
  • AML1a
  • LCR-F1
  • p300
  • RelA
  • Sox9
  • USF-1
  • USF1
  • USF2
  • ZIC2

Genomic Locations for OR5AU1 Gene

Latest Assembly
chr14:21,148,370-21,159,060
(GRCh38/hg38)
Size:
10,691 bases
Orientation:
Minus strand

Previous Assembly
chr14:21,623,024-21,624,222
(GRCh37/hg19 by Entrez Gene)
Size:
1,199 bases
Orientation:
Minus strand

chr14:21,623,026-21,624,222
(GRCh37/hg19 by Ensembl)
Size:
1,197 bases
Orientation:
Minus strand

Genomic View for OR5AU1 Gene

Genes around OR5AU1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5AU1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5AU1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5AU1 Gene

Proteins for OR5AU1 Gene

  • Protein details for OR5AU1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGC0-O5AU1_HUMAN
    Recommended name:
    Olfactory receptor 5AU1
    Protein Accession:
    Q8NGC0
    Secondary Accessions:
    • B2RP78
    • Q6IEU2
    • Q96R10

    Protein attributes for OR5AU1 Gene

    Size:
    362 amino acids
    Molecular mass:
    40658 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC06114.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR5AU1 Gene

Post-translational modifications for OR5AU1 Gene

  • Glycosylation at Asn56
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5AU1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5AU1 Gene

Domains & Families for OR5AU1 Gene

Gene Families for OR5AU1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5AU1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR5AU1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR14-38 (O5AU1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGC0

UniProtKB/Swiss-Prot:

O5AU1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5AU1: view

Function for OR5AU1 Gene

Molecular function for OR5AU1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR5AU1 Gene

Gene Ontology (GO) - Molecular Function for OR5AU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR5AU1: view
genes like me logo Genes that share phenotypes with OR5AU1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5AU1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5AU1 Gene

Localization for OR5AU1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5AU1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5AU1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5AU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5AU1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5AU1 Gene

Pathways & Interactions for OR5AU1 Gene

genes like me logo Genes that share pathways with OR5AU1: view

Pathways by source for OR5AU1 Gene

Interacting Proteins for OR5AU1 Gene

Gene Ontology (GO) - Biological Process for OR5AU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5AU1: view

No data available for SIGNOR curated interactions for OR5AU1 Gene

Drugs & Compounds for OR5AU1 Gene

No Compound Related Data Available

Transcripts for OR5AU1 Gene

mRNA/cDNA for OR5AU1 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5AU1

Alternative Splicing Database (ASD) splice patterns (SP) for OR5AU1 Gene

No ASD Table

Relevant External Links for OR5AU1 Gene

GeneLoc Exon Structure for
OR5AU1

Expression for OR5AU1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR5AU1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR5AU1

SOURCE GeneReport for Unigene cluster for OR5AU1 Gene:

Hs.553768
genes like me logo Genes that share expression patterns with OR5AU1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5AU1 Gene

Orthologs for OR5AU1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5AU1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC473329 29
  • 98.99 (n)
OR5AU1 30
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia OR5AU1 29 30
  • 86.83 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Or5au1 45 Olfr221 29 16 30
  • 84.84 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr1638 29
  • 84.57 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC101734160 29
  • 55.41 (n)
Species where no ortholog for OR5AU1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR5AU1 Gene

ENSEMBL:
Gene Tree for OR5AU1 (if available)
TreeFam:
Gene Tree for OR5AU1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR5AU1: view image
Alliance of Genome Resources:
Additional Orthologs for OR5AU1

Paralogs for OR5AU1 Gene

(452) SIMAP similar genes for OR5AU1 Gene using alignment to 1 proteins:

  • O5AU1_HUMAN
genes like me logo Genes that share paralogs with OR5AU1: view

Variants for OR5AU1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR5AU1 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs17102042 -- p.Val80Met
rs4982419 -- p.Leu117Phe
rs57985939 -- p.Asn274Lys
rs59120409 -- p.Ser194Leu
rs7145814 -- p.Ile299Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR5AU1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR5AU1 Gene

Variant ID Type Subtype PubMed ID
dgv592e212 CNV loss 25503493
esv2660178 CNV deletion 23128226
esv3633704 CNV loss 21293372
esv3633705 CNV loss 21293372
nsv524093 CNV gain 19592680

Variation tolerance for OR5AU1 Gene

Residual Variation Intolerance Score: 97.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.26; 70.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5AU1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5AU1
Leiden Open Variation Database (LOVD)
OR5AU1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5AU1 Gene

Disorders for OR5AU1 Gene

Additional Disease Information for OR5AU1

No disorders were found for OR5AU1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5AU1 Gene

Publications for OR5AU1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 4

Products for OR5AU1 Gene

Sources for OR5AU1 Gene