Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR5AU1 Gene

Aliases for OR5AU1 Gene

  • Olfactory Receptor Family 5 Subfamily AU Member 1 2 3 5
  • Olfactory Receptor OR14-38 3 4
  • Olfactory Receptor, Family 5, Subfamily AU, Member 1 2
  • Olfactory Receptor 5AU1 3
  • OR14-38 3

External Ids for OR5AU1 Gene

Previous GeneCards Identifiers for OR5AU1 Gene

  • GC14U990431
  • GC14M019614
  • GC14M020692
  • GC14M021623

Summaries for OR5AU1 Gene

Entrez Gene Summary for OR5AU1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5AU1 Gene

OR5AU1 (Olfactory Receptor Family 5 Subfamily AU Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5F1.

UniProtKB/Swiss-Prot for OR5AU1 Gene

  • Odorant receptor.

Gene Wiki entry for OR5AU1 Gene

Additional gene information for OR5AU1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5AU1 Gene

Genomics for OR5AU1 Gene

GeneHancer (GH) Regulatory Elements for OR5AU1 Gene

Promoters and enhancers for OR5AU1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J021191 Enhancer 1 Ensembl ENCODE 10.8 -33.0 -33041 1.4 ZFP64 RAD21 ZNF48 YY1 ZNF335 GLIS2 ZNF213 ZNF362 SP3 SP5 OR5AU1 ZNF219 TMEM253 RNASE13 ENSG00000255472 TPPP2 LOC100129923 LINC00641
GH14J021203 Enhancer 0.7 ENCODE 10.2 -45.0 -45034 1.7 SOX13 FOXA2 ARID4B ZNF205 TCF12 POLR2B ZNF614 POLR2A NFATC1 PAF1 SNORD9 UBA52P2 SNORD8 HNRNPC OR5AU1 SUPT16H LINC00641 LOC100129923
GH14J020797 Enhancer 0.8 FANTOM5 ENCODE dbSUPER 1.3 +361.7 361683 0.2 FOSL1 PNP PIP4P1 ARHGEF40 OR6S1 OR5AU1 HNRNPC LOC105370397 RNASE1
GH14J021216 Enhancer 0.3 FANTOM5 2.9 -57.7 -57730 0.3 TRAV8-5 OR10G2 OR5AU1 RNASE8 OR4E2 OR10G3 GC14P021210 GC14P021211 GC14P021259 HNRNPC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR5AU1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR5AU1 gene promoter:
  • LCR-F1
  • ZIC2
  • RelA
  • AML1a
  • p300
  • Sox9
  • USF-1
  • USF2
  • USF1

Genomic Locations for OR5AU1 Gene

Genomic Locations for OR5AU1 Gene
chr14:21,148,370-21,159,060
(GRCh38/hg38)
Size:
10,691 bases
Orientation:
Minus strand
chr14:21,623,026-21,624,222
(GRCh37/hg19)
Size:
1,197 bases
Orientation:
Minus strand

Genomic View for OR5AU1 Gene

Genes around OR5AU1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5AU1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5AU1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5AU1 Gene

Proteins for OR5AU1 Gene

  • Protein details for OR5AU1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGC0-O5AU1_HUMAN
    Recommended name:
    Olfactory receptor 5AU1
    Protein Accession:
    Q8NGC0
    Secondary Accessions:
    • B2RP78
    • Q6IEU2
    • Q96R10

    Protein attributes for OR5AU1 Gene

    Size:
    362 amino acids
    Molecular mass:
    40658 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC06114.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR5AU1 Gene

Post-translational modifications for OR5AU1 Gene

  • Glycosylation at Asn56
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5AU1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5AU1 Gene

Domains & Families for OR5AU1 Gene

Gene Families for OR5AU1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5AU1 Gene

Suggested Antigen Peptide Sequences for OR5AU1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGC0

UniProtKB/Swiss-Prot:

O5AU1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5AU1: view

Function for OR5AU1 Gene

Molecular function for OR5AU1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5AU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5AU1: view
genes like me logo Genes that share phenotypes with OR5AU1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5AU1 Gene

Localization for OR5AU1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5AU1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5AU1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5AU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5AU1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5AU1 Gene

Pathways & Interactions for OR5AU1 Gene

genes like me logo Genes that share pathways with OR5AU1: view

Pathways by source for OR5AU1 Gene

Interacting Proteins for OR5AU1 Gene

Gene Ontology (GO) - Biological Process for OR5AU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA,IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5AU1: view

No data available for SIGNOR curated interactions for OR5AU1 Gene

Drugs & Compounds for OR5AU1 Gene

No Compound Related Data Available

Transcripts for OR5AU1 Gene

mRNA/cDNA for OR5AU1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR5AU1 Gene

Olfactory receptor, family 5, subfamily AU, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5AU1 Gene

No ASD Table

Relevant External Links for OR5AU1 Gene

GeneLoc Exon Structure for
OR5AU1
ECgene alternative splicing isoforms for
OR5AU1

Expression for OR5AU1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5AU1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5AU1 Gene:

OR5AU1

SOURCE GeneReport for Unigene cluster for OR5AU1 Gene:

Hs.553768
genes like me logo Genes that share expression patterns with OR5AU1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5AU1 Gene

Orthologs for OR5AU1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5AU1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC473329 33
  • 98.99 (n)
OR5AU1 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR5AU1 34 33
  • 86.83 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Or5au1 51 Olfr221 16 34 33
  • 84.84 (n)
rat
(Rattus norvegicus)
Mammalia Olr1638 33
  • 84.57 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734160 33
  • 55.41 (n)
Species where no ortholog for OR5AU1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5AU1 Gene

ENSEMBL:
Gene Tree for OR5AU1 (if available)
TreeFam:
Gene Tree for OR5AU1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR5AU1: view image

Paralogs for OR5AU1 Gene

Paralogs for OR5AU1 Gene

(452) SIMAP similar genes for OR5AU1 Gene using alignment to 1 proteins:

  • O5AU1_HUMAN
genes like me logo Genes that share paralogs with OR5AU1: view

Variants for OR5AU1 Gene

Sequence variations from dbSNP and Humsavar for OR5AU1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000805546 -- 21,156,490(-) G/A upstream_transcript_variant
rs1002846021 -- 21,154,640(-) G/A downstream_transcript_variant
rs1004390612 -- 21,156,189(-) T/C upstream_transcript_variant
rs1008887811 -- 21,156,516(-) G/T upstream_transcript_variant
rs1009895228 -- 21,157,872(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR5AU1 Gene

Variant ID Type Subtype PubMed ID
dgv592e212 CNV loss 25503493
esv2660178 CNV deletion 23128226
esv3633704 CNV loss 21293372
esv3633705 CNV loss 21293372
nsv524093 CNV gain 19592680

Variation tolerance for OR5AU1 Gene

Residual Variation Intolerance Score: 97.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.26; 70.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5AU1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5AU1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5AU1 Gene

Disorders for OR5AU1 Gene

Additional Disease Information for OR5AU1

No disorders were found for OR5AU1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5AU1 Gene

Publications for OR5AU1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for OR5AU1 Gene

Sources for OR5AU1 Gene

Content
Loading form....