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Aliases for OR5AR1 Gene

Aliases for OR5AR1 Gene

  • Olfactory Receptor Family 5 Subfamily AR Member 1 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 5, Subfamily AR, Member 1 2 3
  • Olfactory Receptor OR11-209 3 4
  • Olfactory Receptor, Family 5, Subfamily AR, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor 5AR1 3
  • OR11-209 3

External Ids for OR5AR1 Gene

Previous GeneCards Identifiers for OR5AR1 Gene

  • GC11U990454
  • GC11P056207
  • GC11P056187
  • GC11P056431

Summaries for OR5AR1 Gene

Entrez Gene Summary for OR5AR1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR5AR1 Gene

OR5AR1 (Olfactory Receptor Family 5 Subfamily AR Member 1 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5W2.

UniProtKB/Swiss-Prot for OR5AR1 Gene

  • Odorant receptor.

Gene Wiki entry for OR5AR1 Gene

Additional gene information for OR5AR1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5AR1 Gene

Genomics for OR5AR1 Gene

GeneHancer (GH) Regulatory Elements for OR5AR1 Gene

Promoters and enhancers for OR5AR1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J056895 Enhancer 0.2 FANTOM5 7 +232.2 232154 0 OR5M10 OR5M9 OR5AP2 OR5M1 OR5M3 OR5AR1 OR5M8 OR5R1 OR5M11 FADS2P1
GH11J056659 Enhancer 0.5 ENCODE 0.7 -3.7 -3732 1.1 SP1 NANOG POLR2A POU5F1 OR5AR1 OR5AP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR5AR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR5AR1 gene promoter:
  • RP58
  • Nkx3-1
  • Nkx3-1 v4
  • Nkx3-1 v3
  • Nkx3-1 v2
  • Nkx3-1 v1
  • Pax-6
  • E47
  • Tal-1

Genomic Locations for OR5AR1 Gene

Genomic Locations for OR5AR1 Gene
1,026 bases
Plus strand
1,026 bases
Plus strand

Genomic View for OR5AR1 Gene

Genes around OR5AR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5AR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5AR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5AR1 Gene

Proteins for OR5AR1 Gene

  • Protein details for OR5AR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 5AR1
    Protein Accession:
    Secondary Accessions:
    • Q6IF61

    Protein attributes for OR5AR1 Gene

    310 amino acids
    Molecular mass:
    34815 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5AR1 Gene

Post-translational modifications for OR5AR1 Gene

  • Glycosylation at isoforms=5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5AR1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5AR1 Gene

Domains & Families for OR5AR1 Gene

Gene Families for OR5AR1 Gene

Protein Domains for OR5AR1 Gene

Suggested Antigen Peptide Sequences for OR5AR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5AR1: view

Function for OR5AR1 Gene

Molecular function for OR5AR1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5AR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5AR1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5AR1 Gene

Localization for OR5AR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5AR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5AR1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5AR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5AR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5AR1 Gene

Pathways & Interactions for OR5AR1 Gene

genes like me logo Genes that share pathways with OR5AR1: view

Pathways by source for OR5AR1 Gene

Interacting Proteins for OR5AR1 Gene

Gene Ontology (GO) - Biological Process for OR5AR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA,IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5AR1: view

No data available for SIGNOR curated interactions for OR5AR1 Gene

Drugs & Compounds for OR5AR1 Gene

No Compound Related Data Available

Transcripts for OR5AR1 Gene

mRNA/cDNA for OR5AR1 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR5AR1 Gene

Olfactory receptor, family 5, subfamily AR, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5AR1 Gene

No ASD Table

Relevant External Links for OR5AR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR5AR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5AR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5AR1 Gene:


SOURCE GeneReport for Unigene cluster for OR5AR1 Gene:

genes like me logo Genes that share expression patterns with OR5AR1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5AR1 Gene

Orthologs for OR5AR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5AR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC747894 33
  • 99.25 (n)
OR5AR1 34
  • 98 (a)
(Bos Taurus)
Mammalia OR5AR1 34 33
  • 90.86 (n)
(Canis familiaris)
Mammalia OR5AR1 34 33
  • 90.54 (n)
(Rattus norvegicus)
Mammalia Olr462 33
  • 87.74 (n)
(Mus musculus)
Mammalia Or5ar1 51 Olfr1019 16 34 33
  • 87.63 (n)
(Monodelphis domestica)
Mammalia OR5AR1 34
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia OR5AR1 34
  • 57 (a)
(Anolis carolinensis)
Reptilia OR5AR1 34
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732693 33
  • 55.74 (n)
Species where no ortholog for OR5AR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5AR1 Gene

Gene Tree for OR5AR1 (if available)
Gene Tree for OR5AR1 (if available)

Paralogs for OR5AR1 Gene

Paralogs for OR5AR1 Gene

(459) SIMAP similar genes for OR5AR1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR5AR1: view

Variants for OR5AR1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR5AR1 Gene

A stop codon in the gene coding for this protein at position Gln-19 is responsible for functional diversity thus producing a pseudogene.

Sequence variations from dbSNP and Humsavar for OR5AR1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1001776832 -- 56,663,546(+) T/C upstream_transcript_variant
rs1003447470 -- 56,664,708(+) C/T downstream_transcript_variant
rs1004205029 -- 56,664,934(+) C/T downstream_transcript_variant
rs1005175713 -- 56,662,875(+) G/C upstream_transcript_variant
rs1005880593 -- 56,663,933(+) C/T coding_sequence_variant, missense_variant

Variation tolerance for OR5AR1 Gene

Residual Variation Intolerance Score: 64.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.59; 65.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5AR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Structural Variations from Database of Genomic Variants (DGV) for OR5AR1 Gene

Disorders for OR5AR1 Gene

Additional Disease Information for OR5AR1

No disorders were found for OR5AR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5AR1 Gene

Publications for OR5AR1 Gene

  1. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q … O'Donnell CJ (BMC medical genetics 2007) 3 44 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 3 58
  4. Genetic elucidation of human hyperosmia to isovaleric acid. (PMID: 17973576) Menashe I … Lancet D (PLoS biology 2007) 4 58
  5. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I … Lancet D (BMC bioinformatics 2006) 3 58

Products for OR5AR1 Gene

Sources for OR5AR1 Gene

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