Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR5AR1 Gene

Aliases for OR5AR1 Gene

  • Olfactory Receptor Family 5 Subfamily AR Member 1 2 3
  • Olfactory Receptor Family 5 Subfamily AR Member 1 (Gene/Pseudogene) 2 5
  • Olfactory Receptor OR11-209 3 4
  • Olfactory Receptor 5AR1 3 4
  • Olfactory Receptor, Family 5, Subfamily AR, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 5, Subfamily AR, Member 1 2
  • OR11-209 3
  • OR5AR1 5

External Ids for OR5AR1 Gene

Previous GeneCards Identifiers for OR5AR1 Gene

  • GC11U990454
  • GC11P056207
  • GC11P056187
  • GC11P056431

Summaries for OR5AR1 Gene

Entrez Gene Summary for OR5AR1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR5AR1 Gene

OR5AR1 (Olfactory Receptor Family 5 Subfamily AR Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR5B12.

UniProtKB/Swiss-Prot Summary for OR5AR1 Gene

Gene Wiki entry for OR5AR1 Gene

Additional gene information for OR5AR1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR5AR1 Gene

Genomics for OR5AR1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR5AR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J056624 Enhancer 0.6 Ensembl 10.9 -38.6 -38562 0.2 RELA CTCF PKNOX1 ARID3A DPF2 RELB BMI1 SMARCA5 ATF2 MTA2 piR-38351-075 OR5AR1 OR2AH1P OR5AM1P OR5M1 OR5AP2 lnc-OR5AR1-1 lnc-OR9G1-1
GH11J056895 Enhancer 0.2 FANTOM5 7 +232.2 232154 0 OR5M10 OR5M9 OR5AP2 OR5M1 OR5M3 OR5AR1 OR5M8 OR5R1 OR5M11 FADS2B
GH11J056659 Enhancer 0.5 ENCODE 0.7 -3.7 -3732 1.1 TEAD4 POLR2A CHD1 TAF1 NANOG TBP SP1 POU5F1 OR5AR1 piR-45932-012 OR5AP2 lnc-OR9G1-1
GH11J056660 Enhancer 0.2 Ensembl 0.7 -4.6 -4561 0.2 piR-45932-012 OR5AR1 OR5AP2 lnc-OR9G1-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR5AR1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR5AR1

Top Transcription factor binding sites by QIAGEN in the OR5AR1 gene promoter:
  • E47
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • Pax-6
  • RP58
  • Tal-1

Genomic Locations for OR5AR1 Gene

Genomic Locations for OR5AR1 Gene
chr11:56,663,662-56,664,687
(GRCh38/hg38)
Size:
1,026 bases
Orientation:
Plus strand
chr11:56,431,138-56,432,163
(GRCh37/hg19)
Size:
1,026 bases
Orientation:
Plus strand

Genomic View for OR5AR1 Gene

Genes around OR5AR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5AR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5AR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5AR1 Gene

Proteins for OR5AR1 Gene

  • Protein details for OR5AR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGP9-O5AR1_HUMAN
    Recommended name:
    Olfactory receptor 5AR1
    Protein Accession:
    Q8NGP9
    Secondary Accessions:
    • Q6IF61

    Protein attributes for OR5AR1 Gene

    Size:
    310 amino acids
    Molecular mass:
    34815 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5AR1 Gene

Post-translational modifications for OR5AR1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5AR1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5AR1 Gene

Domains & Families for OR5AR1 Gene

Gene Families for OR5AR1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5AR1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR5AR1 Gene

GenScript: Design optimal peptide antigens:
  • OR5AR1 protein (B9EIN0_HUMAN)
  • Olfactory receptor OR11-209 (O5AR1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGP9

UniProtKB/Swiss-Prot:

O5AR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5AR1: view

Function for OR5AR1 Gene

Molecular function for OR5AR1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR5AR1 Gene

Gene Ontology (GO) - Molecular Function for OR5AR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005507 copper ion binding IEA --
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR5AR1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5AR1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5AR1 Gene

Localization for OR5AR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5AR1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5AR1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5AR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5AR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5AR1 Gene

Pathways & Interactions for OR5AR1 Gene

genes like me logo Genes that share pathways with OR5AR1: view

Pathways by source for OR5AR1 Gene

Interacting Proteins for OR5AR1 Gene

Gene Ontology (GO) - Biological Process for OR5AR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IEA --
genes like me logo Genes that share ontologies with OR5AR1: view

No data available for SIGNOR curated interactions for OR5AR1 Gene

Drugs & Compounds for OR5AR1 Gene

No Compound Related Data Available

Transcripts for OR5AR1 Gene

mRNA/cDNA for OR5AR1 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5AR1

Alternative Splicing Database (ASD) splice patterns (SP) for OR5AR1 Gene

No ASD Table

Relevant External Links for OR5AR1 Gene

GeneLoc Exon Structure for
OR5AR1

Expression for OR5AR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR5AR1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR5AR1

SOURCE GeneReport for Unigene cluster for OR5AR1 Gene:

Hs.553633
genes like me logo Genes that share expression patterns with OR5AR1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5AR1 Gene

Orthologs for OR5AR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5AR1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC747894 30
  • 99.25 (n)
OR5AR1 31
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia OR5AR1 30 31
  • 90.86 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia OR5AR1 30 31
  • 90.54 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr462 30
  • 87.74 (n)
Mouse
(Mus musculus)
Mammalia Or5ar1 46 Olfr1019 30 17 31
  • 87.63 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia OR5AR1 31
  • 85 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia OR5AR1 31
  • 57 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia OR5AR1 31
  • 61 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC101732693 30
  • 55.74 (n)
Species where no ortholog for OR5AR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR5AR1 Gene

ENSEMBL:
Gene Tree for OR5AR1 (if available)
TreeFam:
Gene Tree for OR5AR1 (if available)

Paralogs for OR5AR1 Gene

(459) SIMAP similar genes for OR5AR1 Gene using alignment to 2 proteins:

  • O5AR1_HUMAN
  • B9EIN0_HUMAN
genes like me logo Genes that share paralogs with OR5AR1: view

Variants for OR5AR1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR5AR1 Gene

O5AR1_HUMAN-Q8NGP9
A stop codon in the gene coding for this protein at position Gln-19 is responsible for functional diversity thus producing a pseudogene.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR5AR1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
713757 Benign: not provided 56,664,617(+) A/T STOP_LOST
rs56067375 - p.Ile225Val

Additional dbSNP identifiers (rs#s) for OR5AR1 Gene

Variation tolerance for OR5AR1 Gene

Residual Variation Intolerance Score: 64.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.59; 65.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5AR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5AR1

No data available for Structural Variations from Database of Genomic Variants (DGV) for OR5AR1 Gene

Disorders for OR5AR1 Gene

Additional Disease Information for OR5AR1

No disorders were found for OR5AR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5AR1 Gene

Publications for OR5AR1 Gene

  1. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q … O'Donnell CJ (BMC medical genetics 2007) 3 41
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Genetic elucidation of human hyperosmia to isovaleric acid. (PMID: 17973576) Menashe I … Lancet D (PLoS biology 2007) 4

Products for OR5AR1 Gene

Sources for OR5AR1 Gene