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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR5AP2 (Olfactory Receptor Family 5 Subfamily AP Member 2) is a Protein Coding gene. Diseases associated with OR5AP2 include Miles-Carpenter Syndrome. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR5B12.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J056895 | Enhancer | 0.2 | FANTOM5 | 12.8 | -253.3 | -253345 | 0 | OR5M10 OR5M9 OR5AP2 OR5M1 OR5M3 OR5AR1 OR5M8 OR5R1 OR5M11 FADS2B | ||
GH11J056533 | Enhancer | 0.2 | ENCODE | 9.9 | +108.9 | 108881 | 0.1 | OR5AP2 OR5G5P OR5M11 OR5M5P OR5M8 | ||
GH11J056624 | Enhancer | 0.6 | Ensembl | 0.4 | +17.4 | 17371 | 0.2 | RELA CTCF PKNOX1 ARID3A DPF2 RELB BMI1 SMARCA5 ATF2 MTA2 | piR-38351-075 OR5AR1 OR2AH1P OR5AM1P OR5M1 OR5AP2 lnc-OR5AR1-1 lnc-OR9G1-1 | |
GH11J056659 | Enhancer | 0.5 | ENCODE | 0.4 | -17.5 | -17459 | 1.1 | TEAD4 POLR2A CHD1 TAF1 NANOG TBP SP1 POU5F1 | OR5AR1 piR-45932-012 OR5AP2 lnc-OR9G1-1 | |
GH11J056660 | Enhancer | 0.2 | Ensembl | 0.4 | -16.6 | -16630 | 0.2 | piR-45932-012 OR5AR1 OR5AP2 lnc-OR9G1-1 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IBA | -- |
GO:0005549 | odorant binding | IBA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IBA | -- |
GO:0007608 | sensory perception of smell | IBA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC466575 30 |
|
||
OR5AP2 31 |
|
OneToOne | |||
Dog (Canis familiaris) |
Mammalia | OR5AP2 31 |
|
OneToOne | |
LOC100683182 30 |
|
||||
Rat (Rattus norvegicus) |
Mammalia | Olr463 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Or5ap2 46 Olfr1020 30 17 31 |
|
OneToOne |
|
Or5ap2b-ps 46 Olfr1021-ps1 |
|
|
|||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | OR5AP2 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | LOC430735 30 |
|
||
COR6 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs11606499 | - | p.Ala105Thr |
Disorder | Aliases | PubMed IDs |
---|---|---|
miles-carpenter syndrome |
|
|