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Aliases for OR5AK2 Gene

Aliases for OR5AK2 Gene

  • Olfactory Receptor Family 5 Subfamily AK Member 2 2 3 5
  • Olfactory Receptor, Family 5, Subfamily AK, Member 2 2
  • Olfactory Receptor 5AK2 3

External Ids for OR5AK2 Gene

Previous GeneCards Identifiers for OR5AK2 Gene

  • GC11U990463
  • GC11P056532
  • GC11P056512
  • GC11P056756

Summaries for OR5AK2 Gene

Entrez Gene Summary for OR5AK2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5AK2 Gene

OR5AK2 (Olfactory Receptor Family 5 Subfamily AK Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and odorant binding.

UniProtKB/Swiss-Prot for OR5AK2 Gene

  • Odorant receptor.

Gene Wiki entry for OR5AK2 Gene

Additional gene information for OR5AK2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5AK2 Gene

Genomics for OR5AK2 Gene

GeneHancer (GH) Regulatory Elements for OR5AK2 Gene

Promoters and enhancers for OR5AK2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J057475 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 2.1 +487.5 487495 1.7 HDGF CTCF USF1 BACH1 MAX EBF1 RAD21 RELA E2F1 POLR2A ENSG00000255301 GC11P057477 TIMM10 OR5AK2 UBE2L6 BTBD18 SSRP1 RTN4RL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR5AK2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR5AK2 gene promoter:
  • Hand1
  • E47
  • Ik-3
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • Tal-1beta
  • ITF-2

Genomic Locations for OR5AK2 Gene

Genomic Locations for OR5AK2 Gene
996 bases
Plus strand
996 bases
Plus strand

Genomic View for OR5AK2 Gene

Genes around OR5AK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5AK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5AK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5AK2 Gene

Proteins for OR5AK2 Gene

  • Protein details for OR5AK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 5AK2
    Protein Accession:
    Secondary Accessions:
    • B2RNZ9

    Protein attributes for OR5AK2 Gene

    309 amino acids
    Molecular mass:
    34627 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5AK2 Gene

Post-translational modifications for OR5AK2 Gene

  • Glycosylation at Asn265, isoforms=155, and Asn5

Other Protein References for OR5AK2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5AK2 Gene

Domains & Families for OR5AK2 Gene

Gene Families for OR5AK2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5AK2 Gene

Suggested Antigen Peptide Sequences for OR5AK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5AK2: view

Function for OR5AK2 Gene

Molecular function for OR5AK2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5AK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5AK2: view
genes like me logo Genes that share phenotypes with OR5AK2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5AK2 Gene

Localization for OR5AK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5AK2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5AK2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5AK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5AK2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5AK2 Gene

Pathways & Interactions for OR5AK2 Gene

genes like me logo Genes that share pathways with OR5AK2: view

Pathways by source for OR5AK2 Gene

Interacting Proteins for OR5AK2 Gene

Gene Ontology (GO) - Biological Process for OR5AK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA,IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5AK2: view

No data available for SIGNOR curated interactions for OR5AK2 Gene

Drugs & Compounds for OR5AK2 Gene

No Compound Related Data Available

Transcripts for OR5AK2 Gene

mRNA/cDNA for OR5AK2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR5AK2 Gene

Olfactory receptor, family 5, subfamily AK, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5AK2 Gene

No ASD Table

Relevant External Links for OR5AK2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR5AK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5AK2 Gene

mRNA differential expression in normal tissues according to GTEx for OR5AK2 Gene

This gene is overexpressed in Spleen (x49.5).

Protein differential expression in normal tissues from HIPED for OR5AK2 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR5AK2 Gene

Protein tissue co-expression partners for OR5AK2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5AK2 Gene:


SOURCE GeneReport for Unigene cluster for OR5AK2 Gene:

genes like me logo Genes that share expression patterns with OR5AK2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5AK2 Gene

Orthologs for OR5AK2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5AK2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466581 33
  • 98.27 (n)
OR5AK2 34
  • 97 (a)
(Bos Taurus)
Mammalia LOC100139408 33
  • 84.04 (n)
OR5AK2 34
  • 77 (a)
(Canis familiaris)
Mammalia OR5AK2 34 33
  • 83.06 (n)
(Mus musculus)
Mammalia Olfr993 16 34 33
  • 78.69 (n)
Olfr994 34
  • 74 (a)
Olfr995 34
  • 73 (a)
Or5ak19-ps 51 Olfr1400-ps1
  • chr12:48,903,854-48,904,481
(Rattus norvegicus)
Mammalia Olr440 33
  • 77.6 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 66 (a)
-- 34
  • 65 (a)
-- 34
  • 61 (a)
-- 34
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia OR5AK2 34
  • 49 (a)
(Gallus gallus)
Aves OR8D4 34
  • 45 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 49 (a)
-- 34
  • 43 (a)
-- 34
  • 43 (a)
-- 34
  • 41 (a)
-- 34
  • 41 (a)
Species where no ortholog for OR5AK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5AK2 Gene

Gene Tree for OR5AK2 (if available)
Gene Tree for OR5AK2 (if available)
Evolutionary constrained regions (ECRs) for OR5AK2: view image

Paralogs for OR5AK2 Gene

(442) SIMAP similar genes for OR5AK2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR5AK2: view

No data available for Paralogs for OR5AK2 Gene

Variants for OR5AK2 Gene

Sequence variations from dbSNP and Humsavar for OR5AK2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000977692 -- 56,987,435(+) A/T upstream_transcript_variant
rs1000993545 -- 56,987,532(+) G/A upstream_transcript_variant
rs1001046104 -- 56,987,352(+) G/A upstream_transcript_variant
rs1001087199 -- 56,987,745(+) A/C upstream_transcript_variant
rs1001711455 -- 56,989,829(+) A/G coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for OR5AK2 Gene

Variant ID Type Subtype PubMed ID
nsv832162 CNV loss 17160897

Variation tolerance for OR5AK2 Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.12; 61.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5AK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5AK2 Gene

Disorders for OR5AK2 Gene

Additional Disease Information for OR5AK2

No disorders were found for OR5AK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5AK2 Gene

Publications for OR5AK2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR5AK2 Gene

Sources for OR5AK2 Gene

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