Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR5AK2 Gene

Aliases for OR5AK2 Gene

  • Olfactory Receptor Family 5 Subfamily AK Member 2 2 3 5
  • Olfactory Receptor 5AK2 3 4
  • Olfactory Receptor, Family 5, Subfamily AK, Member 2 2
  • OR5AK2 5

External Ids for OR5AK2 Gene

Previous GeneCards Identifiers for OR5AK2 Gene

  • GC11U990463
  • GC11P056532
  • GC11P056512
  • GC11P056756

Summaries for OR5AK2 Gene

Entrez Gene Summary for OR5AK2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5AK2 Gene

OR5AK2 (Olfactory Receptor Family 5 Subfamily AK Member 2) is a Protein Coding gene. Diseases associated with OR5AK2 include Gastrointestinal Lymphoma. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR5AK3P.

UniProtKB/Swiss-Prot Summary for OR5AK2 Gene

Gene Wiki entry for OR5AK2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR5AK2 Gene

Genomics for OR5AK2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR5AK2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J057475 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 2.1 +487.5 487495 1.7 POLR2A TRIM22 CTCF MAX SMC3 EBF1 BHLHE40 TAF1 ZBTB33 IKZF1 ENSG00000255301 TIMM10 OR5AK2 UBE2L6 BTBD18 SSRP1 RTN4RL2 SLC43A1
GH11J056932 Enhancer 0.6 ENCODE 0.2 -56.0 -55973 1.1 JUND CEBPB EP300 INSM2 ZNF24 ZNF362 SP7 ZNF366 ATF3 ZNF629 SLC43A3 HSALNG0084230 piR-44198-003 LOC105369310 OR5AK2 OR9G4
GH11J057071 Enhancer 0.7 Ensembl ENCODE 0.2 +83.9 83929 2.4 JUND EP300 BHLHE40 POLR2A SPI1 FOS CEBPB SIN3A YPEL4 P2RX3 lnc-APLNR-3 OR5BP1P HSALNG0084239 OR5AK2 LRRC55 LOC105369309
GH11J057126 Enhancer 1 Ensembl ENCODE 0.1 +138.4 138382 1.4 NCOR1 IKZF1 ZNF592 NFIC HES1 ARNT TAL1 STAT3 TCF7L2 ZFP91 APLNR PRG2 piR-57460-088 HSALNG0084243 LRRC55 LOC105369309 OR5AK2
GH11J056884 Enhancer 0.7 Ensembl ENCODE 0.2 -103.2 -103195 1.8 CEBPA ZNF316 MAFG MAFF TFAP4 HDAC2 MAFK ZFP36 KDM1A OR5G5P FADS2B HSALNG0084223-001 HSALNG0084223-002 LINC02735 HSALNG0084226 OR5AK2 OR9G4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR5AK2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR5AK2

Top Transcription factor binding sites by QIAGEN in the OR5AK2 gene promoter:
  • E47
  • Hand1
  • Ik-3
  • ITF-2
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • Tal-1beta

Genomic Locations for OR5AK2 Gene

Latest Assembly
chr11:56,988,872-56,989,867
(GRCh38/hg38)
Size:
996 bases
Orientation:
Plus strand

Previous Assembly
chr11:56,756,389-56,757,318
(GRCh37/hg19 by Entrez Gene)
Size:
930 bases
Orientation:
Plus strand

chr11:56,756,347-56,757,342
(GRCh37/hg19 by Ensembl)
Size:
996 bases
Orientation:
Plus strand

Genomic View for OR5AK2 Gene

Genes around OR5AK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5AK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5AK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5AK2 Gene

Proteins for OR5AK2 Gene

  • Protein details for OR5AK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH90-O5AK2_HUMAN
    Recommended name:
    Olfactory receptor 5AK2
    Protein Accession:
    Q8NH90
    Secondary Accessions:
    • B2RNZ9

    Protein attributes for OR5AK2 Gene

    Size:
    309 amino acids
    Molecular mass:
    34627 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5AK2 Gene

Post-translational modifications for OR5AK2 Gene

  • Glycosylation at Asn5, Asn155, and Asn265

Other Protein References for OR5AK2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5AK2 Gene

Domains & Families for OR5AK2 Gene

Gene Families for OR5AK2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5AK2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR5AK2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 5AK2 (O5AK2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NH90

UniProtKB/Swiss-Prot:

O5AK2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5AK2: view

Function for OR5AK2 Gene

Molecular function for OR5AK2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR5AK2 Gene

Gene Ontology (GO) - Molecular Function for OR5AK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR5AK2: view
genes like me logo Genes that share phenotypes with OR5AK2: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5AK2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5AK2 Gene

Localization for OR5AK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5AK2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5AK2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5AK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5AK2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5AK2 Gene

Pathways & Interactions for OR5AK2 Gene

genes like me logo Genes that share pathways with OR5AK2: view

Pathways by source for OR5AK2 Gene

Interacting Proteins for OR5AK2 Gene

Gene Ontology (GO) - Biological Process for OR5AK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IBA 21873635
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5AK2: view

No data available for SIGNOR curated interactions for OR5AK2 Gene

Drugs & Compounds for OR5AK2 Gene

No Compound Related Data Available

Transcripts for OR5AK2 Gene

mRNA/cDNA for OR5AK2 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5AK2

Alternative Splicing Database (ASD) splice patterns (SP) for OR5AK2 Gene

No ASD Table

Relevant External Links for OR5AK2 Gene

GeneLoc Exon Structure for
OR5AK2

Expression for OR5AK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR5AK2 Gene

mRNA differential expression in normal tissues according to GTEx for OR5AK2 Gene

This gene is overexpressed in Spleen (x49.5).

Protein differential expression in normal tissues from HIPED for OR5AK2 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR5AK2 Gene



Protein tissue co-expression partners for OR5AK2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR5AK2

SOURCE GeneReport for Unigene cluster for OR5AK2 Gene:

Hs.554520
genes like me logo Genes that share expression patterns with OR5AK2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5AK2 Gene

Orthologs for OR5AK2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5AK2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466581 29
  • 98.27 (n)
OR5AK2 30
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC100139408 29
  • 84.04 (n)
OR5AK2 30
  • 77 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia OR5AK2 29 30
  • 83.06 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Olfr993 29 16 30
  • 78.69 (n)
OneToMany
Olfr994 30
  • 74 (a)
OneToMany
Olfr995 30
  • 73 (a)
OneToMany
Or5ak19-ps 45 Olfr1400-ps1
  • chr12:48,903,854-48,904,481
Rat
(Rattus norvegicus)
Mammalia Olr440 29
  • 77.6 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 66 (a)
OneToMany
-- 30
  • 65 (a)
OneToMany
-- 30
  • 61 (a)
OneToMany
-- 30
  • 61 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia OR5AK2 30
  • 49 (a)
OneToOne
Chicken
(Gallus gallus)
Aves OR8D4 30
  • 45 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 49 (a)
ManyToMany
-- 30
  • 43 (a)
ManyToMany
-- 30
  • 43 (a)
ManyToMany
-- 30
  • 41 (a)
ManyToMany
-- 30
  • 41 (a)
ManyToMany
Species where no ortholog for OR5AK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR5AK2 Gene

ENSEMBL:
Gene Tree for OR5AK2 (if available)
TreeFam:
Gene Tree for OR5AK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR5AK2: view image
Alliance of Genome Resources:
Additional Orthologs for OR5AK2

Paralogs for OR5AK2 Gene

(442) SIMAP similar genes for OR5AK2 Gene using alignment to 1 proteins:

  • O5AK2_HUMAN
genes like me logo Genes that share paralogs with OR5AK2: view

Variants for OR5AK2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR5AK2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs10896563 -- p.Gly4Val
rs12420424 -- p.Ser43Thr
rs2853083 -- p.Met92Ile

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR5AK2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR5AK2 Gene

Variant ID Type Subtype PubMed ID
nsv832162 CNV loss 17160897

Variation tolerance for OR5AK2 Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.12; 61.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5AK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5AK2
Leiden Open Variation Database (LOVD)
OR5AK2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5AK2 Gene

Disorders for OR5AK2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR5AK2 Gene - From: COP

Disorder Aliases PubMed IDs
gastrointestinal lymphoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for OR5AK2

genes like me logo Genes that share disorders with OR5AK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR5AK2 Gene

Publications for OR5AK2 Gene

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for OR5AK2 Gene

Sources for OR5AK2 Gene