Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR5AC2 Gene

Aliases for OR5AC2 Gene

  • Olfactory Receptor Family 5 Subfamily AC Member 2 2 3 5
  • HSA1 2 3 4
  • Olfactory Receptor 5AC2 3 4
  • Olfactory Receptor, Family 5, Subfamily AC, Member 2 2
  • OR5AC2 5

External Ids for OR5AC2 Gene

Previous GeneCards Identifiers for OR5AC2 Gene

  • GC03P094426
  • GC00U905518
  • GC03P099126
  • GC03P099104
  • GC03P099289
  • GC03P097806

Summaries for OR5AC2 Gene

Entrez Gene Summary for OR5AC2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5AC2 Gene

OR5AC2 (Olfactory Receptor Family 5 Subfamily AC Member 2) is a Protein Coding gene. Diseases associated with OR5AC2 include Cataract 37 and Cataract 21, Multiple Types. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR5H2.

UniProtKB/Swiss-Prot Summary for OR5AC2 Gene

Gene Wiki entry for OR5AC2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR5AC2 Gene

Genomics for OR5AC2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR5AC2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J098058 Enhancer 0.4 Ensembl 12 -28.6 -28583 2 SPI1 POLR2A REST OR5AC2 OR5AC1 lnc-OR5AC2-2 GABRR3
GH03J097981 Enhancer 0.9 FANTOM5 Ensembl ENCODE 2.8 -104.2 -104197 3 FOXA2 RXRA RARA JUND BCL6 BATF HNF4A SP1 ATF3 ARL6 RIOX2 OR5K3 OR5AC2 ENSG00000285614 HSALNG0027470 GABRR3
GH03J098050 Enhancer 0.2 Ensembl 11.3 -36.5 -36472 0.6 OR5AC2 CPOX CRYBG3 OR5BM1P GABRR3
GH03J098047 Enhancer 0.2 Ensembl 11.3 -38.7 -38672 1 CRYBG3 OR5AC2 CPOX OR5BM1P GABRR3
GH03J098341 Enhancer 0.2 FANTOM5 3 +254.1 254127 0 OR5H2 OR5H6 OR5K4 OR5AC2 piR-30791-067 ENSG00000251088
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR5AC2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR5AC2

Top Transcription factor binding sites by QIAGEN in the OR5AC2 gene promoter:
  • Brachyury
  • FOXC1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • Nkx6-1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for OR5AC2 Gene

Latest Assembly
chr3:98,087,173-98,088,102
(GRCh38/hg38)
Size:
930 bases
Orientation:
Plus strand

Previous Assembly
chr3:97,806,017-97,806,946
(GRCh37/hg19 by Entrez Gene)
Size:
930 bases
Orientation:
Plus strand

chr3:97,806,017-97,806,946
(GRCh37/hg19 by Ensembl)
Size:
930 bases
Orientation:
Plus strand

Genomic View for OR5AC2 Gene

Genes around OR5AC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5AC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5AC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5AC2 Gene

Proteins for OR5AC2 Gene

  • Protein details for OR5AC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZP5-O5AC2_HUMAN
    Recommended name:
    Olfactory receptor 5AC2
    Protein Accession:
    Q9NZP5

    Protein attributes for OR5AC2 Gene

    Size:
    309 amino acids
    Molecular mass:
    35304 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5AC2 Gene

Post-translational modifications for OR5AC2 Gene

  • Glycosylation at Asn7
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5AC2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5AC2 Gene

Domains & Families for OR5AC2 Gene

Gene Families for OR5AC2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5AC2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR5AC2 Gene

GenScript: Design optimal peptide antigens:
  • HSA1 (O5AC2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NZP5

UniProtKB/Swiss-Prot:

O5AC2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5AC2: view

Function for OR5AC2 Gene

Molecular function for OR5AC2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5AC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 10706615
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR5AC2: view
genes like me logo Genes that share phenotypes with OR5AC2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5AC2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5AC2 Gene

Localization for OR5AC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5AC2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5AC2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5AC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 10706615
genes like me logo Genes that share ontologies with OR5AC2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5AC2 Gene

Pathways & Interactions for OR5AC2 Gene

genes like me logo Genes that share pathways with OR5AC2: view

Pathways by source for OR5AC2 Gene

1 BioSystems pathway for OR5AC2 Gene
1 KEGG pathway for OR5AC2 Gene

Interacting Proteins for OR5AC2 Gene

Gene Ontology (GO) - Biological Process for OR5AC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 10706615
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5AC2: view

No data available for SIGNOR curated interactions for OR5AC2 Gene

Drugs & Compounds for OR5AC2 Gene

No Compound Related Data Available

Transcripts for OR5AC2 Gene

mRNA/cDNA for OR5AC2 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR5AC2

Alternative Splicing Database (ASD) splice patterns (SP) for OR5AC2 Gene

No ASD Table

Relevant External Links for OR5AC2 Gene

GeneLoc Exon Structure for
OR5AC2

Expression for OR5AC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR5AC2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR5AC2

SOURCE GeneReport for Unigene cluster for OR5AC2 Gene:

Hs.554715
genes like me logo Genes that share expression patterns with OR5AC2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5AC2 Gene

Orthologs for OR5AC2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5AC2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC738237 29
  • 79.04 (n)
Cow
(Bos Taurus)
Mammalia LOC783655 29
  • 78.25 (n)
-- 30
  • 71 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia LOC487942 29
  • 77.63 (n)
-- 30
  • 74 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Olfr198 29 16 30
  • 73.62 (n)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Olr1537 29
  • 72.63 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 71 (a)
ManyToMany
-- 30
  • 67 (a)
ManyToMany
-- 30
  • 65 (a)
ManyToMany
-- 30
  • 64 (a)
ManyToMany
-- 30
  • 62 (a)
ManyToMany
Species where no ortholog for OR5AC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR5AC2 Gene

ENSEMBL:
Gene Tree for OR5AC2 (if available)
TreeFam:
Gene Tree for OR5AC2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR5AC2: view image
Alliance of Genome Resources:
Additional Orthologs for OR5AC2

Paralogs for OR5AC2 Gene

(453) SIMAP similar genes for OR5AC2 Gene using alignment to 1 proteins:

  • O5AC2_HUMAN

Pseudogenes.org Pseudogenes for OR5AC2 Gene

genes like me logo Genes that share paralogs with OR5AC2: view

Variants for OR5AC2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR5AC2 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs113439845 Benign: not provided 98,087,454(+) AT/A
NM_054106.1(OR5AC2):c.283del (p.Ser95fs)
FRAMESHIFT
rs193920759 Uncertain Significance: Malignant tumor of prostate 98,087,902(+) G/A
NM_054106.1(OR5AC2):c.730G>A (p.Gly244Ser)
MISSENSE
rs76417121 Benign: not provided 98,087,607(+) G/T
NM_054106.1(OR5AC2):c.435G>T (p.Gln145His)
MISSENSE
rs4518168 -- p.Met200Ile

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR5AC2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR5AC2 Gene

Variant ID Type Subtype PubMed ID
nsv1013060 CNV gain 25217958

Variation tolerance for OR5AC2 Gene

Residual Variation Intolerance Score: 77.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.71; 57.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5AC2 Gene

Human Gene Mutation Database (HGMD)
OR5AC2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5AC2
Leiden Open Variation Database (LOVD)
OR5AC2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5AC2 Gene

Disorders for OR5AC2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for OR5AC2 Gene - From: COP

Disorder Aliases PubMed IDs
cataract 37
  • ctrct37
cataract 21, multiple types
  • ctrct21
cataract 3, multiple types
  • ctrct3
skull base meningioma
  • meningioma of the skull base
skull base cancer
  • tumors of skull base
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for OR5AC2

genes like me logo Genes that share disorders with OR5AC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR5AC2 Gene

Publications for OR5AC2 Gene

  1. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 3 4
  2. The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates. (PMID: 10706615) Rouquier S … Giorgi D (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4
  3. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR5AC2 Gene

Sources for OR5AC2 Gene