Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR5AC1 Gene

Aliases for OR5AC1 Gene

  • Olfactory Receptor Family 5 Subfamily AC Member 1 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 5, Subfamily AC, Member 1 Pseudogene 2 3
  • Olfactory Receptor 5AC1 3 4
  • OR5AC1P 3 4
  • Olfactory Receptor, Family 5, Subfamily AC, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor OR3-2 4
  • OR5AC1 5

External Ids for OR5AC1 Gene

Previous HGNC Symbols for OR5AC1 Gene

  • OR5AC1P

Previous GeneCards Identifiers for OR5AC1 Gene

  • GC03P099267
  • GC03P097784
  • GC03P095153

Summaries for OR5AC1 Gene

Entrez Gene Summary for OR5AC1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]

GeneCards Summary for OR5AC1 Gene

OR5AC1 (Olfactory Receptor Family 5 Subfamily AC Member 1 (Gene/Pseudogene)) is a Pseudogene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR5H14.

UniProtKB/Swiss-Prot Summary for OR5AC1 Gene

Additional gene information for OR5AC1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR5AC1 Gene

Genomics for OR5AC1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR5AC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J098058 Enhancer 0.4 Ensembl 0.4 -5.9 -5881 2 SPI1 POLR2A REST OR5AC2 OR5AC1 lnc-OR5AC2-2 GABRR3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR5AC1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for OR5AC1 Gene

Latest Assembly
chr3:98,064,471-98,065,396
(GRCh38/hg38)
Size:
926 bases
Orientation:
Plus strand

Previous Assembly
chr3:97,783,315-97,784,236
(GRCh37/hg19 by Entrez Gene)
Size:
922 bases
Orientation:
Plus strand

chr3:97,783,316-97,784,240
(GRCh37/hg19 by Ensembl)
Size:
925 bases
Orientation:
Plus strand

Genomic View for OR5AC1 Gene

Genes around OR5AC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5AC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5AC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5AC1 Gene

Proteins for OR5AC1 Gene

  • Protein details for OR5AC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C628-O5AC1_HUMAN
    Recommended name:
    Olfactory receptor 5AC1
    Protein Accession:
    P0C628

    Protein attributes for OR5AC1 Gene

    Size:
    307 amino acids
    Molecular mass:
    34762 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5AC1 Gene

Post-translational modifications for OR5AC1 Gene

No Post-translational modifications

Other Protein References for OR5AC1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for OR5AC1 Gene

Domains & Families for OR5AC1 Gene

Gene Families for OR5AC1 Gene

Protein Domains for OR5AC1 Gene

Suggested Antigen Peptide Sequences for OR5AC1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR3-2 (O5AC1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0C628

UniProtKB/Swiss-Prot:

O5AC1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5AC1: view

Function for OR5AC1 Gene

Molecular function for OR5AC1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR5AC1 Gene

Gene Ontology (GO) - Molecular Function for OR5AC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR5AC1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5AC1 Gene

Localization for OR5AC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5AC1 Gene

Cell membrane. Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OR5AC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5AC1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for OR5AC1 Gene

Pathways & Interactions for OR5AC1 Gene

PathCards logo

SuperPathways for OR5AC1 Gene

genes like me logo Genes that share pathways with OR5AC1: view

Pathways by source for OR5AC1 Gene

Gene Ontology (GO) - Biological Process for OR5AC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5AC1: view

No data available for Interacting Proteins and SIGNOR curated interactions for OR5AC1 Gene

Drugs & Compounds for OR5AC1 Gene

No Compound Related Data Available

Transcripts for OR5AC1 Gene

mRNA/cDNA for OR5AC1 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR5AC1 Gene

No ASD Table

Relevant External Links for OR5AC1 Gene

GeneLoc Exon Structure for
OR5AC1

Expression for OR5AC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR5AC1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR5AC1 Gene



genes like me logo Genes that share expression patterns with OR5AC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5AC1 Gene

Orthologs for OR5AC1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5AC1 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia -- 30
  • 35 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Or5ac20 45 Olfr202 30
  • 35 (a)
ManyToMany
Or5ac19 45 Olfr201 30
  • 33 (a)
ManyToMany
Or5ac17 45 Olfr199 30
  • 33 (a)
ManyToMany
Or5ac15 45 Olfr194
  • chr16:59,119,151-59,120,068
Or5ac16 45 Olfr198
  • chr16:59,201,507-59,202,424
Or5ac18 45 Olfr200
  • chr16:59,255,059-59,256,000
Or5ac21 45 Olfr203
  • chr16:59,303,155-59,304,072
Or5ac22 45 Olfr204
  • chr16:59,314,491-59,315,405
Or5ac23 45 Olfr205
  • chr16:59,328,593-59,329,507
Or5ac24 45 Olfr206
  • chr16:59,344,782-59,345,699
Or5ac25 45 Olfr207_Olfr209
  • chr16:59,361,302-59,362,216
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 34 (a)
ManyToMany
-- 30
  • 33 (a)
ManyToMany
-- 30
  • 32 (a)
ManyToMany
-- 30
  • 32 (a)
ManyToMany
-- 30
  • 30 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 31 (a)
ManyToMany
Species where no ortholog for OR5AC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR5AC1 Gene

ENSEMBL:
Gene Tree for OR5AC1 (if available)
TreeFam:
Gene Tree for OR5AC1 (if available)
Alliance of Genome Resources:
Additional Orthologs for OR5AC1

Paralogs for OR5AC1 Gene

(454) SIMAP similar genes for OR5AC1 Gene using alignment to 1 proteins:

  • O5AC1_HUMAN
genes like me logo Genes that share paralogs with OR5AC1: view

Variants for OR5AC1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR5AC1 Gene

O5AC1_HUMAN-P0C628
A single nucleotide deletion at position Phe-85 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene.

Additional Variant Information for OR5AC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5AC1
Leiden Open Variation Database (LOVD)
OR5AC1

No data available for Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for OR5AC1 Gene

Disorders for OR5AC1 Gene

No disorders were found for OR5AC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for OR5AC1 Gene

Publications for OR5AC1 Gene

  1. Genetic elucidation of human hyperosmia to isovaleric acid. (PMID: 17973576) Menashe I … Lancet D (PLoS biology 2007) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR5AC1 Gene

Sources for OR5AC1 Gene