OR5A2 Gene (Protein Coding)

Olfactory Receptor Family 5 Subfamily A Member 2

GC11M059606
GIFtS:
31
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR5A2 Gene

Aliases for OR5A2 Gene

  • Olfactory Receptor Family 5 Subfamily A Member 2 2 3 5
  • Olfactory Receptor OR11-248 3 4
  • Olfactory Receptor 5A2 3 4
  • Olfactory Receptor, Family 5, Subfamily A, Member 2 2

External Ids for OR5A2 Gene

Previous GeneCards Identifiers for OR5A2 Gene

  • GC11U990465
  • GC11M058946
  • GC11M059189
  • GC11M059421

Summaries for OR5A2 Gene

Entrez Gene Summary for OR5A2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5A2 Gene

OR5A2 (Olfactory Receptor Family 5 Subfamily A Member 2) is a Protein Coding gene. Among its related pathways are Olfactory transduction and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR5A1.

UniProtKB/Swiss-Prot Summary for OR5A2 Gene

Gene Wiki entry for OR5A2 Gene

Additional gene information for OR5A2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR5A2 Gene

Genomics for OR5A2 Gene

GeneHancer (GH) Regulatory Elements for OR5A2 Gene

Promoters and enhancers for OR5A2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR5A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR5A2 gene promoter:
  • AML1a
  • Arnt
  • HFH-1
  • NF-1
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2

Genomic Locations for OR5A2 Gene

Genomic Locations for OR5A2 Gene
chr11:59,416,969-59,426,412
(GRCh38/hg38)
Size:
9,444 bases
Orientation:
Minus strand
chr11:59,189,416-59,190,449
(GRCh37/hg19)
Size:
1,034 bases
Orientation:
Minus strand

Genomic View for OR5A2 Gene

Genes around OR5A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5A2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OR5A2 Gene

Proteins for OR5A2 Gene

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  • Protein details for OR5A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGI9-OR5A2_HUMAN
    Recommended name:
    Olfactory receptor 5A2
    Protein Accession:
    Q8NGI9
    Secondary Accessions:
    • B9EH21
    • Q6IFF4
    • Q96RB0

    Protein attributes for OR5A2 Gene

    Size:
    324 amino acids
    Molecular mass:
    36016 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5A2 Gene

Post-translational modifications for OR5A2 Gene

  • Glycosylation at Asn6
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5A2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5A2 Gene

Domains & Families for OR5A2 Gene

Gene Families for OR5A2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5A2 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OR5A2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-248 (OR5A2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGI9

UniProtKB/Swiss-Prot:

OR5A2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5A2: view

Function for OR5A2 Gene

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Molecular function for OR5A2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR5A2 Gene

Gene Ontology (GO) - Molecular Function for OR5A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR5A2: view
genes like me logo Genes that share phenotypes with OR5A2: view

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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5A2 Gene

Localization for OR5A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5A2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5A2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5A2 Gene

Pathways & Interactions for OR5A2 Gene

genes like me logo Genes that share pathways with OR5A2: view

Pathways by source for OR5A2 Gene

1 KEGG pathway for OR5A2 Gene

Interacting Proteins for OR5A2 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000303834 Q8NGI9-OR5A2_HUMAN for OR5A2 Gene via STRING IID

GPS-Prot Interaction Network for OR5A2

Gene Ontology (GO) - Biological Process for OR5A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IBA 21873635
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5A2: view

No data available for SIGNOR curated interactions for OR5A2 Gene

Drugs & Compounds for OR5A2 Gene

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  1. Drug
No Compound Related Data Available

Transcripts for OR5A2 Gene

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mRNA/cDNA for OR5A2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5A2 Gene

No ASD Table

Relevant External Links for OR5A2 Gene

GeneLoc Exon Structure for
OR5A2
ECgene alternative splicing isoforms for
OR5A2

Expression for OR5A2 Gene

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  1. Primer
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5A2 Gene

mRNA expression in normal human tissues for OR5A2 Gene
mRNA expression by GTEx for OR5A2 GenemRNA expression by BioGPS for OR5A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5A2 Gene:

OR5A2

SOURCE GeneReport for Unigene cluster for OR5A2 Gene:

Hs.553648
genes like me logo Genes that share expression patterns with OR5A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5A2 Gene

Orthologs for OR5A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia LOC466611 32
  • 98.97 (n)
OR5A2 33
  • 98 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia LOC483455 32
  • 88.3 (n)
-- 33
  • 88 (a)
 OneToMany
-- 33
  • 85 (a)
 OneToMany
rat
(Rattus norvegicus)
 Mammalia Olr332 32
  • 83.02 (n)
oppossum
(Monodelphis domestica)
 Mammalia OR5A2 33
  • 75 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 33
  • 65 (a)
 OneToMany
-- 33
  • 64 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Olfr1441 33
  • 62 (a)
 ManyToMany
Or5a21 49 Olfr1438
  • chr19:12,332,898-12,333,854
cow
(Bos Taurus)
 Mammalia -- 33
  • 59 (a)
 ManyToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100491961 32
  • 54.06 (n)
Species where no ortholog for OR5A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5A2 Gene

ENSEMBL:
Gene Tree for OR5A2 (if available)
TreeFam:
Gene Tree for OR5A2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR5A2: view image

Paralogs for OR5A2 Gene

Paralogs for OR5A2 Gene

(450) SIMAP similar genes for OR5A2 Gene using alignment to 1 proteins:

  • OR5A2_HUMAN
genes like me logo Genes that share paralogs with OR5A2: view

Variants for OR5A2 Gene

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Sequence variations from dbSNP and Humsavar for OR5A2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000087784 -- 59,422,847(-) T/G coding_sequence_variant, missense_variant
rs1000816131 -- 59,424,433(-) AAAA/AAA upstream_transcript_variant
rs1001186228 -- 59,424,783(-) C/T upstream_transcript_variant
rs1001384879 -- 59,421,680(-) T/G downstream_transcript_variant
rs1001964831 -- 59,424,008(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR5A2 Gene

Variant ID Type Subtype PubMed ID
nsv1050013 CNV gain 25217958

Variation tolerance for OR5A2 Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.66; 82.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5A2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5A2 Gene

Disorders for OR5A2 Gene

Additional Disease Information for OR5A2

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OR5A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5A2 Gene

Publications for OR5A2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 56
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 56
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 56
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 56

ExternalLinks

View latest publications for OR5A2 gene in Mastermind

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