Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR5A1 Gene

Aliases for OR5A1 Gene

  • Olfactory Receptor Family 5 Subfamily A Member 1 2 3 5
  • Olfactory Receptor OR11-249 3 4
  • Olfactory Receptor 5A1 3 4
  • OR5A1P 3 4
  • OST181 3 4
  • Olfactory Receptor, Family 5, Subfamily A, Member 1 Pseudogene 3
  • Olfactory Receptor, Family 5, Subfamily A, Member 1 2
  • OR11-249 3

External Ids for OR5A1 Gene

Previous HGNC Symbols for OR5A1 Gene

  • OR5A1P

Previous GeneCards Identifiers for OR5A1 Gene

  • GC11U990236
  • GC11P058987
  • GC11P058967
  • GC11P059210

Summaries for OR5A1 Gene

Entrez Gene Summary for OR5A1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5A1 Gene

OR5A1 (Olfactory Receptor Family 5 Subfamily A Member 1) is a Protein Coding gene. Among its related pathways are Olfactory transduction and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and odorant binding. An important paralog of this gene is OR5A2.

UniProtKB/Swiss-Prot Summary for OR5A1 Gene

Gene Wiki entry for OR5A1 Gene

Additional gene information for OR5A1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR5A1 Gene

Genomics for OR5A1 Gene

GeneHancer (GH) Regulatory Elements for OR5A1 Gene

Promoters and enhancers for OR5A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J059544 Promoter/Enhancer 1.8 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 9.6 +112.6 112639 8.8 GTF3C2 ZNF24 ZBTB40 CTCF LCORL ZBTB6 RBPJ SMARCE1 MCM5 USF2 TRV-TAC1-1 TRV-TAC2-1 lnc-OR4D9-1-002 ENSG00000269570 ENSG00000255139 PATL1 ENSG00000255008 ZFP91 FAM111A-DT FAM111A
GH11J059193 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -237.4 -237369 6.2 ZNF24 ZBTB40 CTCF FOXA1 ETV6 RELA RAD21 SP1 ZNF687 TRIM24 DTX4 PATL1 OR4D6 MS4A2 OR5A2 OR5A1 ENSG00000255008 OR5AN1 MPEG1 FAM111A
GH11J059220 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 9.9 -213.7 -213653 4.7 ZNF512 SP1 CEBPB IKZF2 JUN JUND DPF2 EP300 RUNX3 RFX5 lnc-MPEG1-8 PATL1 MPEG1 DTX4 OR4D6 OR5A2 OR5A1 OR5AN1 FAM111A OSBP
GH11J059182 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.4 -247.7 -247725 12.9 CTCF HLF RAD21 ELF3 SP1 MAFK ZNF687 ZNF644 RXRA TRIM22 DTX4 MPEG1 OR5A2 OR5A1 OR4D6 lnc-MPEG1-4 HSALNG0084392
GH11J059510 Promoter/Enhancer 1 FANTOM5 Ensembl ENCODE 10.4 +74.6 74632 1 NFE2 MAFG CEBPG CEBPB EMSY OR4D9 OR4D6 OR4D10 OR5A1 OR5A2 PATL1 MPEG1 STX3 OR4D11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR5A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR5A1 gene promoter:
  • AML1a
  • c-Myc
  • FOXD3
  • Max1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • YY1

Genomic Locations for OR5A1 Gene

Genomic Locations for OR5A1 Gene
chr11:59,436,469-59,451,380
(GRCh38/hg38)
Size:
14,912 bases
Orientation:
Plus strand
chr11:59,210,617-59,211,667
(GRCh37/hg19)
Size:
1,051 bases
Orientation:
Plus strand

Genomic View for OR5A1 Gene

Genes around OR5A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5A1 Gene

Proteins for OR5A1 Gene

  • Protein details for OR5A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGJ0-OR5A1_HUMAN
    Recommended name:
    Olfactory receptor 5A1
    Protein Accession:
    Q8NGJ0
    Secondary Accessions:
    • B9EH58
    • Q6IFF2
    • Q96RB1

    Protein attributes for OR5A1 Gene

    Size:
    315 amino acids
    Molecular mass:
    35152 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5A1 Gene

Post-translational modifications for OR5A1 Gene

  • Glycosylation at Asn8
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5A1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5A1 Gene

Domains & Families for OR5A1 Gene

Gene Families for OR5A1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5A1 Gene

Suggested Antigen Peptide Sequences for OR5A1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-249 (OR5A1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGJ0

UniProtKB/Swiss-Prot:

OR5A1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5A1: view

Function for OR5A1 Gene

Molecular function for OR5A1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR5A1 Gene

Gene Ontology (GO) - Molecular Function for OR5A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
GO:0005549 odorant binding IBA 21873635
genes like me logo Genes that share ontologies with OR5A1: view

Phenotypes for OR5A1 Gene

genes like me logo Genes that share phenotypes with OR5A1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5A1 Gene

Localization for OR5A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5A1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5A1 Gene

Pathways & Interactions for OR5A1 Gene

genes like me logo Genes that share pathways with OR5A1: view

Pathways by source for OR5A1 Gene

Interacting Proteins for OR5A1 Gene

Gene Ontology (GO) - Biological Process for OR5A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007608 sensory perception of smell IBA 21873635
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5A1: view

No data available for SIGNOR curated interactions for OR5A1 Gene

Drugs & Compounds for OR5A1 Gene

No Compound Related Data Available

Transcripts for OR5A1 Gene

mRNA/cDNA for OR5A1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5A1 Gene

No ASD Table

Relevant External Links for OR5A1 Gene

GeneLoc Exon Structure for
OR5A1
ECgene alternative splicing isoforms for
OR5A1

Expression for OR5A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5A1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR5A1 Gene



NURSA nuclear receptor signaling pathways regulating expression of OR5A1 Gene:

OR5A1

SOURCE GeneReport for Unigene cluster for OR5A1 Gene:

Hs.553649
genes like me logo Genes that share expression patterns with OR5A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5A1 Gene

Orthologs for OR5A1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OR5A1 33
  • 99 (a)
OneToOne
LOC466612 32
  • 98.84 (n)
dog
(Canis familiaris)
Mammalia LOC100856789 32
  • 86.84 (n)
OR5A1 33
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR5A1 33 32
  • 84.34 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Or5a1 49 Olfr76 17 33 32
  • 83.23 (n)
Or5a3 49 Olfr1441
  • chr19:12,422,311-12,423,264
Or5af1 49 Olfr312
  • chr11:58,831,156-58,832,079
Or5af2 49 Olfr313
  • chr11:58,817,010-58,817,933
rat
(Rattus norvegicus)
Mammalia Olr326 32
  • 82.22 (n)
oppossum
(Monodelphis domestica)
Mammalia OPOR80 33
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 61 (a)
ManyToMany
Species where no ortholog for OR5A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5A1 Gene

ENSEMBL:
Gene Tree for OR5A1 (if available)
TreeFam:
Gene Tree for OR5A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR5A1: view image

Paralogs for OR5A1 Gene

(453) SIMAP similar genes for OR5A1 Gene using alignment to 1 proteins:

  • OR5A1_HUMAN

Pseudogenes.org Pseudogenes for OR5A1 Gene

genes like me logo Genes that share paralogs with OR5A1: view

Variants for OR5A1 Gene

Sequence variations from dbSNP and Humsavar for OR5A1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000881278 -- 59,441,987(+) G/T upstream_transcript_variant
rs1001752259 -- 59,441,775(+) G/T upstream_transcript_variant
rs1001834605 -- 59,441,717(+) C/G upstream_transcript_variant
rs1005121032 -- 59,444,509(+) G/A downstream_transcript_variant
rs1005979095 -- 59,441,658(+) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR5A1 Gene

Variant ID Type Subtype PubMed ID
nsv1050013 CNV gain 25217958

Variation tolerance for OR5A1 Gene

Residual Variation Intolerance Score: 90.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.66; 56.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR5A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5A1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5A1 Gene

Disorders for OR5A1 Gene

Additional Disease Information for OR5A1

No disorders were found for OR5A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5A1 Gene

Publications for OR5A1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 56
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 56
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 56
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 56

Products for OR5A1 Gene

Sources for OR5A1 Gene