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Aliases for OR56B4 Gene

Aliases for OR56B4 Gene

  • Olfactory Receptor Family 56 Subfamily B Member 4 2 3 5
  • Olfactory Receptor OR11-67 3 4
  • Olfactory Receptor, Family 56, Subfamily B, Member 4 2
  • Olfactory Receptor 56B4 3
  • OR11-67 3

External Ids for OR56B4 Gene

Previous GeneCards Identifiers for OR56B4 Gene

  • GC11U990466
  • GC11P006094

Summaries for OR56B4 Gene

Entrez Gene Summary for OR56B4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR56B4 Gene

OR56B4 (Olfactory Receptor Family 56 Subfamily B Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR56B1.

UniProtKB/Swiss-Prot for OR56B4 Gene

  • Odorant receptor.

Gene Wiki entry for OR56B4 Gene

Additional gene information for OR56B4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR56B4 Gene

Genomics for OR56B4 Gene

GeneHancer (GH) Regulatory Elements for OR56B4 Gene

Promoters and enhancers for OR56B4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J006468 Enhancer 1.2 FANTOM5 Ensembl ENCODE 3.5 +361.7 361687 1.5 HDGF PKNOX1 ZNF335 POLR2B GLIS2 POLR2A ZBTB48 PATZ1 ZFP91 ATF7 OR56A1 OR10A4 OR2AG2 OR10A2 OR56A4 OR52W1 OR2AG1 OR56B4 OR10A5 OR6A2
GH11J005623 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 1.9 -482.2 -482248 3.2 HDAC1 PKNOX1 SMAD1 SREBF2 ZBTB40 IRF4 RAD21 RFX5 YY1 ZFP91 TRIM34 TRIM5 TRIM22 OR51B2 OR56B4 OR56A1 OR56A3 OR52N4 OR51Q1 OR52E6
GH11J006094 Enhancer 0.2 FANTOM5 1.5 -13.3 -13265 0.1 OR56A1 OR52W1 FAM160A2 C11orf42 TRIM5 TRIM34 OR52N1 OR56A3 OR52E8 TRIM22
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR56B4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR56B4 gene promoter:
  • RelA
  • CP2
  • NF-1
  • ATF6
  • FOXF2
  • ITF-2
  • Tal-1beta
  • FOXO4
  • Pax-4a

Genomic Locations for OR56B4 Gene

Genomic Locations for OR56B4 Gene
1,152 bases
Plus strand
1,152 bases
Plus strand

Genomic View for OR56B4 Gene

Genes around OR56B4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR56B4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR56B4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR56B4 Gene

Proteins for OR56B4 Gene

  • Protein details for OR56B4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 56B4
    Protein Accession:
    Secondary Accessions:
    • Q6IFD7

    Protein attributes for OR56B4 Gene

    319 amino acids
    Molecular mass:
    35454 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR56B4 Gene

Post-translational modifications for OR56B4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR56B4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR56B4 Gene

Domains & Families for OR56B4 Gene

Gene Families for OR56B4 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR56B4 Gene

Suggested Antigen Peptide Sequences for OR56B4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR56B4: view

Function for OR56B4 Gene

Molecular function for OR56B4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR56B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR56B4: view
genes like me logo Genes that share phenotypes with OR56B4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR56B4 Gene

Localization for OR56B4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR56B4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR56B4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR56B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR56B4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR56B4 Gene

Pathways & Interactions for OR56B4 Gene

genes like me logo Genes that share pathways with OR56B4: view

Pathways by source for OR56B4 Gene

Interacting Proteins for OR56B4 Gene

Gene Ontology (GO) - Biological Process for OR56B4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR56B4: view

No data available for SIGNOR curated interactions for OR56B4 Gene

Drugs & Compounds for OR56B4 Gene

No Compound Related Data Available

Transcripts for OR56B4 Gene

mRNA/cDNA for OR56B4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR56B4 Gene

Olfactory receptor, family 56, subfamily B, member 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR56B4 Gene

No ASD Table

Relevant External Links for OR56B4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR56B4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR56B4 Gene

mRNA differential expression in normal tissues according to GTEx for OR56B4 Gene

This gene is overexpressed in Whole Blood (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of OR56B4 Gene:


SOURCE GeneReport for Unigene cluster for OR56B4 Gene:


Evidence on tissue expression from TISSUES for OR56B4 Gene

  • Stomach(2.5)
  • Heart(2)
genes like me logo Genes that share expression patterns with OR56B4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR56B4 Gene

Orthologs for OR56B4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR56B4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466409 33
  • 98.75 (n)
OR56B4 34
  • 98 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 74 (a)
(Bos Taurus)
Mammalia LOC787843 33
  • 71.32 (n)
-- 34
  • 66 (a)
(Rattus norvegicus)
Mammalia LOC100910716 33
  • 69.85 (n)
(Mus musculus)
Mammalia Olfr663 16 33
  • 69.46 (n)
Olfr661 34
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 62 (a)
-- 34
  • 61 (a)
-- 34
  • 61 (a)
-- 34
  • 61 (a)
-- 34
  • 60 (a)
-- 34
  • 49 (a)
(Canis familiaris)
Mammalia -- 34
  • 51 (a)
Species where no ortholog for OR56B4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR56B4 Gene

Gene Tree for OR56B4 (if available)
Gene Tree for OR56B4 (if available)
Evolutionary constrained regions (ECRs) for OR56B4: view image

Paralogs for OR56B4 Gene

Paralogs for OR56B4 Gene

(391) SIMAP similar genes for OR56B4 Gene using alignment to 1 proteins:

  • O56B4_HUMAN Pseudogenes for OR56B4 Gene

genes like me logo Genes that share paralogs with OR56B4: view

Variants for OR56B4 Gene

Sequence variations from dbSNP and Humsavar for OR56B4 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000858106 -- 6,107,007(+) T/C upstream_transcript_variant
rs1000908823 -- 6,106,653(+) C/T upstream_transcript_variant
rs1001731648 -- 6,105,968(+) T/C upstream_transcript_variant
rs1002544136 -- 6,107,522(+) G/A upstream_transcript_variant
rs1002616242 -- 6,107,846(+) T/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for OR56B4 Gene

Variant ID Type Subtype PubMed ID
nsv553241 CNV gain 21841781

Variation tolerance for OR56B4 Gene

Residual Variation Intolerance Score: 56.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.82; 34.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR56B4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR56B4 Gene

Disorders for OR56B4 Gene

Additional Disease Information for OR56B4

No disorders were found for OR56B4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR56B4 Gene

Publications for OR56B4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR56B4 Gene

Sources for OR56B4 Gene

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