Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR56A5 Gene

Aliases for OR56A5 Gene

  • Olfactory Receptor Family 56 Subfamily A Member 5 2 3 5
  • Olfactory Receptor 56A5 3 4
  • OR56A5P 3 4
  • Olfactory Receptor, Family 56, Subfamily A, Member 5 Pseudogene 3
  • Olfactory Receptor, Family 56, Subfamily A, Member 5 2
  • OR56A5 5

External Ids for OR56A5 Gene

Previous HGNC Symbols for OR56A5 Gene

  • OR56A5P

Previous GeneCards Identifiers for OR56A5 Gene

  • GC11U900569
  • GC11M005946
  • GC11M005949
  • GC11M005993

Summaries for OR56A5 Gene

Entrez Gene Summary for OR56A5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Mar 2009]

GeneCards Summary for OR56A5 Gene

OR56A5 (Olfactory Receptor Family 56 Subfamily A Member 5) is a Protein Coding gene. Diseases associated with OR56A5 include Acrofacial Dysostosis 1, Nager Type and Acrofacial Dysostosis. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR56A4.

UniProtKB/Swiss-Prot Summary for OR56A5 Gene

Additional gene information for OR56A5 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR56A5 Gene

Genomics for OR56A5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR56A5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J005546 Enhancer 0.2 FANTOM5 8.7 +422.2 422248 0.1 OR56A1 OR56A3 OR51Q1 OR52E8 OR52N1 OR56A4 OR52N4 OR52E2 OR52E4 OR52A1
GH11J006094 Enhancer 0.4 FANTOM5 Ensembl 1.4 -125.8 -125807 1.4 MF281466-001 MF281466-002 MF281504 OR56A1 OR52W1 FHIP1B C11orf42 CAVIN3 TRIM5 TRIM34
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR56A5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR56A5

Top Transcription factor binding sites by QIAGEN in the OR56A5 gene promoter:
  • AML1a
  • GATA-1
  • HEN1
  • HNF-4alpha1
  • HNF-4alpha2
  • Pax-6
  • STAT5A
  • USF-1
  • USF1

Genomic Locations for OR56A5 Gene

Latest Assembly
chr11:5,967,177-5,968,494
(GRCh38/hg38)
Size:
1,318 bases
Orientation:
Minus strand

Previous Assembly
chr11:5,988,783-5,989,724
(GRCh37/hg19 by Entrez Gene)
Size:
942 bases
Orientation:
Minus strand

chr11:5,988,407-5,989,724
(GRCh37/hg19 by Ensembl)
Size:
1,318 bases
Orientation:
Minus strand

Genomic View for OR56A5 Gene

Genes around OR56A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR56A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR56A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR56A5 Gene

Proteins for OR56A5 Gene

  • Protein details for OR56A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C7T3-O56A5_HUMAN
    Recommended name:
    Olfactory receptor 56A5
    Protein Accession:
    P0C7T3

    Protein attributes for OR56A5 Gene

    Size:
    313 amino acids
    Molecular mass:
    35317 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR56A5 Gene

Post-translational modifications for OR56A5 Gene

  • Glycosylation at Asn6, Asn7, Asn184, and Asn198

Other Protein References for OR56A5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR56A5 Gene

Domains & Families for OR56A5 Gene

Gene Families for OR56A5 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR56A5 Gene

Suggested Antigen Peptide Sequences for OR56A5 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 56A5 (O56A5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0C7T3

UniProtKB/Swiss-Prot:

O56A5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR56A5: view

Function for OR56A5 Gene

Molecular function for OR56A5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR56A5 Gene

Gene Ontology (GO) - Molecular Function for OR56A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR56A5: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR56A5

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR56A5 Gene

Localization for OR56A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR56A5 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR56A5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR56A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR56A5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR56A5 Gene

Pathways & Interactions for OR56A5 Gene

genes like me logo Genes that share pathways with OR56A5: view

Pathways by source for OR56A5 Gene

Interacting Proteins for OR56A5 Gene

Gene Ontology (GO) - Biological Process for OR56A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR56A5: view

No data available for SIGNOR curated interactions for OR56A5 Gene

Drugs & Compounds for OR56A5 Gene

No Compound Related Data Available

Transcripts for OR56A5 Gene

mRNA/cDNA for OR56A5 Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR56A5

Alternative Splicing Database (ASD) splice patterns (SP) for OR56A5 Gene

ExUns: 1a · 1b ^ 2
SP1:
SP2:

Relevant External Links for OR56A5 Gene

GeneLoc Exon Structure for
OR56A5

Expression for OR56A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR56A5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR56A5

SOURCE GeneReport for Unigene cluster for OR56A5 Gene:

Hs.719888
genes like me logo Genes that share expression patterns with OR56A5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR56A5 Gene

Orthologs for OR56A5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR56A5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia OR56A5 29
  • 99.47 (n)
Dog
(Canis familiaris)
Mammalia cOR56A24 29
  • 88.18 (n)
Cow
(Bos Taurus)
Mammalia OR56A4 29
  • 85.73 (n)
Mouse
(Mus musculus)
Mammalia Or56a5 45 Olfr683 29 16
  • 85.42 (n)
Rat
(Rattus norvegicus)
Mammalia Olr192 29
  • 84.46 (n)
Species where no ortholog for OR56A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR56A5 Gene

ENSEMBL:
Gene Tree for OR56A5 (if available)
TreeFam:
Gene Tree for OR56A5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR56A5: view image
Alliance of Genome Resources:
Additional Orthologs for OR56A5

Paralogs for OR56A5 Gene

(429) SIMAP similar genes for OR56A5 Gene using alignment to 1 proteins:

  • O56A5_HUMAN
genes like me logo Genes that share paralogs with OR56A5: view

Variants for OR56A5 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR56A5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR56A5 Gene

Variant ID Type Subtype PubMed ID
esv2759801 CNV gain+loss 17122850
nsv1046068 CNV gain 25217958
nsv1053414 CNV gain 25217958
nsv553241 CNV gain 21841781
nsv553277 CNV gain 21841781
nsv975875 CNV duplication 23825009

Additional Variant Information for OR56A5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR56A5
Leiden Open Variation Database (LOVD)
OR56A5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for OR56A5 Gene

Disorders for OR56A5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for OR56A5 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for OR56A5

genes like me logo Genes that share disorders with OR56A5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR56A5 Gene

Publications for OR56A5 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR56A5 Gene

Sources for OR56A5 Gene