Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR56A4 Gene

Aliases for OR56A4 Gene

  • Olfactory Receptor Family 56 Subfamily A Member 4 2 3 5
  • Olfactory Receptor OR11-49 3 4
  • Olfactory Receptor 56A4 3 4
  • Olfactory Receptor, Family 56, Subfamily A, Member 4 2
  • OR11-49 3
  • OR56A4 5

External Ids for OR56A4 Gene

Previous GeneCards Identifiers for OR56A4 Gene

  • GC11U990297
  • GC11M005991
  • GC11M005981
  • GC11M005982

Summaries for OR56A4 Gene

Entrez Gene Summary for OR56A4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR56A4 Gene

OR56A4 (Olfactory Receptor Family 56 Subfamily A Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR56A5.

UniProtKB/Swiss-Prot Summary for OR56A4 Gene

Gene Wiki entry for OR56A4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR56A4 Gene

Genomics for OR56A4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR56A4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J006468 Enhancer 1.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas 7.7 -462.4 -462425 1.5 ZNF10 NFIC POLR2A MBD2 KLF9 SP2 ELF1 ZFP91 ZBTB48 SUPT5H OR56A1 OR10A4 OR2AG2 OR10A2 OR56A4 OR52W1 OR2AG1 OR56B4 OR10A5 OR6A2
GH11J005546 Enhancer 0.2 FANTOM5 12 +460.7 460700 0.1 OR56A1 OR56A3 OR51Q1 OR52E8 OR52N1 OR56A4 OR52N4 OR52E2 OR52E4 OR52A1
GH11J006048 Enhancer 0.2 Ensembl 10 -41.4 -41355 0.2 OR56A7P OR56A4 OR52L2P OR56A1 OR56B4 lnc-OR56A3-1
GH11J006054 Enhancer 0.2 Ensembl 9.7 -47.8 -47755 0.2 OR56A1 OR56A4 OR52W1 C11orf42 FHIP1B OR52B2 CAVIN3 OR52L2P OR56A7P OR56B4
GH11J006052 Enhancer 0.2 Ensembl 9.7 -45.6 -45555 0.2 OR56A4 OR52W1 C11orf42 FHIP1B OR52B2 CAVIN3 OR52L2P OR56A7P OR56A1 OR56B4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR56A4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR56A4

Top Transcription factor binding sites by QIAGEN in the OR56A4 gene promoter:
  • FOXD1
  • HOXA9
  • HOXA9B
  • Ik-3
  • Lmo2
  • Meis-1
  • Meis-1b
  • MRF-2
  • Sox9
  • YY1

Genomic Locations for OR56A4 Gene

Latest Assembly
chr11:5,999,445-6,006,946
(GRCh38/hg38)
Size:
7,502 bases
Orientation:
Minus strand

Previous Assembly
chr11:6,020,675-6,028,176
(GRCh37/hg19 by Entrez Gene)
Size:
7,502 bases
Orientation:
Minus strand

chr11:6,023,216-6,024,424
(GRCh37/hg19 by Ensembl)
Size:
1,209 bases
Orientation:
Minus strand

Genomic View for OR56A4 Gene

Genes around OR56A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR56A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR56A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR56A4 Gene

Proteins for OR56A4 Gene

  • Protein details for OR56A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGH8-O56A4_HUMAN
    Recommended name:
    Olfactory receptor 56A4
    Protein Accession:
    Q8NGH8
    Secondary Accessions:
    • B9EH17

    Protein attributes for OR56A4 Gene

    Size:
    313 amino acids
    Molecular mass:
    35116 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI36987.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR56A4 Gene

Post-translational modifications for OR56A4 Gene

  • Glycosylation at Asn6 and Asn184

Other Protein References for OR56A4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR56A4 Gene

Domains & Families for OR56A4 Gene

Gene Families for OR56A4 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR56A4 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR56A4 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-49 (O56A4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGH8

UniProtKB/Swiss-Prot:

O56A4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR56A4: view

Function for OR56A4 Gene

Molecular function for OR56A4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR56A4 Gene

Gene Ontology (GO) - Molecular Function for OR56A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR56A4: view
genes like me logo Genes that share phenotypes with OR56A4: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR56A4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR56A4 Gene

Localization for OR56A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR56A4 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR56A4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR56A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR56A4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR56A4 Gene

Pathways & Interactions for OR56A4 Gene

genes like me logo Genes that share pathways with OR56A4: view

Pathways by source for OR56A4 Gene

Interacting Proteins for OR56A4 Gene

Gene Ontology (GO) - Biological Process for OR56A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR56A4: view

No data available for SIGNOR curated interactions for OR56A4 Gene

Drugs & Compounds for OR56A4 Gene

No Compound Related Data Available

Transcripts for OR56A4 Gene

mRNA/cDNA for OR56A4 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR56A4

Alternative Splicing Database (ASD) splice patterns (SP) for OR56A4 Gene

No ASD Table

Relevant External Links for OR56A4 Gene

GeneLoc Exon Structure for
OR56A4

Expression for OR56A4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR56A4 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR56A4 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR56A4

SOURCE GeneReport for Unigene cluster for OR56A4 Gene:

Hs.553571
genes like me logo Genes that share expression patterns with OR56A4: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR56A4 Gene

Orthologs for OR56A4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR56A4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466405 29
  • 99.18 (n)
OR56A4 30
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 30
  • 91 (a)
OneToMany
-- 30
  • 88 (a)
OneToMany
-- 30
  • 88 (a)
OneToMany
LOC610901 29
  • 79.98 (n)
Cow
(Bos Taurus)
Mammalia LOC100298165 29
  • 88.07 (n)
-- 30
  • 88 (a)
OneToMany
-- 30
  • 88 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Olr193 29
  • 84.4 (n)
Mouse
(Mus musculus)
Mammalia Or56a4 45 Olfr684 29 16 30
  • 83.82 (n)
OneToMany
Olfr683 30
  • 82 (a)
OneToMany
Or56a42-ps 45 Olfr682-ps1
  • chr7:105,126,369-105,127,029
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 82 (a)
OneToMany
-- 30
  • 80 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 69 (a)
ManyToMany
-- 30
  • 67 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii -- 29
Species where no ortholog for OR56A4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for OR56A4 Gene

ENSEMBL:
Gene Tree for OR56A4 (if available)
TreeFam:
Gene Tree for OR56A4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR56A4: view image
Alliance of Genome Resources:
Additional Orthologs for OR56A4

Paralogs for OR56A4 Gene

(443) SIMAP similar genes for OR56A4 Gene using alignment to 1 proteins:

  • O56A4_HUMAN
genes like me logo Genes that share paralogs with OR56A4: view

Variants for OR56A4 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR56A4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR56A4 Gene

Variant ID Type Subtype PubMed ID
dgv1054n100 CNV gain 25217958
nsv1046068 CNV gain 25217958
nsv1053414 CNV gain 25217958
nsv553241 CNV gain 21841781

Variation tolerance for OR56A4 Gene

Residual Variation Intolerance Score: 44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.04; 75.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR56A4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR56A4
Leiden Open Variation Database (LOVD)
OR56A4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR56A4 Gene

Disorders for OR56A4 Gene

Additional Disease Information for OR56A4

No disorders were found for OR56A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR56A4 Gene

Publications for OR56A4 Gene

  1. Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. (PMID: 32694731) Aregger M … Moffat J (Nature metabolism 2020) 3
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4
  4. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for OR56A4 Gene

Sources for OR56A4 Gene