Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR56A3 Gene

Aliases for OR56A3 Gene

  • Olfactory Receptor Family 56 Subfamily A Member 3 2 3 5
  • Olfactory Receptor 56A3 3 4
  • Olfactory Receptor 56A6 3 4
  • OR56A3P 3 4
  • OR56A6 3 4
  • Olfactory Receptor, Family 56, Subfamily A, Member 2 Pseudogene 3
  • Olfactory Receptor, Family 56, Subfamily A, Member 3 Pseudogene 3
  • Olfactory Receptor, Family 56, Subfamily A, Member 3 2
  • Olfactory Receptor, Family 56, Subfamily A, Member 6 3
  • Olfactory Receptor OR11-51 3
  • OR56A2P 3
  • OR56A3 5

External Ids for OR56A3 Gene

Previous HGNC Symbols for OR56A3 Gene

  • OR56A6
  • OR56A3P

Previous GeneCards Identifiers for OR56A3 Gene

  • GC11P005933
  • GC11P005925
  • GC11P005968
  • GC11P005946
  • GC11P005947

Summaries for OR56A3 Gene

Entrez Gene Summary for OR56A3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR56A3 Gene

OR56A3 (Olfactory Receptor Family 56 Subfamily A Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR56A1.

UniProtKB/Swiss-Prot Summary for OR56A3 Gene

Gene Wiki entry for OR56A3 Gene

Additional gene information for OR56A3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR56A3 Gene

Genomics for OR56A3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR56A3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J005938 Promoter 0.5 EPDnew 600.7 -0.1 -110 0.1 RFX1 FOXA1 OR56A3 TRIM5 lnc-OR56A3-1 piR-46220-001 piR-54280 piR-54630 OR52N3P LOC112268071
GH11J005546 Enhancer 0.2 FANTOM5 19.5 -392.5 -392505 0.1 OR56A1 OR56A3 OR51Q1 OR52E8 OR52N1 OR56A4 OR52N4 OR52E2 OR52E4 OR52A1
GH11J005623 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 1.4 -313.3 -313315 3.2 SP1 REST POLR2A STAT3 RELA PKNOX1 SMAD5 RCOR1 HDAC1 CEBPB TRIM34 lnc-OR52H1-1 TRIM5 TRIM22 OR51B2 OR56B4 OR56A1 OR56A3 OR52N4 OR51Q1
GH11J006094 Enhancer 0.4 FANTOM5 Ensembl 2.5 +155.6 155550 1.4 MF281466-001 MF281466-002 OR56A1 OR52W1 FAM160A2 C11orf42 CAVIN3 TRIM5 TRIM34 OR52N1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR56A3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR56A3

Top Transcription factor binding sites by QIAGEN in the OR56A3 gene promoter:
  • C/EBPalpha
  • E47
  • GATA-1
  • Pbx1a
  • POU2F1a
  • PPAR-gamma1
  • PPAR-gamma2
  • RP58
  • Tal-1

Genomic Locations for OR56A3 Gene

Genomic Locations for OR56A3 Gene
chr11:5,938,751-5,951,347
(GRCh38/hg38)
Size:
12,597 bases
Orientation:
Plus strand
chr11:5,968,570-5,969,591
(GRCh37/hg19)
Size:
1,022 bases
Orientation:
Plus strand

Genomic View for OR56A3 Gene

Genes around OR56A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR56A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR56A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR56A3 Gene

Proteins for OR56A3 Gene

  • Protein details for OR56A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH54-O56A3_HUMAN
    Recommended name:
    Olfactory receptor 56A3
    Protein Accession:
    Q8NH54
    Secondary Accessions:
    • A6NN77
    • Q6IFF7

    Protein attributes for OR56A3 Gene

    Size:
    315 amino acids
    Molecular mass:
    35611 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05783.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for OR56A3 Gene

Post-translational modifications for OR56A3 Gene

  • Glycosylation at Asn6 and Asn185
  • Modification sites at PhosphoSitePlus

Other Protein References for OR56A3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR56A3 Gene

Domains & Families for OR56A3 Gene

Gene Families for OR56A3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR56A3 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR56A3 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 56A6 (O56A3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NH54

UniProtKB/Swiss-Prot:

O56A3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR56A3: view

Function for OR56A3 Gene

Molecular function for OR56A3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR56A3 Gene

Gene Ontology (GO) - Molecular Function for OR56A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR56A3: view
genes like me logo Genes that share phenotypes with OR56A3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR56A3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR56A3 Gene

Localization for OR56A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR56A3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR56A3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR56A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR56A3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR56A3 Gene

Pathways & Interactions for OR56A3 Gene

genes like me logo Genes that share pathways with OR56A3: view

Pathways by source for OR56A3 Gene

Interacting Proteins for OR56A3 Gene

Gene Ontology (GO) - Biological Process for OR56A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR56A3: view

No data available for SIGNOR curated interactions for OR56A3 Gene

Drugs & Compounds for OR56A3 Gene

No Compound Related Data Available

Transcripts for OR56A3 Gene

mRNA/cDNA for OR56A3 Gene

1 REFSEQ mRNAs :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR56A3

Alternative Splicing Database (ASD) splice patterns (SP) for OR56A3 Gene

No ASD Table

Relevant External Links for OR56A3 Gene

GeneLoc Exon Structure for
OR56A3

Expression for OR56A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR56A3 Gene

mRNA differential expression in normal tissues according to GTEx for OR56A3 Gene

This gene is overexpressed in Testis (x30.8), Liver (x10.7), Bladder (x6.0), and Cervix - Endocervix (x5.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR56A3

SOURCE GeneReport for Unigene cluster for OR56A3 Gene:

Hs.553741
genes like me logo Genes that share expression patterns with OR56A3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR56A3 Gene

Orthologs for OR56A3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR56A3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466402 30
  • 99.05 (n)
OR56A3 31
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia OR56A3 30 31
  • 87.05 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 86 (a)
OneToMany
LOC485316 30
  • 85.99 (n)
-- 31
  • 83 (a)
OneToMany
-- 31
  • 83 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Or56a3b 46 Olfr681 17 31
  • 85 (a)
OneToMany
Or56a3 46 Olfr679 30 17 31
  • 83.55 (n)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 84 (a)
OneToMany
-- 31
  • 80 (a)
OneToMany
-- 31
  • 80 (a)
OneToMany
-- 31
  • 80 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Olr190 30
  • 83.86 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 68 (a)
ManyToMany
-- 31
  • 67 (a)
ManyToMany
Species where no ortholog for OR56A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR56A3 Gene

ENSEMBL:
Gene Tree for OR56A3 (if available)
TreeFam:
Gene Tree for OR56A3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR56A3: view image

Paralogs for OR56A3 Gene

(421) SIMAP similar genes for OR56A3 Gene using alignment to 1 proteins:

  • O56A3_HUMAN
genes like me logo Genes that share paralogs with OR56A3: view

Variants for OR56A3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR56A3 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs1840178 - p.Met51Thr

Additional dbSNP identifiers (rs#s) for OR56A3 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR56A3 Gene

Variant ID Type Subtype PubMed ID
dgv40e55 CNV gain 17911159
esv2759801 CNV gain+loss 17122850
nsv1046068 CNV gain 25217958
nsv1051615 CNV gain 25217958
nsv1053414 CNV gain 25217958
nsv553241 CNV gain 21841781
nsv553277 CNV gain 21841781

Variation tolerance for OR56A3 Gene

Residual Variation Intolerance Score: 60.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR56A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR56A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR56A3 Gene

Disorders for OR56A3 Gene

Additional Disease Information for OR56A3

No disorders were found for OR56A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR56A3 Gene

Publications for OR56A3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4

Products for OR56A3 Gene

Sources for OR56A3 Gene