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Aliases for OR52W1 Gene

Aliases for OR52W1 Gene

  • Olfactory Receptor Family 52 Subfamily W Member 1 2 3 5
  • Olfactory Receptor OR11-71 3 4
  • OR52W1P 3 4
  • Olfactory Receptor, Family 52, Subfamily W, Member 1 Pseudogene 3
  • Olfactory Receptor, Family 52, Subfamily W, Member 1 2
  • Olfactory Receptor 52W1 3
  • OR11-71 3

External Ids for OR52W1 Gene

Previous HGNC Symbols for OR52W1 Gene

  • OR52W1P

Previous GeneCards Identifiers for OR52W1 Gene

  • GC11P006186
  • GC11P006177
  • GC11P006221

Summaries for OR52W1 Gene

Entrez Gene Summary for OR52W1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52W1 Gene

OR52W1 (Olfactory Receptor Family 52 Subfamily W Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot for OR52W1 Gene

  • Odorant receptor.

Gene Wiki entry for OR52W1 Gene

Additional gene information for OR52W1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52W1 Gene

Genomics for OR52W1 Gene

GeneHancer (GH) Regulatory Elements for OR52W1 Gene

Promoters and enhancers for OR52W1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I006249 Enhancer 1 Ensembl ENCODE 10.9 +51.0 50980 1.1 BRCA1 ZBTB40 ZNF335 TCF12 ZNF766 GATA2 RCOR1 FOS ZBTB11 USF2 GC11M006236 C11orf42 OR52W1 CAVIN3 OR56A1 CCKBR
GH11I006250 Enhancer 0.9 Ensembl ENCODE 10.5 +53.2 53194 2.8 CTCF FOXA2 TEAD4 TAL1 RAD21 TCF12 NCOR1 EGR1 POLR2A ZNF143 FAM160A2 CCKBR C11orf42 OR52W1 OR56A1 GC11M006236
GH11I006468 Enhancer 1.2 FANTOM5 Ensembl ENCODE 7.6 +270.2 270225 1.5 HDGF PKNOX1 ZNF335 POLR2B GLIS2 POLR2A ZBTB48 PATZ1 ATF7 CREM OR56A1 OR10A4 OR2AG2 OR10A2 OR56A4 OR52W1 OR2AG1 OR56B4 OR10A5 OR6A2
GH11I006239 Promoter 0.6 EPDnew 10.9 +39.9 39924 0.1 ZNF449 CNGA4 CCKBR C11orf42 OR52W1 CAVIN3 GC11M006236
GH11I006287 Enhancer 0.6 ENCODE 10 +89.5 89505 2.1 RFX1 CEBPB CEBPG DPF2 SKIL JUND GATA3 CTBP1 FOS CAVIN3 CCKBR FAM160A2 C11orf42 OR52W1 OR52B2 OR56A1 ENSG00000270435 GC11M006277
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR52W1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR52W1 gene promoter:

Genomic Locations for OR52W1 Gene

Genomic Locations for OR52W1 Gene
1,114 bases
Plus strand

Genomic View for OR52W1 Gene

Genes around OR52W1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52W1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52W1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52W1 Gene

Proteins for OR52W1 Gene

  • Protein details for OR52W1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 52W1
    Protein Accession:
    Secondary Accessions:
    • Q8NH78

    Protein attributes for OR52W1 Gene

    320 amino acids
    Molecular mass:
    34414 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52W1 Gene

Post-translational modifications for OR52W1 Gene

  • Glycosylation at Asn8
  • Modification sites at PhosphoSitePlus

Other Protein References for OR52W1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52W1 Gene

Domains & Families for OR52W1 Gene

Gene Families for OR52W1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR52W1 Gene

Suggested Antigen Peptide Sequences for OR52W1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52W1: view

Function for OR52W1 Gene

Molecular function for OR52W1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR52W1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR52W1: view
genes like me logo Genes that share phenotypes with OR52W1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52W1 Gene

Localization for OR52W1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52W1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR52W1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52W1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52W1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR52W1 Gene

Pathways & Interactions for OR52W1 Gene

genes like me logo Genes that share pathways with OR52W1: view

Pathways by source for OR52W1 Gene

Interacting Proteins for OR52W1 Gene

Gene Ontology (GO) - Biological Process for OR52W1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52W1: view

No data available for SIGNOR curated interactions for OR52W1 Gene

Drugs & Compounds for OR52W1 Gene

No Compound Related Data Available

Transcripts for OR52W1 Gene

mRNA/cDNA for OR52W1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR52W1 Gene

No ASD Table

Relevant External Links for OR52W1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR52W1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR52W1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR52W1 Gene:


SOURCE GeneReport for Unigene cluster for OR52W1 Gene:

genes like me logo Genes that share expression patterns with OR52W1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52W1 Gene

Orthologs for OR52W1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52W1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC747058 33
  • 99.06 (n)
OR52W1 34
  • 98 (a)
(Canis familiaris)
Mammalia OR52W1 33 34
  • 88.02 (n)
(Bos Taurus)
Mammalia OR52W1 33 34
  • 87.63 (n)
(Rattus norvegicus)
Mammalia LOC686660 33
  • 83.96 (n)
(Mus musculus)
Mammalia Or52w1 51 Olfr692 33 16 34
  • 83.33 (n)
(Monodelphis domestica)
Mammalia OR52W1 34
  • 74 (a)
Species where no ortholog for OR52W1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52W1 Gene

Gene Tree for OR52W1 (if available)
Gene Tree for OR52W1 (if available)

Paralogs for OR52W1 Gene

(267) SIMAP similar genes for OR52W1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR52W1: view

No data available for Paralogs for OR52W1 Gene

Variants for OR52W1 Gene

Sequence variations from dbSNP and Humsavar for OR52W1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1001617260 -- 6,197,287(+) T/A upstream_transcript_variant
rs1002620091 -- 6,198,790(+) T/C upstream_transcript_variant
rs1002630039 -- 6,198,460(+) C/T upstream_transcript_variant
rs1003628764 -- 6,200,176(+) G/T coding_sequence_variant, missense_variant
rs1005588239 -- 6,200,488(+) T/C downstream_transcript_variant

Variation tolerance for OR52W1 Gene

Residual Variation Intolerance Score: 65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.32; 63.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR52W1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR52W1 Gene

Disorders for OR52W1 Gene

Additional Disease Information for OR52W1

No disorders were found for OR52W1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52W1 Gene

Publications for OR52W1 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for OR52W1 Gene

Sources for OR52W1 Gene

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