Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR52W1 Gene

Aliases for OR52W1 Gene

  • Olfactory Receptor Family 52 Subfamily W Member 1 2 3 5
  • Olfactory Receptor OR11-71 3 4
  • Olfactory Receptor 52W1 3 4
  • OR52W1P 3 4
  • Olfactory Receptor, Family 52, Subfamily W, Member 1 Pseudogene 3
  • Olfactory Receptor, Family 52, Subfamily W, Member 1 2
  • OR11-71 3
  • OR52W1 5

External Ids for OR52W1 Gene

Previous HGNC Symbols for OR52W1 Gene

  • OR52W1P

Previous GeneCards Identifiers for OR52W1 Gene

  • GC11P006186
  • GC11P006177
  • GC11P006221

Summaries for OR52W1 Gene

Entrez Gene Summary for OR52W1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52W1 Gene

OR52W1 (Olfactory Receptor Family 52 Subfamily W Member 1) is a Protein Coding gene. Diseases associated with OR52W1 include Neuropathy, Hereditary, With Liability To Pressure Palsies. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52L1.

UniProtKB/Swiss-Prot Summary for OR52W1 Gene

Gene Wiki entry for OR52W1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR52W1 Gene

Genomics for OR52W1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR52W1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J006249 Enhancer 0.9 Ensembl ENCODE 10.9 +50.9 50887 1.3 NCOR1 BRCA1 NFIC CEBPB EP300 TAL1 STAT3 TBP USF2 MYNN C11orf42 OR52W1 CAVIN3 OR56A1 CCKBR CNGA4
GH11J006468 Enhancer 1.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas 7.6 +270.2 270225 1.5 ZNF10 NFIC POLR2A MBD2 KLF9 SP2 ELF1 ZFP91 ZBTB48 SUPT5H OR56A1 OR10A4 OR2AG2 OR10A2 OR56A4 OR52W1 OR2AG1 OR56B4 OR10A5 OR6A2
GH11J006239 Promoter/Enhancer 0.7 EPDnew FANTOM5 Ensembl 10.9 +41.1 41055 2.8 CNGA4 CCKBR C11orf42 OR52W1 CAVIN3 OR52B2 TPP1 FHIP1B
GH11J006250 Enhancer 0.7 ENCODE 10.5 +53.2 53194 2.8 ZNF654 IKZF1 CTCF REST BHLHE40 FOXA2 RAD21 SMC3 TAL1 EGR1 FHIP1B CCKBR C11orf42 OR52W1 OR56A1 CNGA4
GH11J006287 Enhancer 0.7 Ensembl ENCODE 10 +89.5 89505 2.1 CTBP1 SKIL JUND DPF2 RFX1 CEBPB FOS CEBPG CAVIN3 CCKBR FHIP1B OR52W1 C11orf42 OR52B2 OR56A1 HSALNG0082404 lnc-CCKBR-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR52W1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR52W1

Top Transcription factor binding sites by QIAGEN in the OR52W1 gene promoter:
  • AML1a
  • Evi-1
  • Pax-2
  • Pax-2a
  • RREB-1
  • Sox9
  • SRY
  • USF-1
  • USF1
  • YY1

Genomic Locations for OR52W1 Gene

Latest Assembly
chr11:6,199,146-6,200,259
(GRCh38/hg38)
Size:
1,114 bases
Orientation:
Plus strand

Previous Assembly
chr11:6,220,454-6,221,416
(GRCh37/hg19 by Entrez Gene)
Size:
963 bases
Orientation:
Plus strand

chr11:6,220,376-6,221,489
(GRCh37/hg19 by Ensembl)
Size:
1,114 bases
Orientation:
Plus strand

Genomic View for OR52W1 Gene

Genes around OR52W1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52W1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52W1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52W1 Gene

Proteins for OR52W1 Gene

  • Protein details for OR52W1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IF63-O52W1_HUMAN
    Recommended name:
    Olfactory receptor 52W1
    Protein Accession:
    Q6IF63
    Secondary Accessions:
    • Q8NH78

    Protein attributes for OR52W1 Gene

    Size:
    320 amino acids
    Molecular mass:
    34414 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52W1 Gene

Post-translational modifications for OR52W1 Gene

  • Glycosylation at Asn8
  • Modification sites at PhosphoSitePlus

Other Protein References for OR52W1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52W1 Gene

Domains & Families for OR52W1 Gene

Gene Families for OR52W1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR52W1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR52W1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-71 (O52W1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6IF63

UniProtKB/Swiss-Prot:

O52W1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52W1: view

Function for OR52W1 Gene

Molecular function for OR52W1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR52W1 Gene

Gene Ontology (GO) - Molecular Function for OR52W1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR52W1: view
genes like me logo Genes that share phenotypes with OR52W1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR52W1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52W1 Gene

Localization for OR52W1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52W1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR52W1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52W1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52W1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR52W1 Gene

Pathways & Interactions for OR52W1 Gene

genes like me logo Genes that share pathways with OR52W1: view

Pathways by source for OR52W1 Gene

Interacting Proteins for OR52W1 Gene

Gene Ontology (GO) - Biological Process for OR52W1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52W1: view

No data available for SIGNOR curated interactions for OR52W1 Gene

Drugs & Compounds for OR52W1 Gene

No Compound Related Data Available

Transcripts for OR52W1 Gene

mRNA/cDNA for OR52W1 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR52W1

Alternative Splicing Database (ASD) splice patterns (SP) for OR52W1 Gene

No ASD Table

Relevant External Links for OR52W1 Gene

GeneLoc Exon Structure for
OR52W1

Expression for OR52W1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR52W1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR52W1

SOURCE GeneReport for Unigene cluster for OR52W1 Gene:

Hs.553570
genes like me logo Genes that share expression patterns with OR52W1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52W1 Gene

Orthologs for OR52W1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52W1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC747058 29
  • 99.06 (n)
OR52W1 30
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia OR52W1 29 30
  • 88.02 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia OR52W1 29 30
  • 87.63 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC686660 29
  • 83.96 (n)
Mouse
(Mus musculus)
Mammalia Or52w1 45 Olfr692 29 16 30
  • 83.33 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia OR52W1 30
  • 74 (a)
OneToOne
Species where no ortholog for OR52W1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR52W1 Gene

ENSEMBL:
Gene Tree for OR52W1 (if available)
TreeFam:
Gene Tree for OR52W1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR52W1: view image
Alliance of Genome Resources:
Additional Orthologs for OR52W1

Paralogs for OR52W1 Gene

(267) SIMAP similar genes for OR52W1 Gene using alignment to 1 proteins:

  • O52W1_HUMAN
genes like me logo Genes that share paralogs with OR52W1: view

Variants for OR52W1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR52W1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs10839531 -- p.His239Arg
rs11040799 -- p.Leu254Gln
rs325609 -- p.Thr266Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR52W1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for OR52W1 Gene

Residual Variation Intolerance Score: 65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.32; 63.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR52W1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR52W1
Leiden Open Variation Database (LOVD)
OR52W1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR52W1 Gene

Disorders for OR52W1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR52W1 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for OR52W1

genes like me logo Genes that share disorders with OR52W1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR52W1 Gene

Publications for OR52W1 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for OR52W1 Gene

Sources for OR52W1 Gene