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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...
Aliases for OR52W1 Gene
Aliases for OR52W1 Gene
External Ids for OR52W1 Gene
- HGNC: 15239
- Entrez Gene: 120787
- Ensembl: ENSG00000175485
- UniProtKB: Q6IF63
- HORDE: OR52W1
Previous HGNC Symbols for OR52W1 Gene
- OR52W1P
Previous GeneCards Identifiers for OR52W1 Gene
- GC11P006186
- GC11P006177
- GC11P006221
Summaries for OR52W1 Gene
-
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
GeneCards Summary for OR52W1 Gene
OR52W1 (Olfactory Receptor Family 52 Subfamily W Member 1) is a Protein Coding gene. Diseases associated with OR52W1 include Neuropathy, Hereditary, With Liability To Pressure Palsies. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52L1.
UniProtKB/Swiss-Prot Summary for OR52W1 Gene
-
Odorant receptor.
Additional gene information for OR52W1 Gene
- HGNC(15239)
- Entrez Gene(120787)
- Ensembl(ENSG00000175485)
- UniProtKB(Q6IF63)
- Open Targets Platform(ENSG00000175485)
- Search for OR52W1 at DataMed
- Search for OR52W1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR52W1 Gene
Genomics for OR52W1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for OR52W1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around OR52W1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR52W1
- Top Transcription factor binding sites by QIAGEN in the OR52W1 gene promoter:
-
- AML1a
- Evi-1
- Pax-2
- Pax-2a
- RREB-1
- Sox9
- SRY
- USF-1
- USF1
- YY1
Genomic Locations for OR52W1 Gene
Genomic Locations for OR52W1 Gene
- chr11:6,199,146-6,200,259
- (GRCh38/hg38)
- Size:
- 1,114 bases
- Orientation:
- Plus strand
- chr11:6,220,376-6,221,489
- (GRCh37/hg19)
- Size:
- 1,114 bases
- Orientation:
- Plus strand
Genomic View for OR52W1 Gene
Genes around OR52W1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p15.4 by HGNC
- 11p15.4 by Entrez Gene
- 11p15.4 by Ensembl
OR52W1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for OR52W1 Gene
Proteins for OR52W1 Gene
-
Protein details for OR52W1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6IF63-O52W1_HUMAN
- Recommended name:
- Olfactory receptor 52W1
- Protein Accession:
- Q6IF63
- Q8NH78
Protein attributes for OR52W1 Gene
- Size:
- 320 amino acids
- Molecular mass:
- 34414 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for OR52W1 Gene
Other Protein References for OR52W1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
- HORDE protein sequence:
Antibody Products
- Invitrogen Antibodies for OR52W1 (AFLGC-OR52W1)
- antibodies-online: Show 5 available OR52W1 Antibodies ranked by validation data
- Compare Top OR52W1 Antibodies
-
Quality Products:
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for OR52W1
- Origene Custom Protein Services for OR52W1
- Novus Biologicals proteins for OR52W1
Assay Products
No data available for DME Specific Peptides for OR52W1 Gene
Domains & Families for OR52W1 Gene
Gene Families for OR52W1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Predicted membrane proteins
Protein Domains for OR52W1 Gene
- InterPro:
- Blocks:
-
- Olfactory receptor signature
- ProtoNet:
Suggested Antigen Peptide Sequences for OR52W1 Gene
- GenScript: Design optimal peptide antigens:
-
- Olfactory receptor OR11-71 (O52W1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q6IF63- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for OR52W1 Gene
Molecular function for OR52W1 Gene
- UniProtKB/Swiss-Prot Function:
- Odorant receptor.
Phenotypes From GWAS Catalog for OR52W1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G protein-coupled receptor activity | IEA | -- |
| GO:0004984 | olfactory receptor activity | IBA | -- |
Phenotypes for OR52W1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for OR52W1 - Select products 50% OFF >
- * OR52W1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for OR52W1
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for OR52W1 - Select products 50% OFF >
- * OR52W1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for OR52W1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for OR52W1
Cell Line Products
-
Horizon Cell Lines for OR52W1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52W1 Gene
Localization for OR52W1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for OR52W1 Gene
- Cell membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR52W1 Gene
Pathways & Interactions for OR52W1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by GPCR | ||
| 2 | Olfactory transduction | ||
Pathways by source for OR52W1 Gene
4 Reactome pathways for OR52W1 Gene
1 KEGG pathway for OR52W1 Gene
Interacting Proteins for OR52W1 Gene
GPS-Prot Interaction Network for OR52W1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
| GO:0007608 | sensory perception of smell | IEA | -- |
| GO:0050896 | response to stimulus | IEA | -- |
| GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
No data available for SIGNOR curated interactions for OR52W1 Gene
Transcripts for OR52W1 Gene
mRNA/cDNA for OR52W1 Gene
- 1 REFSEQ mRNAs :
- 1 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000311352 1114 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for OR52W1 - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for OR52W1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for OR52W1
-
Santa Cruz Biotechnology (SCBT) CRISPR for OR52W1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for OR52W1
- Browse OriGene Inhibitory RNA Products For OR52W1
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Clone Products
- Applied Biological Materials (abm): Clones for OR52W1 - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for OR52W1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for OR52W1
Relevant External Links for OR52W1 Gene
- GeneLoc Exon Structure for
- OR52W1
Expression for OR52W1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR52W1
SOURCE GeneReport for Unigene cluster for OR52W1 Gene:
Hs.553570Primer Products
-
OriGene qPCR primer pairs for OR52W1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52W1 Gene
Orthologs for OR52W1 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LOC747058 30 |
|
||
| OR52W1 31 |
|
OneToOne | |||
| Dog (Canis familiaris) |
Mammalia | OR52W1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | OR52W1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | LOC686660 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Or52w1 46 Olfr692 30 17 31 |
|
OneToOne |
|
| Oppossum (Monodelphis domestica) |
Mammalia | OR52W1 31 |
|
OneToOne |
- Species where no ortholog for OR52W1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for OR52W1 Gene
- ENSEMBL:
- Gene Tree for OR52W1 (if available)
- TreeFam:
- Gene Tree for OR52W1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for OR52W1: view image
Paralogs for OR52W1 Gene
Paralogs for OR52W1 Gene
- OR52L1 5
- OR52R1 5
- OR52D1 5
- OR52K2 5
- OR52K1 5
- OR52M1 5
- OR51L1 5
- OR52E2 5
- OR52E8 5
- OR52A5 5
- OR52N4 5
- OR51E2 5
- OR52J3 5
- OR52A1 5
- OR52N1 5
- OR52N5 5
- OR52B6 5
- OR52N2 5
- OR51S1 5
- OR52E5 5
- OR52E4 5
- OR52B2 5
- OR51E1 5
- OR51G1 5
- OR51B5 5
- OR52E6 5
- OR52H1 5
- OR51D1 5
- OR51F2 5
- OR51I2 5
- OR51G2 5
- OR51T1 5
- OR51M1 5
- OR51I1 5
- OR56B4 5
- OR52I2 5
- OR52I1 5
- OR52E1 5
- OR51V1 5
- OR51B2 5
- OR51B6 5
- OR52B4 5
- OR51C1P 5
- OR51B4 5
- OR56B1 5
- OR51Q1 5
- OR51A7 5
- OR51A4 5
- OR51A2 5
(267) SIMAP similar genes for OR52W1 Gene using alignment to 1 proteins:
- O52W1_HUMAN
- OR52L2P
- OR52L1
- OR52D1
- OR52J3
- OR52N1
- OR51L1
- OR52A5
- OR52P1P
- OR52M1
- OR52E5
- OR52N2
- OR52E4
- OR52R1
- OR52K2
- OR52E2
- OR52A1
- OR51E1
- OR52Z1
- OR52N5
- OR52N4
- OR52K1
- OR52E8
- OR51G1
- OR51E2
- OR52I2
- OR52E6
- OR51G2
- OR52E1
- OR52B2
- OR52H1
- OR51S1
- OR51A7
- OR51I1
- OR51A2
- OR51I2
- OR52I1
- OR52B6
- OR52A4
- OR51F2
- OR51H1P
- OR51D1
- OR51A4
- OR56A4
- OR51Q1
- OR56A5
- OR56A1
- OR51F1
- OR51B6
- OR51B5
- OR51V1
- OR51M1
- OR56B4
- OR56B3P
- OR56B2P
- OR56B1
- OR52B1P
- OR51A1P
- OR56A3
- OR52B4
- OR51B4
- OR51B2
- OR51T1
- OR2AT4
- FKSG35
- OR10H3
- OR2D3
- OR2A7
- OR2A14
- OR2A4
- OR13C9
- OR13C8
- OR10H4
- OR6V1
- OR5B2
- OR6S1
- OR6B3
- OR6B2
- OR4C3
- OR2A25
- OR1F12
- OR1C1
- OR10A4
- OR2D2
- OR2AG1
- OR2A2
- OR10R3P
- OR10A3
- OR2A1
- OR2A5
- OR8K3
- OR6C4
- OR5M3
- OR5B17
- OR4K2
- OR4A47
- OR2V2
- OR2V1
- OR2T33
- OR2T12
- OR2K2
- OR2J1
- OR2F1
- OR2AG2
- OR2A42
- OR1S1
- OR1F2P
- OR1A1
- OR13C3
- OR11G2
- OR2Z1
- OR2W1
- OR2L8
- OR2L3
- OR1Q1
- OR1J4
- OR1J2
- OR13C4
- OR10V1
- OR10T2
- OR10H2
- OR10G7
- OR10C1
- OR8G5
- OR6N1
- OR5F1
- OR8U8
- OR8K1
- OR8D1
- OR8A1
- OR7E24
- OR6N2
- OR6K3
- OR6F1
- OR5D16
- OR5B21
- OR5B12
- OR5A2
- OR5A1
- OR51J1
- OR4Q2
- OR3A1
- OR2T8
- OR2T4
- OR2T27
- OR2L2
- OR2G6
- OR2G2
- OR2AJ1
- OR2A12
- OR1L3
- OR1L1
- OR1J1
- OR1E1
- OR11L1
- OR10R2
- OR10P1
- OR10H5
- OR10G8
- OR10G3
- OR2S2
- OR2M4
- OR2L5
- OR2J3
- OR2J2
- OR2G3
- OR2AP1
- OR1N1
- OR1A2
- OR13G1
- OR13F1
- OR10J5
- OR10G9
- OR10G2
- OR10A6
- OR9Q2
- OR8H3
- OR8H1
- OR7A10
- OR6X1
- OR6B1
- OR5R1
- OR5AS1
- OR5AR1
- OR8U9
- OR8I2
- OR8H2
- OR7G3
- OR6Y1
- OR6M1
- OR6C74
- OR5T1
- OR5D18
- OR5C1
- OR5AC1
- OR4A15
- OR3A2
- OR2Y1
- OR2W6P
- OR2T5
- OR2T34
- OR2T29
- OR2T11
- OR2M7
- OR2M3
- OR2L13
- OR2C3
- OR2C1
- OR2B11
- OR1L6
- OR1L4
- OR1F1
- OR1E3
- OR1D2
- OR13A1
- OR11H7
- OR11H6
- OR10Z1
- OR10K2
- OR10J1
- OR10D4P
- OR10AG1
- OR10A5
- OR10A2
- OR1K1
- OR13C2
- OR10H1
- OR10G4
- OR7D4
- OR2W3
- OR8B12
- OR7D2
- OR5V1
- olfr89
- OR8D4
- OR7A2P
- OR6Q1
- OR6P1
- OR6C6
- OR5H2
- OR5H15
- OR5H1
- OR5AP2
- OR4F17
- OR3A3
- OR2T7
- OR2T6
- OR2T3
- OR2T1
- OR2M5
- OR2M2
- OR2AK2
- OR1N2
- OR13J1
- OR11H4
- OR11H2
- OR11H12
- OR11H1
- OR10X1
- OR10G6
- OR4D5
- OR2F2
- OR2B3
- OR1E2
- OR11A1
- OR10K1
- OR10D3
- OR10A7
Variants for OR52W1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR52W1 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs10839531 | - | p.His239Arg | |||
| rs11040799 | - | p.Leu254Gln | |||
| rs325609 | - | p.Thr266Ala |
Residual Variation Intolerance Score:
65.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.32;
63.00% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for OR52W1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- OR52W1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR52W1 Gene
Disorders for OR52W1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| neuropathy, hereditary, with liability to pressure palsies |
|
|
Search OR52W1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for OR52W1
No data available for UniProtKB/Swiss-Prot and Genatlas for OR52W1 Gene
Publications for OR52W1 Gene
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4
- The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
- Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
ExternalLinks
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- OriGene qPCR primer pairs for OR52W1
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- Invitrogen Antibodies for OR52W1 (AFLGC-OR52W1)
- VectorBuilder Custom and pre-made DNA vectors for OR52W1 (ie. gene expression, shRNA knockdown, CRISPR)
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- antibodies-online: Show 5 available OR52W1 Antibodies ranked by validation data
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Sources for OR52W1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
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