Free for academic non-profit institutions. Other users need a Commercial license
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR52W1 (Olfactory Receptor Family 52 Subfamily W Member 1) is a Protein Coding gene. Diseases associated with OR52W1 include Neuropathy, Hereditary, With Liability To Pressure Palsies. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52L1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IBA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
GO:0007608 | sensory perception of smell | IEA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC747058 30 |
|
||
OR52W1 31 |
|
OneToOne | |||
Dog (Canis familiaris) |
Mammalia | OR52W1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | OR52W1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | LOC686660 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Or52w1 46 Olfr692 30 17 31 |
|
OneToOne |
|
Oppossum (Monodelphis domestica) |
Mammalia | OR52W1 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs10839531 | - | p.His239Arg | |||
rs11040799 | - | p.Leu254Gln | |||
rs325609 | - | p.Thr266Ala |
Disorder | Aliases | PubMed IDs |
---|---|---|
neuropathy, hereditary, with liability to pressure palsies |
|
|