Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR52R1 Gene

Aliases for OR52R1 Gene

  • Olfactory Receptor Family 52 Subfamily R Member 1 2 3 5
  • Olfactory Receptor OR11-22 3 4
  • Olfactory Receptor 52R1 3 4
  • Olfactory Receptor, Family 52, Subfamily R, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor Family 52 Subfamily R Member 1 (Gene/Pseudogene) 2
  • OR11-22 3
  • OR52R1 5

External Ids for OR52R1 Gene

Previous GeneCards Identifiers for OR52R1 Gene

  • GC11U990479
  • GC11M004789
  • GC11M004781

Summaries for OR52R1 Gene

Entrez Gene Summary for OR52R1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR52R1 Gene

OR52R1 (Olfactory Receptor Family 52 Subfamily R Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52L1.

UniProtKB/Swiss-Prot Summary for OR52R1 Gene

Gene Wiki entry for OR52R1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR52R1 Gene

Genomics for OR52R1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR52R1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J004492 Enhancer 0.2 FANTOM5 6.4 +312.0 311964 0.1 OR52K2 OR51F1 OR52B4 OR51S1 OR51G2 OR51A4 OR52K1 C11orf40 OR52R1 OR51A7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR52R1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR52R1

Top Transcription factor binding sites by QIAGEN in the OR52R1 gene promoter:
  • AML1a
  • COMP1
  • HOXA9
  • HOXA9B
  • Ik-3
  • Meis-1
  • Meis-1a
  • Pbx1a
  • POU3F2
  • POU3F2 (N-Oct-5a)

Genomic Locations for OR52R1 Gene

Latest Assembly
chr11:4,803,433-4,804,380
(GRCh38/hg38)
Size:
948 bases
Orientation:
Minus strand

Previous Assembly
chr11:4,824,663-4,825,610
(GRCh37/hg19 by Entrez Gene)
Size:
948 bases
Orientation:
Minus strand

Genomic View for OR52R1 Gene

Genes around OR52R1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52R1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52R1 Gene

Proteins for OR52R1 Gene

  • Protein details for OR52R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGF1-O52R1_HUMAN
    Recommended name:
    Olfactory receptor 52R1
    Protein Accession:
    Q8NGF1
    Secondary Accessions:
    • Q6IFI0

    Protein attributes for OR52R1 Gene

    Size:
    315 amino acids
    Molecular mass:
    34943 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA04680.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR52R1 Gene

Post-translational modifications for OR52R1 Gene

  • Glycosylation at Asn7

Other Protein References for OR52R1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52R1 Gene

Domains & Families for OR52R1 Gene

Gene Families for OR52R1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR52R1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR52R1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-22 (O52R1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGF1

UniProtKB/Swiss-Prot:

O52R1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52R1: view

Function for OR52R1 Gene

Molecular function for OR52R1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR52R1 Gene

Gene Ontology (GO) - Molecular Function for OR52R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR52R1: view

Phenotypes for OR52R1 Gene

genes like me logo Genes that share phenotypes with OR52R1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR52R1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52R1 Gene

Localization for OR52R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52R1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR52R1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52R1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR52R1 Gene

Pathways & Interactions for OR52R1 Gene

genes like me logo Genes that share pathways with OR52R1: view

Pathways by source for OR52R1 Gene

Interacting Proteins for OR52R1 Gene

Gene Ontology (GO) - Biological Process for OR52R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52R1: view

No data available for SIGNOR curated interactions for OR52R1 Gene

Drugs & Compounds for OR52R1 Gene

No Compound Related Data Available

Transcripts for OR52R1 Gene

mRNA/cDNA for OR52R1 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR52R1

Alternative Splicing Database (ASD) splice patterns (SP) for OR52R1 Gene

No ASD Table

Relevant External Links for OR52R1 Gene

GeneLoc Exon Structure for
OR52R1

Expression for OR52R1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR52R1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR52R1

SOURCE GeneReport for Unigene cluster for OR52R1 Gene:

Hs.553563
genes like me logo Genes that share expression patterns with OR52R1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52R1 Gene

Orthologs for OR52R1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR52R1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466351 29
  • 99.15 (n)
Cow
(Bos Taurus)
Mammalia LOC782046 29
  • 85.21 (n)
Dog
(Canis familiaris)
Mammalia LOC100684682 29
  • 85.03 (n)
Mouse
(Mus musculus)
Mammalia Or52r1 45 Olfr569 29 16
  • 84.96 (n)
Or52r1b 45 Olfr582
  • chr7:103,041,481-103,042,437
Or52r1c 45 Olfr584
  • chr7:103,085,520-103,086,476
Or52r6-ps 45 Olfr567-ps1
  • chr7:102,863,922-102,864,778
Rat
(Rattus norvegicus)
Mammalia Olr50 29
  • 84.42 (n)
Chicken
(Gallus gallus)
Aves LOC100857813 29
  • 66.78 (n)
Species where no ortholog for OR52R1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR52R1 Gene

ENSEMBL:
Gene Tree for OR52R1 (if available)
TreeFam:
Gene Tree for OR52R1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR52R1: view image
Alliance of Genome Resources:
Additional Orthologs for OR52R1

Paralogs for OR52R1 Gene

(445) SIMAP similar genes for OR52R1 Gene using alignment to 2 proteins:

  • O52R1_HUMAN
  • J3KPH5_HUMAN
genes like me logo Genes that share paralogs with OR52R1: view

Variants for OR52R1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR52R1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs17327254 -- p.Phe88Leu
rs2053116 -- p.Ser245Ala
rs6578533 -- p.Asn201Tyr
rs7941731 -- p.Ile129Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR52R1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR52R1 Gene

Variant ID Type Subtype PubMed ID
dgv1026n100 CNV loss 25217958
dgv1587n54 CNV loss 21841781
dgv1588n54 CNV loss 21841781
esv2673268 CNV deletion 23128226
esv2760633 CNV loss 21179565
esv3579253 CNV loss 25503493
esv3625193 CNV loss 21293372
esv3625194 CNV loss 21293372
esv3891914 CNV gain 25118596
nsv1054847 CNV gain 25217958
nsv467666 CNV loss 19166990
nsv832056 CNV gain 17160897

Variation tolerance for OR52R1 Gene

Residual Variation Intolerance Score: 91.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.65; 98.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR52R1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR52R1
Leiden Open Variation Database (LOVD)
OR52R1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52R1 Gene

Disorders for OR52R1 Gene

Additional Disease Information for OR52R1

No disorders were found for OR52R1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52R1 Gene

Publications for OR52R1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I … Lancet D (BMC bioinformatics 2006) 3
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4

Products for OR52R1 Gene

Sources for OR52R1 Gene