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Aliases for OR52N5 Gene

Aliases for OR52N5 Gene

  • Olfactory Receptor Family 52 Subfamily N Member 5 2 3 5
  • Olfactory Receptor OR11-62 3 4
  • Olfactory Receptor, Family 52, Subfamily N, Member 5 2
  • Olfactory Receptor 52N5 3
  • OR11-62 3
  • OR52N5Q 3

External Ids for OR52N5 Gene

Previous GeneCards Identifiers for OR52N5 Gene

  • GC11U990483

Summaries for OR52N5 Gene

Entrez Gene Summary for OR52N5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52N5 Gene

OR52N5 (Olfactory Receptor Family 52 Subfamily N Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52N2.

UniProtKB/Swiss-Prot for OR52N5 Gene

  • Odorant receptor.

Gene Wiki entry for OR52N5 Gene

Additional gene information for OR52N5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52N5 Gene

Genomics for OR52N5 Gene

GeneHancer (GH) Regulatory Elements for OR52N5 Gene

Promoters and enhancers for OR52N5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J005546 Enhancer 0.2 FANTOM5 9.2 +237.1 237109 0.1 OR56A1 OR56A3 OR51Q1 OR52E8 OR52N1 OR56A4 OR52N4 OR52E2 OR52E4 OR52A1
GH11J005815 Enhancer 1.2 FANTOM5 Ensembl ENCODE 1.4 -32.3 -32318 0.5 HDAC1 TEAD4 EBF1 CEBPG CHAMP1 ZNF316 CBX5 POLR2A NFE2 ATF7 OR52N3P DNHD1 RRP8 ENSG00000254641 TRIM22 TRIM34 TRIM5 FAM160A2 OR52N5 OR52N2
GH11J005379 Enhancer 0.2 FANTOM5 3.9 +403.4 403363 0 OR51V1 OR51T1 HBB OR51B5 OR51G1 OR56B1 OR52J3 OR51L1 OR52N4 OR52D1
GH11J005328 Enhancer 0.2 FANTOM5 3 +454.2 454177 0.4 OR51G1 OR51T1 OR52N2 OR52N4 OR52D1 OR52J3 MMP26 OR51L1 OR51B2 OR51M1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR52N5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR52N5 gene promoter:
  • AREB6
  • Tal-1beta
  • E47
  • GCNF-2
  • GCNF-1
  • GCNF
  • AML1a

Genomic Locations for OR52N5 Gene

Genomic Locations for OR52N5 Gene
7,191 bases
Minus strand
1,034 bases
Minus strand

Genomic View for OR52N5 Gene

Genes around OR52N5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52N5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52N5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52N5 Gene

Proteins for OR52N5 Gene

  • Protein details for OR52N5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 52N5
    Protein Accession:
    Secondary Accessions:
    • B9EH12
    • Q6IFG2

    Protein attributes for OR52N5 Gene

    324 amino acids
    Molecular mass:
    36212 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52N5 Gene

Post-translational modifications for OR52N5 Gene

No Post-translational modifications

Other Protein References for OR52N5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52N5 Gene

Domains & Families for OR52N5 Gene

Gene Families for OR52N5 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR52N5 Gene

Suggested Antigen Peptide Sequences for OR52N5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52N5: view

Function for OR52N5 Gene

Molecular function for OR52N5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR52N5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR52N5: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52N5 Gene

Localization for OR52N5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52N5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR52N5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52N5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52N5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR52N5 Gene

Pathways & Interactions for OR52N5 Gene

genes like me logo Genes that share pathways with OR52N5: view

Pathways by source for OR52N5 Gene

Interacting Proteins for OR52N5 Gene

Gene Ontology (GO) - Biological Process for OR52N5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52N5: view

No data available for SIGNOR curated interactions for OR52N5 Gene

Drugs & Compounds for OR52N5 Gene

No Compound Related Data Available

Transcripts for OR52N5 Gene

mRNA/cDNA for OR52N5 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR52N5 Gene

Olfactory receptor, family 52, subfamily N, member 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR52N5 Gene

No ASD Table

Relevant External Links for OR52N5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR52N5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR52N5 Gene

mRNA differential expression in normal tissues according to GTEx for OR52N5 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x23.7) and Fallopian Tube (x4.9).

Protein differential expression in normal tissues from HIPED for OR52N5 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR52N5 Gene

Protein tissue co-expression partners for OR52N5 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR52N5 Gene:


SOURCE GeneReport for Unigene cluster for OR52N5 Gene:

genes like me logo Genes that share expression patterns with OR52N5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52N5 Gene

Orthologs for OR52N5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52N5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466394 33
  • 98.61 (n)
(Bos Taurus)
Mammalia LOC787779 33
  • 87.31 (n)
-- 34
  • 84 (a)
-- 34
  • 83 (a)
(Mus musculus)
Mammalia Or52n5 51 Olfr669 34
  • 87 (a)
(Monodelphis domestica)
Mammalia OR52N5 34
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 70 (a)
-- 34
  • 68 (a)
-- 34
  • 65 (a)
(Canis familiaris)
Mammalia -- 34
  • 69 (a)
-- 34
  • 49 (a)
Species where no ortholog for OR52N5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52N5 Gene

Gene Tree for OR52N5 (if available)
Gene Tree for OR52N5 (if available)
Evolutionary constrained regions (ECRs) for OR52N5: view image

Paralogs for OR52N5 Gene

Paralogs for OR52N5 Gene

(445) SIMAP similar genes for OR52N5 Gene using alignment to 1 proteins:

  • O52N5_HUMAN
genes like me logo Genes that share paralogs with OR52N5: view

Variants for OR52N5 Gene

Sequence variations from dbSNP and Humsavar for OR52N5 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1001790192 -- 5,778,654(-) C/T 5_prime_UTR_variant
rs1003065940 -- 5,777,154(-) T/A downstream_transcript_variant
rs1004875153 -- 5,779,537(-) TTT/TT upstream_transcript_variant
rs1008969390 -- 5,779,937(-) T/C upstream_transcript_variant
rs1010736759 -- 5,779,061(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR52N5 Gene

Variant ID Type Subtype PubMed ID
dgv1044n100 CNV loss 25217958
dgv1045n100 CNV loss 25217958
dgv1046n100 CNV gain+loss 25217958
dgv1047n100 CNV loss 25217958
dgv1048n100 CNV loss 25217958
dgv1049n100 CNV gain+loss 25217958
dgv1050n100 CNV loss 25217958
dgv1051n100 CNV loss 25217958
dgv1052n100 CNV loss 25217958
dgv11n50 CNV loss 21212237
dgv1612n54 CNV loss 21841781
dgv1616n54 CNV loss 21841781
dgv1617n54 CNV loss 21841781
dgv1618n54 CNV loss 21841781
dgv1619n54 CNV gain+loss 21841781
dgv1620n54 CNV loss 21841781
dgv17e203 CNV loss 21179565
dgv189e199 CNV deletion 23128226
dgv197n67 CNV loss 20364138
dgv198n67 CNV gain 20364138
dgv20e180 CNV gain 20482838
dgv312e212 CNV loss 25503493
dgv313e212 CNV gain 25503493
dgv314e212 CNV loss 25503493
dgv315e212 CNV gain 25503493
dgv316e212 CNV loss 25503493
dgv317e212 CNV loss 25503493
dgv318e212 CNV loss 25503493
dgv42n111 CNV deletion 26073780
dgv580n106 CNV deletion 24896259
dgv5n31 CNV loss 19718026
dgv9e213 CNV loss 24956385
esv2144298 CNV deletion 18987734
esv2421614 CNV deletion 20811451
esv2507539 CNV loss 19546169
esv2631490 CNV deletion 19546169
esv2744067 CNV deletion 23290073
esv2759801 CNV gain+loss 17122850
esv28265 CNV gain 19812545
esv33544 CNV gain+loss 17666407
esv3547262 CNV deletion 23714750
esv3579304 CNV loss 25503493
esv3625250 CNV loss 21293372
nsv1041196 CNV loss 25217958
nsv1046040 CNV gain 25217958
nsv1046068 CNV gain 25217958
nsv1050353 CNV gain+loss 25217958
nsv1052250 CNV gain+loss 25217958
nsv1053414 CNV gain 25217958
nsv1054371 CNV gain+loss 25217958
nsv1055011 CNV loss 25217958
nsv1076237 CNV deletion 25765185
nsv1147526 CNV deletion 26484159
nsv1159822 CNV deletion 26073780
nsv435927 CNV deletion 17901297
nsv442598 CNV loss 18776908
nsv443001 CNV deletion 18674749
nsv498749 CNV loss 21111241
nsv508616 CNV deletion 20534489
nsv514624 CNV loss 21397061
nsv519652 CNV loss 19592680
nsv553241 CNV gain 21841781
nsv553273 CNV gain 21841781
nsv553277 CNV gain 21841781
nsv553310 CNV gain+loss 21841781
nsv553344 CNV loss 21841781
nsv65 CNV deletion 15895083
nsv7654 CNV deletion 18451855
nsv819430 CNV gain 19587683
nsv821028 CNV deletion 20802225
nsv832058 CNV gain 17160897
nsv8784 CNV gain+loss 18304495
nsv951301 CNV deletion 24416366

Variation tolerance for OR52N5 Gene

Residual Variation Intolerance Score: 86.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.79; 73.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR52N5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52N5 Gene

Disorders for OR52N5 Gene

Additional Disease Information for OR52N5

No disorders were found for OR52N5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52N5 Gene

Publications for OR52N5 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR52N5 Gene

Sources for OR52N5 Gene

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