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Aliases for OR52N4 Gene

Aliases for OR52N4 Gene

  • Olfactory Receptor Family 52 Subfamily N Member 4 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 52, Subfamily N, Member 4 2 3
  • Olfactory Receptor OR11-64 3 4
  • Olfactory Receptor 52N4 3 4
  • Olfactory Receptor, Family 52, Subfamily N, Member 4 (Gene/Pseudogene) 2
  • OR11-64 3

External Ids for OR52N4 Gene

Previous GeneCards Identifiers for OR52N4 Gene

  • GC11U990484
  • GC11P005741
  • GC11P005732

Summaries for OR52N4 Gene

Entrez Gene Summary for OR52N4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52N4 Gene

OR52N4 (Olfactory Receptor Family 52 Subfamily N Member 4 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52N1.

UniProtKB/Swiss-Prot for OR52N4 Gene

Gene Wiki entry for OR52N4 Gene

Additional gene information for OR52N4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52N4 Gene

Genomics for OR52N4 Gene

GeneHancer (GH) Regulatory Elements for OR52N4 Gene

Promoters and enhancers for OR52N4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J005712 Enhancer 0.7 Ensembl ENCODE 10.4 -9.8 -9798 0.5 CTCF RAD21 REST NFE2 SMC3 ATF2 OR52N4 TRIM22 OR52U1P GC11M005701 GC11M005696 TRIM5
GH11J005700 Enhancer 0.5 ENCODE 10.1 -21.7 -21710 0.8 MLLT1 ZBTB33 NBN ADNP ZNF217 OR52N4 OR52P1P TRIM22 GC11M005696 OR52U1P TRIM5
GH11J005719 Enhancer 0.3 Ensembl 12.8 -2.0 -2040 0.8 POLR2A OR52U1P OR52N4 GC11M005701 TRIM22 TRIM5
GH11J005623 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 1.4 -96.8 -96823 3.2 SP1 RELA ZBED1 IKZF1 POLR2A RXRA IKZF2 PKNOX1 SMAD5 HDAC1 TRIM34 TRIM5 TRIM22 OR51B2 OR56B4 OR56A1 OR56A3 OR52N4 OR51Q1 OR52E6
GH11J005546 Enhancer 0.2 FANTOM5 11.5 -176.0 -176013 0.1 OR56A1 OR56A3 OR51Q1 OR52E8 OR52N1 OR56A4 OR52N4 OR52E2 OR52E4 OR52A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR52N4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR52N4 gene promoter:
  • Evi-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • GCNF
  • GCNF-1
  • GCNF-2
  • HNF-1
  • HNF-1A
  • Nkx5-1
  • RP58

Genomic Locations for OR52N4 Gene

Genomic Locations for OR52N4 Gene
33,700 bases
Plus strand
1,037 bases
Plus strand

Genomic View for OR52N4 Gene

Genes around OR52N4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52N4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52N4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52N4 Gene

Proteins for OR52N4 Gene

  • Protein details for OR52N4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 52N4
    Protein Accession:
    Secondary Accessions:
    • B2RNP8
    • Q6IF77

    Protein attributes for OR52N4 Gene

    321 amino acids
    Molecular mass:
    36080 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52N4 Gene

Post-translational modifications for OR52N4 Gene

  • Glycosylation at isoforms=5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR52N4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52N4 Gene

Domains & Families for OR52N4 Gene

Gene Families for OR52N4 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR52N4 Gene

Suggested Antigen Peptide Sequences for OR52N4 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-64 (O52N4_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52N4: view

Function for OR52N4 Gene

Molecular function for OR52N4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR52N4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR52N4: view
genes like me logo Genes that share phenotypes with OR52N4: view

Animal Model Products

CRISPR Products

miRNA for OR52N4 Gene

Clone Products

  • Applied Biological Materials (abm): Clones for OR52N4 - Now 50% OFF >
  • * OR52N4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * OR52N4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR52N4 Gene

Localization for OR52N4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52N4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR52N4 gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
nucleus 0

Gene Ontology (GO) - Cellular Components for OR52N4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52N4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR52N4 Gene

Pathways & Interactions for OR52N4 Gene

genes like me logo Genes that share pathways with OR52N4: view

Pathways by source for OR52N4 Gene

Interacting Proteins for OR52N4 Gene

Gene Ontology (GO) - Biological Process for OR52N4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52N4: view

No data available for SIGNOR curated interactions for OR52N4 Gene

Drugs & Compounds for OR52N4 Gene

No Compound Related Data Available

Transcripts for OR52N4 Gene

mRNA/cDNA for OR52N4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for OR52N4 Gene

Olfactory receptor, family 52, subfamily N, member 4:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for OR52N4 - Now 50% OFF >
  • * OR52N4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * OR52N4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for OR52N4 Gene

No ASD Table

Relevant External Links for OR52N4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR52N4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR52N4 Gene

mRNA differential expression in normal tissues according to GTEx for OR52N4 Gene

This gene is overexpressed in Nerve - Tibial (x4.3) and Spleen (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of OR52N4 Gene:


SOURCE GeneReport for Unigene cluster for OR52N4 Gene:

genes like me logo Genes that share expression patterns with OR52N4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52N4 Gene

Orthologs for OR52N4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR52N4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466392 34
  • 99.17 (n)
OR52N4 35
  • 98 (a)
(Canis familiaris)
Mammalia OR52N4 35
  • 89 (a)
LOC485294 34
  • 87.75 (n)
(Bos Taurus)
Mammalia OR52N4 35 34
  • 85.46 (n)
(Mus musculus)
Mammalia Or52n4 51 Olfr658 17 35 34
  • 84.94 (n)
Or52n4b 51 Olfr503 35
  • 83 (a)
Or52n20 51 Olfr659
  • chr7:104,670,704-104,671,669
(Rattus norvegicus)
Mammalia Olr159 34
  • 84.11 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 80 (a)
-- 35
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 75 (a)
-- 35
  • 74 (a)
-- 35
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490566 34
  • 58.55 (n)
Species where no ortholog for OR52N4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52N4 Gene

Gene Tree for OR52N4 (if available)
Gene Tree for OR52N4 (if available)
Evolutionary constrained regions (ECRs) for OR52N4: view image

Paralogs for OR52N4 Gene

(432) SIMAP similar genes for OR52N4 Gene using alignment to 1 proteins:

  • O52N4_HUMAN
genes like me logo Genes that share paralogs with OR52N4: view

Variants for OR52N4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR52N4 Gene

A stop codon at position Arg-172 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in non-Africans than in African-Americans.

Sequence variations from dbSNP and Humsavar for OR52N4 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000176316 -- 5,738,176(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000191759 -- 5,749,264(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000198692 -- 5,754,894(+) C/T coding_sequence_variant, missense_variant
rs1000433196 -- 5,754,671(+) T/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000465746 -- 5,726,421(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR52N4 Gene

Variant ID Type Subtype PubMed ID
dgv1044n100 CNV loss 25217958
dgv1612n54 CNV loss 21841781
dgv1616n54 CNV loss 21841781
esv2759801 CNV gain+loss 17122850
esv33342 CNV loss 17666407
esv3625249 CNV loss 21293372
nsv1046068 CNV gain 25217958
nsv1053414 CNV gain 25217958
nsv1055011 CNV loss 25217958
nsv553241 CNV gain 21841781
nsv553273 CNV gain 21841781
nsv553277 CNV gain 21841781
nsv832058 CNV gain 17160897

Variation tolerance for OR52N4 Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.60; 86.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR52N4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Human Gene Mutation Database (HGMD)

Disorders for OR52N4 Gene

Additional Disease Information for OR52N4

No disorders were found for OR52N4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52N4 Gene

Publications for OR52N4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 58
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Different noses for different people. (PMID: 12730696) Menashe I … Gilad Y (Nature genetics 2003) 4 58

Products for OR52N4 Gene

Sources for OR52N4 Gene

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