Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR52N4 Gene

Aliases for OR52N4 Gene

  • Olfactory Receptor Family 52 Subfamily N Member 4 2 3
  • Olfactory Receptor Family 52 Subfamily N Member 4 (Gene/Pseudogene) 2 5
  • Olfactory Receptor OR11-64 3 4
  • Olfactory Receptor 52N4 3 4
  • Olfactory Receptor, Family 52, Subfamily N, Member 4 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 52, Subfamily N, Member 4 2
  • OR11-64 3
  • OR52N4 5

External Ids for OR52N4 Gene

Previous GeneCards Identifiers for OR52N4 Gene

  • GC11U990484
  • GC11P005741
  • GC11P005732

Summaries for OR52N4 Gene

Entrez Gene Summary for OR52N4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52N4 Gene

OR52N4 (Olfactory Receptor Family 52 Subfamily N Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52N1.

UniProtKB/Swiss-Prot Summary for OR52N4 Gene

Gene Wiki entry for OR52N4 Gene

Additional gene information for OR52N4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR52N4 Gene

Genomics for OR52N4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR52N4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J005712 Enhancer 0.7 Ensembl ENCODE 10.4 -14.0 -14001 0.5 CTCF POLR2A REST RAD21 ARID3A NFE2 SMC3 ATF2 OR52N4 TRIM22 piR-61580-069 lnc-OR52N5-1 TRIM5
GH11J005700 Enhancer 0.5 ENCODE 10.1 -25.9 -25913 0.8 NBN ADNP TBX21 ZBTB33 ZNF217 MLLT1 OR52N4 OR52P1P TRIM22 lnc-OR52N5-1 piR-61580-069 TRIM5
GH11J005623 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 1.4 -101.0 -101026 3.2 SP1 REST POLR2A STAT3 RELA PKNOX1 SMAD5 RCOR1 HDAC1 CEBPB TRIM34 lnc-OR52H1-1 TRIM5 TRIM22 OR51B2 OR56B4 OR56A1 OR56A3 OR52N4 OR51Q1
GH11J005546 Enhancer 0.2 FANTOM5 11.5 -180.2 -180216 0.1 OR56A1 OR56A3 OR51Q1 OR52E8 OR52N1 OR56A4 OR52N4 OR52E2 OR52E4 OR52A1
GH11J005737 Enhancer 0.2 Ensembl 10.1 +11.3 11339 0.4 OR56B1 OR52N4 OR56B2P OR52N5 TRIM5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR52N4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR52N4

Top Transcription factor binding sites by QIAGEN in the OR52N4 gene promoter:
  • Evi-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • GCNF
  • GCNF-1
  • GCNF-2
  • HNF-1
  • HNF-1A
  • Nkx5-1
  • RP58

Genomic Locations for OR52N4 Gene

Genomic Locations for OR52N4 Gene
chr11:5,726,462-5,755,958
(GRCh38/hg38)
Size:
29,497 bases
Orientation:
Plus strand
chr11:5,775,923-5,776,959
(GRCh37/hg19)
Size:
1,037 bases
Orientation:
Plus strand

Genomic View for OR52N4 Gene

Genes around OR52N4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52N4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52N4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52N4 Gene

Proteins for OR52N4 Gene

  • Protein details for OR52N4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGI2-O52N4_HUMAN
    Recommended name:
    Olfactory receptor 52N4
    Protein Accession:
    Q8NGI2
    Secondary Accessions:
    • B2RNP8
    • Q6IF77

    Protein attributes for OR52N4 Gene

    Size:
    321 amino acids
    Molecular mass:
    36080 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52N4 Gene

Post-translational modifications for OR52N4 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR52N4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52N4 Gene

Domains & Families for OR52N4 Gene

Gene Families for OR52N4 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR52N4 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR52N4 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-64 (O52N4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGI2

UniProtKB/Swiss-Prot:

O52N4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52N4: view

Function for OR52N4 Gene

Molecular function for OR52N4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR52N4 Gene

Gene Ontology (GO) - Molecular Function for OR52N4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR52N4: view
genes like me logo Genes that share phenotypes with OR52N4: view

Animal Model Products

CRISPR Products

miRNA for OR52N4 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR52N4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR52N4 Gene

Localization for OR52N4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52N4 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR52N4 gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1
nucleus 0

Gene Ontology (GO) - Cellular Components for OR52N4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52N4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR52N4 Gene

Pathways & Interactions for OR52N4 Gene

genes like me logo Genes that share pathways with OR52N4: view

Pathways by source for OR52N4 Gene

Interacting Proteins for OR52N4 Gene

Gene Ontology (GO) - Biological Process for OR52N4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52N4: view

No data available for SIGNOR curated interactions for OR52N4 Gene

Drugs & Compounds for OR52N4 Gene

No Compound Related Data Available

Transcripts for OR52N4 Gene

mRNA/cDNA for OR52N4 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR52N4

Alternative Splicing Database (ASD) splice patterns (SP) for OR52N4 Gene

No ASD Table

Relevant External Links for OR52N4 Gene

GeneLoc Exon Structure for
OR52N4

Expression for OR52N4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR52N4 Gene

mRNA differential expression in normal tissues according to GTEx for OR52N4 Gene

This gene is overexpressed in Nerve - Tibial (x4.3) and Spleen (x4.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR52N4

SOURCE GeneReport for Unigene cluster for OR52N4 Gene:

Hs.553735
genes like me logo Genes that share expression patterns with OR52N4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52N4 Gene

Orthologs for OR52N4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR52N4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466392 30
  • 99.17 (n)
OR52N4 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia OR52N4 31
  • 89 (a)
OneToOne
LOC485294 30
  • 87.75 (n)
Cow
(Bos Taurus)
Mammalia OR52N4 30 31
  • 85.46 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Or52n4 46 Olfr658 30 17 31
  • 84.94 (n)
OneToMany
Or52n4b 46 Olfr503 31
  • 83 (a)
OneToMany
Or52n20 46 Olfr659
  • chr7:104,670,704-104,671,669
Rat
(Rattus norvegicus)
Mammalia Olr159 30
  • 84.11 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 80 (a)
OneToMany
-- 31
  • 79 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 75 (a)
ManyToMany
-- 31
  • 74 (a)
ManyToMany
-- 31
  • 66 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100490566 30
  • 58.55 (n)
Species where no ortholog for OR52N4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR52N4 Gene

ENSEMBL:
Gene Tree for OR52N4 (if available)
TreeFam:
Gene Tree for OR52N4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR52N4: view image

Paralogs for OR52N4 Gene

(432) SIMAP similar genes for OR52N4 Gene using alignment to 1 proteins:

  • O52N4_HUMAN
genes like me logo Genes that share paralogs with OR52N4: view

Variants for OR52N4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR52N4 Gene

O52N4_HUMAN-Q8NGI2
A stop codon at position Arg-172 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in non-Africans than in African-Americans.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR52N4 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
731526 Benign: not provided 5,755,696(+) A/G MISSENSE_VARIANT
782293 Benign: not provided 5,755,396(+) C/T MISSENSE_VARIANT
rs12363178 - p.Trp209Gly
rs7394584 - p.Leu167Arg
rs7396938 - p.Asn218Ile

Additional dbSNP identifiers (rs#s) for OR52N4 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR52N4 Gene

Variant ID Type Subtype PubMed ID
dgv1044n100 CNV loss 25217958
dgv1612n54 CNV loss 21841781
dgv1616n54 CNV loss 21841781
esv2759801 CNV gain+loss 17122850
esv33342 CNV loss 17666407
esv3625249 CNV loss 21293372
nsv1046068 CNV gain 25217958
nsv1053414 CNV gain 25217958
nsv1055011 CNV loss 25217958
nsv553241 CNV gain 21841781
nsv553273 CNV gain 21841781
nsv553277 CNV gain 21841781
nsv832058 CNV gain 17160897

Variation tolerance for OR52N4 Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.60; 86.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR52N4 Gene

Human Gene Mutation Database (HGMD)
OR52N4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR52N4

Disorders for OR52N4 Gene

No disorders were found for OR52N4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52N4 Gene

Publications for OR52N4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Different noses for different people. (PMID: 12730696) Menashe I … Gilad Y (Nature genetics 2003) 4

Products for OR52N4 Gene

Sources for OR52N4 Gene