Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR52N2 Gene

Aliases for OR52N2 Gene

  • Olfactory Receptor Family 52 Subfamily N Member 2 2 3 5
  • Olfactory Receptor OR11-57 3 4
  • Olfactory Receptor 52N2 3 4
  • Olfactory Receptor, Family 52, Subfamily N, Member 2 2
  • OR11-57 3
  • OR52N2 5

External Ids for OR52N2 Gene

Previous GeneCards Identifiers for OR52N2 Gene

  • GC11U990486
  • GC11P005806
  • GC11P005798

Summaries for OR52N2 Gene

Entrez Gene Summary for OR52N2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52N2 Gene

OR52N2 (Olfactory Receptor Family 52 Subfamily N Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52N1.

UniProtKB/Swiss-Prot Summary for OR52N2 Gene

Gene Wiki entry for OR52N2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR52N2 Gene

Genomics for OR52N2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR52N2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J005808 Promoter/Enhancer 1 ENCODE CraniofacialAtlas 250.7 -0.2 -238 0.6 ZNF207 ZNF654 CTCF REST TRIM22 RAD21 SMC3 EBF1 SMARCA5 KDM5A OR52N2 OR52N3P TRIM22 TRIM5 TRIM6 HSALNG0082390 OR52N1
GH11J005809 Enhancer 0.8 ENCODE 250.7 +1.5 1528 1 NCOR1 IKZF1 ARNT NBN TAL1 STAT5A SPI1 SMARCA4 EHMT2 FOXM1 OR52N2 OR52N3P TRIM5 TRIM22 TRIM6 piR-48209-082 OR52E6
GH11J005811 Enhancer 0.2 ENCODE 250.7 +0.5 482 0.2 OR52N2 OR52N3P TRIM22 TRIM5 TRIM6 piR-48209-082 OR52E6
GH11J006354 Enhancer 0.7 Ensembl ENCODE 4.4 +546.1 546077 1.2 YY1 RXRA JUND ZFP91 HNF4A ZNF24 RAD21 SP1 HNF1A CAVIN3 OR52N2 HSALNG0082411 piR-56133-037 LOC101927825 SMPD1 lnc-APBB1-2-001
GH11J005623 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 1.2 -183.5 -183488 3.2 SP1 POLR2A YY1 SIN3A IRF2 PRDM1 RXRA IRF4 RFX5 TBP TRIM34 lnc-OR52H1-1 TRIM5 TRIM22 OR51B2 OR56B4 OR56A1 OR56A3 OR52N4 OR51Q1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR52N2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR52N2

Top Transcription factor binding sites by QIAGEN in the OR52N2 gene promoter:
  • AREB6
  • CUTL1
  • E47
  • GATA-2
  • Hand1
  • ITF-2
  • POU2F1
  • POU2F1a
  • RP58
  • Tal-1beta

Genomic Locations for OR52N2 Gene

Latest Assembly
chr11:5,808,924-5,821,483
(GRCh38/hg38)
Size:
12,560 bases
Orientation:
Plus strand

Previous Assembly
chr11:5,841,566-5,842,531
(GRCh37/hg19 by Entrez Gene)
Size:
966 bases
Orientation:
Plus strand

chr11:5,841,544-5,842,578
(GRCh37/hg19 by Ensembl)
Size:
1,035 bases
Orientation:
Plus strand

Genomic View for OR52N2 Gene

Genes around OR52N2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52N2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52N2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52N2 Gene

Proteins for OR52N2 Gene

  • Protein details for OR52N2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGI0-O52N2_HUMAN
    Recommended name:
    Olfactory receptor 52N2
    Protein Accession:
    Q8NGI0
    Secondary Accessions:
    • B9EIL8
    • Q6IFF9

    Protein attributes for OR52N2 Gene

    Size:
    321 amino acids
    Molecular mass:
    35940 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52N2 Gene

Post-translational modifications for OR52N2 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR52N2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52N2 Gene

Domains & Families for OR52N2 Gene

Gene Families for OR52N2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR52N2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR52N2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor, family 52, subfamily N, member 2 (B9EIL8_HUMAN)
  • Olfactory receptor OR11-57 (O52N2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGI0

UniProtKB/Swiss-Prot:

O52N2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52N2: view

Function for OR52N2 Gene

Molecular function for OR52N2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR52N2 Gene

Gene Ontology (GO) - Molecular Function for OR52N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR52N2: view
genes like me logo Genes that share phenotypes with OR52N2: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR52N2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52N2 Gene

Localization for OR52N2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52N2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR52N2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52N2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR52N2 Gene

Pathways & Interactions for OR52N2 Gene

genes like me logo Genes that share pathways with OR52N2: view

Pathways by source for OR52N2 Gene

Interacting Proteins for OR52N2 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000322801 Q8NGI0-O52N2_HUMAN for OR52N2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR52N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52N2: view

No data available for SIGNOR curated interactions for OR52N2 Gene

Drugs & Compounds for OR52N2 Gene

No Compound Related Data Available

Transcripts for OR52N2 Gene

mRNA/cDNA for OR52N2 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR52N2

Alternative Splicing Database (ASD) splice patterns (SP) for OR52N2 Gene

No ASD Table

Relevant External Links for OR52N2 Gene

GeneLoc Exon Structure for
OR52N2

Expression for OR52N2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR52N2 Gene

mRNA differential expression in normal tissues according to GTEx for OR52N2 Gene

This gene is overexpressed in Testis (x5.8) and Nerve - Tibial (x5.3).

Protein differential expression in normal tissues from HIPED for OR52N2 Gene

This gene is overexpressed in Stomach (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR52N2 Gene



Protein tissue co-expression partners for OR52N2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR52N2

SOURCE GeneReport for Unigene cluster for OR52N2 Gene:

Hs.553737
genes like me logo Genes that share expression patterns with OR52N2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52N2 Gene

Orthologs for OR52N2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52N2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466397 29
  • 98.86 (n)
OR52N2 30
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC485302 29
  • 89.45 (n)
cOR52N9 30
  • 83 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC507428 29
  • 88.54 (n)
-- 30
  • 88 (a)
OneToMany
-- 30
  • 87 (a)
OneToMany
-- 30
  • 84 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Or52n2c 45 Olfr668 30
  • 88 (a)
OneToMany
Or52n2 45 Olfr666 29 16 30
  • 86.48 (n)
OneToMany
Or52n2b 45 Olfr667 30
  • 79 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Olr172 29
  • 86.5 (n)
Oppossum
(Monodelphis domestica)
Mammalia OR52N2 30
  • 86 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 74 (a)
ManyToMany
-- 30
  • 73 (a)
ManyToMany
-- 30
  • 69 (a)
ManyToMany
Species where no ortholog for OR52N2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR52N2 Gene

ENSEMBL:
Gene Tree for OR52N2 (if available)
TreeFam:
Gene Tree for OR52N2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR52N2: view image
Alliance of Genome Resources:
Additional Orthologs for OR52N2

Paralogs for OR52N2 Gene

(450) SIMAP similar genes for OR52N2 Gene using alignment to 2 proteins:

  • O52N2_HUMAN
  • B9EIL8_HUMAN

Pseudogenes.org Pseudogenes for OR52N2 Gene

genes like me logo Genes that share paralogs with OR52N2: view

Variants for OR52N2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR52N2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs78496237 Benign: not provided 5,821,018(+) T/C
NM_001005174.1(OR52N2):c.683T>C (p.Met228Thr)
MISSENSE
rs8181512 -- p.His264Arg
rs8181529 -- p.Ser249Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR52N2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR52N2 Gene

Variant ID Type Subtype PubMed ID
esv2759801 CNV gain+loss 17122850
nsv1046068 CNV gain 25217958
nsv1053414 CNV gain 25217958
nsv515929 CNV loss 19592680
nsv553241 CNV gain 21841781
nsv553273 CNV gain 21841781
nsv553277 CNV gain 21841781
nsv832058 CNV gain 17160897

Variation tolerance for OR52N2 Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.76; 93.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR52N2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR52N2
Leiden Open Variation Database (LOVD)
OR52N2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52N2 Gene

Disorders for OR52N2 Gene

Additional Disease Information for OR52N2

No disorders were found for OR52N2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52N2 Gene

Publications for OR52N2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for OR52N2 Gene

Sources for OR52N2 Gene