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Aliases for OR52N2 Gene

Aliases for OR52N2 Gene

  • Olfactory Receptor Family 52 Subfamily N Member 2 2 3 5
  • Olfactory Receptor OR11-57 3 4
  • Olfactory Receptor, Family 52, Subfamily N, Member 2 2
  • Olfactory Receptor 52N2 3
  • OR11-57 3

External Ids for OR52N2 Gene

Previous GeneCards Identifiers for OR52N2 Gene

  • GC11U990486
  • GC11P005806
  • GC11P005798

Summaries for OR52N2 Gene

Entrez Gene Summary for OR52N2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52N2 Gene

OR52N2 (Olfactory Receptor Family 52 Subfamily N Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52N1.

UniProtKB/Swiss-Prot for OR52N2 Gene

  • Odorant receptor.

Gene Wiki entry for OR52N2 Gene

Additional gene information for OR52N2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52N2 Gene

Genomics for OR52N2 Gene

GeneHancer (GH) Regulatory Elements for OR52N2 Gene

Promoters and enhancers for OR52N2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J005808 Enhancer 0.9 Ensembl ENCODE 650.7 +0.1 96 1.2 CTCF RB1 IRF3 ERF EBF1 RAD21 ZBTB48 ZNF207 SMC3 ZNF143 OR52N2 OR52N3P TRIM22 TRIM5 TRIM6 OR52N1 OR52E6
GH11J005809 Enhancer 0.8 ENCODE 650.7 +1.5 1547 1 HDAC1 PKNOX1 ARNT NFRKB CHAMP1 TCF12 ATF7 NCOA1 ZEB2 ZNF148 OR52N2 OR52N3P TRIM5 TRIM22 TRIM6 OR52E6
GH11J006354 Enhancer 0.6 ENCODE 4.4 +546.1 546114 0.8 FOXA2 RXRA RAD21 YY1 SP1 JUND HNF1A POLR2A ZFP91 ZNF24 CAVIN3 OR52N2 ENSG00000254443 PIR52604
GH11J005623 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 1.2 -183.5 -183469 3.2 HDAC1 PKNOX1 SMAD1 SREBF2 ZBTB40 IRF4 RAD21 RFX5 YY1 ZFP91 TRIM34 TRIM5 TRIM22 OR51B2 OR56B4 OR56A1 OR56A3 OR52N4 OR51Q1 OR52E6
GH11J005831 Enhancer 0.3 ENCODE 6.9 +22.9 22891 0.5 ZFP36 OR52N2 OR52E6 TRIM5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR52N2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR52N2 gene promoter:
  • AREB6
  • Hand1
  • E47
  • GATA-2
  • RP58
  • CUTL1
  • Tal-1beta
  • ITF-2
  • POU2F1
  • POU2F1a

Genomic Locations for OR52N2 Gene

Genomic Locations for OR52N2 Gene
12,496 bases
Plus strand
1,035 bases
Plus strand

Genomic View for OR52N2 Gene

Genes around OR52N2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52N2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52N2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52N2 Gene

Proteins for OR52N2 Gene

  • Protein details for OR52N2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 52N2
    Protein Accession:
    Secondary Accessions:
    • Q6IFF9

    Protein attributes for OR52N2 Gene

    321 amino acids
    Molecular mass:
    35940 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52N2 Gene

Post-translational modifications for OR52N2 Gene

  • Glycosylation at isoforms=5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR52N2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52N2 Gene

Domains & Families for OR52N2 Gene

Gene Families for OR52N2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR52N2 Gene

Suggested Antigen Peptide Sequences for OR52N2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52N2: view

Function for OR52N2 Gene

Molecular function for OR52N2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR52N2 Gene

Gene Ontology (GO) - Molecular Function for OR52N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR52N2: view
genes like me logo Genes that share phenotypes with OR52N2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52N2 Gene

Localization for OR52N2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52N2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR52N2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52N2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR52N2 Gene

Pathways & Interactions for OR52N2 Gene

genes like me logo Genes that share pathways with OR52N2: view

Pathways by source for OR52N2 Gene

Interacting Proteins for OR52N2 Gene

Gene Ontology (GO) - Biological Process for OR52N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52N2: view

No data available for SIGNOR curated interactions for OR52N2 Gene

Drugs & Compounds for OR52N2 Gene

No Compound Related Data Available

Transcripts for OR52N2 Gene

mRNA/cDNA for OR52N2 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR52N2 Gene

Olfactory receptor, family 52, subfamily N, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR52N2 Gene

No ASD Table

Relevant External Links for OR52N2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR52N2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR52N2 Gene

mRNA differential expression in normal tissues according to GTEx for OR52N2 Gene

This gene is overexpressed in Testis (x5.8) and Nerve - Tibial (x5.3).

Protein differential expression in normal tissues from HIPED for OR52N2 Gene

This gene is overexpressed in Stomach (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR52N2 Gene

Protein tissue co-expression partners for OR52N2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR52N2 Gene:


SOURCE GeneReport for Unigene cluster for OR52N2 Gene:

genes like me logo Genes that share expression patterns with OR52N2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52N2 Gene

Orthologs for OR52N2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52N2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466397 33
  • 98.86 (n)
OR52N2 34
  • 98 (a)
(Canis familiaris)
Mammalia LOC485302 33
  • 89.45 (n)
cOR52N9 34
  • 83 (a)
(Bos Taurus)
Mammalia LOC507428 33
  • 88.54 (n)
-- 34
  • 88 (a)
-- 34
  • 87 (a)
-- 34
  • 84 (a)
(Mus musculus)
Mammalia Or52n2c 51 Olfr668 34
  • 88 (a)
Or52n2 51 Olfr666 16 34 33
  • 86.48 (n)
Or52n2b 51 Olfr667 34
  • 79 (a)
(Rattus norvegicus)
Mammalia Olr172 33
  • 86.5 (n)
(Monodelphis domestica)
Mammalia OR52N2 34
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 74 (a)
-- 34
  • 73 (a)
-- 34
  • 69 (a)
Species where no ortholog for OR52N2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52N2 Gene

Gene Tree for OR52N2 (if available)
Gene Tree for OR52N2 (if available)
Evolutionary constrained regions (ECRs) for OR52N2: view image

Paralogs for OR52N2 Gene

Paralogs for OR52N2 Gene

(450) SIMAP similar genes for OR52N2 Gene using alignment to 2 proteins:

  • O52N2_HUMAN
  • B9EIL8_HUMAN Pseudogenes for OR52N2 Gene

genes like me logo Genes that share paralogs with OR52N2: view

Variants for OR52N2 Gene

Sequence variations from dbSNP and Humsavar for OR52N2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000017003 -- 5,811,564(+) A/C genic_upstream_transcript_variant, intron_variant
rs1000150519 -- 5,805,051(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1000151819 -- 5,820,411(+) C/A/T coding_sequence_variant, missense_variant
rs1000222019 -- 5,805,766(+) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1000403189 -- 5,816,302(+) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OR52N2 Gene

Variant ID Type Subtype PubMed ID
esv2759801 CNV gain+loss 17122850
nsv1046068 CNV gain 25217958
nsv1053414 CNV gain 25217958
nsv515929 CNV loss 19592680
nsv553241 CNV gain 21841781
nsv553273 CNV gain 21841781
nsv553277 CNV gain 21841781
nsv832058 CNV gain 17160897

Variation tolerance for OR52N2 Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.76; 93.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR52N2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52N2 Gene

Disorders for OR52N2 Gene

Additional Disease Information for OR52N2

No disorders were found for OR52N2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52N2 Gene

Publications for OR52N2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR52N2 Gene

Sources for OR52N2 Gene

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