Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR52N1 Gene

Aliases for OR52N1 Gene

  • Olfactory Receptor Family 52 Subfamily N Member 1 2 3 5
  • Olfactory Receptor OR11-61 3 4
  • Olfactory Receptor 52N1 3 4
  • Olfactory Receptor, Family 52, Subfamily N, Member 1 2
  • OR11-61 3
  • OR52N1 5

External Ids for OR52N1 Gene

Previous GeneCards Identifiers for OR52N1 Gene

  • GC11U990333
  • GC11M005767

Summaries for OR52N1 Gene

Entrez Gene Summary for OR52N1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52N1 Gene

OR52N1 (Olfactory Receptor Family 52 Subfamily N Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52N2.

UniProtKB/Swiss-Prot Summary for OR52N1 Gene

Gene Wiki entry for OR52N1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR52N1 Gene

Genomics for OR52N1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR52N1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J005688 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 10.6 +100.5 100523 4.5 NCOR1 POLR2A REST BHLHE40 TAL1 EBF1 TAF1 ELF1 ZNF24 FOXK2 TRIM22 TRIM5 HSALNG0082385 OR52N1 TRIM6 OR52D1 HBG2 OR52N4
GH11J005546 Enhancer 0.2 FANTOM5 13.9 +245.0 245019 0.1 OR56A1 OR56A3 OR51Q1 OR52E8 OR52N1 OR56A4 OR52N4 OR52E2 OR52E4 OR52A1
GH11J006094 Enhancer 0.4 FANTOM5 Ensembl 2.5 -303.0 -303036 1.4 MF281466-001 MF281466-002 MF281504 OR56A1 OR52W1 FHIP1B C11orf42 CAVIN3 TRIM5 TRIM34
GH11J005379 Enhancer 0.2 FANTOM5 3 +411.3 411273 0 piR-48209-078 OR51V1 OR51T1 HBB OR51B5 OR51G1 OR56B1 OR52J3 OR51L1 OR52N4
GH11J005328 Enhancer 0.2 FANTOM5 2.1 +462.1 462087 0.4 HSALNG0082369 piR-48209-076 OR51G1 OR51T1 OR52N2 OR52N4 OR52D1 OR52J3 MMP26 OR51L1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR52N1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR52N1

Top Transcription factor binding sites by QIAGEN in the OR52N1 gene promoter:
  • AML1a
  • AREB6
  • E47
  • GATA-2
  • GCNF
  • GCNF-1
  • GCNF-2
  • Hand1
  • Tal-1beta

Genomic Locations for OR52N1 Gene

Latest Assembly
chr11:5,786,471-5,791,265
(GRCh38/hg38)
Size:
4,795 bases
Orientation:
Minus strand

Previous Assembly
chr11:5,807,701-5,812,495
(GRCh37/hg19 by Entrez Gene)
Size:
4,795 bases
Orientation:
Minus strand

chr11:5,809,084-5,810,046
(GRCh37/hg19 by Ensembl)
Size:
963 bases
Orientation:
Minus strand

Genomic View for OR52N1 Gene

Genes around OR52N1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52N1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52N1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52N1 Gene

Proteins for OR52N1 Gene

  • Protein details for OR52N1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH53-O52N1_HUMAN
    Recommended name:
    Olfactory receptor 52N1
    Protein Accession:
    Q8NH53
    Secondary Accessions:
    • Q6IFF6

    Protein attributes for OR52N1 Gene

    Size:
    320 amino acids
    Molecular mass:
    35785 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52N1 Gene

Post-translational modifications for OR52N1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR52N1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52N1 Gene

Domains & Families for OR52N1 Gene

Gene Families for OR52N1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR52N1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR52N1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-61 (O52N1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NH53

UniProtKB/Swiss-Prot:

O52N1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52N1: view

Function for OR52N1 Gene

Molecular function for OR52N1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR52N1 Gene

Gene Ontology (GO) - Molecular Function for OR52N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR52N1: view

Phenotypes for OR52N1 Gene

genes like me logo Genes that share phenotypes with OR52N1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR52N1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52N1 Gene

Localization for OR52N1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52N1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR52N1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52N1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR52N1 Gene

Pathways & Interactions for OR52N1 Gene

genes like me logo Genes that share pathways with OR52N1: view

Pathways by source for OR52N1 Gene

Interacting Proteins for OR52N1 Gene

Gene Ontology (GO) - Biological Process for OR52N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52N1: view

No data available for SIGNOR curated interactions for OR52N1 Gene

Drugs & Compounds for OR52N1 Gene

No Compound Related Data Available

Transcripts for OR52N1 Gene

mRNA/cDNA for OR52N1 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR52N1

Alternative Splicing Database (ASD) splice patterns (SP) for OR52N1 Gene

No ASD Table

Relevant External Links for OR52N1 Gene

GeneLoc Exon Structure for
OR52N1

Expression for OR52N1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR52N1 Gene

mRNA differential expression in normal tissues according to GTEx for OR52N1 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x17.0).

Protein differential expression in normal tissues from HIPED for OR52N1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR52N1 Gene



Protein tissue co-expression partners for OR52N1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR52N1

SOURCE GeneReport for Unigene cluster for OR52N1 Gene:

Hs.690209
genes like me logo Genes that share expression patterns with OR52N1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52N1 Gene

Orthologs for OR52N1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52N1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466395 29
  • 98.96 (n)
OR52N1 30
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia OR52N1 30
  • 91 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC618803 29
  • 88.4 (n)
OR52N1 30
  • 87 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr170 29
  • 85.17 (n)
Mouse
(Mus musculus)
Mammalia Olfr669 29 16
  • 72.31 (n)
Olfr659 30
  • 68 (a)
ManyToMany
Olfr686 30
  • 48 (a)
ManyToMany
Or52n1-ps 45 Olfr664-ps1
  • chr7:104,733,391-104,734,356
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 70 (a)
ManyToMany
-- 30
  • 70 (a)
ManyToMany
-- 30
  • 65 (a)
ManyToMany
Species where no ortholog for OR52N1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR52N1 Gene

ENSEMBL:
Gene Tree for OR52N1 (if available)
TreeFam:
Gene Tree for OR52N1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR52N1: view image
Alliance of Genome Resources:
Additional Orthologs for OR52N1

Paralogs for OR52N1 Gene

(415) SIMAP similar genes for OR52N1 Gene using alignment to 1 proteins:

  • O52N1_HUMAN
genes like me logo Genes that share paralogs with OR52N1: view

Variants for OR52N1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR52N1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs10742787 -- p.Ala101Thr
rs10769224 -- p.Cys125Tyr
rs12365487 -- p.Thr79Asn
rs7934670 -- p.Phe247Ile
rs7948009 -- p.Arg167Cys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR52N1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR52N1 Gene

Variant ID Type Subtype PubMed ID
dgv1044n100 CNV loss 25217958
dgv1046n100 CNV gain+loss 25217958
dgv1048n100 CNV loss 25217958
dgv1049n100 CNV gain+loss 25217958
dgv1050n100 CNV loss 25217958
dgv1051n100 CNV loss 25217958
dgv1052n100 CNV loss 25217958
dgv11n50 CNV loss 21212237
dgv1612n54 CNV loss 21841781
dgv1616n54 CNV loss 21841781
dgv1617n54 CNV loss 21841781
dgv1619n54 CNV gain+loss 21841781
dgv1620n54 CNV loss 21841781
dgv17e203 CNV loss 21179565
dgv189e199 CNV deletion 23128226
dgv197n67 CNV loss 20364138
dgv20e180 CNV gain 20482838
dgv312e212 CNV loss 25503493
dgv313e212 CNV gain 25503493
dgv315e212 CNV gain 25503493
dgv316e212 CNV loss 25503493
dgv318e212 CNV loss 25503493
dgv42n111 CNV deletion 26073780
dgv580n106 CNV deletion 24896259
dgv5n31 CNV loss 19718026
dgv9e213 CNV loss 24956385
esv2144298 CNV deletion 18987734
esv2421614 CNV deletion 20811451
esv2507539 CNV loss 19546169
esv2631490 CNV deletion 19546169
esv2744067 CNV deletion 23290073
esv2759801 CNV gain+loss 17122850
esv28265 CNV gain 19812545
esv32705 CNV gain 17666407
esv33544 CNV gain+loss 17666407
esv3547262 CNV deletion 23714750
esv3625250 CNV loss 21293372
nsv1041196 CNV loss 25217958
nsv1046068 CNV gain 25217958
nsv1053414 CNV gain 25217958
nsv1054371 CNV gain+loss 25217958
nsv1055011 CNV loss 25217958
nsv1076237 CNV deletion 25765185
nsv1147526 CNV deletion 26484159
nsv1159822 CNV deletion 26073780
nsv435927 CNV deletion 17901297
nsv442598 CNV loss 18776908
nsv443001 CNV deletion 18674749
nsv471361 CNV loss 19718026
nsv498749 CNV loss 21111241
nsv514624 CNV loss 21397061
nsv553241 CNV gain 21841781
nsv553273 CNV gain 21841781
nsv553277 CNV gain 21841781
nsv553344 CNV loss 21841781
nsv65 CNV deletion 15895083
nsv7654 CNV deletion 18451855
nsv819430 CNV gain 19587683
nsv821028 CNV deletion 20802225
nsv832058 CNV gain 17160897
nsv8784 CNV gain+loss 18304495
nsv951301 CNV deletion 24416366

Variation tolerance for OR52N1 Gene

Residual Variation Intolerance Score: 91.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.94; 97.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR52N1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR52N1
Leiden Open Variation Database (LOVD)
OR52N1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52N1 Gene

Disorders for OR52N1 Gene

Additional Disease Information for OR52N1

No disorders were found for OR52N1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52N1 Gene

Publications for OR52N1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR52N1 Gene

Sources for OR52N1 Gene