Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR52M1 Gene

Aliases for OR52M1 Gene

  • Olfactory Receptor Family 52 Subfamily M Member 1 2 3 5
  • Olfactory Receptor, Family 52, Subfamily M, Member 1 Pseudogene 2 3
  • Olfactory Receptor OR11-11 3 4
  • Olfactory Receptor 52M1 3 4
  • OR52M1P 3 4
  • Olfactory Receptor, Family 52, Subfamily M, Member 3 Pseudogene 3
  • Olfactory Receptor, Family 52, Subfamily M, Member 1 2
  • OR11-11 3
  • OR52M3P 3

External Ids for OR52M1 Gene

Previous HGNC Symbols for OR52M1 Gene

  • OR52M1P

Previous GeneCards Identifiers for OR52M1 Gene

  • GC11U900029
  • GC11P004529
  • GC11P004523

Summaries for OR52M1 Gene

Entrez Gene Summary for OR52M1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52M1 Gene

OR52M1 (Olfactory Receptor Family 52 Subfamily M Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52R1.

UniProtKB/Swiss-Prot Summary for OR52M1 Gene

Gene Wiki entry for OR52M1 Gene

Additional gene information for OR52M1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR52M1 Gene

Genomics for OR52M1 Gene

GeneHancer (GH) Regulatory Elements for OR52M1 Gene

Promoters and enhancers for OR52M1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J004546 Enhancer 0.6 ENCODE 500.7 +1.9 1895 1.1 FOXA2 NR2F2 ZBTB33 JUND RXRA MAX HNF4A REST FOXA1 YY1 OR52M1 piR-48209-072 OR52K3P TRIM68
GH11J004543 Enhancer 0.5 Ensembl 500.7 -1.5 -1490 0.2 ZNF316 GABPA NFE2 FOS MAFG NFE2L2 MAFK IKZF1 EMSY STAT3 OR52M1 piR-55194-059
GH11J004636 Promoter/Enhancer 1 Ensembl ENCODE 10.1 +92.0 91995 0.4 CTCF MYC TEAD4 ZBTB10 REST RAD21 CTBP1 TRIM22 SMC3 YY1 OR51D1 TRIM68 OR52M1 lnc-OR51D1-1
GH11J004458 Enhancer 0.6 FANTOM5 ENCODE 9.8 -84.9 -84869 3.7 CEBPG SPI1 OR52K3P OR52K1 OR52M1 TRIM21 OR52K2
GH11J004511 Enhancer 0.3 Ensembl 11.5 -33.4 -33404 1.1 POLR2A OR52M1 OR52K1 OR52K3P OR52K2 OR51D1 OR51E1 TRIM68 OR52M2P HSALNG0082349
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR52M1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR52M1

Top Transcription factor binding sites by QIAGEN in the OR52M1 gene promoter:
  • AREB6
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • NF-kappaB
  • NF-kappaB1
  • Nkx3-1

Genomic Locations for OR52M1 Gene

Genomic Locations for OR52M1 Gene
chr11:4,545,191-4,546,144
(GRCh38/hg38)
Size:
954 bases
Orientation:
Plus strand
chr11:4,566,421-4,567,374
(GRCh37/hg19)
Size:
954 bases
Orientation:
Plus strand

Genomic View for OR52M1 Gene

Genes around OR52M1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52M1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52M1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52M1 Gene

Proteins for OR52M1 Gene

  • Protein details for OR52M1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGK5-O52M1_HUMAN
    Recommended name:
    Olfactory receptor 52M1
    Protein Accession:
    Q8NGK5

    Protein attributes for OR52M1 Gene

    Size:
    317 amino acids
    Molecular mass:
    35037 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52M1 Gene

Post-translational modifications for OR52M1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR52M1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52M1 Gene

Domains & Families for OR52M1 Gene

Gene Families for OR52M1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR52M1 Gene

Blocks:
  • Olfactory receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OR52M1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-11 (O52M1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGK5

UniProtKB/Swiss-Prot:

O52M1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52M1: view

Function for OR52M1 Gene

Molecular function for OR52M1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR52M1 Gene

Gene Ontology (GO) - Molecular Function for OR52M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR52M1: view
genes like me logo Genes that share phenotypes with OR52M1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52M1 Gene

Localization for OR52M1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52M1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR52M1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52M1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR52M1 Gene

Pathways & Interactions for OR52M1 Gene

genes like me logo Genes that share pathways with OR52M1: view

Pathways by source for OR52M1 Gene

Interacting Proteins for OR52M1 Gene

;

Gene Ontology (GO) - Biological Process for OR52M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52M1: view

No data available for SIGNOR curated interactions for OR52M1 Gene

Drugs & Compounds for OR52M1 Gene

No Compound Related Data Available

Transcripts for OR52M1 Gene

mRNA/cDNA for OR52M1 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR52M1 Gene

No ASD Table

Relevant External Links for OR52M1 Gene

GeneLoc Exon Structure for
OR52M1

Expression for OR52M1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR52M1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR52M1

SOURCE GeneReport for Unigene cluster for OR52M1 Gene:

Hs.553567
genes like me logo Genes that share expression patterns with OR52M1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52M1 Gene

Orthologs for OR52M1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52M1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466337 30
  • 98.63 (n)
OR52M1 31
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR52M1 31
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or52m1 47 Olfr554 17 31 30
  • 87.07 (n)
rat
(Rattus norvegicus)
Mammalia Olr48 30
  • 87.07 (n)
cow
(Bos Taurus)
Mammalia OR52M1 31 30
  • 86.23 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OR52M1 31
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 45 (a)
ManyToMany
Species where no ortholog for OR52M1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52M1 Gene

ENSEMBL:
Gene Tree for OR52M1 (if available)
TreeFam:
Gene Tree for OR52M1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR52M1: view image

Paralogs for OR52M1 Gene

(418) SIMAP similar genes for OR52M1 Gene using alignment to 1 proteins:

  • O52M1_HUMAN

Pseudogenes.org Pseudogenes for OR52M1 Gene

genes like me logo Genes that share paralogs with OR52M1: view

Variants for OR52M1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR52M1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs2657167 - p.Ser305Arg
rs7112010 - p.Ser9Leu

Additional dbSNP identifiers (rs#s) for OR52M1 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR52M1 Gene

Variant ID Type Subtype PubMed ID
dgv1583n54 CNV loss 21841781
esv2751024 CNV loss 17911159
esv2762892 CNV loss 21179565
esv3579247 CNV loss 25503493
esv3579248 CNV loss 25503493
esv3625188 CNV loss 21293372
esv3625191 CNV loss 21293372
nsv1039206 CNV loss 25217958
nsv1044093 CNV loss 25217958
nsv1047280 CNV loss 25217958
nsv1047344 CNV loss 25217958
nsv1050498 CNV loss 25217958
nsv553159 CNV gain 21841781
nsv832055 CNV loss 17160897

Variation tolerance for OR52M1 Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.48; 64.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR52M1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR52M1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52M1 Gene

Disorders for OR52M1 Gene

Additional Disease Information for OR52M1

No disorders were found for OR52M1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52M1 Gene

Publications for OR52M1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 54
  2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 54
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  4. Novel human G-protein-coupled receptors. (PMID: 12732197) Vanti WB … O'Dowd BF (Biochemical and biophysical research communications 2003) 3 54
  5. Population differences in the human functional olfactory repertoire. (PMID: 12644552) Gilad Y … Lancet D (Molecular biology and evolution 2003) 3 54

Products for OR52M1 Gene

Sources for OR52M1 Gene