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Aliases for OR52L1 Gene

Aliases for OR52L1 Gene

  • Olfactory Receptor Family 52 Subfamily L Member 1 2 3 5
  • Olfactory Receptor OR11-50 3 4
  • Olfactory Receptor, Family 52, Subfamily L, Member 1 2
  • Olfactory Receptor 52L1 3
  • OR11-50 3

External Ids for OR52L1 Gene

Previous GeneCards Identifiers for OR52L1 Gene

  • GC11U990301
  • GC11M005972
  • GC11M005963

Summaries for OR52L1 Gene

Entrez Gene Summary for OR52L1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52L1 Gene

OR52L1 (Olfactory Receptor Family 52 Subfamily L Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52R1.

UniProtKB/Swiss-Prot for OR52L1 Gene

  • Odorant receptor.

Gene Wiki entry for OR52L1 Gene

Additional gene information for OR52L1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52L1 Gene

Genomics for OR52L1 Gene

GeneHancer (GH) Regulatory Elements for OR52L1 Gene

Top Transcription factor binding sites by QIAGEN in the OR52L1 gene promoter:

Genomic Locations for OR52L1 Gene

Genomic Locations for OR52L1 Gene
1,094 bases
Minus strand

Genomic View for OR52L1 Gene

Genes around OR52L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52L1 Gene

Proteins for OR52L1 Gene

  • Protein details for OR52L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 52L1
    Protein Accession:
    Secondary Accessions:
    • B2RPA6
    • Q6IFK9

    Protein attributes for OR52L1 Gene

    329 amino acids
    Molecular mass:
    36221 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52L1 Gene

Post-translational modifications for OR52L1 Gene

Other Protein References for OR52L1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52L1 Gene

Domains & Families for OR52L1 Gene

Gene Families for OR52L1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR52L1 Gene

Suggested Antigen Peptide Sequences for OR52L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52L1: view

Function for OR52L1 Gene

Molecular function for OR52L1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR52L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR52L1: view
genes like me logo Genes that share phenotypes with OR52L1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52L1 Gene

Localization for OR52L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52L1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR52L1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52L1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR52L1 Gene

Pathways & Interactions for OR52L1 Gene

genes like me logo Genes that share pathways with OR52L1: view

Pathways by source for OR52L1 Gene

Interacting Proteins for OR52L1 Gene

Gene Ontology (GO) - Biological Process for OR52L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52L1: view

No data available for SIGNOR curated interactions for OR52L1 Gene

Drugs & Compounds for OR52L1 Gene

No Compound Related Data Available

Transcripts for OR52L1 Gene

mRNA/cDNA for OR52L1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR52L1 Gene

No ASD Table

Relevant External Links for OR52L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR52L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR52L1 Gene

mRNA differential expression in normal tissues according to GTEx for OR52L1 Gene

This gene is overexpressed in Testis (x14.5) and Whole Blood (x9.4).

Protein differential expression in normal tissues from HIPED for OR52L1 Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR52L1 Gene

Protein tissue co-expression partners for OR52L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR52L1 Gene:


SOURCE GeneReport for Unigene cluster for OR52L1 Gene:

genes like me logo Genes that share expression patterns with OR52L1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52L1 Gene

Orthologs for OR52L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR52L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OR52L1 33 34
  • 97.87 (n)
(Canis familiaris)
Mammalia LOC485325 33
  • 86.14 (n)
-- 34
  • 85 (a)
-- 34
  • 84 (a)
(Bos Taurus)
Mammalia LOC100848074 33
  • 86.07 (n)
-- 34
  • 85 (a)
-- 34
  • 85 (a)
(Rattus norvegicus)
Mammalia Olr196 33
  • 84.35 (n)
(Mus musculus)
Mammalia Or52l1 51 Olfr685 33 16 34
  • 83.71 (n)
(Monodelphis domestica)
Mammalia OR52L1 34
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 50 (a)
(Gallus gallus)
Aves -- 34
  • 45 (a)
Species where no ortholog for OR52L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52L1 Gene

Gene Tree for OR52L1 (if available)
Gene Tree for OR52L1 (if available)

Paralogs for OR52L1 Gene

Paralogs for OR52L1 Gene

(455) SIMAP similar genes for OR52L1 Gene using alignment to 1 proteins: Pseudogenes for OR52L1 Gene

genes like me logo Genes that share paralogs with OR52L1: view

Variants for OR52L1 Gene

Sequence variations from dbSNP and Humsavar for OR52L1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1002690347 -- 5,988,333(-) C/T upstream_transcript_variant
rs1002721715 -- 5,988,033(-) T/C upstream_transcript_variant
rs1003339790 -- 5,987,154(-) G/A upstream_transcript_variant
rs1004432983 -- 5,986,526(-) G/T coding_sequence_variant, synonymous_variant
rs1006049813 -- 5,987,824(-) TTT/TT upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR52L1 Gene

Variant ID Type Subtype PubMed ID
dgv1054n100 CNV gain 25217958
esv2759801 CNV gain+loss 17122850
nsv1046068 CNV gain 25217958
nsv1053414 CNV gain 25217958
nsv553241 CNV gain 21841781
nsv553277 CNV gain 21841781
nsv975145 CNV duplication 23825009

Variation tolerance for OR52L1 Gene

Residual Variation Intolerance Score: 96.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.65; 93.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR52L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52L1 Gene

Disorders for OR52L1 Gene

Additional Disease Information for OR52L1

No disorders were found for OR52L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52L1 Gene

Publications for OR52L1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PMID: 17903293) Benjamin EJ … Vasan RS (BMC medical genetics 2007) 44 58
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Natural selection on the olfactory receptor gene family in humans and chimpanzees. (PMID: 12908129) Gilad Y … Pääbo S (American journal of human genetics 2003) 3 58

Products for OR52L1 Gene

Sources for OR52L1 Gene

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