Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR52I2 Gene

Aliases for OR52I2 Gene

  • Olfactory Receptor Family 52 Subfamily I Member 2 2 3 5
  • Olfactory Receptor OR11-12 3 4
  • Olfactory Receptor 52I2 3 4
  • Olfactory Receptor, Family 52, Subfamily I, Member 2 2
  • OR11-12 3
  • OR52I1 3
  • OR52I2 5

External Ids for OR52I2 Gene

Previous GeneCards Identifiers for OR52I2 Gene

  • GC11U990493
  • GC11P004573

Summaries for OR52I2 Gene

Entrez Gene Summary for OR52I2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52I2 Gene

OR52I2 (Olfactory Receptor Family 52 Subfamily I Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52I1.

UniProtKB/Swiss-Prot Summary for OR52I2 Gene

Gene Wiki entry for OR52I2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR52I2 Gene

Genomics for OR52I2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR52I2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J004626 Enhancer 0.8 Ensembl ENCODE 9.8 +44.7 44703 0.3 ZNF654 CTCF REST RAD21 SMC3 ZNF316 ZNF2 ARID2 MAFK ZNF143 OR51F2 OR52I2 C11orf40 TRIM68 HSALNG0082351 lnc-OR51D1-1 OR51D1
GH11J004559 Enhancer 0.5 Ensembl ENCODE 10.3 -21.7 -21652 1.4 ATF2 ATF7 OR52I2 OR52K1 OR52K3P OR52K2 TRIM68 piR-31534-067 piR-48209-072 OR52M1 C11orf40
GH11J004627 Enhancer 0.3 Ensembl 9.9 +45.9 45858 1.6 CTCF OR51F2 OR52I2 C11orf40 OR51F1 OR52B4 TRIM68 HSALNG0082351 lnc-OR51D1-1 OR51D1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR52I2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR52I2

Genomic Locations for OR52I2 Gene

Latest Assembly
chr11:4,581,743-4,593,340
(GRCh38/hg38)
Size:
11,598 bases
Orientation:
Plus strand

Previous Assembly
chr11:4,608,021-4,609,135
(GRCh37/hg19 by Entrez Gene)
Size:
1,115 bases
Orientation:
Plus strand

chr11:4,608,021-4,609,135
(GRCh37/hg19 by Ensembl)
Size:
1,115 bases
Orientation:
Plus strand

Genomic View for OR52I2 Gene

Genes around OR52I2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52I2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52I2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52I2 Gene

Proteins for OR52I2 Gene

  • Protein details for OR52I2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH67-O52I2_HUMAN
    Recommended name:
    Olfactory receptor 52I2
    Protein Accession:
    Q8NH67
    Secondary Accessions:
    • B2RNJ5
    • B9EKV8
    • Q6IFJ8

    Protein attributes for OR52I2 Gene

    Size:
    350 amino acids
    Molecular mass:
    38353 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05770.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR52I2 Gene

Post-translational modifications for OR52I2 Gene

  • Glycosylation at Asn33
  • Modification sites at PhosphoSitePlus

Other Protein References for OR52I2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52I2 Gene

Domains & Families for OR52I2 Gene

Gene Families for OR52I2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR52I2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR52I2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-12 (O52I2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NH67

UniProtKB/Swiss-Prot:

O52I2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52I2: view

Function for OR52I2 Gene

Molecular function for OR52I2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR52I2 Gene

Gene Ontology (GO) - Molecular Function for OR52I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR52I2: view
genes like me logo Genes that share phenotypes with OR52I2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR52I2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52I2 Gene

Localization for OR52I2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52I2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR52I2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52I2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR52I2 Gene

Pathways & Interactions for OR52I2 Gene

genes like me logo Genes that share pathways with OR52I2: view

Pathways by source for OR52I2 Gene

Interacting Proteins for OR52I2 Gene

Gene Ontology (GO) - Biological Process for OR52I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52I2: view

No data available for SIGNOR curated interactions for OR52I2 Gene

Drugs & Compounds for OR52I2 Gene

No Compound Related Data Available

Transcripts for OR52I2 Gene

mRNA/cDNA for OR52I2 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR52I2

Alternative Splicing Database (ASD) splice patterns (SP) for OR52I2 Gene

No ASD Table

Relevant External Links for OR52I2 Gene

GeneLoc Exon Structure for
OR52I2

Expression for OR52I2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR52I2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR52I2

SOURCE GeneReport for Unigene cluster for OR52I2 Gene:

Hs.553607
genes like me logo Genes that share expression patterns with OR52I2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52I2 Gene

Orthologs for OR52I2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR52I2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466338 29
  • 98.29 (n)
OR52I2 30
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC100683809 29
  • 86.32 (n)
Cow
(Bos Taurus)
Mammalia OR52I2 29
  • 85.55 (n)
-- 30
  • 79 (a)
ManyToMany
-- 30
  • 78 (a)
ManyToMany
-- 30
  • 78 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia LOC684179 29
  • 83.01 (n)
Mouse
(Mus musculus)
Mammalia Or52i2 45 Olfr556 29 16 30
  • 81.58 (n)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 72 (a)
ManyToMany
-- 30
  • 72 (a)
ManyToMany
-- 30
  • 70 (a)
ManyToMany
-- 30
  • 68 (a)
ManyToMany
-- 30
  • 66 (a)
ManyToMany
-- 30
  • 45 (a)
ManyToMany
-- 30
  • 45 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves LOC428119 29
  • 61.11 (n)
-- 30
  • 51 (a)
OneToMany
Species where no ortholog for OR52I2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR52I2 Gene

ENSEMBL:
Gene Tree for OR52I2 (if available)
TreeFam:
Gene Tree for OR52I2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR52I2: view image
Alliance of Genome Resources:
Additional Orthologs for OR52I2

Paralogs for OR52I2 Gene

(448) SIMAP similar genes for OR52I2 Gene using alignment to 1 proteins:

  • O52I2_HUMAN
genes like me logo Genes that share paralogs with OR52I2: view

Variants for OR52I2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR52I2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs12793957 -- p.Ile74Leu
rs1847632 -- p.Thr167Met
rs7128702 -- p.Leu25Pro
rs7947426 -- p.Ile178Val
rs7947432 -- p.Ile183Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR52I2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR52I2 Gene

Variant ID Type Subtype PubMed ID
dgv1586n54 CNV loss 21841781
esv2762892 CNV loss 21179565
nsv1047344 CNV loss 25217958
nsv1054705 CNV loss 25217958
nsv832055 CNV loss 17160897
nsv971980 CNV duplication 23825009

Variation tolerance for OR52I2 Gene

Residual Variation Intolerance Score: 93.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.40; 95.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR52I2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR52I2
Leiden Open Variation Database (LOVD)
OR52I2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52I2 Gene

Disorders for OR52I2 Gene

Additional Disease Information for OR52I2

No disorders were found for OR52I2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52I2 Gene

Publications for OR52I2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  4. Novel human G-protein-coupled receptors. (PMID: 12732197) Vanti WB … O'Dowd BF (Biochemical and biophysical research communications 2003) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for OR52I2 Gene

Sources for OR52I2 Gene