Free for academic non-profit institutions. Other users need a Commercial license
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR52I1 (Olfactory Receptor Family 52 Subfamily I Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52I2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J004210 | Enhancer | 0.2 | FANTOM5 | 7.6 | -382.7 | -382664 | 0.3 | RDXP1 lnc-SSU72P2-2 OR52K2 C11orf40 OR52I1 OR51D1 OR52K1 OR52M1 lnc-SSU72P2-3 RRM1 | ||
GH11J004492 | Enhancer | 0.2 | FANTOM5 | 4.8 | -101.2 | -101198 | 0.1 | OR52K2 OR51F1 OR52B4 OR51S1 OR51G2 OR51A4 OR52K1 C11orf40 OR52R1 OR51A7 | ||
GH11J004606 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE CraniofacialAtlas | 0.4 | +14.4 | 14369 | 2.4 | SP1 PRDM10 ZNF629 ZNF512 IKZF1 POLR2A FOS DDX20 MTA2 ZNF143 | TRIM68 lnc-C11orf40-2 RRM1 NUP98 lnc-C11orf40-1 OR52I1 | |
GH11J004108 | Enhancer | 0.2 | FANTOM5 | 3.2 | -484.8 | -484794 | 0.3 | RRM1-AS1 ART1 ART5 C11orf40 OR52I1 OR52K2 OR52K1 OR52M1 RRM1 piR-40176-005 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IEA,TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
GO:0007608 | sensory perception of smell | IEA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC466339 30 |
|
||
OR52I1 31 |
|
OneToOne | |||
Mouse (Mus musculus) |
Mammalia | Olfr556 31 |
|
OneToMany | |
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1586n54 | CNV | loss | 21841781 |
esv2762892 | CNV | loss | 21179565 |
nsv1047344 | CNV | loss | 25217958 |
nsv1054705 | CNV | loss | 25217958 |
nsv832055 | CNV | loss | 17160897 |
nsv971982 | CNV | duplication | 23825009 |
No disorders were found for OR52I1 Gene.