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Aliases for OR52E8 Gene

Aliases for OR52E8 Gene

  • Olfactory Receptor Family 52 Subfamily E Member 8 2 3 5
  • Olfactory Receptor, Family 52, Subfamily E, Member 8 Pseudogene 2 3
  • Olfactory Receptor OR11-54 3 4
  • Olfactory Receptor, Family 52, Subfamily E, Member 8 2
  • Olfactory Receptor 52E8 3
  • OR11-54 3

External Ids for OR52E8 Gene

Previous GeneCards Identifiers for OR52E8 Gene

  • GC11U990497
  • GC11M005843

Summaries for OR52E8 Gene

Entrez Gene Summary for OR52E8 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52E8 Gene

OR52E8 (Olfactory Receptor Family 52 Subfamily E Member 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52E6.

UniProtKB/Swiss-Prot for OR52E8 Gene

  • Odorant receptor.

Gene Wiki entry for OR52E8 Gene

Additional gene information for OR52E8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52E8 Gene

Genomics for OR52E8 Gene

GeneHancer (GH) Regulatory Elements for OR52E8 Gene

Promoters and enhancers for OR52E8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I005546 Enhancer 0.2 FANTOM5 14.8 +311.5 311488 0.1 OR56A1 OR56A3 OR51Q1 OR52E8 OR52N1 OR56A4 OR52N4 OR52E2 OR52E4 OR52A1
GH11I006094 Enhancer 0.2 FANTOM5 2.3 -236.7 -236685 0.1 OR56A1 OR52W1 FAM160A2 C11orf42 TRIM5 TRIM34 OR52N1 OR56A3 OR52E8 TRIM22
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR52E8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR52E8 gene promoter:

Genomic Locations for OR52E8 Gene

Genomic Locations for OR52E8 Gene
1,061 bases
Minus strand

Genomic View for OR52E8 Gene

Genes around OR52E8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52E8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52E8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52E8 Gene

Proteins for OR52E8 Gene

  • Protein details for OR52E8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 52E8
    Protein Accession:
    Secondary Accessions:
    • B9EH38

    Protein attributes for OR52E8 Gene

    317 amino acids
    Molecular mass:
    35913 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52E8 Gene

Post-translational modifications for OR52E8 Gene

  • Glycosylation at isoforms=9
  • Modification sites at PhosphoSitePlus

Other Protein References for OR52E8 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52E8 Gene

Domains & Families for OR52E8 Gene

Gene Families for OR52E8 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR52E8 Gene

Suggested Antigen Peptide Sequences for OR52E8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52E8: view

Function for OR52E8 Gene

Molecular function for OR52E8 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR52E8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR52E8: view

Phenotypes for OR52E8 Gene

GenomeRNAi human phenotypes for OR52E8:
genes like me logo Genes that share phenotypes with OR52E8: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52E8 Gene

Localization for OR52E8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52E8 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR52E8 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52E8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52E8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR52E8 Gene

Pathways & Interactions for OR52E8 Gene

genes like me logo Genes that share pathways with OR52E8: view

Pathways by source for OR52E8 Gene

Interacting Proteins for OR52E8 Gene

Gene Ontology (GO) - Biological Process for OR52E8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52E8: view

No data available for SIGNOR curated interactions for OR52E8 Gene

Drugs & Compounds for OR52E8 Gene

No Compound Related Data Available

Transcripts for OR52E8 Gene

mRNA/cDNA for OR52E8 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR52E8 Gene

Olfactory receptor, family 52, subfamily E, member 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR52E8 Gene

No ASD Table

Relevant External Links for OR52E8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR52E8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR52E8 Gene

mRNA differential expression in normal tissues according to GTEx for OR52E8 Gene

This gene is overexpressed in Whole Blood (x10.9), Brain - Caudate (basal ganglia) (x6.3), Brain - Substantia nigra (x4.8), and Thyroid (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of OR52E8 Gene:


SOURCE GeneReport for Unigene cluster for OR52E8 Gene:

genes like me logo Genes that share expression patterns with OR52E8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52E8 Gene

Orthologs for OR52E8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52E8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OR52E8 34
  • 100 (a)
LOC466399 33
  • 99.79 (n)
(Canis familiaris)
Mammalia -- 34
  • 89 (a)
OR52E8 33
  • 88.14 (n)
-- 34
  • 88 (a)
-- 34
  • 86 (a)
(Bos Taurus)
Mammalia LOC613909 33
  • 85.17 (n)
-- 34
  • 81 (a)
(Mus musculus)
Mammalia Or52e8b 51 Olfr675 16 34
  • 84 (a)
Or52e8 51 Olfr671 33 34
  • 83.81 (n)
Or52e15 51 Olfr672
  • chr7:104,995,967-104,996,902
Or52e18 51 Olfr670
  • chr7:104,959,795-104,960,895
Or52e53-ps 51 Olfr674-ps1
  • chr7:105,006,316-105,007,258
Or52e54-ps 51 Olfr673-ps1
  • chr7:105,004,277-105,004,653
Or52f1 51 Olfr647
  • chr7:104,167,488-104,168,378
(Rattus norvegicus)
Mammalia Olr184 33
  • 82.75 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 75 (a)
-- 34
  • 74 (a)
-- 34
  • 73 (a)
-- 34
  • 73 (a)
-- 34
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 69 (a)
-- 34
  • 67 (a)
Species where no ortholog for OR52E8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52E8 Gene

Gene Tree for OR52E8 (if available)
Gene Tree for OR52E8 (if available)

Paralogs for OR52E8 Gene

Paralogs for OR52E8 Gene

(456) SIMAP similar genes for OR52E8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR52E8: view

Variants for OR52E8 Gene

Sequence variations from dbSNP and Humsavar for OR52E8 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000555315 -- 5,858,970(-) G/A upstream_transcript_variant
rs1000752539 -- 5,858,719(-) C/T upstream_transcript_variant
rs1002017393 -- 5,859,171(-) G/A upstream_transcript_variant
rs1004377768 -- 5,858,632(-) A/G upstream_transcript_variant
rs1005561161 -- 5,859,617(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR52E8 Gene

Variant ID Type Subtype PubMed ID
dgv1053n100 CNV loss 25217958
dgv130n27 CNV gain 19166990
dgv1621n54 CNV gain 21841781
esv22550 CNV loss 19812545
esv2421670 CNV deletion 20811451
esv2673496 CNV deletion 23128226
esv2759801 CNV gain+loss 17122850
esv3625252 CNV loss 21293372
nsv1046068 CNV gain 25217958
nsv1046910 CNV loss 25217958
nsv1053414 CNV gain 25217958
nsv1149836 CNV deletion 26484159
nsv442600 CNV loss 18776908
nsv443002 CNV deletion 18674749
nsv498750 CNV loss 21111241
nsv514627 CNV gain+loss 21397061
nsv515489 CNV gain 19592680
nsv553241 CNV gain 21841781
nsv553277 CNV gain 21841781
nsv553347 CNV gain 21841781
nsv7655 CNV deletion 18451855
nsv832058 CNV gain 17160897
nsv8786 CNV gain+loss 18304495
nsv975376 CNV deletion 23825009

Variation tolerance for OR52E8 Gene

Residual Variation Intolerance Score: 91.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.21; 76.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR52E8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52E8 Gene

Disorders for OR52E8 Gene

Additional Disease Information for OR52E8

No disorders were found for OR52E8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52E8 Gene

Publications for OR52E8 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for OR52E8 Gene

Sources for OR52E8 Gene

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