Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR52E6 Gene

Aliases for OR52E6 Gene

  • Olfactory Receptor Family 52 Subfamily E Member 6 2 3 5
  • Olfactory Receptor OR11-58 3 4
  • Olfactory Receptor 52E6 3 4
  • Olfactory Receptor, Family 52, Subfamily E, Member 6 2
  • OR11-58 3
  • OR52E6 5

External Ids for OR52E6 Gene

Previous GeneCards Identifiers for OR52E6 Gene

  • GC11U990499
  • GC11M005827

Summaries for OR52E6 Gene

Entrez Gene Summary for OR52E6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52E6 Gene

OR52E6 (Olfactory Receptor Family 52 Subfamily E Member 6) is a Protein Coding gene. Diseases associated with OR52E6 include Growth Hormone Secreting Pituitary Adenoma. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52E8.

UniProtKB/Swiss-Prot Summary for OR52E6 Gene

Gene Wiki entry for OR52E6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR52E6 Gene

Genomics for OR52E6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR52E6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J005623 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 1.2 +216.5 216516 3.2 SP1 POLR2A YY1 SIN3A IRF2 PRDM1 RXRA IRF4 RFX5 TBP TRIM34 lnc-OR52H1-1 TRIM5 TRIM22 OR51B2 OR56B4 OR56A1 OR56A3 OR52N4 OR51Q1
GH11J005546 Enhancer 0.2 FANTOM5 8.3 +295.7 295706 0.1 OR56A1 OR56A3 OR51Q1 OR52E8 OR52N1 OR56A4 OR52N4 OR52E2 OR52E4 OR52A1
GH11J006094 Enhancer 0.4 FANTOM5 Ensembl 1.5 -252.3 -252349 1.4 MF281466-001 MF281466-002 MF281504 OR56A1 OR52W1 FHIP1B C11orf42 CAVIN3 TRIM5 TRIM34
GH11J005815 Enhancer 1.1 FANTOM5 Ensembl ENCODE 0.3 +26.9 26851 3.4 ZNF316 EBF1 NFE2 ZNF318 CBX1 SPI1 EP400 ZNF24 MAFG ATF4 OR52N3P TRIM22 TRIM34 TRIM5 FHIP1B OR52N5 OR52N2 piR-48209-082 OR52E6
GH11J005379 Enhancer 0.2 FANTOM5 1.6 +462.0 461960 0 piR-48209-078 OR51V1 OR51T1 HBB OR51B5 OR51G1 OR56B1 OR52J3 OR51L1 OR52N4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR52E6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR52E6

Top Transcription factor binding sites by QIAGEN in the OR52E6 gene promoter:
  • AhR
  • AML1a
  • Arnt
  • ATF6
  • C/EBPalpha
  • E47
  • POU3F1

Genomic Locations for OR52E6 Gene

Latest Assembly
chr11:5,840,928-5,841,952
(GRCh38/hg38)
Size:
1,025 bases
Orientation:
Minus strand

Previous Assembly
chr11:5,862,158-5,863,127
(GRCh37/hg19 by Entrez Gene)
Size:
970 bases
Orientation:
Minus strand

chr11:5,862,158-5,863,182
(GRCh37/hg19 by Ensembl)
Size:
1,025 bases
Orientation:
Minus strand

Genomic View for OR52E6 Gene

Genes around OR52E6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52E6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52E6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52E6 Gene

Proteins for OR52E6 Gene

  • Protein details for OR52E6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RD3-O52E6_HUMAN
    Recommended name:
    Olfactory receptor 52E6
    Protein Accession:
    Q96RD3
    Secondary Accessions:
    • Q6IFF8

    Protein attributes for OR52E6 Gene

    Size:
    313 amino acids
    Molecular mass:
    35524 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52E6 Gene

Post-translational modifications for OR52E6 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR52E6 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52E6 Gene

Domains & Families for OR52E6 Gene

Gene Families for OR52E6 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR52E6 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR52E6 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-58 (O52E6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96RD3

UniProtKB/Swiss-Prot:

O52E6_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52E6: view

Function for OR52E6 Gene

Molecular function for OR52E6 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR52E6 Gene

Gene Ontology (GO) - Molecular Function for OR52E6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR52E6: view
genes like me logo Genes that share phenotypes with OR52E6: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR52E6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52E6 Gene

Localization for OR52E6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52E6 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR52E6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52E6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52E6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR52E6 Gene

Pathways & Interactions for OR52E6 Gene

genes like me logo Genes that share pathways with OR52E6: view

Pathways by source for OR52E6 Gene

Interacting Proteins for OR52E6 Gene

Gene Ontology (GO) - Biological Process for OR52E6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52E6: view

No data available for SIGNOR curated interactions for OR52E6 Gene

Drugs & Compounds for OR52E6 Gene

No Compound Related Data Available

Transcripts for OR52E6 Gene

mRNA/cDNA for OR52E6 Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR52E6

Alternative Splicing Database (ASD) splice patterns (SP) for OR52E6 Gene

No ASD Table

Relevant External Links for OR52E6 Gene

GeneLoc Exon Structure for
OR52E6

Expression for OR52E6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR52E6 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR52E6

SOURCE GeneReport for Unigene cluster for OR52E6 Gene:

Hs.534693
genes like me logo Genes that share expression patterns with OR52E6: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52E6 Gene

Orthologs for OR52E6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52E6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466398 29
  • 98.83 (n)
OR52E6 30
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 30
  • 85 (a)
ManyToMany
-- 30
  • 84 (a)
ManyToMany
-- 30
  • 82 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Olfr675 30
  • 82 (a)
ManyToMany
Olfr671 30
  • 81 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 30
  • 78 (a)
OneToMany
LOC528515 29
  • 71.49 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 69 (a)
ManyToMany
-- 30
  • 69 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 67 (a)
ManyToMany
-- 30
  • 65 (a)
ManyToMany
Species where no ortholog for OR52E6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR52E6 Gene

ENSEMBL:
Gene Tree for OR52E6 (if available)
TreeFam:
Gene Tree for OR52E6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR52E6: view image
Alliance of Genome Resources:
Additional Orthologs for OR52E6

Paralogs for OR52E6 Gene

(450) SIMAP similar genes for OR52E6 Gene using alignment to 2 proteins:

  • O52E6_HUMAN
  • J3KPH0_HUMAN
genes like me logo Genes that share paralogs with OR52E6: view

Variants for OR52E6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR52E6 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs10838719 Benign: not provided 5,841,501(-) A/Gp.Trp133Arg
NM_001005167.2(OR52E6):c.397T>C (p.Trp133Arg)
MISSENSE
rs142759166 Benign: not provided 5,841,212(-) A/C
NM_001005167.2(OR52E6):c.686T>G (p.Leu229Arg)
MISSENSE
rs200523283 Benign: not provided 5,841,870(-) G/A
NM_001005167.2(OR52E6):c.28C>T (p.His10Tyr)
MISSENSE
rs10742809 -- p.Met199Arg
rs10769272 -- p.Phe48Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR52E6 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR52E6 Gene

Variant ID Type Subtype PubMed ID
dgv1053n100 CNV loss 25217958
esv2759801 CNV gain+loss 17122850
nsv1046068 CNV gain 25217958
nsv1053414 CNV gain 25217958
nsv515489 CNV gain 19592680
nsv553241 CNV gain 21841781
nsv553273 CNV gain 21841781
nsv553277 CNV gain 21841781
nsv832058 CNV gain 17160897
nsv971983 CNV duplication 23825009

Variation tolerance for OR52E6 Gene

Residual Variation Intolerance Score: 97.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.24; 99.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR52E6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR52E6
Leiden Open Variation Database (LOVD)
OR52E6

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52E6 Gene

Disorders for OR52E6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR52E6 Gene - From: COP

Disorder Aliases PubMed IDs
growth hormone secreting pituitary adenoma
  • growth hormone producing adenoma of the pituitary
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for OR52E6

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with OR52E6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR52E6 Gene

Publications for OR52E6 Gene

  1. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 40
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR52E6 Gene

Sources for OR52E6 Gene