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Aliases for OR52E6 Gene

Aliases for OR52E6 Gene

  • Olfactory Receptor Family 52 Subfamily E Member 6 2 3 5
  • Olfactory Receptor OR11-58 3 4
  • Olfactory Receptor, Family 52, Subfamily E, Member 6 2
  • Olfactory Receptor 52E6 3
  • OR11-58 3

External Ids for OR52E6 Gene

Previous GeneCards Identifiers for OR52E6 Gene

  • GC11U990499
  • GC11M005827

Summaries for OR52E6 Gene

Entrez Gene Summary for OR52E6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52E6 Gene

OR52E6 (Olfactory Receptor Family 52 Subfamily E Member 6) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52E8.

UniProtKB/Swiss-Prot for OR52E6 Gene

  • Odorant receptor.

Gene Wiki entry for OR52E6 Gene

Additional gene information for OR52E6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52E6 Gene

Genomics for OR52E6 Gene

GeneHancer (GH) Regulatory Elements for OR52E6 Gene

Promoters and enhancers for OR52E6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I005623 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 1.2 +216.5 216516 3.2 HDAC1 PKNOX1 SMAD1 SREBF2 ZBTB40 IRF4 RAD21 RFX5 YY1 FOS TRIM34 ENSG00000239920 TRIM5 TRIM22 OR51B2 OR56B4 OR56A1 OR56A3 OR52N4 OR51Q1
GH11I005546 Enhancer 0.2 FANTOM5 8.3 +295.7 295706 0.1 OR56A1 OR56A3 OR51Q1 OR52E8 OR52N1 OR56A4 OR52N4 OR52E2 OR52E4 OR52A1
GH11I005815 Enhancer 1.2 FANTOM5 Ensembl ENCODE 0.3 +26.3 26279 0.5 HDAC1 TEAD4 EBF1 CEBPG CHAMP1 ZNF316 CBX5 POLR2A NFE2 ATF7 OR52N3P TRIM22 TRIM34 TRIM5 FAM160A2 OR52N5 OR52N2 OR52E6
GH11I005379 Enhancer 0.2 FANTOM5 1.6 +462.0 461960 0 OR51V1 OR51T1 HBB OR51B5 OR51G1 OR56B1 OR52J3 OR51L1 OR52N4 OR52D1
GH11I006094 Enhancer 0.2 FANTOM5 1.5 -252.5 -252467 0.1 OR56A1 OR52W1 FAM160A2 C11orf42 TRIM5 TRIM34 OR52N1 OR56A3 OR52E8 TRIM22
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR52E6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR52E6 gene promoter:

Genomic Locations for OR52E6 Gene

Genomic Locations for OR52E6 Gene
1,025 bases
Minus strand

Genomic View for OR52E6 Gene

Genes around OR52E6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52E6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52E6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52E6 Gene

Proteins for OR52E6 Gene

  • Protein details for OR52E6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 52E6
    Protein Accession:
    Secondary Accessions:
    • Q6IFF8

    Protein attributes for OR52E6 Gene

    313 amino acids
    Molecular mass:
    35524 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52E6 Gene

Post-translational modifications for OR52E6 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR52E6 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52E6 Gene

Domains & Families for OR52E6 Gene

Gene Families for OR52E6 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR52E6 Gene

Suggested Antigen Peptide Sequences for OR52E6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52E6: view

Function for OR52E6 Gene

Molecular function for OR52E6 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR52E6 Gene

Gene Ontology (GO) - Molecular Function for OR52E6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA,IBA --
genes like me logo Genes that share ontologies with OR52E6: view
genes like me logo Genes that share phenotypes with OR52E6: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52E6 Gene

Localization for OR52E6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52E6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR52E6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52E6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52E6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR52E6 Gene

Pathways & Interactions for OR52E6 Gene

genes like me logo Genes that share pathways with OR52E6: view

Pathways by source for OR52E6 Gene

Interacting Proteins for OR52E6 Gene

Gene Ontology (GO) - Biological Process for OR52E6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA,IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52E6: view

No data available for SIGNOR curated interactions for OR52E6 Gene

Drugs & Compounds for OR52E6 Gene

No Compound Related Data Available

Transcripts for OR52E6 Gene

mRNA/cDNA for OR52E6 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR52E6 Gene

Olfactory receptor, family 52, subfamily E, member 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR52E6 Gene

No ASD Table

Relevant External Links for OR52E6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR52E6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR52E6 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR52E6 Gene:


SOURCE GeneReport for Unigene cluster for OR52E6 Gene:

genes like me logo Genes that share expression patterns with OR52E6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52E6 Gene

Orthologs for OR52E6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52E6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466398 33
  • 98.83 (n)
OR52E6 34
  • 97 (a)
(Canis familiaris)
Mammalia -- 34
  • 85 (a)
-- 34
  • 84 (a)
-- 34
  • 82 (a)
(Mus musculus)
Mammalia Olfr675 34
  • 82 (a)
Olfr671 34
  • 81 (a)
(Bos Taurus)
Mammalia -- 34
  • 78 (a)
LOC528515 33
  • 71.49 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 69 (a)
-- 34
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 67 (a)
-- 34
  • 65 (a)
Species where no ortholog for OR52E6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52E6 Gene

Gene Tree for OR52E6 (if available)
Gene Tree for OR52E6 (if available)

Paralogs for OR52E6 Gene

Paralogs for OR52E6 Gene

(450) SIMAP similar genes for OR52E6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR52E6: view

Variants for OR52E6 Gene

Sequence variations from dbSNP and Humsavar for OR52E6 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000195468 -- 5,841,776(-) A/C coding_sequence_variant, missense_variant
rs1001553966 -- 5,842,624(-) C/T upstream_transcript_variant
rs1001918432 -- 5,843,341(-) G/A upstream_transcript_variant
rs1001970790 -- 5,843,083(-) T/A upstream_transcript_variant
rs1002514621 -- 5,843,845(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR52E6 Gene

Variant ID Type Subtype PubMed ID
dgv1053n100 CNV loss 25217958
esv2759801 CNV gain+loss 17122850
nsv1046068 CNV gain 25217958
nsv1053414 CNV gain 25217958
nsv515489 CNV gain 19592680
nsv553241 CNV gain 21841781
nsv553273 CNV gain 21841781
nsv553277 CNV gain 21841781
nsv832058 CNV gain 17160897
nsv971983 CNV duplication 23825009

Variation tolerance for OR52E6 Gene

Residual Variation Intolerance Score: 97.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.24; 99.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR52E6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52E6 Gene

Disorders for OR52E6 Gene

Additional Disease Information for OR52E6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OR52E6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52E6 Gene

Publications for OR52E6 Gene

  1. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 44 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58

Products for OR52E6 Gene

Sources for OR52E6 Gene

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