Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR52E5 Gene

Aliases for OR52E5 Gene

  • Olfactory Receptor Family 52 Subfamily E Member 5 2 3 5
  • Olfactory Receptor 52E5 3 4
  • Olfactory Receptor, Family 52, Subfamily E, Member 5 2
  • Olfactory Receptor OR11-56 Pseudogene 3
  • OR11-56 3
  • OR52E5 5

External Ids for OR52E5 Gene

Previous GeneCards Identifiers for OR52E5 Gene

  • GC11U990500
  • GC11P005887
  • GC11P005878
  • GC11P005922

Summaries for OR52E5 Gene

Entrez Gene Summary for OR52E5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52E5 Gene

OR52E5 (Olfactory Receptor Family 52 Subfamily E Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52E2.

UniProtKB/Swiss-Prot Summary for OR52E5 Gene

Gene Wiki entry for OR52E5 Gene

Additional gene information for OR52E5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR52E5 Gene

Genomics for OR52E5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR52E5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J005923 Enhancer 0.5 ENCODE 0.3 +30.1 30078 0.2 EBF1 NFE2 BATF JUNB BACH1 ATF3 ZNF687 FOS RELB piR-48209-084 HSALNG0082393 lnc-OR56A3-1 TRIM5 LOC112268071 OR52E5
GH11J005899 Enhancer 0.3 Ensembl 0.4 +6.6 6593 0.4 CEBPG OR52N3P OR52Q1P OR52E5 TRIM5 LOC112268071
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR52E5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR52E5

Genomic Locations for OR52E5 Gene

Latest Assembly
chr11:5,893,208-5,902,730
(GRCh38/hg38)
Size:
9,523 bases
Orientation:
Plus strand

Previous Assembly
chr11:5,914,438-5,923,960
(GRCh37/hg19 by Entrez Gene)
Size:
9,523 bases
Orientation:
Plus strand

Genomic View for OR52E5 Gene

Genes around OR52E5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52E5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52E5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52E5 Gene

Proteins for OR52E5 Gene

  • Protein details for OR52E5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH55-O52E5_HUMAN
    Recommended name:
    Olfactory receptor 52E5
    Protein Accession:
    Q8NH55

    Protein attributes for OR52E5 Gene

    Size:
    327 amino acids
    Molecular mass:
    36851 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05782.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for OR52E5 Gene

Post-translational modifications for OR52E5 Gene

  • Glycosylation at Asn5

Other Protein References for OR52E5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52E5 Gene

Domains & Families for OR52E5 Gene

Gene Families for OR52E5 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR52E5 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR52E5 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 52E5 (O52E5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NH55

UniProtKB/Swiss-Prot:

O52E5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52E5: view

Function for OR52E5 Gene

Molecular function for OR52E5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR52E5 Gene

Gene Ontology (GO) - Molecular Function for OR52E5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR52E5: view
genes like me logo Genes that share phenotypes with OR52E5: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR52E5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52E5 Gene

Localization for OR52E5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52E5 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR52E5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52E5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52E5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR52E5 Gene

Pathways & Interactions for OR52E5 Gene

genes like me logo Genes that share pathways with OR52E5: view

Pathways by source for OR52E5 Gene

Interacting Proteins for OR52E5 Gene

Gene Ontology (GO) - Biological Process for OR52E5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52E5: view

No data available for SIGNOR curated interactions for OR52E5 Gene

Drugs & Compounds for OR52E5 Gene

No Compound Related Data Available

Transcripts for OR52E5 Gene

mRNA/cDNA for OR52E5 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR52E5

Alternative Splicing Database (ASD) splice patterns (SP) for OR52E5 Gene

No ASD Table

Relevant External Links for OR52E5 Gene

GeneLoc Exon Structure for
OR52E5

Expression for OR52E5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR52E5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR52E5

genes like me logo Genes that share expression patterns with OR52E5: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52E5 Gene

Orthologs for OR52E5 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for OR52E5 Gene

Organism Taxonomy Gene Similarity Type Details
Mouse
(Mus musculus)
Mammalia Or52e5 45 Olfr678
  • chr7:105,069,469-105,070,407
Species where no ortholog for OR52E5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR52E5 Gene

ENSEMBL:
Gene Tree for OR52E5 (if available)
TreeFam:
Gene Tree for OR52E5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR52E5: view image
Alliance of Genome Resources:
Additional Orthologs for OR52E5

Paralogs for OR52E5 Gene

(438) SIMAP similar genes for OR52E5 Gene using alignment to 1 proteins:

  • O52E5_HUMAN
genes like me logo Genes that share paralogs with OR52E5: view

Variants for OR52E5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR52E5 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs16926732 -- p.Asp209Gly
rs17234326 -- p.Ile165Thr
rs7106300 -- p.Pro234Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR52E5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for OR52E5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR52E5
Leiden Open Variation Database (LOVD)
OR52E5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for OR52E5 Gene

Disorders for OR52E5 Gene

Additional Disease Information for OR52E5

No disorders were found for OR52E5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52E5 Gene

Publications for OR52E5 Gene

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3

Products for OR52E5 Gene

Sources for OR52E5 Gene