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Aliases for OR52E4 Gene

Aliases for OR52E4 Gene

  • Olfactory Receptor Family 52 Subfamily E Member 4 2 3 5
  • Olfactory Receptor OR11-55 3 4
  • Olfactory Receptor, Family 52, Subfamily E, Member 4 2
  • Olfactory Receptor 52E4 3
  • OR11-55 3

External Ids for OR52E4 Gene

Previous GeneCards Identifiers for OR52E4 Gene

  • GC11U990501
  • GC11P005870
  • GC11P005862
  • GC11P005905

Summaries for OR52E4 Gene

Entrez Gene Summary for OR52E4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52E4 Gene

OR52E4 (Olfactory Receptor Family 52 Subfamily E Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52E2.

UniProtKB/Swiss-Prot for OR52E4 Gene

  • Odorant receptor.

Gene Wiki entry for OR52E4 Gene

Additional gene information for OR52E4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52E4 Gene

Genomics for OR52E4 Gene

GeneHancer (GH) Regulatory Elements for OR52E4 Gene

Promoters and enhancers for OR52E4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J005546 Enhancer 0.2 FANTOM5 10.9 -334.4 -334383 0.1 OR56A1 OR56A3 OR51Q1 OR52E8 OR52N1 OR56A4 OR52N4 OR52E2 OR52E4 OR52A1
GH11J006094 Enhancer 0.2 FANTOM5 1.9 +213.8 213790 0.1 OR56A1 OR52W1 FAM160A2 C11orf42 TRIM5 TRIM34 OR52N1 OR56A3 OR52E8 TRIM22
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR52E4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR52E4 gene promoter:
  • E2F-4
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • Meis-1b
  • E2F-5
  • HOXA9
  • HOXA9B
  • Meis-1

Genomic Locations for OR52E4 Gene

Genomic Locations for OR52E4 Gene
6,451 bases
Plus strand
1,027 bases
Plus strand

Genomic View for OR52E4 Gene

Genes around OR52E4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52E4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52E4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52E4 Gene

Proteins for OR52E4 Gene

  • Protein details for OR52E4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 52E4
    Protein Accession:
    Secondary Accessions:
    • Q6IFG0

    Protein attributes for OR52E4 Gene

    312 amino acids
    Molecular mass:
    35480 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52E4 Gene

Post-translational modifications for OR52E4 Gene

Other Protein References for OR52E4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52E4 Gene

Domains & Families for OR52E4 Gene

Gene Families for OR52E4 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR52E4 Gene

Suggested Antigen Peptide Sequences for OR52E4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52E4: view

Function for OR52E4 Gene

Molecular function for OR52E4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR52E4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR52E4: view
genes like me logo Genes that share phenotypes with OR52E4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52E4 Gene

Localization for OR52E4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52E4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR52E4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52E4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52E4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR52E4 Gene

Pathways & Interactions for OR52E4 Gene

genes like me logo Genes that share pathways with OR52E4: view

Pathways by source for OR52E4 Gene

Interacting Proteins for OR52E4 Gene

Gene Ontology (GO) - Biological Process for OR52E4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52E4: view

No data available for SIGNOR curated interactions for OR52E4 Gene

Drugs & Compounds for OR52E4 Gene

No Compound Related Data Available

Transcripts for OR52E4 Gene

mRNA/cDNA for OR52E4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR52E4 Gene

Olfactory receptor, family 52, subfamily E, member 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR52E4 Gene

No ASD Table

Relevant External Links for OR52E4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR52E4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR52E4 Gene

Protein differential expression in normal tissues from HIPED for OR52E4 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR52E4 Gene

Protein tissue co-expression partners for OR52E4 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR52E4 Gene:


SOURCE GeneReport for Unigene cluster for OR52E4 Gene:

genes like me logo Genes that share expression patterns with OR52E4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52E4 Gene

Orthologs for OR52E4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52E4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466400 33
  • 99.15 (n)
OR52E4 34
  • 99 (a)
(Canis familiaris)
Mammalia cOR52E4 33
  • 88.96 (n)
OR52E4 34
  • 86 (a)
(Bos Taurus)
Mammalia OR52E4 34 33
  • 88.24 (n)
(Rattus norvegicus)
Mammalia Olr188 33
  • 85.36 (n)
(Mus musculus)
Mammalia Or52e4 51 Olfr677 16 34 33
  • 84.62 (n)
Or52e19 51 Olfr596
  • chr7:103,309,723-103,310,658
Or52e52 51 Olfr603
  • chr7:103,383,065-103,384,000
(Monodelphis domestica)
Mammalia OR52E4 34
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 65 (a)
-- 34
  • 65 (a)
Species where no ortholog for OR52E4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52E4 Gene

Gene Tree for OR52E4 (if available)
Gene Tree for OR52E4 (if available)
Evolutionary constrained regions (ECRs) for OR52E4: view image

Paralogs for OR52E4 Gene

Paralogs for OR52E4 Gene

(456) SIMAP similar genes for OR52E4 Gene using alignment to 2 proteins:

  • O52E4_HUMAN
  • B9EH08_HUMAN Pseudogenes for OR52E4 Gene

genes like me logo Genes that share paralogs with OR52E4: view

Variants for OR52E4 Gene

Sequence variations from dbSNP and Humsavar for OR52E4 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1002509812 -- 5,882,913(+) T/C upstream_transcript_variant
rs1002744926 -- 5,884,472(+) C/T coding_sequence_variant, synonymous_variant
rs1003630929 -- 5,883,028(+) A/G upstream_transcript_variant
rs1004321964 -- 5,882,994(+) T/C upstream_transcript_variant
rs1004438306 -- 5,883,263(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR52E4 Gene

Variant ID Type Subtype PubMed ID
dgv130n27 CNV gain 19166990
dgv131n27 CNV gain 19166990
dgv132n27 CNV gain 19166990
dgv1621n54 CNV gain 21841781
dgv1622n54 CNV gain 21841781
dgv1623n54 CNV gain 21841781
dgv39e55 CNV gain 17911159
dgv40e55 CNV gain 17911159
dgv43n111 CNV duplication 26073780
esv2759801 CNV gain+loss 17122850
esv2760344 CNV gain+loss 21179565
esv3578227 CNV gain 25503493
esv3625255 CNV gain 21293372
esv3625258 CNV gain 21293372
esv3891921 CNV gain 25118596
nsv1041535 CNV gain 25217958
nsv1046068 CNV gain 25217958
nsv1050954 CNV loss 25217958
nsv1053414 CNV gain 25217958
nsv442217 CNV gain 18776908
nsv469935 CNV gain 18288195
nsv471362 CNV gain 19718026
nsv515489 CNV gain 19592680
nsv553241 CNV gain 21841781
nsv553277 CNV gain 21841781
nsv818796 CNV gain 17921354
nsv825754 CNV gain 20364138
nsv832058 CNV gain 17160897
nsv8786 CNV gain+loss 18304495

Variation tolerance for OR52E4 Gene

Residual Variation Intolerance Score: 92.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.77; 98.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR52E4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52E4 Gene

Disorders for OR52E4 Gene

Additional Disease Information for OR52E4

No disorders were found for OR52E4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52E4 Gene

Publications for OR52E4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR52E4 Gene

Sources for OR52E4 Gene

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