Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR52E1 Gene

Aliases for OR52E1 Gene

  • Olfactory Receptor Family 52 Subfamily E Member 1 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 52, Subfamily E, Member 1 Pseudogene 2 3
  • Olfactory Receptor 52E1 3 4
  • OR52E1P 3 4
  • Olfactory Receptor, Family 52, Subfamily E, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 52, Subfamily E, Member 1 Gene/Pseudogene 2
  • Seven Transmembrane Helix Receptor 3
  • OR52E1 5

External Ids for OR52E1 Gene

Previous HGNC Symbols for OR52E1 Gene

  • OR52E1P

Previous GeneCards Identifiers for OR52E1 Gene

  • GC11U990310
  • GC11P005048

Summaries for OR52E1 Gene

Entrez Gene Summary for OR52E1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]

GeneCards Summary for OR52E1 Gene

OR52E1 (Olfactory Receptor Family 52 Subfamily E Member 1 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52E2.

UniProtKB/Swiss-Prot Summary for OR52E1 Gene

Additional gene information for OR52E1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR52E1 Gene

Genomics for OR52E1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR52E1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J005087 Enhancer 0.6 ENCODE 0.4 +17.9 17913 0.4 TAL1 ZNF316 TCF12 TEAD4 DPF2 ARID1B RNF2 SOX6 CBFA2T3 SMARCA4 OR52E3P OR52S1P OR52E1 OR52A5
GH11J005129 Enhancer 0.8 Ensembl 0.2 +59.9 59929 1 NCOR1 ZNF592 CEBPB HES1 TBP TAF9B TAL1 MYNN ATF1 STAT5A HNRNPA1P53 OR52A4P OR52A5 OR52E1
GH11J005124 Enhancer 0.8 ENCODE 0.2 +54.7 54694 0.2 ZNF654 ZNF592 CEBPA YY1 CEBPB REST TRIM22 CTCF ARNT RAD21 OR52A4P piR-48209-074 OR52A5 OR52E1
GH11J005125 Enhancer 0.7 Ensembl 0.2 +55.0 55028 0.4 ZNF592 YY1 REST TRIM22 ARNT MYNN HLTF CTCF ZC3H8 RB1 OR52A4P OR52A5 OR52E1
GH11J005136 Enhancer 0.2 Ensembl 0.2 +67.6 67629 0.8 OR52A5 OR52A4P OR52E1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR52E1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR52E1

Genomic Locations for OR52E1 Gene

Latest Assembly
chr11:5,069,572-5,070,497
(GRCh38/hg38)
Size:
926 bases
Orientation:
Plus strand

Previous Assembly
chr11:5,090,602-5,091,926
(GRCh37/hg19 by Entrez Gene)
Size:
1,325 bases
Orientation:
Plus strand

chr11:5,090,802-5,091,727
(GRCh37/hg19 by Ensembl)
Size:
926 bases
Orientation:
Plus strand

Genomic View for OR52E1 Gene

Genes around OR52E1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52E1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52E1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52E1 Gene

Proteins for OR52E1 Gene

  • Protein details for OR52E1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGJ3-O52E1_HUMAN
    Recommended name:
    Olfactory receptor 52E1
    Protein Accession:
    Q8NGJ3

    Protein attributes for OR52E1 Gene

    Size:
    308 amino acids
    Molecular mass:
    34714 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52E1 Gene

Post-translational modifications for OR52E1 Gene

  • Glycosylation at Asn2

Other Protein References for OR52E1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OR52E1 Gene

Domains & Families for OR52E1 Gene

Gene Families for OR52E1 Gene

Protein Domains for OR52E1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR52E1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 52E1 (O52E1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGJ3

UniProtKB/Swiss-Prot:

O52E1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52E1: view

Function for OR52E1 Gene

Molecular function for OR52E1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR52E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR52E1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52E1 Gene

Localization for OR52E1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52E1 Gene

Cell membrane. Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OR52E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52E1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for OR52E1 Gene

Pathways & Interactions for OR52E1 Gene

genes like me logo Genes that share pathways with OR52E1: view

Pathways by source for OR52E1 Gene

Interacting Proteins for OR52E1 Gene

Gene Ontology (GO) - Biological Process for OR52E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52E1: view

No data available for SIGNOR curated interactions for OR52E1 Gene

Drugs & Compounds for OR52E1 Gene

No Compound Related Data Available

Transcripts for OR52E1 Gene

mRNA/cDNA for OR52E1 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR52E1 Gene

No ASD Table

Relevant External Links for OR52E1 Gene

GeneLoc Exon Structure for
OR52E1

Expression for OR52E1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR52E1 Gene

Protein differential expression in normal tissues from HIPED for OR52E1 Gene

This gene is overexpressed in Milk (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR52E1 Gene



Protein tissue co-expression partners for OR52E1 Gene

genes like me logo Genes that share expression patterns with OR52E1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52E1 Gene

Orthologs for OR52E1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52E1 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia -- 30
  • 71 (a)
OneToMany
-- 30
  • 71 (a)
OneToMany
-- 30
  • 68 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 70 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 30
  • 62 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Olfr594 30
  • 61 (a)
ManyToMany
Or52c1-ps 45 Olfr590-ps1
  • chr7:103,165,907-103,166,747
Or52e51-ps 45 Olfr595-ps1
  • chr7:103,235,686-103,236,582
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 54 (a)
ManyToMany
-- 30
  • 52 (a)
ManyToMany
Species where no ortholog for OR52E1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR52E1 Gene

ENSEMBL:
Gene Tree for OR52E1 (if available)
TreeFam:
Gene Tree for OR52E1 (if available)
Alliance of Genome Resources:
Additional Orthologs for OR52E1

Paralogs for OR52E1 Gene

(428) SIMAP similar genes for OR52E1 Gene using alignment to 1 proteins:

  • O52E1_HUMAN
genes like me logo Genes that share paralogs with OR52E1: view

Variants for OR52E1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR52E1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for OR52E1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR52E1
Leiden Open Variation Database (LOVD)
OR52E1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for OR52E1 Gene

Disorders for OR52E1 Gene

Additional Disease Information for OR52E1

No disorders were found for OR52E1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52E1 Gene

Publications for OR52E1 Gene

  1. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 3
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR52E1 Gene

Sources for OR52E1 Gene