Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR52B6 Gene

Aliases for OR52B6 Gene

  • Olfactory Receptor Family 52 Subfamily B Member 6 2 3 5
  • Olfactory Receptor OR11-47 3 4
  • Olfactory Receptor 52B6 3 4
  • Olfactory Receptor, Family 52, Subfamily B, Member 6 2
  • OR11-47 3
  • OR52B6 5

External Ids for OR52B6 Gene

Previous GeneCards Identifiers for OR52B6 Gene

  • GC11U990503
  • GC11P005566
  • GC11P005558
  • GC11P005603
  • GC11P005604

Summaries for OR52B6 Gene

Entrez Gene Summary for OR52B6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52B6 Gene

OR52B6 (Olfactory Receptor Family 52 Subfamily B Member 6) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52B2.

UniProtKB/Swiss-Prot Summary for OR52B6 Gene

Gene Wiki entry for OR52B6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR52B6 Gene

Genomics for OR52B6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR52B6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J005565 Enhancer 0.6 Ensembl 0.4 -16.5 -16476 0.4 MYC ZNF592 BHLHE40 ZNF316 RAD51 EP400 ATF4 L3MBTL2 CEBPB ATF3 TRIM6 OR52D1 OR52E4 OR51I2 OR52T1P HSALNG0082372 OR52B5P OR52B6 OR52H1 ENSG00000239920
GH11J005550 Enhancer 0.7 Ensembl ENCODE 0.3 -30.0 -29976 1.4 JUND BHLHE40 DPF2 ARID1B SMARCE1 ATF3 FOS MTA2 SMARCA4 OR52H2P lnc-OR52H1-2 HBE1 HBG2 OR51B5 TRIM6 OR52D1 OR51I2 OLFM5P UBQLNL
GH11J005564 Enhancer 0.5 Ensembl 0.4 -16.0 -15976 0.2 GABPA ZNF316 SPI1 EP400 CEBPB GABPB1 CEBPG TRIM6 OR52D1 OR52E4 OR51I2 OR52T1P HSALNG0082372 OR52B5P OR52B6 OR52H1 ENSG00000239920
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR52B6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR52B6

Top Transcription factor binding sites by QIAGEN in the OR52B6 gene promoter:
  • AML1a
  • AP-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • IRF-2
  • LCR-F1
  • Meis-1a
  • Meis-1b
  • MyoD
  • p53

Genomic Locations for OR52B6 Gene

Latest Assembly
chr11:5,580,877-5,581,884
(GRCh38/hg38)
Size:
1,008 bases
Orientation:
Plus strand

Previous Assembly
chr11:5,602,107-5,603,114
(GRCh37/hg19 by Entrez Gene)
Size:
1,008 bases
Orientation:
Plus strand

chr11:5,602,107-5,603,114
(GRCh37/hg19 by Ensembl)
Size:
1,008 bases
Orientation:
Plus strand

Genomic View for OR52B6 Gene

Genes around OR52B6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52B6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52B6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52B6 Gene

Proteins for OR52B6 Gene

  • Protein details for OR52B6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGF0-O52B6_HUMAN
    Recommended name:
    Olfactory receptor 52B6
    Protein Accession:
    Q8NGF0
    Secondary Accessions:
    • Q6IFI7

    Protein attributes for OR52B6 Gene

    Size:
    335 amino acids
    Molecular mass:
    36963 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52B6 Gene

Post-translational modifications for OR52B6 Gene

  • Glycosylation at Asn23
  • Modification sites at PhosphoSitePlus

Other Protein References for OR52B6 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52B6 Gene

Domains & Families for OR52B6 Gene

Gene Families for OR52B6 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR52B6 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR52B6 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-47 (O52B6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGF0

UniProtKB/Swiss-Prot:

O52B6_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52B6: view

Function for OR52B6 Gene

Molecular function for OR52B6 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR52B6 Gene

Gene Ontology (GO) - Molecular Function for OR52B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR52B6: view
genes like me logo Genes that share phenotypes with OR52B6: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR52B6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52B6 Gene

Localization for OR52B6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52B6 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR52B6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52B6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR52B6 Gene

Pathways & Interactions for OR52B6 Gene

genes like me logo Genes that share pathways with OR52B6: view

Pathways by source for OR52B6 Gene

Interacting Proteins for OR52B6 Gene

Gene Ontology (GO) - Biological Process for OR52B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52B6: view

No data available for SIGNOR curated interactions for OR52B6 Gene

Drugs & Compounds for OR52B6 Gene

No Compound Related Data Available

Transcripts for OR52B6 Gene

mRNA/cDNA for OR52B6 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR52B6

Alternative Splicing Database (ASD) splice patterns (SP) for OR52B6 Gene

No ASD Table

Relevant External Links for OR52B6 Gene

GeneLoc Exon Structure for
OR52B6

Expression for OR52B6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR52B6 Gene

mRNA differential expression in normal tissues according to GTEx for OR52B6 Gene

This gene is overexpressed in Ovary (x4.9).

Protein differential expression in normal tissues from HIPED for OR52B6 Gene

This gene is overexpressed in Fetal testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR52B6 Gene



Protein tissue co-expression partners for OR52B6 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR52B6

SOURCE GeneReport for Unigene cluster for OR52B6 Gene:

Hs.553704
genes like me logo Genes that share expression patterns with OR52B6: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52B6 Gene

Orthologs for OR52B6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR52B6 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia OR52B6 29 30
  • 85.27 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia OR52B6 30
  • 83 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia OR52B6 30
  • 73 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Olfr618 29 16 30
  • 63.94 (n)
OneToMany
Or52b6-ps 45 Olfr650-ps1
  • chr7:104,206,053-104,207,006
Rat
(Rattus norvegicus)
Mammalia Olr111 29
  • 62.9 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia OR52B6 30
  • 55 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 30
  • 56 (a)
OneToMany
Species where no ortholog for OR52B6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR52B6 Gene

ENSEMBL:
Gene Tree for OR52B6 (if available)
TreeFam:
Gene Tree for OR52B6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR52B6: view image
Alliance of Genome Resources:
Additional Orthologs for OR52B6

Paralogs for OR52B6 Gene

(449) SIMAP similar genes for OR52B6 Gene using alignment to 1 proteins:

  • O52B6_HUMAN
genes like me logo Genes that share paralogs with OR52B6: view

Variants for OR52B6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR52B6 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs10769086 -- p.Val288Ile
rs1077126 -- p.Thr57Ala
rs2341432 -- p.Leu111His
rs2341433 -- p.Ala167Thr
rs2341434 -- p.His170Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR52B6 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR52B6 Gene

Variant ID Type Subtype PubMed ID
esv3625236 CNV loss 21293372
esv3625237 CNV loss 21293372
esv3891919 CNV loss 25118596
nsv1041568 CNV loss 25217958
nsv1046068 CNV gain 25217958
nsv1048608 CNV gain 25217958
nsv553241 CNV gain 21841781

Variation tolerance for OR52B6 Gene

Residual Variation Intolerance Score: 92.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.13; 51.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR52B6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR52B6
Leiden Open Variation Database (LOVD)
OR52B6

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52B6 Gene

Disorders for OR52B6 Gene

Additional Disease Information for OR52B6

No disorders were found for OR52B6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52B6 Gene

Publications for OR52B6 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4

Products for OR52B6 Gene

Sources for OR52B6 Gene