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Aliases for OR52B6 Gene

Aliases for OR52B6 Gene

  • Olfactory Receptor Family 52 Subfamily B Member 6 2 3 5
  • Olfactory Receptor OR11-47 3 4
  • Olfactory Receptor, Family 52, Subfamily B, Member 6 2
  • Olfactory Receptor 52B6 3
  • OR11-47 3

External Ids for OR52B6 Gene

Previous GeneCards Identifiers for OR52B6 Gene

  • GC11U990503
  • GC11P005566
  • GC11P005558
  • GC11P005603

Summaries for OR52B6 Gene

Entrez Gene Summary for OR52B6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52B6 Gene

OR52B6 (Olfactory Receptor Family 52 Subfamily B Member 6) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52B2.

UniProtKB/Swiss-Prot for OR52B6 Gene

  • Odorant receptor.

Gene Wiki entry for OR52B6 Gene

Additional gene information for OR52B6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52B6 Gene

Genomics for OR52B6 Gene

GeneHancer (GH) Regulatory Elements for OR52B6 Gene

Top Transcription factor binding sites by QIAGEN in the OR52B6 gene promoter:
  • AML1a
  • AP-1
  • MyoD
  • IRF-2
  • LCR-F1
  • p53
  • Meis-1a
  • Meis-1b
  • FOXJ2
  • FOXJ2 (long isoform)

Genomic Locations for OR52B6 Gene

Genomic Locations for OR52B6 Gene
1,008 bases
Plus strand
1,008 bases
Plus strand

Genomic View for OR52B6 Gene

Genes around OR52B6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52B6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52B6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52B6 Gene

Proteins for OR52B6 Gene

  • Protein details for OR52B6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 52B6
    Protein Accession:
    Secondary Accessions:
    • Q6IFI7

    Protein attributes for OR52B6 Gene

    335 amino acids
    Molecular mass:
    36963 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52B6 Gene

Post-translational modifications for OR52B6 Gene

  • Glycosylation at Asn23
  • Modification sites at PhosphoSitePlus

Other Protein References for OR52B6 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52B6 Gene

Domains & Families for OR52B6 Gene

Gene Families for OR52B6 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR52B6 Gene

Suggested Antigen Peptide Sequences for OR52B6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52B6: view

Function for OR52B6 Gene

Molecular function for OR52B6 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR52B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR52B6: view
genes like me logo Genes that share phenotypes with OR52B6: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52B6 Gene

Localization for OR52B6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52B6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR52B6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52B6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR52B6 Gene

Pathways & Interactions for OR52B6 Gene

genes like me logo Genes that share pathways with OR52B6: view

Pathways by source for OR52B6 Gene

Interacting Proteins for OR52B6 Gene

Gene Ontology (GO) - Biological Process for OR52B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52B6: view

No data available for SIGNOR curated interactions for OR52B6 Gene

Drugs & Compounds for OR52B6 Gene

No Compound Related Data Available

Transcripts for OR52B6 Gene

mRNA/cDNA for OR52B6 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR52B6 Gene

Olfactory receptor, family 52, subfamily B, member 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR52B6 Gene

No ASD Table

Relevant External Links for OR52B6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR52B6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR52B6 Gene

mRNA differential expression in normal tissues according to GTEx for OR52B6 Gene

This gene is overexpressed in Ovary (x4.9).

Protein differential expression in normal tissues from HIPED for OR52B6 Gene

This gene is overexpressed in Fetal testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR52B6 Gene

Protein tissue co-expression partners for OR52B6 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR52B6 Gene:


SOURCE GeneReport for Unigene cluster for OR52B6 Gene:

genes like me logo Genes that share expression patterns with OR52B6: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52B6 Gene

Orthologs for OR52B6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR52B6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OR52B6 34 33
  • 85.27 (n)
(Canis familiaris)
Mammalia OR52B6 34
  • 83 (a)
(Monodelphis domestica)
Mammalia OR52B6 34
  • 73 (a)
(Mus musculus)
Mammalia Olfr618 16 34 33
  • 63.94 (n)
Or52b6-ps 51 Olfr650-ps1
  • chr7:104,206,053-104,207,006
(Rattus norvegicus)
Mammalia Olr111 33
  • 62.9 (n)
(Ornithorhynchus anatinus)
Mammalia OR52B6 34
  • 55 (a)
(Gallus gallus)
Aves -- 34
  • 56 (a)
Species where no ortholog for OR52B6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52B6 Gene

Gene Tree for OR52B6 (if available)
Gene Tree for OR52B6 (if available)
Evolutionary constrained regions (ECRs) for OR52B6: view image

Paralogs for OR52B6 Gene

Paralogs for OR52B6 Gene

(449) SIMAP similar genes for OR52B6 Gene using alignment to 1 proteins:

  • O52B6_HUMAN
genes like me logo Genes that share paralogs with OR52B6: view

Variants for OR52B6 Gene

Sequence variations from dbSNP and Humsavar for OR52B6 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000660153 -- 5,579,406(+) G/A upstream_transcript_variant
rs1001258955 -- 5,580,309(+) AAAAAAAA/AAAAAAA upstream_transcript_variant
rs1002165771 -- 5,579,998(+) C/T upstream_transcript_variant
rs1002660519 -- 5,579,049(+) AT/ upstream_transcript_variant
rs1002912380 -- 5,581,775(+) A/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for OR52B6 Gene

Variant ID Type Subtype PubMed ID
esv3625236 CNV loss 21293372
esv3625237 CNV loss 21293372
esv3891919 CNV loss 25118596
nsv1041568 CNV loss 25217958
nsv1046068 CNV gain 25217958
nsv1048608 CNV gain 25217958
nsv553241 CNV gain 21841781

Variation tolerance for OR52B6 Gene

Residual Variation Intolerance Score: 92.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.13; 51.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR52B6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52B6 Gene

Disorders for OR52B6 Gene

Additional Disease Information for OR52B6

No disorders were found for OR52B6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52B6 Gene

Publications for OR52B6 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR52B6 Gene

Sources for OR52B6 Gene

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