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Aliases for OR52B2 Gene

Aliases for OR52B2 Gene

  • Olfactory Receptor Family 52 Subfamily B Member 2 2 3 5
  • Olfactory Receptor OR11-70 3 4
  • Olfactory Receptor, Family 52, Subfamily B, Member 2 2
  • Olfactory Receptor 52B2 3
  • OR11-70 3

External Ids for OR52B2 Gene

Previous GeneCards Identifiers for OR52B2 Gene

  • GC11U990507
  • GC11M006155
  • GC11M006147
  • GC11M006193

Summaries for OR52B2 Gene

Entrez Gene Summary for OR52B2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52B2 Gene

OR52B2 (Olfactory Receptor Family 52 Subfamily B Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52H1.

UniProtKB/Swiss-Prot for OR52B2 Gene

  • Odorant receptor.

Gene Wiki entry for OR52B2 Gene

Additional gene information for OR52B2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52B2 Gene

Genomics for OR52B2 Gene

GeneHancer (GH) Regulatory Elements for OR52B2 Gene

Promoters and enhancers for OR52B2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J006218 Enhancer 0.8 FANTOM5 Ensembl ENCODE 9.4 -48.9 -48938 1.5 NFYB FAM160A2 OR52B2 CAVIN3 TPP1 C11orf42
GH11J006315 Enhancer 0.8 Ensembl ENCODE 9.2 -145.6 -145574 0.5 CTCF ZNF654 TRIM22 REST ZNF48 RAD21 XRCC5 SKIL EGR1 SMC3 LOC101927825 OR56A1 OR52B2 CAVIN3 ENSG00000270435 GC11M006313
GH11J006287 Enhancer 0.6 ENCODE 10 -118.2 -118243 2.1 RFX1 CEBPB CEBPG DPF2 SKIL JUND GATA3 CTBP1 FOS CAVIN3 CCKBR FAM160A2 C11orf42 OR52W1 OR52B2 OR56A1 ENSG00000270435 GC11M006277
GH11J006281 Enhancer 0.6 ENCODE 10 -111.3 -111342 0.8 CTCF FOXA2 NANOG RNF2 SOX6 ZNF384 ZNF2 RAD21 FOXA1 SP1 CCKBR CAVIN3 OR52B2 OR56A1 FAM160A2 C11orf42 OR52W1 GC11M006277 ENSG00000270435
GH11J006129 Enhancer 0.3 Ensembl 10.8 +40.9 40907 0.6 POLR2A OR56B3P OR52B2 OR56A1 OR52B1P ENSG00000254444
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR52B2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR52B2 gene promoter:
  • IRF-7A
  • Roaz
  • STAT5A
  • AREB6
  • Evi-1
  • AP-1
  • HSF2
  • FOXC1
  • POU2F1a

Genomic Locations for OR52B2 Gene

Genomic Locations for OR52B2 Gene
1,079 bases
Minus strand
1,079 bases
Minus strand

Genomic View for OR52B2 Gene

Genes around OR52B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52B2 Gene

Proteins for OR52B2 Gene

  • Protein details for OR52B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 52B2
    Protein Accession:
    Secondary Accessions:
    • Q8NGM7

    Protein attributes for OR52B2 Gene

    323 amino acids
    Molecular mass:
    36185 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52B2 Gene

Post-translational modifications for OR52B2 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR52B2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52B2 Gene

Domains & Families for OR52B2 Gene

Gene Families for OR52B2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR52B2 Gene

Suggested Antigen Peptide Sequences for OR52B2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52B2: view

Function for OR52B2 Gene

Molecular function for OR52B2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR52B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR52B2: view
genes like me logo Genes that share phenotypes with OR52B2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52B2 Gene

Localization for OR52B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52B2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR52B2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52B2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR52B2 Gene

Pathways & Interactions for OR52B2 Gene

genes like me logo Genes that share pathways with OR52B2: view

Pathways by source for OR52B2 Gene

Interacting Proteins for OR52B2 Gene

Gene Ontology (GO) - Biological Process for OR52B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52B2: view

No data available for SIGNOR curated interactions for OR52B2 Gene

Drugs & Compounds for OR52B2 Gene

No Compound Related Data Available

Transcripts for OR52B2 Gene

mRNA/cDNA for OR52B2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR52B2 Gene

Olfactory receptor, family 52, subfamily B, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR52B2 Gene

No ASD Table

Relevant External Links for OR52B2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR52B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR52B2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR52B2 Gene:


SOURCE GeneReport for Unigene cluster for OR52B2 Gene:


Evidence on tissue expression from TISSUES for OR52B2 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with OR52B2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52B2 Gene

Orthologs for OR52B2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR52B2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia OR52B2 34 33
  • 89.23 (n)
(Bos Taurus)
Mammalia OR52B2 34 33
  • 86.54 (n)
(Rattus norvegicus)
Mammalia Olr202 33
  • 85.09 (n)
(Mus musculus)
Mammalia Or52b2 51 Olfr691 16 34 33
  • 84.58 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 81 (a)
-- 34
  • 77 (a)
-- 34
  • 70 (a)
(Gallus gallus)
Aves OR52B2 33
  • 65.57 (n)
-- 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497123 33
  • 57.81 (n)
Species where no ortholog for OR52B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52B2 Gene

Gene Tree for OR52B2 (if available)
Gene Tree for OR52B2 (if available)
Evolutionary constrained regions (ECRs) for OR52B2: view image

Paralogs for OR52B2 Gene

Paralogs for OR52B2 Gene

(426) SIMAP similar genes for OR52B2 Gene using alignment to 1 proteins:

  • O52B2_HUMAN Pseudogenes for OR52B2 Gene

genes like me logo Genes that share paralogs with OR52B2: view

Variants for OR52B2 Gene

Sequence variations from dbSNP and Humsavar for OR52B2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000027535 -- 6,171,239(-) A/G upstream_transcript_variant
rs1000040505 -- 6,170,284(-) C/T coding_sequence_variant, missense_variant
rs1001192342 -- 6,170,159(-) G/T coding_sequence_variant, missense_variant
rs1002813982 -- 6,171,177(-) C/T upstream_transcript_variant
rs1005186092 -- 6,172,267(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR52B2 Gene

Variant ID Type Subtype PubMed ID
esv2421684 CNV deletion 20811451
esv2658298 CNV deletion 23128226
esv28312 CNV loss 19812545
esv3625262 CNV loss 21293372
esv3891923 CNV loss 25118596
nsv523933 CNV loss 19592680
nsv553241 CNV gain 21841781

Variation tolerance for OR52B2 Gene

Residual Variation Intolerance Score: 96.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.88; 67.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR52B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52B2 Gene

Disorders for OR52B2 Gene

Additional Disease Information for OR52B2

No disorders were found for OR52B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52B2 Gene

Publications for OR52B2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR52B2 Gene

Sources for OR52B2 Gene

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