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Aliases for OR52A5 Gene

Aliases for OR52A5 Gene

  • Olfactory Receptor Family 52 Subfamily A Member 5 2 3 5
  • Odorant Receptor HOR3beta5 3 4
  • Olfactory Receptor OR11-33 3 4
  • Olfactory Receptor, Family 52, Subfamily A, Member 5 2
  • Olfactory Receptor 52A5 3
  • OR11-33 3

External Ids for OR52A5 Gene

Previous GeneCards Identifiers for OR52A5 Gene

  • GC00U903047
  • GC11M005118
  • GC11M005109

Summaries for OR52A5 Gene

Entrez Gene Summary for OR52A5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52A5 Gene

OR52A5 (Olfactory Receptor Family 52 Subfamily A Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52A1.

UniProtKB/Swiss-Prot for OR52A5 Gene

  • Odorant receptor.

Gene Wiki entry for OR52A5 Gene

Additional gene information for OR52A5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR52A5 Gene

Genomics for OR52A5 Gene

GeneHancer (GH) Regulatory Elements for OR52A5 Gene

Top Transcription factor binding sites by QIAGEN in the OR52A5 gene promoter:
  • Tal-1beta
  • ITF-2
  • Evi-1
  • PPAR-gamma2
  • PPAR-gamma1
  • USF1
  • USF-1
  • LyF-1
  • Max1
  • c-Myc

Genomic Locations for OR52A5 Gene

Genomic Locations for OR52A5 Gene
9,581 bases
Minus strand
951 bases
Minus strand

Genomic View for OR52A5 Gene

Genes around OR52A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52A5 Gene

Proteins for OR52A5 Gene

  • Protein details for OR52A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 52A5
    Protein Accession:

    Protein attributes for OR52A5 Gene

    316 amino acids
    Molecular mass:
    35955 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52A5 Gene

Post-translational modifications for OR52A5 Gene

Other Protein References for OR52A5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52A5 Gene

Domains & Families for OR52A5 Gene

Gene Families for OR52A5 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR52A5 Gene

Suggested Antigen Peptide Sequences for OR52A5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52A5: view

Function for OR52A5 Gene

Molecular function for OR52A5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR52A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 11121057
genes like me logo Genes that share ontologies with OR52A5: view
genes like me logo Genes that share phenotypes with OR52A5: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52A5 Gene

Localization for OR52A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52A5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR52A5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 11121057
genes like me logo Genes that share ontologies with OR52A5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR52A5 Gene

Pathways & Interactions for OR52A5 Gene

genes like me logo Genes that share pathways with OR52A5: view

Pathways by source for OR52A5 Gene

Interacting Proteins for OR52A5 Gene

Gene Ontology (GO) - Biological Process for OR52A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 11121057
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52A5: view

No data available for SIGNOR curated interactions for OR52A5 Gene

Drugs & Compounds for OR52A5 Gene

No Compound Related Data Available

Transcripts for OR52A5 Gene

mRNA/cDNA for OR52A5 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR52A5 Gene

Olfactory receptor, family 52, subfamily A, member 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR52A5 Gene

No ASD Table

Relevant External Links for OR52A5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR52A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR52A5 Gene

Protein differential expression in normal tissues from HIPED for OR52A5 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR52A5 Gene

Protein tissue co-expression partners for OR52A5 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR52A5 Gene:


SOURCE GeneReport for Unigene cluster for OR52A5 Gene:

genes like me logo Genes that share expression patterns with OR52A5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52A5 Gene

Orthologs for OR52A5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52A5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466370 33
  • 98.63 (n)
-- 34
  • 98 (a)
-- 34
  • 98 (a)
(Bos Taurus)
Mammalia LOC781324 33
  • 84.41 (n)
-- 34
  • 84 (a)
-- 34
  • 83 (a)
(Mus musculus)
Mammalia Or52a5b 51 Olfr69 16 34 33
  • 81.1 (n)
Or52a5 51 Olfr68 34
  • 81 (a)
Or52a20 51 Olfr243
  • chr7:103,716,596-103,717,543
Or52a24 51 Olfr628
  • chr7:103,731,928-103,732,875
Or52ab4 51 Olfr599
  • chr7:103,338,056-103,339,000
(Rattus norvegicus)
Mammalia Olr126 33
  • 80.04 (n)
(Canis familiaris)
Mammalia -- 34
  • 79 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 79 (a)
-- 34
  • 78 (a)
-- 34
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 55 (a)
Species where no ortholog for OR52A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR52A5 Gene

Gene Tree for OR52A5 (if available)
Gene Tree for OR52A5 (if available)
Evolutionary constrained regions (ECRs) for OR52A5: view image

Paralogs for OR52A5 Gene

Paralogs for OR52A5 Gene

(324) SIMAP similar genes for OR52A5 Gene using alignment to 1 proteins:

  • O52A5_HUMAN Pseudogenes for OR52A5 Gene

genes like me logo Genes that share paralogs with OR52A5: view

Variants for OR52A5 Gene

Sequence variations from dbSNP and Humsavar for OR52A5 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1001734666 -- 5,131,427(-) A/C/G downstream_transcript_variant
rs1003015901 -- 5,133,380(-) A/G upstream_transcript_variant
rs1003479408 -- 5,133,707(-) G/A upstream_transcript_variant
rs1004828211 -- 5,134,634(-) C/T upstream_transcript_variant
rs1005419498 -- 5,134,350(-) TTTTT/TTTTTT upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR52A5 Gene

Variant ID Type Subtype PubMed ID
esv2760169 CNV gain+loss 21179565
esv3625206 CNV loss 21293372
esv3625207 CNV loss 21293372
esv3891917 CNV loss 25118596
nsv1054847 CNV gain 25217958
nsv553219 CNV gain 21841781
nsv553224 CNV loss 21841781

Variation tolerance for OR52A5 Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.13; 51.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR52A5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR52A5 Gene

Disorders for OR52A5 Gene

Additional Disease Information for OR52A5

No disorders were found for OR52A5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52A5 Gene

Publications for OR52A5 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PMID: 11121057) Bulger M … Hardison R (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 58
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR52A5 Gene

Sources for OR52A5 Gene

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