Free for academic non-profit institutions. Other users need a Commercial license
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR52A5 (Olfactory Receptor Family 52 Subfamily A Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52A1.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J005136 | Enhancer | 0.2 | Ensembl | 250.7 | +1.2 | 1155 | 0.8 | OR52A5 OR52A4P OR52E1 | ||
GH11J005129 | Enhancer | 0.8 | Ensembl | 0.4 | +8.9 | 8855 | 1 | TBP HES1 CEBPB GTF2E2 ZEB2 TAL1 TAF9B MYNN FOSL1 IRF9 | HNRNPA1P53 OR52A4P OR52A5 OR52E1 | |
GH11J005124 | Enhancer | 0.8 | ENCODE | 0.4 | +14.1 | 14090 | 0.2 | CEBPA CTCF CEBPB ARNT REST TRIM22 EBF1 SMC3 RAD21 YY1 | OR52A4P piR-48209-074 OR52A5 OR52E1 | |
GH11J005125 | Enhancer | 0.7 | Ensembl | 0.4 | +13.8 | 13756 | 0.4 | ARNT REST CTCF TRIM22 MYNN HLTF RB1 ZC3H8 CEBPG RAD21 | OR52A4P OR52A5 OR52E1 | |
GH11J005087 | Enhancer | 0.6 | ENCODE | 0.2 | +50.9 | 50871 | 0.4 | TAL1 ZNF316 TCF12 TEAD4 ARID1B DPF2 RNF2 SOX6 CBFA2T3 SMARCA4 | OR52E3P OR52S1P OR52E1 OR52A5 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | NAS | 11121057 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | NAS | 11121057 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
GO:0007608 | sensory perception of smell | NAS | 11121057 |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC466370 30 |
|
||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | LOC781324 30 |
|
||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Mouse (Mus musculus) |
Mammalia | Or52a5b 46 Olfr69 30 17 31 |
|
OneToMany |
|
Or52a5 46 Olfr68 31 |
|
OneToMany |
|
||
Or52a20 46 Olfr243 |
|
|
|||
Or52a24 46 Olfr628 |
|
|
|||
Or52ab4 46 Olfr599 |
|
|
|||
Rat (Rattus norvegicus) |
Mammalia | Olr126 30 |
|
||
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
ManyToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2760169 | CNV | gain+loss | 21179565 |
esv3625206 | CNV | loss | 21293372 |
esv3625207 | CNV | loss | 21293372 |
esv3891917 | CNV | loss | 25118596 |
nsv1054847 | CNV | gain | 25217958 |
nsv553219 | CNV | gain | 21841781 |
nsv553224 | CNV | loss | 21841781 |
No disorders were found for OR52A5 Gene.