Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR52A5 Gene

Aliases for OR52A5 Gene

  • Olfactory Receptor Family 52 Subfamily A Member 5 2 3 5
  • Odorant Receptor HOR3'Beta5 3 4
  • Olfactory Receptor OR11-33 3 4
  • Olfactory Receptor 52A5 3 4
  • Olfactory Receptor, Family 52, Subfamily A, Member 5 2
  • OR11-33 3
  • OR52A5 5

External Ids for OR52A5 Gene

Previous GeneCards Identifiers for OR52A5 Gene

  • GC00U903047
  • GC11M005118
  • GC11M005109
  • GC11M005152

Summaries for OR52A5 Gene

Entrez Gene Summary for OR52A5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR52A5 Gene

OR52A5 (Olfactory Receptor Family 52 Subfamily A Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR52A1.

UniProtKB/Swiss-Prot Summary for OR52A5 Gene

Gene Wiki entry for OR52A5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR52A5 Gene

Genomics for OR52A5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR52A5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J005136 Enhancer 0.2 Ensembl 250.7 +1.2 1155 0.8 OR52A5 OR52A4P OR52E1
GH11J005129 Enhancer 0.8 Ensembl 0.4 +8.9 8855 1 NCOR1 ZNF592 CEBPB HES1 TBP TAF9B TAL1 MYNN ATF1 STAT5A HNRNPA1P53 OR52A4P OR52A5 OR52E1
GH11J005124 Enhancer 0.8 ENCODE 0.4 +14.1 14090 0.2 ZNF654 ZNF592 CEBPA YY1 CEBPB REST TRIM22 CTCF ARNT RAD21 OR52A4P piR-48209-074 OR52A5 OR52E1
GH11J005125 Enhancer 0.7 Ensembl 0.4 +13.8 13756 0.4 ZNF592 YY1 REST TRIM22 ARNT MYNN HLTF CTCF ZC3H8 RB1 OR52A4P OR52A5 OR52E1
GH11J005087 Enhancer 0.6 ENCODE 0.2 +50.9 50871 0.4 TAL1 ZNF316 TCF12 TEAD4 DPF2 ARID1B RNF2 SOX6 CBFA2T3 SMARCA4 OR52E3P OR52S1P OR52E1 OR52A5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR52A5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR52A5

Top Transcription factor binding sites by QIAGEN in the OR52A5 gene promoter:
  • c-Myc
  • Evi-1
  • ITF-2
  • LyF-1
  • Max1
  • PPAR-gamma1
  • PPAR-gamma2
  • Tal-1beta
  • USF-1
  • USF1

Genomic Locations for OR52A5 Gene

Latest Assembly
chr11:5,128,776-5,138,356
(GRCh38/hg38)
Size:
9,581 bases
Orientation:
Minus strand

Previous Assembly
chr11:5,150,006-5,159,586
(GRCh37/hg19 by Entrez Gene)
Size:
9,581 bases
Orientation:
Minus strand

chr11:5,152,922-5,153,872
(GRCh37/hg19 by Ensembl)
Size:
951 bases
Orientation:
Minus strand

Genomic View for OR52A5 Gene

Genes around OR52A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52A5 Gene

Proteins for OR52A5 Gene

  • Protein details for OR52A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2C5-O52A5_HUMAN
    Recommended name:
    Olfactory receptor 52A5
    Protein Accession:
    Q9H2C5

    Protein attributes for OR52A5 Gene

    Size:
    316 amino acids
    Molecular mass:
    35955 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52A5 Gene

Post-translational modifications for OR52A5 Gene

  • Glycosylation at Asn5

Other Protein References for OR52A5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR52A5 Gene

Domains & Families for OR52A5 Gene

Gene Families for OR52A5 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR52A5 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR52A5 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-33 (O52A5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H2C5

UniProtKB/Swiss-Prot:

O52A5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52A5: view

Function for OR52A5 Gene

Molecular function for OR52A5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR52A5 Gene

Gene Ontology (GO) - Molecular Function for OR52A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 11121057
genes like me logo Genes that share ontologies with OR52A5: view
genes like me logo Genes that share phenotypes with OR52A5: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR52A5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52A5 Gene

Localization for OR52A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52A5 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR52A5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR52A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 11121057
genes like me logo Genes that share ontologies with OR52A5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR52A5 Gene

Pathways & Interactions for OR52A5 Gene

genes like me logo Genes that share pathways with OR52A5: view

Pathways by source for OR52A5 Gene

Interacting Proteins for OR52A5 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000303469 Q9H2C5-O52A5_HUMAN for OR52A5 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR52A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 11121057
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52A5: view

No data available for SIGNOR curated interactions for OR52A5 Gene

Drugs & Compounds for OR52A5 Gene

No Compound Related Data Available

Transcripts for OR52A5 Gene

mRNA/cDNA for OR52A5 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR52A5

Alternative Splicing Database (ASD) splice patterns (SP) for OR52A5 Gene

No ASD Table

Relevant External Links for OR52A5 Gene

GeneLoc Exon Structure for
OR52A5

Expression for OR52A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR52A5 Gene

Protein differential expression in normal tissues from HIPED for OR52A5 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR52A5 Gene



Protein tissue co-expression partners for OR52A5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR52A5

SOURCE GeneReport for Unigene cluster for OR52A5 Gene:

Hs.546593
genes like me logo Genes that share expression patterns with OR52A5: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52A5 Gene

Orthologs for OR52A5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR52A5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466370 29
  • 98.63 (n)
-- 30
  • 98 (a)
OneToMany
-- 30
  • 98 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia LOC781324 29
  • 84.41 (n)
-- 30
  • 84 (a)
OneToMany
-- 30
  • 83 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Or52a5b 45 Olfr69 29 16 30
  • 81.1 (n)
OneToMany
Or52a5 45 Olfr68 30
  • 81 (a)
OneToMany
Or52a20 45 Olfr243
  • chr7:103,716,596-103,717,543
Or52a24 45 Olfr628
  • chr7:103,731,928-103,732,875
Or52ab4 45 Olfr599
  • chr7:103,338,056-103,339,000
Rat
(Rattus norvegicus)
Mammalia Olr126 29
  • 80.04 (n)
Dog
(Canis familiaris)
Mammalia -- 30
  • 79 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 79 (a)
ManyToMany
-- 30
  • 78 (a)
ManyToMany
-- 30
  • 74 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 55 (a)
OneToMany
Species where no ortholog for OR52A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR52A5 Gene

ENSEMBL:
Gene Tree for OR52A5 (if available)
TreeFam:
Gene Tree for OR52A5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR52A5: view image
Alliance of Genome Resources:
Additional Orthologs for OR52A5

Paralogs for OR52A5 Gene

(324) SIMAP similar genes for OR52A5 Gene using alignment to 1 proteins:

  • O52A5_HUMAN

Pseudogenes.org Pseudogenes for OR52A5 Gene

genes like me logo Genes that share paralogs with OR52A5: view

Variants for OR52A5 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR52A5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR52A5 Gene

Variant ID Type Subtype PubMed ID
esv2760169 CNV gain+loss 21179565
esv3625206 CNV loss 21293372
esv3625207 CNV loss 21293372
esv3891917 CNV loss 25118596
nsv1054847 CNV gain 25217958
nsv553219 CNV gain 21841781
nsv553224 CNV loss 21841781

Variation tolerance for OR52A5 Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.13; 51.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR52A5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR52A5
Leiden Open Variation Database (LOVD)
OR52A5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR52A5 Gene

Disorders for OR52A5 Gene

Additional Disease Information for OR52A5

No disorders were found for OR52A5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52A5 Gene

Publications for OR52A5 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PMID: 11121057) Bulger M … Hardison R (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR52A5 Gene

Sources for OR52A5 Gene