Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR52A4P Gene

Aliases for OR52A4P Gene

  • Olfactory Receptor Family 52 Subfamily A Member 4 Pseudogene 2 3 5
  • OR52A4 3 4
  • Olfactory Receptor, Family 52, Subfamily A, Member 4, Pseudogene 2
  • Olfactory Receptor, Family 52, Subfamily A, Member 4 2
  • Putative Olfactory Receptor 52A4 3
  • Olfactory Receptor 52A4 4

External Ids for OR52A4P Gene

Previous HGNC Symbols for OR52A4P Gene

  • OR52A4

Summaries for OR52A4P Gene

Entrez Gene Summary for OR52A4P Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. Although originally considered to be a functional olfactory receptor, this family member is now considered to be pseudogene due to the presence of a C-terminal frameshift compared to other family members; this is also consistent with the Classifier for Olfactory Receptor Pseudogenes (CORP), as described in PMID:16939646. [provided by RefSeq, Jun 2011]

GeneCards Summary for OR52A4P Gene

OR52A4P (Olfactory Receptor Family 52 Subfamily A Member 4 Pseudogene) is a Pseudogene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot Summary for OR52A4P Gene

Additional gene information for OR52A4P Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR52A4P Gene

Genomics for OR52A4P Gene

GeneHancer (GH) Regulatory Elements for OR52A4P Gene

Promoters and enhancers for OR52A4P Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J005124 Enhancer 0.8 ENCODE 500.7 +0.2 247 0.2 CTCF REST RAD21 CTBP1 TRIM22 SMC3 ARNT MYNN TRIM28 CEBPG OR52A4P piR-48209-074
GH11J005125 Enhancer 0.7 Ensembl 500.7 -0.1 -87 0.4 CTCF REST CTBP1 TRIM22 SMC3 ARNT MYNN TRIM28 ZNF592 MEF2B OR52A4P OR52A5
GH11J005272 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10 -158.1 -158088 21.6 CTCF TCF12 BCLAF1 JUND PHB2 FOS ZBTB11 AFF1 TARDBP REST lnc-OR51B4-3 HBD HBG2 HBG1 HBB HBBP1 ENSG00000224091 ENSG00000221031 OR51V1 OR52A4P
GH11J005361 Enhancer 0.9 Ensembl ENCODE 10.1 -241.0 -241020 7.4 HINFP RELA ZNF316 NFIC POLR2A ZNF592 GTF2A2 PBX2 JUN NFE2 OR51B5 ENSG00000224091 OR51B4 OR51J1 OR51V1 OR52A4P HBB ENSG00000221031 OR51I2 ENSG00000236248
GH11J005129 Enhancer 0.8 Ensembl 0.7 -5.0 -4988 1 GTF2E2 AFF1 HES1 MYC CTBP1 JUN TAF9B NCOR1 NFRKB NEUROD1 HNRNPA1P53 OR52A4P OR52A5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR52A4P on UCSC Golden Path with GeneCards custom track

Genomic Locations for OR52A4P Gene

Genomic Locations for OR52A4P Gene
chr11:5,120,621-5,124,513
(GRCh38/hg38)
Size:
3,893 bases
Orientation:
Minus strand
chr11:5,141,849-5,145,743
(GRCh37/hg19)
Size:
3,895 bases
Orientation:
Minus strand

Genomic View for OR52A4P Gene

Genes around OR52A4P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR52A4P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR52A4P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR52A4P Gene

Proteins for OR52A4P Gene

  • Protein details for OR52A4P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMU1-O52A4_HUMAN
    Recommended name:
    Olfactory receptor 52A4
    Protein Accession:
    A6NMU1
    Secondary Accessions:
    • B9EIN7

    Protein attributes for OR52A4P Gene

    Size:
    304 amino acids
    Molecular mass:
    34901 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR52A4P Gene

Post-translational modifications for OR52A4P Gene

  • Glycosylation at Asn7

No data available for DME Specific Peptides for OR52A4P Gene

Domains & Families for OR52A4P Gene

Gene Families for OR52A4P Gene

Protein Domains for OR52A4P Gene

Suggested Antigen Peptide Sequences for OR52A4P Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor, family 52, subfamily A, member 4 (B9EIN7_HUMAN)
  • Putative olfactory receptor 52A4 (O52A4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NMU1

UniProtKB/Swiss-Prot:

O52A4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR52A4P: view

Function for OR52A4P Gene

Molecular function for OR52A4P Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR52A4P Gene

Gene Ontology (GO) - Molecular Function for OR52A4P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR52A4P: view

Phenotypes for OR52A4P Gene

genes like me logo Genes that share phenotypes with OR52A4P: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR52A4P Gene

Localization for OR52A4P Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR52A4P Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OR52A4P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR52A4P: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for OR52A4P Gene

Pathways & Interactions for OR52A4P Gene

PathCards logo

SuperPathways for OR52A4P Gene

genes like me logo Genes that share pathways with OR52A4P: view

Pathways by source for OR52A4P Gene

Interacting Proteins for OR52A4P Gene

Selected Interacting proteins: A6NMU1-O52A4_HUMAN for OR52A4P Gene via IID

;

Gene Ontology (GO) - Biological Process for OR52A4P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR52A4P: view

No data available for SIGNOR curated interactions for OR52A4P Gene

Drugs & Compounds for OR52A4P Gene

No Compound Related Data Available

Transcripts for OR52A4P Gene

mRNA/cDNA for OR52A4P Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR52A4P Gene

No ASD Table

Relevant External Links for OR52A4P Gene

GeneLoc Exon Structure for
OR52A4P

Expression for OR52A4P Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR52A4P Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR52A4P Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR52A4P

genes like me logo Genes that share expression patterns with OR52A4P: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR52A4P Gene

Orthologs for OR52A4P Gene

Evolution for OR52A4P Gene

ENSEMBL:
Gene Tree for OR52A4P (if available)
TreeFam:
Gene Tree for OR52A4P (if available)

No data available for Orthologs for OR52A4P Gene

Paralogs for OR52A4P Gene

No data available for Paralogs for OR52A4P Gene

Variants for OR52A4P Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR52A4P Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs10837374 - p.Thr303Ala
rs10837375 - p.Tyr180Ser
rs4426129 - p.Cys277Arg
rs7947334 - p.Asp87Gly

Additional Variant Information for OR52A4P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR52A4P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for OR52A4P Gene

Disorders for OR52A4P Gene

Additional Disease Information for OR52A4P

No disorders were found for OR52A4P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR52A4P Gene

Publications for OR52A4P Gene

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 54
  3. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I … Lancet D (BMC bioinformatics 2006) 3 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

Products for OR52A4P Gene

Sources for OR52A4P Gene