Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR51V1 Gene

Aliases for OR51V1 Gene

  • Olfactory Receptor Family 51 Subfamily V Member 1 2 3 5
  • Odorant Receptor HOR3'Beta1 3 4
  • Olfactory Receptor OR11-36 3 4
  • Olfactory Receptor 51A12 3 4
  • Olfactory Receptor 51V1 3 4
  • OR51A12 3 4
  • Olfactory Receptor, Family 51, Subfamily V, Member 1 2
  • OR11-36 3
  • OR51V1 5

External Ids for OR51V1 Gene

Previous HGNC Symbols for OR51V1 Gene

  • OR51A12

Previous GeneCards Identifiers for OR51V1 Gene

  • GC00U903061
  • GC11M005187
  • GC11M005177
  • GC11M005220

Summaries for OR51V1 Gene

Entrez Gene Summary for OR51V1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51V1 Gene

OR51V1 (Olfactory Receptor Family 51 Subfamily V Member 1) is a Protein Coding gene. Diseases associated with OR51V1 include Spherocytosis, Type 2 and Spherocytosis, Type 4. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51G1.

UniProtKB/Swiss-Prot Summary for OR51V1 Gene

Gene Wiki entry for OR51V1 Gene

Additional gene information for OR51V1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR51V1 Gene

Genomics for OR51V1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR51V1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J005272 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -81.9 -81901 21.6 CTCF ATF7 RFX1 LEF1 IKZF1 BACH1 JUND ETV6 DDX20 MTA2 lnc-OR51B4-3 HBD HBG2 HBG1 HBB HBBP1 ENSG00000224091 ENSG00000221031 OR51V1 OR52A4P
GH11J005361 Enhancer 0.9 Ensembl ENCODE 10.1 -164.8 -164833 7.4 CTCF ZNF512 ZNF740 FOXJ2 HMBOX1 CEBPB NFE2 ZNF316 JUN MEF2D OR51B5 ENSG00000224091 OR51B4 OR51J1 OR51V1 OR52A4P HBB ENSG00000221031 OR51I2 ENSG00000236248
GH11J005269 Promoter 0.9 EPDnew 10.2 -69.3 -69265 0.1 HNRNPUL1 PKNOX1 NR2C1 POLR2A MTA3 TAF9B NR2C2 NCOR1 TBP TFDP1 HBE1 HBBP1 HBD HBB FAM160A2 ENSG00000221031 HBG1 OR51V1 OR51B4 lnc-OR51B4-3
GH11J005383 Enhancer 0.3 Ensembl 10.3 -183.4 -183401 0.6 EZH2 OR51M1 OR51B5 OR51V1 HBB piR-48209-079 OR51J1 HBE1 HBG2 lnc-HBE1-1 ENSG00000239920
GH11J005270 Enhancer 0.3 Ensembl 10.2 -70.0 -70001 0.6 NR2F1 HBG1 HBBP1 HBD HBB ENSG00000221031 OR51V1 OR51B4 HBG2 lnc-OR51B4-3 ENSG00000284931
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR51V1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR51V1

Top Transcription factor binding sites by QIAGEN in the OR51V1 gene promoter:
  • C/EBPalpha
  • CHOP-10
  • HOXA5
  • LCR-F1
  • NRSF form 1
  • NRSF form 2
  • YY1

Genomic Locations for OR51V1 Gene

Genomic Locations for OR51V1 Gene
chr11:5,199,735-5,200,700
(GRCh38/hg38)
Size:
966 bases
Orientation:
Minus strand
chr11:5,220,965-5,221,930
(GRCh37/hg19)
Size:
966 bases
Orientation:
Minus strand

Genomic View for OR51V1 Gene

Genes around OR51V1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51V1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51V1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51V1 Gene

Proteins for OR51V1 Gene

  • Protein details for OR51V1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2C8-O51V1_HUMAN
    Recommended name:
    Olfactory receptor 51V1
    Protein Accession:
    Q9H2C8

    Protein attributes for OR51V1 Gene

    Size:
    321 amino acids
    Molecular mass:
    36749 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51V1 Gene

Post-translational modifications for OR51V1 Gene

  • Glycosylation at Asn18
  • Modification sites at PhosphoSitePlus

Other Protein References for OR51V1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51V1 Gene

Domains & Families for OR51V1 Gene

Gene Families for OR51V1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR51V1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR51V1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-36 (O51V1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H2C8

UniProtKB/Swiss-Prot:

O51V1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51V1: view

Function for OR51V1 Gene

Molecular function for OR51V1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR51V1 Gene

Gene Ontology (GO) - Molecular Function for OR51V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 11121057
genes like me logo Genes that share ontologies with OR51V1: view
genes like me logo Genes that share phenotypes with OR51V1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR51V1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR51V1 Gene

Localization for OR51V1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51V1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR51V1 gene
Compartment Confidence
plasma membrane 5
cytosol 1

Gene Ontology (GO) - Cellular Components for OR51V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 11121057
genes like me logo Genes that share ontologies with OR51V1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR51V1 Gene

Pathways & Interactions for OR51V1 Gene

genes like me logo Genes that share pathways with OR51V1: view

Pathways by source for OR51V1 Gene

Interacting Proteins for OR51V1 Gene

Gene Ontology (GO) - Biological Process for OR51V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 11121057
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR51V1: view

No data available for SIGNOR curated interactions for OR51V1 Gene

Drugs & Compounds for OR51V1 Gene

No Compound Related Data Available

Transcripts for OR51V1 Gene

mRNA/cDNA for OR51V1 Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR51V1

Alternative Splicing Database (ASD) splice patterns (SP) for OR51V1 Gene

No ASD Table

Relevant External Links for OR51V1 Gene

GeneLoc Exon Structure for
OR51V1

Expression for OR51V1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR51V1 Gene

Protein differential expression in normal tissues from HIPED for OR51V1 Gene

This gene is overexpressed in Bone marrow stromal cell (55.4) and Adipocyte (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR51V1 Gene



Protein tissue co-expression partners for OR51V1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR51V1

SOURCE GeneReport for Unigene cluster for OR51V1 Gene:

Hs.553670
genes like me logo Genes that share expression patterns with OR51V1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR51V1 Gene

Orthologs for OR51V1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR51V1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466373 30
  • 99.27 (n)
OR51V1 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC100855687 30
  • 87.16 (n)
OR51V1 31
  • 85 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia OR51V1 30 31
  • 85.91 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 82 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Or51v8 46 Olfr624 31
  • 76 (a)
OneToMany
Or51v14 46 Olfr620
  • chr7:103,611,413-103,612,351
Or51v15-ps 46 Olfr621-ps1
  • chr7:103,629,018-103,629,943
Or51v16-ps 46 Olfr626-ps1
  • chr7:103,691,755-103,692,102
Platypus
(Ornithorhynchus anatinus)
Mammalia OR51V1 31
  • 60 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 31
  • 49 (a)
OneToMany
Species where no ortholog for OR51V1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR51V1 Gene

ENSEMBL:
Gene Tree for OR51V1 (if available)
TreeFam:
Gene Tree for OR51V1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR51V1: view image

Paralogs for OR51V1 Gene

(377) SIMAP similar genes for OR51V1 Gene using alignment to 1 proteins:

  • O51V1_HUMAN
genes like me logo Genes that share paralogs with OR51V1: view

Variants for OR51V1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR51V1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs7933549 - p.Ser233Leu
VAR_079498 - p.Leu211Val

Additional dbSNP identifiers (rs#s) for OR51V1 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR51V1 Gene

Variant ID Type Subtype PubMed ID
dgv1041n100 CNV loss 25217958
dgv182e214 CNV loss 21293372
esv2760169 CNV gain+loss 21179565
esv3891916 CNV loss 25118596
esv3891917 CNV loss 25118596
nsv1048350 CNV gain 25217958
nsv523914 CNV loss 19592680

Variation tolerance for OR51V1 Gene

Residual Variation Intolerance Score: 75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.37; 76.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR51V1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR51V1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR51V1 Gene

Disorders for OR51V1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for OR51V1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spherocytosis, type 2
  • sph2
spherocytosis, type 4
  • sph4
hereditary spherocytosis
  • spherocytosis, type 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for OR51V1

genes like me logo Genes that share disorders with OR51V1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR51V1 Gene

Publications for OR51V1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PMID: 11121057) Bulger M … Hardison R (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4
  3. EPS8L2 is a new causal gene for childhood onset autosomal recessive progressive hearing loss. (PMID: 26282398) Dahmani M … Petit C (Orphanet journal of rare diseases 2015) 4
  4. Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. (PMID: 26354767) Bailey ML … Hieter P (Genetics 2015) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR51V1 Gene

Sources for OR51V1 Gene