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Aliases for OR51S1 Gene

Aliases for OR51S1 Gene

  • Olfactory Receptor Family 51 Subfamily S Member 1 2 3 5
  • Olfactory Receptor OR11-24 3 4
  • Olfactory Receptor, Family 51, Subfamily S, Member 1 2
  • Olfactory Receptor 51S1 3
  • OR11-24 3

External Ids for OR51S1 Gene

Previous GeneCards Identifiers for OR51S1 Gene

  • GC11U990510
  • GC11M004834
  • GC11M004826
  • GC11M004870

Summaries for OR51S1 Gene

Entrez Gene Summary for OR51S1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51S1 Gene

OR51S1 (Olfactory Receptor Family 51 Subfamily S Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot for OR51S1 Gene

  • Odorant receptor.

Gene Wiki entry for OR51S1 Gene

Additional gene information for OR51S1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR51S1 Gene

Genomics for OR51S1 Gene

GeneHancer (GH) Regulatory Elements for OR51S1 Gene

Promoters and enhancers for OR51S1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J004492 Enhancer 0.2 FANTOM5 8.5 +367.2 367184 0.1 OR52K2 OR51F1 OR52B4 OR51S1 OR51G2 OR51A4 OR52K1 C11orf40 OR52R1 OR51A7
GH11J004862 Enhancer 0.4 ENCODE 0.7 -3.3 -3326 0.7 SP1 NANOG OR51H1 OR51A6P OR51S1 MMP26
GH11J005328 Enhancer 0.2 FANTOM5 1.4 -469.6 -469578 0.4 OR51G1 OR51T1 OR52N2 OR52N4 OR52D1 OR52J3 MMP26 OR51L1 OR51B2 OR51M1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR51S1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR51S1 gene promoter:
  • Tal-1
  • E47
  • AML1a
  • NCX
  • En-1
  • ITF-2
  • Tal-1beta
  • Pax-4a

Genomic Locations for OR51S1 Gene

Genomic Locations for OR51S1 Gene
12,112 bases
Minus strand
1,088 bases
Minus strand

Genomic View for OR51S1 Gene

Genes around OR51S1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51S1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51S1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51S1 Gene

Proteins for OR51S1 Gene

  • Protein details for OR51S1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 51S1
    Protein Accession:
    Secondary Accessions:
    • B9EGZ1
    • Q6IFI2

    Protein attributes for OR51S1 Gene

    323 amino acids
    Molecular mass:
    35313 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51S1 Gene

Post-translational modifications for OR51S1 Gene

Other Protein References for OR51S1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51S1 Gene

Domains & Families for OR51S1 Gene

Gene Families for OR51S1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for OR51S1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51S1: view

Function for OR51S1 Gene

Molecular function for OR51S1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR51S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR51S1: view
genes like me logo Genes that share phenotypes with OR51S1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR51S1 Gene

Localization for OR51S1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51S1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR51S1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR51S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR51S1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR51S1 Gene

Pathways & Interactions for OR51S1 Gene

genes like me logo Genes that share pathways with OR51S1: view

Pathways by source for OR51S1 Gene

Interacting Proteins for OR51S1 Gene

Gene Ontology (GO) - Biological Process for OR51S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR51S1: view

No data available for SIGNOR curated interactions for OR51S1 Gene

Drugs & Compounds for OR51S1 Gene

No Compound Related Data Available

Transcripts for OR51S1 Gene

mRNA/cDNA for OR51S1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR51S1 Gene

Olfactory receptor, family 51, subfamily S, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR51S1 Gene

No ASD Table

Relevant External Links for OR51S1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR51S1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR51S1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR51S1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR51S1 Gene:


SOURCE GeneReport for Unigene cluster for OR51S1 Gene:

genes like me logo Genes that share expression patterns with OR51S1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR51S1 Gene

Orthologs for OR51S1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR51S1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OR51S1 33
  • 85.71 (n)
-- 34
  • 82 (a)
-- 34
  • 81 (a)
(Canis familiaris)
Mammalia LOC100684755 33
  • 85.36 (n)
OR51S1 34
  • 84 (a)
(Rattus norvegicus)
Mammalia Olr49 33
  • 82.41 (n)
(Mus musculus)
Mammalia Or51s1 51 Olfr571 16 34 33
  • 81.26 (n)
(Monodelphis domestica)
Mammalia OR51S1 34
  • 71 (a)
Species where no ortholog for OR51S1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR51S1 Gene

Gene Tree for OR51S1 (if available)
Gene Tree for OR51S1 (if available)
Evolutionary constrained regions (ECRs) for OR51S1: view image

Paralogs for OR51S1 Gene

(242) SIMAP similar genes for OR51S1 Gene using alignment to 1 proteins:

  • O51S1_HUMAN
genes like me logo Genes that share paralogs with OR51S1: view

No data available for Paralogs for OR51S1 Gene

Variants for OR51S1 Gene

Sequence variations from dbSNP and Humsavar for OR51S1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1001188122 -- 4,850,346(-) A/T upstream_transcript_variant
rs1001219434 -- 4,850,102(-) A/G upstream_transcript_variant
rs1001226930 -- 4,847,880(-) G/C/T downstream_transcript_variant
rs1003262993 -- 4,851,192(-) G/T upstream_transcript_variant
rs1003494079 -- 4,850,819(-) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR51S1 Gene

Variant ID Type Subtype PubMed ID
dgv1026n100 CNV loss 25217958
dgv1587n54 CNV loss 21841781
dgv1588n54 CNV loss 21841781
esv2673268 CNV deletion 23128226
esv2760633 CNV loss 21179565
esv3579253 CNV loss 25503493
esv3625193 CNV loss 21293372
esv3625195 CNV loss 21293372
esv3891914 CNV gain 25118596
nsv1054847 CNV gain 25217958
nsv467666 CNV loss 19166990
nsv7651 CNV insertion 18451855

Variation tolerance for OR51S1 Gene

Residual Variation Intolerance Score: 89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.03; 93.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR51S1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR51S1 Gene

Disorders for OR51S1 Gene

Additional Disease Information for OR51S1

No disorders were found for OR51S1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR51S1 Gene

Publications for OR51S1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR51S1 Gene

Sources for OR51S1 Gene

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