Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR51M1 Gene

Aliases for OR51M1 Gene

  • Olfactory Receptor Family 51 Subfamily M Member 1 2 3 5
  • Odorant Receptor HOR5'Beta7 3 4
  • Olfactory Receptor OR11-40 3 4
  • Olfactory Receptor 51M1 3 4
  • Olfactory Receptor, Family 51, Subfamily M, Member 1 2
  • HOR5'Beta7 3
  • OR11-40 3
  • OR51M1 5

External Ids for OR51M1 Gene

Previous GeneCards Identifiers for OR51M1 Gene

  • GC11U990338
  • GC11P005348
  • GC11P005343
  • GC11P005410

Summaries for OR51M1 Gene

Entrez Gene Summary for OR51M1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51M1 Gene

OR51M1 (Olfactory Receptor Family 51 Subfamily M Member 1) is a Protein Coding gene. Diseases associated with OR51M1 include Spherocytosis, Type 4 and Hypotrichosis 2. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51G1.

UniProtKB/Swiss-Prot Summary for OR51M1 Gene

Gene Wiki entry for OR51M1 Gene

Additional gene information for OR51M1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR51M1 Gene

Genomics for OR51M1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR51M1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J005383 Enhancer 0.3 Ensembl 600.7 +0.3 289 0.6 EZH2 OR51M1 OR51B5 OR51V1 HBB piR-48209-079 OR51J1 HBE1 HBG2 lnc-HBE1-1 ENSG00000239920
GH11J005272 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.9 -101.2 -101211 21.6 CTCF ATF7 RFX1 LEF1 IKZF1 BACH1 JUND ETV6 DDX20 MTA2 lnc-OR51B4-3 HBD HBG2 HBG1 HBB HBBP1 ENSG00000224091 ENSG00000221031 OR51V1 OR52A4P
GH11J005546 Enhancer 0.2 FANTOM5 7.5 +162.4 162434 0.1 OR56A1 OR56A3 OR51Q1 OR52E8 OR52N1 OR56A4 OR52N4 OR52E2 OR52E4 OR52A1
GH11J005328 Enhancer 0.2 FANTOM5 3 -54.6 -54634 0.4 piR-48209-076 OR51G1 OR51T1 OR52N2 OR52N4 OR52D1 OR52J3 MMP26 OR51L1 OR51B2
GH11J005379 Enhancer 0.2 FANTOM5 1.8 -3.8 -3820 0 piR-48209-078 OR51V1 OR51T1 HBB OR51B5 OR51G1 OR56B1 OR52J3 OR51L1 OR52N4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR51M1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR51M1

Top Transcription factor binding sites by QIAGEN in the OR51M1 gene promoter:
  • aMEF-2
  • AP-1
  • E47
  • GATA-2
  • LyF-1
  • MEF-2A
  • Nkx3-1
  • Nkx3-1 v1
  • STAT3
  • Tal-1beta

Genomic Locations for OR51M1 Gene

Genomic Locations for OR51M1 Gene
chr11:5,383,812-5,393,263
(GRCh38/hg38)
Size:
9,452 bases
Orientation:
Plus strand
chr11:5,410,607-5,411,664
(GRCh37/hg19)
Size:
1,058 bases
Orientation:
Plus strand

Genomic View for OR51M1 Gene

Genes around OR51M1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51M1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51M1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51M1 Gene

Proteins for OR51M1 Gene

  • Protein details for OR51M1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H341-O51M1_HUMAN
    Recommended name:
    Olfactory receptor 51M1
    Protein Accession:
    Q9H341
    Secondary Accessions:
    • Q6IF80

    Protein attributes for OR51M1 Gene

    Size:
    326 amino acids
    Molecular mass:
    36669 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51M1 Gene

Post-translational modifications for OR51M1 Gene

  • Glycosylation at Asn16
  • Modification sites at PhosphoSitePlus

Other Protein References for OR51M1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51M1 Gene

Domains & Families for OR51M1 Gene

Gene Families for OR51M1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR51M1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR51M1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor, family 51, subfamily M, member 1 (B2RNI9_HUMAN)
  • Olfactory receptor OR11-40 (O51M1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H341

UniProtKB/Swiss-Prot:

O51M1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51M1: view

Function for OR51M1 Gene

Molecular function for OR51M1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR51M1 Gene

Gene Ontology (GO) - Molecular Function for OR51M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 11121057
genes like me logo Genes that share ontologies with OR51M1: view
genes like me logo Genes that share phenotypes with OR51M1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR51M1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR51M1 Gene

Localization for OR51M1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51M1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR51M1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR51M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 11121057
genes like me logo Genes that share ontologies with OR51M1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR51M1 Gene

Pathways & Interactions for OR51M1 Gene

genes like me logo Genes that share pathways with OR51M1: view

Pathways by source for OR51M1 Gene

Interacting Proteins for OR51M1 Gene

Gene Ontology (GO) - Biological Process for OR51M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 11121057
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR51M1: view

No data available for SIGNOR curated interactions for OR51M1 Gene

Drugs & Compounds for OR51M1 Gene

No Compound Related Data Available

Transcripts for OR51M1 Gene

mRNA/cDNA for OR51M1 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR51M1

Alternative Splicing Database (ASD) splice patterns (SP) for OR51M1 Gene

No ASD Table

Relevant External Links for OR51M1 Gene

GeneLoc Exon Structure for
OR51M1

Expression for OR51M1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR51M1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR51M1

SOURCE GeneReport for Unigene cluster for OR51M1 Gene:

Hs.553731
genes like me logo Genes that share expression patterns with OR51M1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR51M1 Gene

Orthologs for OR51M1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR51M1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466376 30
  • 98.56 (n)
OR51M1 31
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia OR51M1 30 31
  • 85.44 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC617878 30
  • 84.37 (n)
OR51M1 31
  • 84 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Or51m1 46 Olfr631 30 17 31
  • 83.7 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 50 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves COR3'BETA 31
  • 52 (a)
OneToOne
Species where no ortholog for OR51M1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR51M1 Gene

ENSEMBL:
Gene Tree for OR51M1 (if available)
TreeFam:
Gene Tree for OR51M1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR51M1: view image

Paralogs for OR51M1 Gene

(422) SIMAP similar genes for OR51M1 Gene using alignment to 2 proteins:

  • O51M1_HUMAN
  • B2RNI9_HUMAN
genes like me logo Genes that share paralogs with OR51M1: view

Variants for OR51M1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR51M1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs10768907 - p.Phe318Leu
rs1498467 - p.His102Gln
rs1498468 - p.Leu135Phe
rs1498469 - p.Ile204Thr
rs2736531 - p.Leu257Arg

Additional dbSNP identifiers (rs#s) for OR51M1 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR51M1 Gene

Variant ID Type Subtype PubMed ID
esv22160 CNV loss 19812545
esv2761646 CNV loss 21179565
nsv1044243 CNV loss 25217958
nsv1046068 CNV gain 25217958
nsv1048608 CNV gain 25217958
nsv524400 CNV loss 19592680
nsv832057 CNV loss 17160897

Variation tolerance for OR51M1 Gene

Residual Variation Intolerance Score: 98.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.16; 92.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR51M1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR51M1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR51M1 Gene

Disorders for OR51M1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for OR51M1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spherocytosis, type 4
  • sph4
hypotrichosis 2
  • hypt2
hereditary spherocytosis
  • spherocytosis, type 1
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with OR51M1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR51M1 Gene

Publications for OR51M1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PMID: 11121057) Bulger M … Hardison R (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3
  5. Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. (PMID: 10220430) Bulger M … von Doorninck JH (Proceedings of the National Academy of Sciences of the United States of America 1999) 3

Products for OR51M1 Gene

Sources for OR51M1 Gene