OR51L1 Gene (Protein Coding)

Olfactory Receptor Family 51 Subfamily L Member 1

GC11P004976
GIFtS:
27
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR51L1 Gene

Aliases for OR51L1 Gene

  • Olfactory Receptor Family 51 Subfamily L Member 1 2 3 5
  • Olfactory Receptor OR11-31 3 4
  • Olfactory Receptor 51L1 3 4
  • Olfactory Receptor, Family 51, Subfamily L, Member 1 2
  • OR11-31 3
  • OR51L1 5

External Ids for OR51L1 Gene

Previous GeneCards Identifiers for OR51L1 Gene

  • GC11U990314
  • GC11P004985

Summaries for OR51L1 Gene

Entrez Gene Summary for OR51L1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51L1 Gene

OR51L1 (Olfactory Receptor Family 51 Subfamily L Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51G2.

UniProtKB/Swiss-Prot Summary for OR51L1 Gene

Gene Wiki entry for OR51L1 Gene

Additional gene information for OR51L1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR51L1 Gene

Genomics for OR51L1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for OR51L1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11J005379 Enhancer 0.2 FANTOM5 6.1 +385.1 385141 0 piR-48209-078 OR51V1 OR51T1 HBB OR51B5 OR51G1 OR56B1 OR52J3 OR51L1 OR52N4
GH11J005328 Enhancer 0.2 FANTOM5 3.8 +334.3 334327 0.4 HSALNG0082369 piR-48209-076 OR51G1 OR51T1 OR52N2 OR52N4 OR52D1 OR52J3 MMP26 OR51L1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR51L1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR51L1

Top Transcription factor binding sites by QIAGEN in the OR51L1 gene promoter:
  • AML1a
  • E47
  • Ik-3
  • Meis-1a
  • Nkx5-1
  • RORalpha1
  • RP58
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for OR51L1 Gene

Latest Assembly
chr11:4,994,851-5,005,536
(GRCh38/hg38)
Size:
10,686 bases
Orientation:
Plus strand

Previous Assembly
chr11:5,016,081-5,026,766
(GRCh37/hg19 by Entrez Gene)
Size:
10,686 bases
Orientation:
Plus strand

chr11:5,020,213-5,021,160
(GRCh37/hg19 by Ensembl)
Size:
948 bases
Orientation:
Plus strand

Genomic View for OR51L1 Gene

Genes around OR51L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51L1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OR51L1 Gene

Proteins for OR51L1 Gene

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  • Protein details for OR51L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGJ5-O51L1_HUMAN
    Recommended name:
    Olfactory receptor 51L1
    Protein Accession:
    Q8NGJ5
    Secondary Accessions:
    • Q6IFE5

    Protein attributes for OR51L1 Gene

    Size:
    315 amino acids
    Molecular mass:
    35369 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51L1 Gene

Post-translational modifications for OR51L1 Gene

  • Glycosylation at Asn5

Other Protein References for OR51L1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51L1 Gene

Domains & Families for OR51L1 Gene

Gene Families for OR51L1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR51L1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR51L1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-31 (O51L1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGJ5

UniProtKB/Swiss-Prot:

O51L1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51L1: view

Function for OR51L1 Gene

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  6. Cell Lines for research

Molecular function for OR51L1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR51L1 Gene

Gene Ontology (GO) - Molecular Function for OR51L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR51L1: view
genes like me logo Genes that share phenotypes with OR51L1: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR51L1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR51L1 Gene

Localization for OR51L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51L1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR51L1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR51L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR51L1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR51L1 Gene

Pathways & Interactions for OR51L1 Gene

genes like me logo Genes that share pathways with OR51L1: view

Pathways by source for OR51L1 Gene

1 KEGG pathway for OR51L1 Gene

Interacting Proteins for OR51L1 Gene

Selected Interacting proteins: Q8NGJ5-O51L1_HUMAN for OR51L1 Gene via IID

GPS-Prot Interaction Network for OR51L1

Gene Ontology (GO) - Biological Process for OR51L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR51L1: view

No data available for SIGNOR curated interactions for OR51L1 Gene

Drugs & Compounds for OR51L1 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for OR51L1 Gene

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mRNA/cDNA for OR51L1 Gene

1 REFSEQ mRNAs :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR51L1

Alternative Splicing Database (ASD) splice patterns (SP) for OR51L1 Gene

No ASD Table

Relevant External Links for OR51L1 Gene

GeneLoc Exon Structure for
OR51L1

Expression for OR51L1 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR51L1 Gene

mRNA expression in normal human tissues for OR51L1 Gene
mRNA expression by GTEx for OR51L1 GenemRNA expression by BioGPS for OR51L1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR51L1

SOURCE GeneReport for Unigene cluster for OR51L1 Gene:

Hs.553559
genes like me logo Genes that share expression patterns with OR51L1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR51L1 Gene

Orthologs for OR51L1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR51L1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia LOC466361 29
  • 99.37 (n)
OR51L1 30
  • 99 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia LOC610109 29
  • 88.1 (n)
OR51L1 30
  • 86 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia LOC788739 29
  • 87.82 (n)
OR51L1 30
  • 86 (a)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Olr78 29
  • 84.44 (n)
Oppossum
(Monodelphis domestica)
 Mammalia -- 30
  • 55 (a)
 OneToMany
Mouse
(Mus musculus)
 Mammalia Olfr609 30
  • 54 (a)
 OneToMany
Or51ai2 45 Olfr632
  • chr7:103,937,382-103,938,332
Or51l1-ps 45 Olfr587-ps1
  • chr7:103,134,376-103,135,302
Platypus
(Ornithorhynchus anatinus)
 Mammalia OR51L1 30
  • 53 (a)
 OneToOne
Species where no ortholog for OR51L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR51L1 Gene

ENSEMBL:
Gene Tree for OR51L1 (if available)
TreeFam:
Gene Tree for OR51L1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR51L1: view image
Alliance of Genome Resources:
Additional Orthologs for OR51L1

Paralogs for OR51L1 Gene

Paralogs for OR51L1 Gene

(418) SIMAP similar genes for OR51L1 Gene using alignment to 1 proteins:

  • O51L1_HUMAN

Pseudogenes.org Pseudogenes for OR51L1 Gene

genes like me logo Genes that share paralogs with OR51L1: view

Variants for OR51L1 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR51L1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs10768448 -- p.Thr196Ile
rs10768450 -- p.Ala207Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR51L1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR51L1 Gene

Variant ID Type Subtype PubMed ID
esv2759799 CNV loss 17122850
esv2760169 CNV gain+loss 21179565
esv33877 CNV gain 17666407
nsv1054847 CNV gain 25217958
nsv526998 CNV loss 19592680

Variation tolerance for OR51L1 Gene

Residual Variation Intolerance Score: 95.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.37; 76.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR51L1 Gene

Human Gene Mutation Database (HGMD)
OR51L1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR51L1
Leiden Open Variation Database (LOVD)
OR51L1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR51L1 Gene

Disorders for OR51L1 Gene

Additional Disease Information for OR51L1

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for OR51L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR51L1 Gene

Publications for OR51L1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3
  3. Genetic determinants of haemolysis in sickle cell anaemia. (PMID: 23406172) Milton JN … Steinberg MH (British journal of haematology 2013) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

ExternalLinks

View latest publications for OR51L1 gene in Mastermind

Products for OR51L1 Gene

Sources for OR51L1 Gene