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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR51L1 (Olfactory Receptor Family 51 Subfamily L Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51G2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J005379 | Enhancer | 0.2 | FANTOM5 | 6.1 | +385.1 | 385141 | 0 | piR-48209-078 OR51V1 OR51T1 HBB OR51B5 OR51G1 OR56B1 OR52J3 OR51L1 OR52N4 | ||
GH11J005328 | Enhancer | 0.2 | FANTOM5 | 3.8 | +334.3 | 334327 | 0.4 | piR-48209-076 OR51G1 OR51T1 OR52N2 OR52N4 OR52D1 OR52J3 MMP26 OR51L1 OR51B2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
GO:0007608 | sensory perception of smell | IEA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC466361 30 |
|
||
OR51L1 31 |
|
OneToOne | |||
Dog (Canis familiaris) |
Mammalia | LOC610109 30 |
|
||
OR51L1 31 |
|
OneToOne | |||
Cow (Bos Taurus) |
Mammalia | LOC788739 30 |
|
||
OR51L1 31 |
|
OneToOne | |||
Rat (Rattus norvegicus) |
Mammalia | Olr78 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Mouse (Mus musculus) |
Mammalia | Olfr609 31 |
|
OneToMany | |
Or51ai2 46 Olfr632 |
|
|
|||
Or51l1-ps 46 Olfr587-ps1 |
|
|
|||
Platypus (Ornithorhynchus anatinus) |
Mammalia | OR51L1 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs10768448 | - | p.Thr196Ile | |||
rs10768450 | - | p.Ala207Val |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759799 | CNV | loss | 17122850 |
esv2760169 | CNV | gain+loss | 21179565 |
esv33877 | CNV | gain | 17666407 |
nsv1054847 | CNV | gain | 25217958 |
nsv526998 | CNV | loss | 19592680 |
No disorders were found for OR51L1 Gene.