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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR51I2 (Olfactory Receptor Family 51 Subfamily I Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51I1.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J005361 | Enhancer | 0.9 | Ensembl ENCODE | 9.4 | -83.8 | -83790 | 7.4 | CTCF ZNF512 ZNF740 FOXJ2 HMBOX1 CEBPB NFE2 ZNF316 JUN MEF2D | OR51B5 ENSG00000224091 OR51B4 OR51J1 OR51V1 OR52A4P HBB ENSG00000221031 OR51I2 ENSG00000236248 | |
GH11J005550 | Enhancer | 0.8 | Ensembl ENCODE | 9.7 | +101.6 | 101578 | 1.4 | JUND FOS FOSL1 CUX1 FOSL2 BHLHE40 DPF2 ATF3 JUN MTA2 | OR52H2P lnc-OR52H1-2 OR51B5 HBE1 HBG2 TRIM6 OR52D1 OR51I2 OLFM5P UBQLNL | |
GH11J005556 | Enhancer | 0.4 | Ensembl | 9.7 | +107.7 | 107678 | 0.4 | IKZF1 HDAC1 MNT ZNF766 | OR52B5P HBE1 HBG2 OR51B5 TRIM6 OR52D1 OR51I2 OLFM5P OR52H2P OR52H1 | |
GH11J005476 | Enhancer | 0.6 | ENCODE | 0.3 | +27.1 | 27073 | 0.1 | CTCF PKNOX1 REST RAD21 TRIM22 SOX6 SMC3 ZNF143 MEIS2 YY1 | piR-46002-065 piR-57176-069 OR51A10P OR52D1 HBE1 HBG2 OR51B5 OR51I2 lnc-HBE1-1 ENSG00000239920 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | NAS | 11121057 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | NAS | 11121057 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
GO:0007608 | sensory perception of smell | NAS | 11121057 |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC466379 30 |
|
||
OR51I2 31 |
|
OneToOne | |||
Dog (Canis familiaris) |
Mammalia | OR51I2 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | LOC508808 30 |
|
||
OR51I2 31 |
|
OneToOne | |||
Rat (Rattus norvegicus) |
Mammalia | Olr143 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Or51i2 46 Olfr641 30 17 31 |
|
OneToOne |
|
Oppossum (Monodelphis domestica) |
Mammalia | OR51I2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs10450603 | - | p.Arg122Cys | |||
rs11037502 | - | p.Arg263His | |||
rs12577167 | - | p.Thr134Ala | |||
rs16931292 | - | p.Arg151Pro |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1042n100 | CNV | gain | 25217958 |
esv2664205 | CNV | deletion | 23128226 |
esv2759800 | CNV | loss | 17122850 |
esv2761647 | CNV | loss | 21179565 |
esv34391 | CNV | loss | 17911159 |
esv3625225 | CNV | loss | 21293372 |
esv3625227 | CNV | loss | 21293372 |
nsv1039047 | CNV | gain | 25217958 |
nsv1046068 | CNV | gain | 25217958 |
nsv1048608 | CNV | gain | 25217958 |
nsv832057 | CNV | loss | 17160897 |
No disorders were found for OR51I2 Gene.