OR51I2 Gene (Protein Coding)

Olfactory Receptor Family 51 Subfamily I Member 2

GC11P005449
GIFtS:
31
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR51I2 Gene

Aliases for OR51I2 Gene

  • Olfactory Receptor Family 51 Subfamily I Member 2 2 3 5
  • Odorant Receptor HOR5'Beta12 3 4
  • Olfactory Receptor OR11-38 3 4
  • Olfactory Receptor 51I2 3 4
  • Olfactory Receptor, Family 51, Subfamily I, Member 2 2
  • HOR5'Beta12 3
  • OR11-38 3
  • OR51I2 5

External Ids for OR51I2 Gene

Previous GeneCards Identifiers for OR51I2 Gene

  • GC11U990513
  • GC11P005439
  • GC11P005431
  • GC11P005476

Summaries for OR51I2 Gene

Entrez Gene Summary for OR51I2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51I2 Gene

OR51I2 (Olfactory Receptor Family 51 Subfamily I Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51I1.

UniProtKB/Swiss-Prot Summary for OR51I2 Gene

Gene Wiki entry for OR51I2 Gene

Additional gene information for OR51I2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR51I2 Gene

Genomics for OR51I2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for OR51I2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR51I2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR51I2

Top Transcription factor binding sites by QIAGEN in the OR51I2 gene promoter:
  • c-Myc
  • C/EBPalpha
  • Evi-1
  • FOXO1
  • FOXO1a
  • HOXA9
  • Max1
  • p53
  • POU2F1
  • POU2F1a

Genomic Locations for OR51I2 Gene

Latest Assembly
chr11:5,449,323-5,456,518
(GRCh38/hg38)
Size:
7,196 bases
Orientation:
Plus strand

Previous Assembly
chr11:5,470,553-5,477,748
(GRCh37/hg19 by Entrez Gene)
Size:
7,196 bases
Orientation:
Plus strand

chr11:5,474,638-5,475,707
(GRCh37/hg19 by Ensembl)
Size:
1,070 bases
Orientation:
Plus strand

Genomic View for OR51I2 Gene

Genes around OR51I2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51I2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51I2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OR51I2 Gene

Proteins for OR51I2 Gene

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  • Protein details for OR51I2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H344-O51I2_HUMAN
    Recommended name:
    Olfactory receptor 51I2
    Protein Accession:
    Q9H344
    Secondary Accessions:
    • B9EIL6
    • Q6IF81

    Protein attributes for OR51I2 Gene

    Size:
    312 amino acids
    Molecular mass:
    35002 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51I2 Gene

Protein Expression for OR51I2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for OR51I2 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR51I2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51I2 Gene

Domains & Families for OR51I2 Gene

Gene Families for OR51I2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR51I2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR51I2 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor, family 51, subfamily I, member 2 (B9EIL6_HUMAN)
  • Olfactory receptor OR11-38 (O51I2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H344

UniProtKB/Swiss-Prot:

O51I2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51I2: view

Function for OR51I2 Gene

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  4. Inhibitory RNAs for research
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  6. Cell Lines for research

Molecular function for OR51I2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR51I2 Gene

Gene Ontology (GO) - Molecular Function for OR51I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 11121057
genes like me logo Genes that share ontologies with OR51I2: view
genes like me logo Genes that share phenotypes with OR51I2: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR51I2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR51I2 Gene

Localization for OR51I2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51I2 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR51I2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR51I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 11121057
genes like me logo Genes that share ontologies with OR51I2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR51I2 Gene

Pathways & Interactions for OR51I2 Gene

genes like me logo Genes that share pathways with OR51I2: view

Pathways by source for OR51I2 Gene

1 KEGG pathway for OR51I2 Gene

Interacting Proteins for OR51I2 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000341987 Q9H344-O51I2_HUMAN for OR51I2 Gene via STRING IID

GPS-Prot Interaction Network for OR51I2

Gene Ontology (GO) - Biological Process for OR51I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 11121057
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR51I2: view

No data available for SIGNOR curated interactions for OR51I2 Gene

Drugs & Compounds for OR51I2 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for OR51I2 Gene

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mRNA/cDNA for OR51I2 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR51I2

Alternative Splicing Database (ASD) splice patterns (SP) for OR51I2 Gene

No ASD Table

Relevant External Links for OR51I2 Gene

GeneLoc Exon Structure for
OR51I2

Expression for OR51I2 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR51I2 Gene

mRNA expression in normal human tissues for OR51I2 Gene
mRNA expression by GTEx for OR51I2 GenemRNA expression by BioGPS for OR51I2 Gene

Protein differential expression in normal tissues from HIPED for OR51I2 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR51I2 Gene



Protein tissue co-expression partners for OR51I2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR51I2

SOURCE GeneReport for Unigene cluster for OR51I2 Gene:

Hs.553733

Evidence on tissue expression from TISSUES for OR51I2 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with OR51I2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR51I2 Gene

Orthologs for OR51I2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR51I2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia LOC466379 29
  • 99.79 (n)
OR51I2 30
  • 99 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia OR51I2 30
  • 90 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia LOC508808 29
  • 89.1 (n)
OR51I2 30
  • 89 (a)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Olr143 29
  • 88.35 (n)
Mouse
(Mus musculus)
 Mammalia Or51i2 45 Olfr641 29 16 30
  • 88.03 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia OR51I2 30
  • 82 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 30
  • 50 (a)
 ManyToMany
Species where no ortholog for OR51I2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR51I2 Gene

ENSEMBL:
Gene Tree for OR51I2 (if available)
TreeFam:
Gene Tree for OR51I2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR51I2: view image
Alliance of Genome Resources:
Additional Orthologs for OR51I2

Paralogs for OR51I2 Gene

Paralogs for OR51I2 Gene

(429) SIMAP similar genes for OR51I2 Gene using alignment to 2 proteins:

  • O51I2_HUMAN
  • B9EIL6_HUMAN

Pseudogenes.org Pseudogenes for OR51I2 Gene

genes like me logo Genes that share paralogs with OR51I2: view

Variants for OR51I2 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR51I2 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs10450603 -- p.Arg122Cys
rs11037502 -- p.Arg263His
rs12577167 -- p.Thr134Ala
rs16931292 -- p.Arg151Pro

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR51I2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR51I2 Gene

Variant ID Type Subtype PubMed ID
dgv1042n100 CNV gain 25217958
esv2664205 CNV deletion 23128226
esv2759800 CNV loss 17122850
esv2761647 CNV loss 21179565
esv34391 CNV loss 17911159
esv3625225 CNV loss 21293372
esv3625227 CNV loss 21293372
nsv1039047 CNV gain 25217958
nsv1046068 CNV gain 25217958
nsv1048608 CNV gain 25217958
nsv832057 CNV loss 17160897

Variation tolerance for OR51I2 Gene

Residual Variation Intolerance Score: 93.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.06; 96.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR51I2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR51I2
Leiden Open Variation Database (LOVD)
OR51I2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR51I2 Gene

Disorders for OR51I2 Gene

Additional Disease Information for OR51I2

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for OR51I2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR51I2 Gene

Publications for OR51I2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PMID: 11121057) Bulger M … Hardison R (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4
  3. Genetic determinants of haemolysis in sickle cell anaemia. (PMID: 23406172) Milton JN … Steinberg MH (British journal of haematology 2013) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

ExternalLinks

View latest publications for OR51I2 gene in Mastermind

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Sources for OR51I2 Gene