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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]
OR51G1 (Olfactory Receptor Family 51 Subfamily G Member 1) is a Protein Coding gene. Diseases associated with OR51G1 include Branchiootorenal Syndrome 1. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51G2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J004891 | Enhancer | 0.6 | Ensembl | 10.8 | +32.4 | 32438 | 0.6 | JUND ZNF24 HMBOX1 NFE2 FOS FOSL1 NFIC ARNT ATF3 SMARCE1 | OR51A6P lnc-OR51G2-1 MMP26 OR51G1 OR51H1 OR51A7 OR51T1 | |
GH11J004892 | Enhancer | 0.6 | ENCODE | 10.8 | +32.1 | 32103 | 0 | JUND ZNF24 HMBOX1 NFE2 FOS FOSL1 NFIC ARNT ATF3 SMARCE1 | OR51A6P lnc-OR51G2-1 OR51G1 OR51H1 OR51A7 OR51T1 MMP26 | |
GH11J005328 | Enhancer | 0.2 | FANTOM5 | 21.1 | -404.8 | -404839 | 0.4 | piR-48209-076 OR51G1 OR51T1 OR52N2 OR52N4 OR52D1 OR52J3 MMP26 OR51L1 OR51B2 | ||
GH11J005379 | Enhancer | 0.2 | FANTOM5 | 8.9 | -455.7 | -455653 | 0 | piR-48209-078 OR51V1 OR51T1 HBB OR51B5 OR51G1 OR56B1 OR52J3 OR51L1 OR52N4 | ||
GH11J004480 | Enhancer | 1 | FANTOM5 Ensembl ENCODE | 1.7 | +442.0 | 442038 | 5 | PRDM10 ZNF692 JUND NFE2 ZNF316 FOS FOSL1 MYNN SPI1 ZFP69B | OR52K1 OR52K3P TRIM68 TRIM21 OR51F2 OR52K2 OR51D1 OR51T1 OR51G1 HSALNG0082349 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
GO:0007608 | sensory perception of smell | IEA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC748426 30 |
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||
Cow (Bos Taurus) |
Mammalia | LOC504551 30 |
|
||
Dog (Canis familiaris) |
Mammalia | OR51G1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Or51g1 46 Olfr578 30 17 |
|
|
|
Rat (Rattus norvegicus) |
Mammalia | Olr70 30 |
|
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs10836954 | - | p.Ser114Leu | |||
rs12796015 | - | p.Ile195Thr | |||
rs1378739 | - | p.Tyr125Ser | |||
rs34742470 | - | p.Arg124His | |||
rs57920748 | - | p.Gln303His |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv306e212 | CNV | loss | 25503493 |
esv2759799 | CNV | loss | 17122850 |
esv3579254 | CNV | loss | 25503493 |
esv3891914 | CNV | gain | 25118596 |
nsv1054847 | CNV | gain | 25217958 |
Disorder | Aliases | PubMed IDs |
---|---|---|
branchiootorenal syndrome 1 |
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